Strain Name:
C57BL/6J-MtgxR6733Btlr/Mmmh
Stock Number:
044851-MU
Citation ID:
RRID:MMRRC_044851-MU
Other Names:
R6733 (G1)
Major Collection:

Strain Information

Kmt2c
Name: lysine (K)-specific methyltransferase 2C
Synonyms: HALR, E330008K23Rik, Mll3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231051
Homologene: 46480
Thop1
Name: thimet oligopeptidase 1
Synonyms: EP24.15
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 50492
Homologene: 55726
Cnot2
Name: CCR4-NOT transcription complex, subunit 2
Synonyms: 2600016M12Rik, 2810470K03Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 72068
HGNC: HGNC:7878
Homologene: 40953
Unk
Name: unkempt family zinc finger
Synonyms: Zc3h5, B230379M23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217331
Homologene: 18194
Phc1
Name: polyhomeotic 1
Synonyms: Edr1, rae28, Mph1, Rae-28
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 13619
HGNC: HGNC:3182
Homologene: 107079
Afdn
Name: afadin, adherens junction formation factor
Synonyms: AF6, S-afadin, 5033403D15Rik, Afadin, I-afadin, Mllt4
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 17356
HGNC: HGNC:7137
Homologene: 21202
Syt9
Name: synaptotagmin IX
Synonyms: Sytv
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 60510
Homologene: 11062
Slc6a11
Name: solute carrier family 6 (neurotransmitter transporter, GABA), member 11
Synonyms: Gabt4, GAT4, E130202I16Rik, D930045G19Rik, Gat3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243616
Homologene: 129935
Ror1
Name: receptor tyrosine kinase-like orphan receptor 1
Synonyms: Ntrkr1, 2810404D04Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 26563
Homologene: 3675
Rasa3
Name: RAS p21 protein activator 3
Synonyms: R-Ras gap, hlb381, Ras GTPase-activating protein III, GAPIII, GAPIII activator 3, scat
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 19414
Homologene: 7217
Dedd2
Name: death effector domain-containing DNA binding protein 2
Synonyms: 2410050E11Rik, FLAME-3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67379
Homologene: 23569
Pkd1l3
Name: polycystic kidney disease 1 like 3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244646
Homologene: 14627
Ccdc125
Name: coiled-coil domain containing 125
Synonyms: 5830436D01Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 76041
VEGA: 13
Homologene: 27932
Zfp942
Name: zinc finger protein 942
Synonyms: 3110048L19Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 73233
Homologene: 133237
Dnah3
Name: dynein, axonemal, heavy chain 3
Synonyms: Dnahc3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 381917
HGNC: HGNC:2949
Homologene: 19674
Ptprh
Name: protein tyrosine phosphatase receptor type H
Synonyms: SAP-1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 545902
HGNC: HGNC:9672
Homologene: 37693
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: OTTMUSG00000005786, LOC380698
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380698
Homologene: 70869
Il25
Name: interleukin 25
Synonyms: Il17e, IL-17E
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 140806
VEGA: 14
Homologene: 15429
Tom1l1
Name: target of myb1-like 1 (chicken)
Synonyms: 2310045L10Rik, Srcasm
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71943
Homologene: 38055
Aoc1l2
Name: amine oxidase copper containing 1-like 2
Synonyms: 1600015I10Rik, Doxl1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 69761
HGNC: HGNC:80
Homologene: 79726
Rsl1
Name: regulator of sex limited protein 1
Synonyms: rslcan-9
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 380855
Homologene: 110878
Zkscan6
Name: zinc finger with KRAB and SCAN domains 6
Synonyms: 1700128E15Rik, Zfp535, KOX11, D11Ertd714e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 52712
Homologene: 12119
Psg20
Name: pregnancy-specific beta-1-glycoprotein 20
Synonyms: EG434540, cea7
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 434540
Homologene: 110989
Prl5a1
Name: prolactin family 5, subfamily a, member 1
Synonyms: PLP-L, 1600013P04Rik, Prlpl, D13Wsu14e
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 28078
Homologene: 11378
Or5b97
Name: olfactory receptor family 5 subfamily B member 97
Synonyms: Olfr1447, GA_x6K02T2RE5P-3231251-3230331, MOR202-3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258698
HGNC: HGNC:8324
Homologene: 74233
Cfd
Name: complement factor D
Synonyms: D component (adipsin) of complement, factor D, Adn, DF
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11537
VEGA: 10
HGNC: HGNC:2771
Homologene: 20453
Slc22a8
Name: solute carrier family 22 (organic anion transporter), member 8
Synonyms: Roct, mOat3, OAT3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 19879
VEGA: 19
Homologene: 20901
H6pd
Name: hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
Synonyms: G6pd1, Gpd1, Gpd-1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100198
HGNC: HGNC:4795
Homologene: 48275
Sgpp1
Name: sphingosine-1-phosphate phosphatase 1
Synonyms: SPP, SPP1, mSPP1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 81535
VEGA: 12
Homologene: 101696
Marveld3
Name: MARVEL (membrane-associating) domain containing 3
Synonyms: MARVD3, Mrvldc3, 1810006A16Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 73608
Homologene: 12504
Msl1
Name: male specific lethal 1
Synonyms: 4930463F05Rik, 4121402D02Rik, 2810017F12Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74026
Homologene: 129785
Zscan25
Name: zinc finger and SCAN domain containing 25
Synonyms: EG666311, Zfp498
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 666311
Homologene: 64820
Fer1l5
Name: fer-1 like family member 5
Synonyms: 4930533C12Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 100534273
Homologene: 85232
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 36,408,672 bp
  • T to C, chromosome 4 at 100,426,055 bp
  • A to T, chromosome 4 at 149,985,121 bp
  • C to T, chromosome 5 at 25,409,293 bp
  • T to A, chromosome 5 at 145,290,913 bp
  • T to C, chromosome 6 at 48,930,530 bp
  • A to G, chromosome 6 at 114,134,898 bp
  • A to T, chromosome 6 at 122,336,886 bp
  • T to C, chromosome 7 at 4,603,044 bp
  • A to T, chromosome 7 at 18,674,622 bp
  • T to C, chromosome 7 at 25,203,907 bp
  • C to T, chromosome 7 at 107,425,296 bp
  • A to G, chromosome 7 at 119,922,974 bp
  • T to C, chromosome 8 at 13,580,037 bp
  • T to A, chromosome 8 at 109,648,494 bp
  • T to C, chromosome 8 at 109,962,049 bp
  • C to A, chromosome 10 at 79,891,802 bp
  • T to A, chromosome 10 at 81,081,412 bp
  • G to A, chromosome 10 at 116,498,153 bp
  • A to T, chromosome 11 at 59,028,595 bp
  • A to G, chromosome 11 at 65,828,635 bp
  • A to G, chromosome 11 at 90,685,060 bp
  • A to G, chromosome 11 at 98,800,056 bp
  • A to G, chromosome 11 at 116,050,755 bp
  • G to C, chromosome 12 at 75,735,469 bp
  • G to T, chromosome 13 at 28,149,936 bp
  • A to G, chromosome 13 at 67,177,142 bp
  • T to A, chromosome 13 at 100,694,487 bp
  • T to C, chromosome 14 at 54,933,033 bp
  • C to T, chromosome 17 at 13,823,353 bp
  • C to A, chromosome 17 at 21,928,752 bp
  • T to C, chromosome 19 at 8,609,292 bp
  • A to T, chromosome 19 at 12,901,241 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6733 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044851-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.