Strain Name:
C57BL/6J-MtgxR6731Btlr/Mmmh
Stock Number:
044849-MU
Citation ID:
RRID:MMRRC_044849-MU
Other Names:
R6731 (G1)
Major Collection:

Strain Information

Fgg
Name: fibrinogen gamma chain
Synonyms: 3010002H13Rik, gamma-fibrinogen
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99571
HGNC: HGNC:3694
Homologene: 429
Chst5
Name: carbohydrate sulfotransferase 5
Synonyms: I-GlcNAc6ST, GST-4
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 56773
Homologene: 56927
B3gnt2
Name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
Synonyms: B3Galt6, B3gnt1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 53625
Homologene: 4797
Naa15
Name: N(alpha)-acetyltransferase 15, NatA auxiliary subunit
Synonyms: Tbdn-1, ASTBDN, Narg1, mNAT1, 5730450D16Rik, tubedown
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74838
Homologene: 14211
Zfp729a
Name: zinc finger protein 729a
Synonyms: A530054K11Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 212281
Homologene: 133713
Rpap1
Name: RNA polymerase II associated protein 1
Synonyms: 1190005L06Rik, A730023M06Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68925
Homologene: 32269
Ubr1
Name: ubiquitin protein ligase E3 component n-recognin 1
Synonyms: E3 alpha
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22222
Homologene: 7582
Trim24
Name: tripartite motif-containing 24
Synonyms: Tif1a, TIF1alpha, D430004I05Rik, A130082H20Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 21848
Homologene: 20830
Os9
Name: amplified in osteosarcoma
Synonyms: 4632413K17Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216440
VEGA: 10
Homologene: 31409
Ank3
Name: ankyrin 3, epithelial
Synonyms: Ank-3, AnkG, 2900054D09Rik, Ankyrin-3, Ankyrin-G
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11735
HGNC: HGNC:494
Homologene: 56908
Rnf17
Name: ring finger protein 17
Synonyms: MMIP-2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 30054
VEGA: 14
Homologene: 23727
Tmem135
Name: transmembrane protein 135
Synonyms: 2810439K08Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72759
Homologene: 11295
Scube2
Name: signal peptide, CUB domain, EGF-like 2
Synonyms: Cegf1, ICRFP703N2430Q5.1, 4932442O19Rik, ICRFP703B1614Q5.1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 56788
Homologene: 36383
Lama5
Name: laminin, alpha 5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16776
HGNC: HGNC:6485
Homologene: 4060
Pcbp2
Name: poly(rC) binding protein 2
Synonyms: alphaCP-2, Hnrpx
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 18521
VEGA: 15
HGNC: HGNC:8648
Homologene: 74536
Ass1
Name: argininosuccinate synthetase 1
Synonyms: fold, ASS, Ass-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11898
HGNC: HGNC:758
Homologene: 6899
Zfp141
Name: zinc finger protein 141
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 434178
Nipbl
Name: NIPBL cohesin loading factor
Synonyms: 4933421G18Rik, 4921518A06Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 71175
VEGA: 15
Homologene: 15850
Lrch3
Name: leucine-rich repeats and calponin homology (CH) domain containing 3
Synonyms: 2210409B11Rik, LOC385628
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 70144
Homologene: 13111
Obi1
Name: ORC ubiquitin ligase 1
Synonyms: 2610206B13Rik, Rnf219, 2810449K13Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 72486
VEGA: 14
Homologene: 11578
Kat2a
Name: K(lysine) acetyltransferase 2A
Synonyms: 1110051E14Rik, Gcn5l2, Gcn5, PCAF-B/GCN5
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14534
HGNC: HGNC:4201
Homologene: 41343
Wnt16
Name: wingless-type MMTV integration site family, member 16
Synonyms: E130309I19Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 93735
Homologene: 62175
Acta1
Name: actin alpha 1, skeletal muscle
Synonyms: Acts, Actsk-1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11459
HGNC: HGNC:129
Homologene: 121702
Pcdhb10
Name: protocadherin beta 10
Synonyms: PcdhbJ, Pcdhb5D
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93881
HGNC: HGNC:8690
Homologene: 88834
Stk32a
Name: serine/threonine kinase 32A
Synonyms: YANK1, A930015B13Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 269019
VEGA: 18
Homologene: 65357
Nalcn
Name: sodium leak channel, non-selective
Synonyms: Vgcnl1, A530023G15Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 338370
VEGA: 14
Homologene: 21832
Ankrd7
Name: ankyrin repeat domain 7
Synonyms: 4930532L20Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 75196
Homologene: 35506
Ahnak
Name: AHNAK nucleoprotein
Synonyms: DY6, 1110004P15Rik, 2310047C17Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 66395
VEGA: 19
HGNC: HGNC:347
Homologene: 67425
Phf8l
Name: PHD finger protein 8 like
Synonyms: 4921501E09Rik, Phf8-ps
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74042
VEGA: 17
Homologene: 66275
Dis3l
Name: DIS3 like exosome 3'-5' exoribonuclease
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 213550
Homologene: 15797
Pou6f1
Name: POU domain, class 6, transcription factor 1
