Strain Name:
C57BL/6J-MtgxR6665Btlr/Mmmh
Stock Number:
044785-MU
Citation ID:
RRID:MMRRC_044785-MU
Other Names:
R6665 (G1)
Major Collection:

Strain Information

Slc6a6
Name: solute carrier family 6 (neurotransmitter transporter, taurine), member 6
Synonyms: Taut
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 21366
Homologene: 2291
Dysf
Name: dysferlin
Synonyms: 2310004N10Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 26903
HGNC: HGNC:3097
Homologene: 20748
Frem2
Name: Fras1 related extracellular matrix protein 2
Synonyms: 8430406N05Rik, ne, b2b1562Clo, 6030440P17Rik, my
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242022
Homologene: 18454
Pik3cb
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
Synonyms: p110beta, 1110001J02Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74769
HGNC: HGNC:8976
Homologene: 21250
Prkdc
Name: protein kinase, DNA activated, catalytic polypeptide
Synonyms: slip, DNAPDcs, DNA-PKcs, DNA-PK, DOXNPH, XRCC7, dxnph
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 19090
HGNC: HGNC:9413
Homologene: 5037
Dock6
Name: dedicator of cytokinesis 6
Synonyms: C330023D02Rik, 2410095B20Rik, 4931431C02Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 319899
VEGA: 9
Homologene: 83291
Atp9b
Name: ATPase, class II, type 9B
Synonyms: IIb
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 50771
VEGA: 18
Homologene: 21915
Slc25a40
Name: solute carrier family 25, member 40
Synonyms: B230315F11Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 319653
Homologene: 6040
Myo9a
Name: myosin IXa
Synonyms: C130068I12Rik, 4732465J09Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270163
HGNC: HGNC:7608
Homologene: 21371
Naca
Name: nascent polypeptide-associated complex alpha polypeptide
Synonyms: LOC380777, skNAC
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 17938
VEGA: 10
HGNC: HGNC:7629
Homologene: 136025
Ice1
Name: interactor of little elongation complex ELL subunit 1
Synonyms: BC018507
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218333
VEGA: 13
Homologene: 18902
Avil
Name: advillin
Synonyms: DOC6
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11567
Homologene: 38200
Stxbp2
Name: syntaxin binding protein 2
Synonyms: Munc-18-2, Munc18b, muSec1, C79054, Sxtp2, Munc-18b
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 20911
Homologene: 55530
Col28a1
Name: collagen, type XXVIII, alpha 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 213945
Homologene: 66345
Dusp8
Name: dual specificity phosphatase 8
Synonyms: 5530400B01Rik, Nttp1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18218
HGNC: HGNC:3074
Homologene: 31239
Slc13a5
Name: solute carrier family 13 (sodium-dependent citrate transporter), member 5
Synonyms: NaC2/NaCT, Nact, Indy, mINDY
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237831
Homologene: 21941
Fhip2b
Name: FHF complex subunit HOOK interacting protein 2B
Synonyms: G430067P06Rik, Rai16, Fam160b2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239170
VEGA: 14
Homologene: 23379
Adamts16
Name: ADAM metallopeptidase with thrombospondin type 1 motif 16
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 271127
Homologene: 15146
Ccdc146
Name: coiled-coil domain containing 146
Synonyms: 4930528G09Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75172
Homologene: 67159
Gpat2
Name: glycerol-3-phosphate acyltransferase 2, mitochondrial
Synonyms: Gpat2, A530057A03Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 215456
Homologene: 19037
Zmynd15
Name: zinc finger, MYND-type containing 15
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 574428
Homologene: 12995
Spef2
Name: sperm flagellar 2
Synonyms: C230086A09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 320277
Homologene: 23371
Serpinb10
Name: serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 10
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241197
HGNC: HGNC:8942
Homologene: 68430
Adamts15
Name: ADAM metallopeptidase with thrombospondin type 1 motif 15
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235130
VEGA: 9
Homologene: 8610
Tmem247
Name: transmembrane protein 247
Synonyms: 1700090G07Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 78469
Homologene: 54379
Rab32
Name: RAB32, member RAS oncogene family
Synonyms: 2810011A17Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67844
HGNC: HGNC:9772
Homologene: 38233
Myod1
Name: myogenic differentiation 1
Synonyms: bHLHc1, MyoD, MYF3, Myod-1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17927
HGNC: HGNC:7611
Homologene: 7857
Myoz3
Name: myozenin 3
Synonyms: 4833419K08Rik, Fatz-3, calsarcin-3
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 170947
Homologene: 15782
Dsc2
Name: desmocollin 2
Synonyms: Dsc2a, Dsc2b
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13506
HGNC: HGNC:3036
Homologene: 8397
Hexb
Name: hexosaminidase B
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 15212
VEGA: 13
HGNC: HGNC:4879
Homologene: 437
Lrif1
Name: ligand dependent nuclear receptor interacting factor 1
Synonyms: 4933421E11Rik, 2010012G17Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 321000
Homologene: 10160
Vmn2r67
Name: vomeronasal 2, receptor 67
Synonyms: EG620672
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 620672
Homologene: 115466
Or6c76
Name: olfactory receptor family 6 subfamily C member 76
Synonyms: GA_x6K02T2PULF-11454600-11455541, MOR108-4, Olfr809
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258321
Homologene: 138308
Cd6
Name: CD6 antigen
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 12511
HGNC: HGNC:1691
Homologene: 4893
Bin2
Name: bridging integrator 2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 668218
HGNC: HGNC:1053
Homologene: 22965
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to C, chromosome 1 at 107,546,867 bp
  • G to C, chromosome 2 at 127,431,918 bp
  • T to C, chromosome 3 at 53,654,656 bp
  • T to A, chromosome 3 at 106,735,343 bp
  • A to G, chromosome 5 at 8,452,788 bp
  • T to C, chromosome 5 at 21,303,094 bp
  • A to G, chromosome 6 at 8,062,277 bp
  • A to G, chromosome 6 at 84,130,116 bp
  • T to C, chromosome 6 at 91,726,039 bp
  • A to T, chromosome 7 at 46,376,857 bp
  • T to C, chromosome 7 at 85,136,692 bp
  • G to A, chromosome 7 at 142,090,105 bp
  • A to G, chromosome 8 at 3,641,998 bp
  • C to T, chromosome 9 at 21,839,912 bp
  • A to G, chromosome 9 at 30,904,479 bp
  • G to T, chromosome 9 at 59,871,872 bp
  • A to G, chromosome 9 at 99,073,649 bp
  • T to C, chromosome 10 at 10,558,102 bp
  • A to G, chromosome 10 at 127,020,525 bp
  • T to A, chromosome 10 at 128,048,358 bp
  • T to C, chromosome 10 at 129,776,247 bp
  • T to C, chromosome 11 at 70,464,810 bp
  • C to T, chromosome 11 at 72,260,360 bp
  • T to C, chromosome 13 at 70,603,473 bp
  • T to G, chromosome 13 at 70,779,570 bp
  • T to C, chromosome 13 at 97,179,385 bp
  • A to T, chromosome 14 at 70,585,638 bp
  • A to T, chromosome 15 at 9,600,518 bp
  • T to C, chromosome 15 at 100,656,795 bp
  • T to C, chromosome 16 at 15,786,050 bp
  • A to T, chromosome 17 at 86,918,570 bp
  • A to G, chromosome 18 at 20,050,148 bp
  • A to C, chromosome 18 at 60,576,423 bp
  • A to C, chromosome 18 at 80,917,735 bp
  • T to C, chromosome 19 at 10,791,003 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6665 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044785-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.