Strain Name:
C57BL/6J-MtgxR6721Btlr/Mmmh
Stock Number:
044839-MU
Citation ID:
RRID:MMRRC_044839-MU
Other Names:
R6721 (G1)
Major Collection:

Strain Information

Npy1r
Name: neuropeptide Y receptor Y1
Synonyms: Y1-R, Npyr
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 18166
HGNC: HGNC:7956
Homologene: 700
Plcb4
Name: phospholipase C, beta 4
Synonyms: A930039J07Rik, C230058B11Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18798
HGNC: HGNC:9059
Homologene: 8471
Taok3
Name: TAO kinase 3
Synonyms: 2900006A08Rik, A430105I05Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 330177
Homologene: 83279
U2surp
Name: U2 snRNP-associated SURP domain containing
Synonyms: 2610101N10Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 67958
Homologene: 13964
Sfmbt2
Name: Scm-like with four mbt domains 2
Synonyms: D330030P06Rik, D2Wsu23e
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 353282
Homologene: 82485
Ythdf3
Name: YTH N6-methyladenosine RNA binding protein 3
Synonyms: 9130022A11Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229096
Homologene: 34991
Ankrd27
Name: ankyrin repeat domain 27
Synonyms: Varp, D330003H11Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 245886
Homologene: 12956
Lefty2
Name: left-right determination factor 2
Synonyms: Ebaf, Leftb, 6030463A22Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 320202
HGNC: HGNC:3122
Homologene: 2434
Gabbr1
Name: gamma-aminobutyric acid type B receptor subunit 1
Synonyms: GABAB1, GABAbR1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 54393
HGNC: HGNC:4070
Homologene: 1132
Plxna4
Name: plexin A4
Synonyms: Plxa4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243743
HGNC: HGNC:9102
Homologene: 77587
Ern1
Name: endoplasmic reticulum to nucleus signalling 1
Synonyms: Ire1alpha, 9030414B18Rik, Ire1p, Ire1a
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 78943
HGNC: HGNC:3449
Homologene: 55580
Nup153
Name: nucleoporin 153
Synonyms: B130015D15Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218210
HGNC: HGNC:8062
Homologene: 68442
Tlr3
Name: toll-like receptor 3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 142980
Homologene: 20696
Cngb1
Name: cyclic nucleotide gated channel beta 1
Synonyms: BC016201, Cngb1, Cngb1b
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 333329
HGNC: HGNC:2151
Homologene: 136420
Galnt12
Name: polypeptide N-acetylgalactosaminyltransferase 12
Synonyms: A630062B03Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230145
Homologene: 11637
Mecom
Name: MDS1 and EVI1 complex locus
Synonyms: Evi-1, Jbo, ZNFPR1B1, D630039M04Rik, Prdm3, Mds1, Evi1, MDS1-EVI1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14013
HGNC: HGNC:3498
Homologene: 21086
Jag1
Name: jagged 1
Synonyms: Serrate-1, Headturner, Ozz, Htu, Gsfabe2, ABE2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16449
HGNC: HGNC:6188
Homologene: 180
Il16
Name: interleukin 16
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16170
HGNC: HGNC:5980
Homologene: 18157
Muc5ac
Name: mucin 5, subtypes A and C, tracheobronchial/gastric
Synonyms: MGM, 2210005L13Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17833
HGNC: HGNC:7515
Homologene: 137237
Bltp2
Name: bridge-like lipid transfer protein family member 2
Synonyms: 2610507B11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 72503
Homologene: 34730
Chd3
Name: chromodomain helicase DNA binding protein 3
Synonyms: Prp9-1, Chd7, 2600010P09Rik, Mi-2 alpha, Prp7
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216848
HGNC: HGNC:1918
Homologene: 62693
Tmem209
Name: transmembrane protein 209
Synonyms: 2700094F01Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 72649
Homologene: 18021
Adgrv1
Name: adhesion G protein-coupled receptor V1
Synonyms: Mgr1, Mass1, Gpr98, VLGR1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 110789
Homologene: 19815
Aplp1
Name: amyloid beta precursor like protein 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11803
HGNC: HGNC:597
Homologene: 68447
Perm1
Name: PPARGC1 and ESRR induced regulator, muscle 1
Synonyms: 2310042D19Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 74183
Homologene: 135954
Arhgef10l
Name: Rho guanine nucleotide exchange factor 10-like
Synonyms: 2810441C07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 72754
Homologene: 10017
Or10h5
Name: olfactory receptor family 10 subfamily H member 5
Synonyms: Olfr1564, Gm4461
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 100043474
Homologene: 133726
Ogfr
Name: opioid growth factor receptor
Synonyms: 2010013E17Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 72075
Homologene: 7199
Gmpr2
Name: guanosine monophosphate reductase 2
Synonyms: 5730544D12Rik, 1810008P16Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105446
VEGA: 14
HGNC: HGNC:4377
