Strain Name:
C57BL/6J-MtgxR6648Btlr/Mmmh
Stock Number:
044769-MU
Citation ID:
RRID:MMRRC_044769-MU
Other Names:
R6648 (G1)
Major Collection:

Strain Information

Myh9
Name: myosin, heavy polypeptide 9, non-muscle
Synonyms: myosin IIA, E030044M24Rik, NMHC II-A, Fltn, Myhn-1, Myhn1, D0Jmb2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 17886
HGNC: HGNC:7579
Homologene: 129835
Chat
Name: choline acetyltransferase
Synonyms: B230380D24Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12647
VEGA: 14
HGNC: HGNC:1912
Homologene: 40693
Cacna1g
Name: calcium channel, voltage-dependent, T type, alpha 1G subunit
Synonyms: a1G, Cav3.1d
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12291
HGNC: HGNC:1394
Homologene: 22544
Dst
Name: dystonin
Synonyms: Macf2, A830042E19Rik, Bpag1, Bpag, bullous pemphigoid antigen 1, nmf203, athetoid, nmf339, BPAG1, BPAG1-n, 2310001O04Rik, bullous pemphigoid antigen 1, ah
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Ece1
Name: endothelin converting enzyme 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230857
HGNC: HGNC:3146
Homologene: 1068
Iqgap2
Name: IQ motif containing GTPase activating protein 2
Synonyms: 4933417J23Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 544963
VEGA: 13
HGNC: HGNC:6111
Homologene: 101543
Ccar2
Name: cell cycle activator and apoptosis regulator 2
Synonyms: 2610301G19Rik, Dbc1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219158
VEGA: 14
Homologene: 10910
Rsf1
Name: remodeling and spacing factor 1
Synonyms: Hbxap, p325, XAP8, C030033M12Rik, 4832420A03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233532
Homologene: 41142
Mki67
Name: antigen identified by monoclonal antibody Ki 67
Synonyms: Ki67, Ki-67, D630048A14Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17345
HGNC: HGNC:7107
Homologene: 1814
Slc41a3
Name: solute carrier family 41, member 3
Synonyms: 1010001P06Rik, SLC41A1-L2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 71699
Homologene: 23052
Osbpl9
Name: oxysterol binding protein-like 9
Synonyms: 2600011I06Rik, ORP-9
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100273
Homologene: 69380
Ubr4
Name: ubiquitin protein ligase E3 component n-recognin 4
Synonyms: LOC381562, A930005E13Rik, D930005K06Rik, Zubr1, p600, 1810009A16Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 69116
Homologene: 10804
Nbeal2
Name: neurobeachin-like 2
Synonyms: 1110014F23Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235627
Homologene: 86422
Ecrg4
Name: ECRG4 augurin precursor
Synonyms: augurin, 1500015O10Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 78896
Homologene: 11505
Ddx24
Name: DEAD box helicase 24
Synonyms: DEAD (Asp-Glu-Ala-Asp) box polypeptide 24, 2510027P10Rik, 1700055J08Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 27225
VEGA: 12
Homologene: 10702
Zmynd11
Name: zinc finger, MYND domain containing 11
Synonyms: 2210402G22Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 66505
Homologene: 4828
Cep76
Name: centrosomal protein 76
Synonyms: 6230425F05Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225659
VEGA: 18
Homologene: 11774
Zswim4
Name: zinc finger SWIM-type containing 4
Synonyms: E130119J17Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 212168
Homologene: 18183
Plcd4
Name: phospholipase C, delta 4
Synonyms: 4921507K24Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18802
HGNC: HGNC:9062
Homologene: 88782
Hydin
Name: HYDIN, axonemal central pair apparatus protein
Synonyms: 4930545D19Rik, hyrh, hy-3, hy3, 1700034M11Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244653
Homologene: 52118
Pgm5
Name: phosphoglucomutase 5
Synonyms: aciculin, 9530034F03Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226041
HGNC: HGNC:8908
Homologene: 74881
Pcsk5
Name: proprotein convertase subtilisin/kexin type 5
Synonyms: b2b585Clo, PC6, SPC6, PC5/6A, PC5A, b2b1549Clo
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18552
VEGA: 19
HGNC: HGNC:8747
Homologene: 21244
Rnf213
Name: ring finger protein 213
Synonyms: D11Ertd759e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 672511
Homologene: 45439
Arhgef38
Name: Rho guanine nucleotide exchange factor 38
Synonyms: D630013G24Rik, 9130221D24Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 77669
Homologene: 137396
Vmn1r194
Name: vomeronasal 1 receptor 194
Synonyms: Gm11294
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 626299
Homologene: 110880
Mybpc1
Name: myosin binding protein C, slow-type
Synonyms: Slow-type C-protein, 8030451F13Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 109272
HGNC: HGNC:7549
Homologene: 1846
Trim46
Name: tripartite motif-containing 46
Synonyms: TRIFIC
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 360213
