Strain Name:
C57BL/6J-MtgxR6712Btlr/Mmmh
Stock Number:
044830-MU
Citation ID:
RRID:MMRRC_044830-MU
Other Names:
R6712 (G1)
Major Collection:

Strain Information

Myo5a
Name: myosin VA
Synonyms: MVa, Myo5, flail, 9630007J19Rik, MyoVA, Dbv
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17918
HGNC: HGNC:7602
Homologene: 20100
Pknox1
Name: Pbx/knotted 1 homeobox
Synonyms: PREP1, D17Wsu76e
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18771
HGNC: HGNC:9022
Homologene: 3363
Zfp516
Name: zinc finger protein 516
Synonyms: Zfp26l, C330029B10Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 329003
VEGA: 18
Homologene: 37122
Cep350
Name: centrosomal protein 350
Synonyms: 4933409L06Rik, 6430546F08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74081
Homologene: 8879
Akap8l
Name: A kinase anchor protein 8-like
Synonyms: Nakap95
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 54194
VEGA: 17
Homologene: 8658
Ngdn
Name: neuroguidin, EIF4E binding protein
Synonyms: neuroguidin, Ngd, 1500001L15Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 68966
VEGA: 14
Homologene: 44286
Wwc2
Name: WW, C2 and coiled-coil domain containing 2
Synonyms: D8Ertd594e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 52357
Homologene: 32618
Dmxl2
Name: Dmx-like 2
Synonyms: E130119P06Rik, 6430411K14Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235380
HGNC: HGNC:2938
Homologene: 41022
Mmp27
Name: matrix metallopeptidase 27
Synonyms: LOC234911
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 234911
Homologene: 23345
Ube2f
Name: ubiquitin-conjugating enzyme E2F (putative)
Synonyms: 2510010F15Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67921
Homologene: 12212
Pfdn2
Name: prefoldin 2
Synonyms: ESTM27, W48336
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18637
HGNC: HGNC:8867
Homologene: 7887
Nlrc4
Name: NLR family, CARD domain containing 4
Synonyms: Ipaf, Card12, 9530011P19Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 268973
VEGA: 17
Homologene: 10924
Dnah11
Name: dynein, axonemal, heavy chain 11
Synonyms: b2b1203Clo, Dnahc11, avc4, b2b1289Clo, b2b1279Clo, lrd, b2b598Clo, b2b1727Clo
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13411
HGNC: HGNC:2942
Homologene: 2801
Col5a3
Name: collagen, type V, alpha 3
Synonyms: Pro-alpha3(V)
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 53867
Homologene: 9253
Dock10
Name: dedicator of cytokinesis 10
Synonyms: A630054M16Rik, Zizimin3, Jr5, Jr4, ZIZ3, 9330153B10Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 210293
Homologene: 45952
Gpr179
Name: G protein-coupled receptor 179
Synonyms: 5330439C02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217143
Homologene: 34917
Peli2
Name: pellino 2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 93834
VEGA: 14
HGNC: HGNC:8828
Homologene: 41431
Vmn1r231
Name: vomeronasal 1 receptor 231
Synonyms: V1re7
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 171230
Myo1c
Name: myosin IC
Synonyms: mm1beta, C80397, myr2, myosin-Ibeta
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17913
HGNC: HGNC:7597
Homologene: 32046
Tyro3
Name: TYRO3 protein tyrosine kinase 3
Synonyms: Brt, Sky, Tif, Sky, Etk-2, Dtk, Rse
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22174
Homologene: 4585
Tns1
Name: tensin 1
Synonyms: Tns, E030018G17Rik, E030037J05Rik, 1110018I21Rik, 1200014E20Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 21961
Homologene: 11219
Ppp4r4
Name: protein phosphatase 4, regulatory subunit 4
Synonyms: 8430415E04Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 74521
Homologene: 12571