Homologene: 22983
Faxc
Name: failed axon connections homolog
Synonyms: 6230409E13Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 76132
Homologene: 32781
Or10g7
Name: olfactory receptor family 10 subfamily G member 7
Synonyms: GA_x6K02T2PVTD-33692287-33693222, MOR223-3, Olfr978
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 259109
VEGA: 9
Homologene: 88420
Cmtm2b
Name: CKLF-like MARVEL transmembrane domain containing 2B
Synonyms: Cklfsf2b, 1700013O04Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 75502
Homologene: 88915
Cd46
Name: CD46 antigen, complement regulatory protein
Synonyms: CD46, Mcp
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17221
HGNC: HGNC:6953
Homologene: 7832
Hivep3
Name: human immunodeficiency virus type I enhancer binding protein 3
Synonyms: Shn3, E030045D18Rik, Krc, 2900056N03Rik, Schnurri-3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16656
Homologene: 7803
Or7e178
Name: olfactory receptor family 7 subfamily E member 178
Synonyms: MTPCR34, Olfr18, GA_x6K02T2PVTD-14054886-14053957, MOR145-1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 18315
HGNC: HGNC:8396
Homologene: 138313
Rabggta
Name: Rab geranylgeranyl transferase, a subunit
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 56187
VEGA: 14
HGNC: HGNC:9795
Homologene: 32443
Zfp647
Name: zinc finger protein 647
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239546
VEGA: 15
Homologene: 27805
Redic1
Name: regulator of DNA class I crossover intermediates 1
Synonyms: CN725425, Gm5807
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 545126
Creb3l3
Name: cAMP responsive element binding protein 3-like 3
Synonyms: D10Bur1e, CREB-H
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 208677
Homologene: 13080
Cts7
Name: cathepsin 7
Synonyms: CTS1, Epcs71, Epcs24
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 56092
VEGA: 13
Homologene: 75110
Ppl
Name: periplakin
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 19041
VEGA: 16
HGNC: HGNC:9273
Homologene: 2026
Cfap418
Name: cilia and flagella associated protein 418
Synonyms: 2610301B20Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67157
Homologene: 18641
Spc25
Name: SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)
Synonyms: 2600017H08Rik, 2610205L13Rik, Spbc25
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66442
Homologene: 41387
Prop1
Name: paired like homeodomain factor 1
Synonyms: prophet of Pit1, prophet of Pit-1, Prop-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19127
HGNC: HGNC:9455
Homologene: 4558
Ctsd
Name: cathepsin D
Synonyms: CatD, CD
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13033
HGNC: HGNC:2529
Homologene: 55616
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 180,894,601 bp
  • T to C, chromosome 1 at 195,083,631 bp
  • A to G, chromosome 2 at 10,543,025 bp
  • A to C, chromosome 2 at 69,197,173 bp
  • T to C, chromosome 2 at 135,910,237 bp
  • T to C, chromosome 2 at 137,094,474 bp
  • T to A, chromosome 2 at 180,595,428 bp
  • G to A, chromosome 3 at 16,203,861 bp
  • T to C, chromosome 3 at 29,979,874 bp
  • A to G, chromosome 4 at 10,874,744 bp
  • A to T, chromosome 4 at 21,982,672 bp
  • T to A, chromosome 4 at 47,122,529 bp
  • T to A, chromosome 4 at 120,095,099 bp
  • T to C, chromosome 4 at 140,570,344 bp
  • G to T, chromosome 4 at 156,218,319 bp
  • T to C, chromosome 5 at 117,255,863 bp
  • A to G, chromosome 6 at 30,497,175 bp
  • C to T, chromosome 6 at 32,200,859 bp
  • T to C, chromosome 7 at 30,440,295 bp
  • T to C, chromosome 7 at 35,612,551 bp
  • A to T, chromosome 7 at 83,663,062 bp
  • T to A, chromosome 7 at 141,798,992 bp
  • G to A, chromosome 7 at 142,376,853 bp
  • A to G, chromosome 8 at 45,398,880 bp
  • T to A, chromosome 8 at 66,704,289 bp
  • T to C, chromosome 8 at 95,270,888 bp
  • A to G, chromosome 8 at 104,322,445 bp
  • A to C, chromosome 9 at 20,314,280 bp
  • C to T, chromosome 9 at 39,994,307 bp
  • T to C, chromosome 9 at 95,491,104 bp
  • T to C, chromosome 10 at 81,091,143 bp
  • T to C, chromosome 11 at 50,953,386 bp
  • T to C, chromosome 11 at 69,369,219 bp
  • T to C, chromosome 11 at 78,279,799 bp
  • A to G, chromosome 11 at 106,411,652 bp
  • A to G, chromosome 13 at 46,701,026 bp
  • A to T, chromosome 13 at 61,356,294 bp
  • A to G, chromosome 13 at 81,481,515 bp
  • A to T, chromosome 14 at 55,672,734 bp
  • A to G, chromosome 14 at 55,717,203 bp
  • T to C, chromosome 15 at 76,911,876 bp
  • A to G, chromosome 15 at 91,231,618 bp
  • A to T, chromosome 16 at 5,107,469 bp
  • C to T, chromosome 17 at 33,215,534 bp
  • T to C, chromosome 17 at 37,054,192 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6721 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044839-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.