Homologene: 11815
Plxnb1
Name: plexin B1
Synonyms: 2900002G15Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235611
HGNC: HGNC:9103
Homologene: 130508
Tmc3
Name: transmembrane channel-like gene family 3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233424
Homologene: 45588
Rln1
Name: relaxin 1
Synonyms: rlx
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 19773
Homologene: 55524
Kif21b
Name: kinesin family member 21B
Synonyms: N-5 kinesin, 2610511N21Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16565
Homologene: 56868
Fpgs
Name: folylpolyglutamyl synthetase
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14287
HGNC: HGNC:3824
Homologene: 6997
Tiam2
Name: T cell lymphoma invasion and metastasis 2
Synonyms: STEF, 3000002F19Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 24001
VEGA: 17
Homologene: 40796
Aars2
Name: alanyl-tRNA synthetase 2, mitochondrial
Synonyms: Aarsl
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224805
VEGA: 17
Homologene: 56897
Vmn2r112
Name: vomeronasal 2, receptor 112
Synonyms: EG628185
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 628185
Homologene: 86604
Socs4
Name: suppressor of cytokine signaling 4
Synonyms: Socs7, 3110032M18Rik, A730004F22Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 67296
Homologene: 15442
Kif12
Name: kinesin family member 12
Synonyms: N-9 kinesin
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16552
Homologene: 7796
Prss33
Name: serine protease 33
Synonyms: tryptase-6, mT6, Eos
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 353130
Homologene: 77185
Or1ad6
Name: olfactory receptor family 1 subfamily AD member 6
Synonyms: GA_x6K02T2QP88-4469162-4468215, Olfr1378, MOR129-2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258912
HGNC: HGNC:8182
Homologene: 133679
Sh3tc2
Name: SH3 domain and tetratricopeptide repeats 2
Synonyms: D430044G18Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225608
VEGA: 18
Homologene: 11596
Slc35a5
Name: solute carrier family 35, member A5
Synonyms: 1010001J06Rik, D730043G07Rik, D16Ertd450e
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74102
Homologene: 9930
H2-Q4
Name: histocompatibility 2, Q region locus 4
Synonyms: H-2Q4, Qb1, Qat-4, Qa4, Qa-4, Qb-1, H2-Gs10
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 15015
Homologene: 128352
Zfp1002
Name: zinc finger protein 1002
Synonyms: Gm21994
Type: Gene
Species: Mouse
Chromosome: 2
Or5a21
Name: olfactory receptor family 5 subfamily A member 21
Synonyms: MOR215-4, Olfr1438, GA_x6K02T2RE5P-2669245-2668277
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258116
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 34,262,041 bp
  • T to A, chromosome 1 at 43,738,691 bp
  • A to G, chromosome 1 at 74,552,013 bp
  • T to C, chromosome 1 at 136,152,397 bp
  • G to T, chromosome 2 at 32,684,787 bp
  • T to C, chromosome 2 at 150,255,177 bp
  • T to C, chromosome 3 at 89,235,242 bp
  • A to T, chromosome 3 at 133,132,475 bp
  • A to T, chromosome 4 at 63,171,317 bp
  • C to A, chromosome 4 at 109,091,679 bp
  • A to G, chromosome 4 at 137,921,159 bp
  • C to A, chromosome 4 at 139,452,719 bp
  • T to C, chromosome 6 at 90,619,508 bp
  • T to A, chromosome 7 at 83,597,543 bp
  • GGCG to GGCGACGGCCGCG, chromosome 7 at 97,579,906 bp
  • C to G, chromosome 7 at 135,697,440 bp
  • C to A, chromosome 8 at 84,230,914 bp
  • A to G, chromosome 8 at 110,525,667 bp
  • A to T, chromosome 9 at 109,104,330 bp
  • G to A, chromosome 9 at 110,637,642 bp
  • G to A, chromosome 10 at 88,522,999 bp
  • G to A, chromosome 11 at 50,969,173 bp
  • A to T, chromosome 11 at 94,432,569 bp
  • G to A, chromosome 11 at 119,479,920 bp
  • T to A, chromosome 12 at 103,408,375 bp
  • T to G, chromosome 13 at 9,713,021 bp
  • A to T, chromosome 13 at 22,244,524 bp
  • T to C, chromosome 13 at 95,682,211 bp
  • T to G, chromosome 14 at 32,454,694 bp
  • T to A, chromosome 14 at 47,290,176 bp
  • T to G, chromosome 14 at 70,139,225 bp
  • T to C, chromosome 15 at 77,766,772 bp
  • A to T, chromosome 16 at 45,143,917 bp
  • A to T, chromosome 17 at 3,506,873 bp
  • A to T, chromosome 17 at 22,618,486 bp
  • A to G, chromosome 17 at 23,834,702 bp
  • A to T, chromosome 17 at 35,383,005 bp
  • T to C, chromosome 17 at 45,516,564 bp
  • T to C, chromosome 18 at 62,015,040 bp
  • A to T, chromosome 18 at 67,619,734 bp
  • A to T, chromosome 19 at 12,333,766 bp
  • A to T, chromosome 19 at 17,575,821 bp
  • T to C, chromosome 19 at 24,861,632 bp
  • G to T, chromosome 19 at 29,332,121 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6648 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044769-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.