Strain Name:
C57BL/6J-MtgxR6777Btlr/Mmmh
Stock Number:
044893-MU
Citation ID:
RRID:MMRRC_044893-MU
Other Names:
R6777 (G1)
Major Collection:

Strain Information

Gldc
Name: glycine decarboxylase
Synonyms: D030049L12Rik, b2b2679Clo, D19Wsu57e
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 104174
VEGA: 19
HGNC: HGNC:4313
Homologene: 141
Fzr1
Name: fizzy and cell division cycle 20 related 1
Synonyms: Cdh1, Fyr
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 56371
Homologene: 9444
Crybg3
Name: beta-gamma crystallin domain containing 3
Synonyms: Gm9581
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224273
Homologene: 28544
Hspa12a
Name: heat shock protein 12A
Synonyms: 1700063D12Rik, Hspa12a, Gm19925
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 73442
VEGA: 19
Homologene: 18422
Atp2c1
Name: ATPase, Ca++-sequestering
Synonyms: PMR1, SPCA, 1700121J11Rik, D930003G21Rik, ATP2C1A
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235574
Homologene: 56672
Smg1
Name: SMG1 nonsense mediated mRNA decay associated PI3K related kinase
Synonyms: SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans), C130002K18Rik, 5430435M13Rik, 2610207I05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233789
Homologene: 56697
Cux1
Name: cut-like homeobox 1
Synonyms: CDP, Cutl1, Cux-1, Cux
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13047
HGNC: HGNC:2557
Tmem242
Name: transmembrane protein 242
Synonyms: 2310046K16Rik, 5730437N04Rik, 1110008A10Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 70544
Homologene: 44020
Ralgps2
Name: Ral GEF with PH domain and SH3 binding motif 2
Synonyms: 1810020P17Rik, 2210408F11Rik, 9130014M22Rik, 4921528G01Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 78255
Homologene: 23421
Pex1
Name: peroxisomal biogenesis factor 1
Synonyms: 5430414H02Rik, ZWS1, E330005K07Rik, peroxisome biogenesis factor 1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71382
HGNC: HGNC:8850
Homologene: 27006
Galnt9
Name: polypeptide N-acetylgalactosaminyltransferase 9
Synonyms: GalNAc-T9
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231605
HGNC: HGNC:4131
Homologene: 72793
Srp68
Name: signal recognition particle 68
Synonyms: 2610024I03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217337
Homologene: 7056
Adss2
Name: adenylosuccinate synthase 2
Synonyms: AS, Adss
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 11566
HGNC: HGNC:292
Homologene: 875
Serpina3c
Name: serine (or cysteine) peptidase inhibitor, clade A, member 3C
Synonyms: Kalbp, Klkbp, 1A1, alpha-1 antiproteinase
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 16625
HGNC: HGNC:16
Homologene: 111129
Dkk2
Name: dickkopf WNT signaling pathway inhibitor 2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 56811
HGNC: HGNC:2892
Homologene: 8681
Rbp3
Name: retinol binding protein 3, interstitial
Synonyms: Rbp-3, Irbp
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 19661
VEGA: 14
HGNC: HGNC:9921
Homologene: 9261
2900092C05Rik
Name: RIKEN cDNA 2900092C05 gene
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 73090
Homologene: 49900
Pkd1l3
Name: polycystic kidney disease 1 like 3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244646
Homologene: 14627
Pla2g2c
Name: phospholipase A2, group IIC
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18781
HGNC: HGNC:9032
Homologene: 7477
Eml3
Name: echinoderm microtubule associated protein like 3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 225898
VEGA: 19
Homologene: 27044
Or11j4
Name: olfactory receptor family 11 subfamily J member 4
Synonyms: MOR106-5, GA_x6K02T2PMLR-6089963-6090901, Olfr736
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258660
Homologene: 64902
Capn2
Name: calpain 2
Synonyms: Capa-2, Capa2, m-calpain
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12334
HGNC: HGNC:1479
Homologene: 1326
Adam7
Name: a disintegrin and metallopeptidase domain 7
Synonyms: EAP1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 11500
HGNC: HGNC:214
Homologene: 2830
Tmprss13
Name: transmembrane protease, serine 13
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 214531
Homologene: 12936
Slc24a3
Name: solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
Synonyms: NCKX3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 94249
Homologene: 41390
Ssx2ip
Name: SSX family member 2 interacting protein
Synonyms: Adip
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99167
Homologene: 8522
Terf2
Name: telomeric repeat binding factor 2
Synonyms: TRF2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 21750
Homologene: 4133
Ganc
Name: glucosidase, alpha; neutral C
Synonyms: 5830445O15Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 76051
HGNC: HGNC:4139
Homologene: 25627
Ly6g
Name: lymphocyte antigen 6 family member G
Synonyms: Gr-1, Ly-6G, Gr1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 546644
Homologene: 113718
Trgv3
Name: T cell receptor gamma, variable 3
Synonyms: Tcrg-V3, vgamma3
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 21637
Gm49359
Name: predicted gene, 49359
Type: Gene
Species: Mouse
Chromosome: 13
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 156,887,945 bp
  • A to T, chromosome 1 at 177,776,336 bp
  • A to G, chromosome 1 at 182,470,177 bp
  • A to G, chromosome 2 at 120,444,149 bp
  • A to G, chromosome 2 at 145,640,282 bp
  • T to A, chromosome 3 at 132,173,811 bp
  • C to T, chromosome 3 at 146,438,721 bp
  • T to C, chromosome 4 at 138,743,665 bp
  • T to A, chromosome 5 at 3,622,358 bp
  • G to A, chromosome 5 at 110,620,599 bp
  • C to G, chromosome 5 at 136,565,568 bp
  • A to T, chromosome 7 at 12,512,829 bp
  • C to A, chromosome 7 at 118,189,117 bp
  • A to G, chromosome 8 at 107,070,537 bp
  • T to C, chromosome 8 at 109,626,814 bp
  • C to T, chromosome 9 at 45,336,101 bp
  • T to A, chromosome 9 at 105,418,600 bp
  • A to G, chromosome 10 at 81,370,493 bp
  • A to T, chromosome 11 at 116,262,904 bp
  • T to C, chromosome 12 at 104,151,810 bp
  • A to G, chromosome 13 at 19,243,280 bp
  • A to T, chromosome 13 at 62,455,192 bp
  • C to A, chromosome 14 at 33,954,273 bp
  • A to T, chromosome 14 at 50,393,658 bp
  • T to C, chromosome 14 at 68,525,335 bp
  • A to G, chromosome 15 at 75,158,582 bp
  • A to G, chromosome 16 at 59,558,315 bp
  • G to A, chromosome 17 at 5,433,555 bp
  • T to C, chromosome 19 at 8,936,722 bp
  • T to C, chromosome 19 at 30,133,512 bp
  • A to G, chromosome 19 at 58,822,087 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6777 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044893-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.