Strain Name:
C57BL/6J-MtgxR6711Btlr/Mmmh
Stock Number:
044829-MU
Citation ID:
RRID:MMRRC_044829-MU
Other Names:
R6711 (G1)
Major Collection:

Strain Information

Hcfc1
Name: host cell factor C1
Synonyms: HCF1, VP16 accessory protein, HCF-1
Type: Gene
Species: Mouse
Chromosome: X
NCBI: 15161
HGNC: HGNC:4839
Homologene: 3898
Glrb
Name: glycine receptor, beta subunit
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14658
HGNC: HGNC:4329
Homologene: 20224
Lyst
Name: lysosomal trafficking regulator
Synonyms: D13Sfk13
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17101
VEGA: 13
HGNC: HGNC:1968
Homologene: 61
Tlr6
Name: toll-like receptor 6
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 21899
Homologene: 21223
Mtor
Name: mechanistic target of rapamycin kinase
Synonyms: flat, RAPT1, 2610315D21Rik, RAFT1, Frap1, mechanistic target of rapamycin (serine/threonine kinase), FKBP-rapamycin-associated protein FRAP
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56717
HGNC: HGNC:3942
Homologene: 3637
Srfbp1
Name: serum response factor binding protein 1
Synonyms: 2810036K01Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 67222
VEGA: 18
Homologene: 12101
St7
Name: suppression of tumorigenicity 7
Synonyms: SEN4, 9430001H04Rik, Fam4a2, RAY1, TSG7, HELG
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 64213
Homologene: 10185
Scn10a
Name: sodium channel, voltage-gated, type X, alpha
Synonyms: Nav1.8
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20264
VEGA: 9
Homologene: 21300
Vps13b
Name: vacuolar protein sorting 13B
Synonyms: Coh1, 2310042E16Rik, 1810042B05Rik, C330002D13Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 666173
VEGA: 15
HGNC: HGNC:2183
Homologene: 49516
Hoxd10
Name: homeobox D10
Synonyms: Hox-4.5, Hox-5.3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 15430
HGNC: HGNC:5133
Homologene: 1619
Mme
Name: membrane metallo endopeptidase
Synonyms: neutral endopeptidase, NEP, neprilysin, 6030454K05Rik, CD10
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 17380
HGNC: HGNC:7154
Homologene: 5275
Gfra2
Name: glial cell line derived neurotrophic factor family receptor alpha 2
Synonyms: GFR alpha-2, GFR alpha 2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 14586
VEGA: 14
HGNC: HGNC:4244
Homologene: 1145
Ncoa1
Name: nuclear receptor coactivator 1
Synonyms: KAT13A, bHLHe74, SRC-1, SRC-a/NCoA-1, steroid receptor coactivator-1, SRC1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 17977
VEGA: 12
HGNC: HGNC:7668
Homologene: 7859
Pla2g4e
Name: phospholipase A2, group IVE
Synonyms: 2310026J01Rik, Pla2epsilon
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 329502
Homologene: 65339
Kidins220
Name: kinase D-interacting substrate 220
Synonyms: 3110039L19Rik, C330002I19Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 77480
VEGA: 12
Homologene: 14254
Ankrd35
Name: ankyrin repeat domain 35
Synonyms: 4732436F15Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 213121
Homologene: 16977
Neb
Name: nebulin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17996
HGNC: HGNC:7720
Homologene: 136285
Ndrg2
Name: N-myc downstream regulated gene 2
Synonyms: Ndr2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 29811
VEGA: 14
Homologene: 22785
Lmntd1
Name: lamin tail domain containing 1
Synonyms: 4933403M22Rik, Lmna-rs1, Ifltd1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 74071
Homologene: 69453
Rtcb
Name: RNA 2',3'-cyclic phosphate and 5'-OH ligase
Synonyms: HSPC117, D10Wsu52e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 28088
Homologene: 36344
Man1a
Name: mannosidase 1, alpha
Synonyms: PCR1, mannosyl-oligosaccharide alpha-1,2-mannosidase
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 17155
HGNC: HGNC:6821
Homologene: 4316
Impg2
Name: interphotoreceptor matrix proteoglycan 2
Synonyms: PG10.2, IPM200, Spacrcan
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224224
Homologene: 9439
Iba57
Name: IBA57 homolog, iron-sulfur cluster assembly
Synonyms: A230051G13Rik, 4930543L23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216792
Homologene: 13844
Mrps21
Name: mitochondrial ribosomal protein S21
Synonyms: 1810031B19Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 66292
Homologene: 45365
Cdh4
Name: cadherin 4
Synonyms: R-Cadh, Rcad, R-cadherin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12561
HGNC: HGNC:1763
Homologene: 48044
Thbs2
Name: thrombospondin 2
Synonyms: Thrombospondin-2, Thbs-2, TSP2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 21826
VEGA: 17
Homologene: 2438
Ccdc81
Name: coiled-coil domain containing 81
Synonyms: 4921513D09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 70884
Homologene: 128447
Tnrc18
Name: trinucleotide repeat containing 18
Synonyms: Zfp469, EG381742
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231861