Synonyms: 2310038G18Rik, cns-1, Emb
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 19009
HGNC: HGNC:9224
Homologene: 7703
Sacs
Name: sacsin
Synonyms: E130115J16Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 50720
Cps1
Name: carbamoyl-phosphate synthetase 1
Synonyms: CPS, 4732433M03Rik, CPSase I, D1Ucla3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227231
HGNC: HGNC:2323
Homologene: 68208
Pex5l
Name: peroxisomal biogenesis factor 5-like
Synonyms: PXR2, Pex2, 1700016J08Rik, TRIP8b
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 58869
Homologene: 9562
Lcp1
Name: lymphocyte cytosolic protein 1
Synonyms: L-plastin, Pls2, L-fimbrin, D14Ertd310e
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 18826
HGNC: HGNC:6528
Homologene: 80174
Pgm2
Name: phosphoglucomutase 2
Synonyms: Pgm1, Pgm-1, 3230402E02Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 66681
HGNC: HGNC:8906
Homologene: 6693
Cd46
Name: CD46 antigen, complement regulatory protein
Synonyms: CD46, Mcp
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17221
HGNC: HGNC:6953
Homologene: 7832
Hsp90b1
Name: heat shock protein 90, beta (Grp94), member 1
Synonyms: tumor rejection antigen (gp96) 1, Tra1, 90 kDa, GRP94, Targ2, ERp99, Tra-1, endoplasmin, gp96
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 22027
Homologene: 2476
Zfp974
Name: zinc finger protein 974
Synonyms: 1700049G17Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 73430
Sele
Name: selectin, endothelial cell
Synonyms: E-selectin, CD62E, Elam
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20339
Homologene: 389
Tex44
Name: testis expressed 44
Synonyms: 1700019O17Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71863
Homologene: 51874
Poc1b
Name: POC1 centriolar protein B
Synonyms: Wdr51b, 4933430F16Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 382406
Homologene: 41728
Tox2
Name: TOX high mobility group box family member 2
Synonyms: RxHMG1, LOC269389
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 269389
Homologene: 13155
Yod1
Name: YOD1 deubiquitinase
Synonyms: 9930028C20Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226418
Homologene: 13176
Trim21
Name: tripartite motif-containing 21
Synonyms: Ro52, Ssa1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20821
Homologene: 2365
Mroh6
Name: maestro heat-like repeat family member 6
Synonyms: Gm19570
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223645
Homologene: 90414
Aldoc
Name: aldolase C, fructose-bisphosphate
Synonyms: Aldolase C, Aldo3, Scrg2, zebrin II
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11676
HGNC: HGNC:418
Homologene: 21073
Klhl41
Name: kelch-like 41
Synonyms: Kbtbd10, LOC228003
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228003
Homologene: 4421
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 67,160,871 bp
  • T to A, chromosome 1 at 86,426,485 bp
  • G to A, chromosome 1 at 130,717,538 bp
  • C to T, chromosome 1 at 164,053,673 bp
  • T to C, chromosome 1 at 195,083,467 bp
  • A to T, chromosome 2 at 31,514,784 bp
  • T to C, chromosome 2 at 69,674,700 bp
  • T to C, chromosome 2 at 119,778,296 bp
  • G to C, chromosome 2 at 120,955,640 bp
  • A to G, chromosome 2 at 163,320,377 bp
  • A to T, chromosome 2 at 180,188,574 bp
  • A to T, chromosome 3 at 32,958,798 bp
  • T to G, chromosome 3 at 51,455,873 bp
  • T to C, chromosome 3 at 83,012,901 bp
  • T to C, chromosome 5 at 64,100,975 bp
  • G to A, chromosome 6 at 18,866,654 bp
  • T to A, chromosome 6 at 22,297,892 bp
  • T to C, chromosome 6 at 37,943,485 bp
  • A to T, chromosome 7 at 27,911,649 bp
  • T to C, chromosome 7 at 42,489,500 bp
  • A to T, chromosome 7 at 89,243,964 bp
  • A to T, chromosome 7 at 102,559,212 bp
  • G to A, chromosome 7 at 109,810,737 bp
  • G to T, chromosome 8 at 111,890,044 bp
  • G to A, chromosome 8 at 123,893,217 bp
  • T to C, chromosome 9 at 64,310,438 bp
  • T to A, chromosome 10 at 70,014,028 bp
  • T to C, chromosome 10 at 86,701,905 bp
  • T to A, chromosome 10 at 99,152,871 bp
  • C to T, chromosome 10 at 127,098,543 bp
  • G to T, chromosome 11 at 22,836,888 bp
  • T to A, chromosome 11 at 78,326,092 bp
  • A to T, chromosome 11 at 100,708,273 bp
  • C to T, chromosome 13 at 67,620,146 bp
  • A to T, chromosome 14 at 56,524,350 bp
  • C to A, chromosome 14 at 61,180,700 bp
  • A to G, chromosome 14 at 75,206,189 bp
  • C to T, chromosome 14 at 104,479,474 bp
  • T to A, chromosome 14 at 123,599,934 bp
  • T to A, chromosome 15 at 8,322,590 bp
  • T to C, chromosome 15 at 75,888,492 bp
  • T to C, chromosome 15 at 100,579,883 bp
  • T to C, chromosome 15 at 102,488,790 bp
  • A to G, chromosome 16 at 32,950,420 bp
  • A to G, chromosome 17 at 33,066,226 bp
  • G to A, chromosome 18 at 37,413,476 bp
  • A to G, chromosome 18 at 43,305,078 bp
  • T to A, chromosome 19 at 9,011,562 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6731 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044849-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.