Or10h28
Name: olfactory receptor family 10 subfamily H member 28
Synonyms: Olfr63, M4, MOR267-1, GA_x6K02T2NTC5-9778-8828
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258939
Homologene: 130665
Foxn1
Name: forkhead box N1
Synonyms: Hfh11, whn, D11Bhm185e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15218
Homologene: 2664
Tmc8
Name: transmembrane channel-like gene family 8
Synonyms: EVIN2, Ever2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217356
Homologene: 45126
Sipa1
Name: signal-induced proliferation associated gene 1
Synonyms: SPA-1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 20469
VEGA: 19
Homologene: 7940
H2aj
Name: H2J.A histone
Synonyms: H2afj
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232440
Homologene: 128575
Ankmy1
Name: ankyrin repeat and MYND domain containing 1
Synonyms: 4930483I10Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241158
Homologene: 9561
Or52e15
Name: olfactory receptor family 52 subfamily E member 15
Synonyms: Olfr672, MOR32-4, GA_x6K02T2PBJ9-7625746-7624808
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258755
Homologene: 138317
Mis18a
Name: MIS18 kinetochore protein A
Synonyms: 2610039C10Rik, 2810018N07Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 66578
HGNC: HGNC:1286
Homologene: 41294
Zfp764l1
Name: zinc finger protein 764 like 1
Synonyms: E430018J23Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101604
Homologene: 138471
Mfsd9
Name: major facilitator superfamily domain containing 9
Synonyms: 4931419K03Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 211798
Homologene: 13100
Fcmr
Name: Fc fragment of IgM receptor
Synonyms: Faim3, 1810037B05Rik, FcmuR
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 69169
Homologene: 48347
Polh
Name: polymerase (DNA directed), eta (RAD 30 related)
Synonyms: RAD30A
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 80905
VEGA: 17
HGNC: HGNC:9181
Homologene: 38189
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 40,786,441 bp
  • C to A, chromosome 1 at 74,079,301 bp
  • T to A, chromosome 1 at 80,536,866 bp
  • T to A, chromosome 1 at 91,276,449 bp
  • A to T, chromosome 1 at 92,870,922 bp
  • T to C, chromosome 1 at 130,877,851 bp
  • T to C, chromosome 1 at 155,858,106 bp
  • T to A, chromosome 1 at 171,357,851 bp
  • G to A, chromosome 2 at 119,804,854 bp
  • A to G, chromosome 6 at 136,808,526 bp
  • A to T, chromosome 7 at 104,996,418 bp
  • A to T, chromosome 7 at 127,392,310 bp
  • T to A, chromosome 8 at 47,900,803 bp
  • A to T, chromosome 9 at 7,572,176 bp
  • C to T, chromosome 9 at 20,779,033 bp
  • A to G, chromosome 9 at 54,411,624 bp
  • A to C, chromosome 9 at 75,212,900 bp
  • C to T, chromosome 11 at 75,671,635 bp
  • T to G, chromosome 11 at 78,361,259 bp
  • T to C, chromosome 11 at 97,336,167 bp
  • C to A, chromosome 11 at 117,784,813 bp
  • G to A, chromosome 12 at 103,596,443 bp
  • A to T, chromosome 12 at 118,050,722 bp
  • C to A, chromosome 14 at 48,250,594 bp
  • T to C, chromosome 14 at 55,016,188 bp
  • T to C, chromosome 16 at 90,727,157 bp
  • T to C, chromosome 17 at 20,889,730 bp
  • C to A, chromosome 17 at 31,595,316 bp
  • G to A, chromosome 17 at 32,332,888 bp
  • T to G, chromosome 17 at 33,269,268 bp
  • T to C, chromosome 17 at 46,190,729 bp
  • A to T, chromosome 17 at 74,446,836 bp
  • C to T, chromosome 18 at 82,957,308 bp
  • A to T, chromosome 19 at 5,660,819 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6712 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044830-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.