Homologene: 45603
Ces2h
Name: carboxylesterase 2H
Synonyms: Gm5744
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 436059
HGNC: HGNC:1864
Homologene: 128645
Cacna2d1
Name: calcium channel, voltage-dependent, alpha2/delta subunit 1
Synonyms: Cchl2a, Ca(v)alpha2delta1, Cacna2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12293
HGNC: HGNC:1399
Homologene: 579
Akr1c21
Name: aldo-keto reductase family 1, member C21
Synonyms: 9430025F20Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 77337
Homologene: 134114
Tmem168
Name: transmembrane protein 168
Synonyms: 8430437G11Rik, 5730526F17Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 101118
Homologene: 11202
Ano2
Name: anoctamin 2
Synonyms: Tmem16b
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243634
HGNC: HGNC:1183
Homologene: 23221
Fcgbp
Name: Fc fragment of IgG binding protein
Synonyms: A430096B05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 215384
Homologene: 68369
Epb42
Name: erythrocyte membrane protein band 4.2
Synonyms: Epb4.2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13828
HGNC: HGNC:3381
Homologene: 93
Entrep1
Name: endosomal transmembrane epsin interactor 1
Synonyms: LOC381217, Fam189a2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 381217
VEGA: 19
Homologene: 3540
Zdhhc7
Name: zinc finger, DHHC domain containing 7
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 102193
Homologene: 41193
Pih1d2
Name: PIH1 domain containing 2
Synonyms: 2700059L22Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 72614
Homologene: 12474
Dcpp3
Name: demilune cell and parotid protein 3
Synonyms: EG620253
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 620253
VEGA: 17
Homologene: 103921
Ganc
Name: glucosidase, alpha; neutral C
Synonyms: 5830445O15Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 76051
HGNC: HGNC:4139
Homologene: 25627
Rph3al
Name: rabphilin 3A-like (without C2 domains)
Synonyms: Noc2, 6530413F01Rik, LOC385671
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380714
Homologene: 5078
Vmn1r8
Name: vomeronasal 1 receptor 8
Synonyms: V1rc32
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 171205
Homologene: 83427
Zfp213
Name: zinc finger protein 213
Synonyms: D17Ertd197e
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 449521
VEGA: 17
Homologene: 55809
Or8g22
Name: olfactory receptor family 8 subfamily G member 22, pseudogene 1
Synonyms: EG628171, MOR171-37, Olfr936, GA_x6K02T2PVTD-32743332-32742397
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 100503486
VEGA: 9
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to C, chromosome 2 at 52,223,064 bp
  • A to G, chromosome 2 at 52,256,287 bp
  • A to G, chromosome 2 at 74,694,163 bp
  • T to C, chromosome 2 at 120,171,270 bp
  • A to T, chromosome 2 at 120,450,839 bp
  • T to A, chromosome 2 at 121,024,108 bp
  • A to G, chromosome 2 at 179,890,931 bp
  • A to T, chromosome 3 at 63,341,918 bp
  • A to G, chromosome 3 at 80,844,974 bp
  • G to A, chromosome 3 at 95,870,583 bp
  • C to T, chromosome 3 at 96,683,468 bp
  • A to G, chromosome 4 at 148,452,367 bp
  • C to T, chromosome 5 at 16,300,041 bp
  • C to A, chromosome 5 at 64,954,492 bp
  • A to T, chromosome 5 at 142,787,790 bp
  • T to C, chromosome 6 at 13,603,121 bp
  • A to G, chromosome 6 at 17,848,070 bp
  • T to C, chromosome 6 at 57,036,459 bp
  • G to A, chromosome 6 at 125,775,832 bp
  • T to C, chromosome 6 at 145,543,502 bp
  • A to G, chromosome 7 at 25,538,870 bp
  • G to A, chromosome 7 at 28,089,673 bp
  • T to G, chromosome 7 at 89,887,798 bp
  • A to T, chromosome 8 at 105,018,083 bp
  • A to G, chromosome 8 at 120,083,327 bp
  • A to G, chromosome 9 at 39,046,866 bp
  • T to A, chromosome 9 at 50,618,010 bp
  • A to G, chromosome 9 at 119,609,913 bp
  • G to A, chromosome 10 at 53,933,492 bp
  • A to T, chromosome 10 at 74,642,387 bp
  • A to T, chromosome 10 at 85,939,099 bp
  • T to C, chromosome 11 at 59,158,543 bp
  • C to A, chromosome 11 at 75,908,984 bp
  • C to A, chromosome 12 at 4,322,904 bp
  • A to G, chromosome 12 at 24,998,751 bp
  • A to G, chromosome 13 at 4,577,375 bp
  • A to T, chromosome 13 at 13,635,235 bp
  • A to T, chromosome 14 at 51,910,325 bp
  • A to G, chromosome 14 at 70,966,275 bp
  • A to G, chromosome 15 at 35,887,249 bp
  • C to A, chromosome 16 at 56,265,086 bp
  • T to C, chromosome 17 at 14,690,265 bp
  • A to G, chromosome 17 at 23,559,511 bp
  • AGGCCATGCTGGCC to AGGCC, chromosome 17 at 23,917,598 bp
  • T to C, chromosome 18 at 52,488,301 bp
  • T to C, chromosome 19 at 23,978,099 bp
  • A to T, chromosome X at 73,950,065 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6711 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044829-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.