Strain Name:
C57BL/6J-MtgxR6782Btlr/Mmmh
Stock Number:
044896-MU
Citation ID:
RRID:MMRRC_044896-MU
Other Names:
R6782 (G1)
Major Collection:

Strain Information

Npr1
Name: natriuretic peptide receptor 1
Synonyms: NPR-A, GC-A, NPRA, guanylyl cyclase-A
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18160
HGNC: HGNC:7943
Homologene: 37367
Htr5b
Name: 5-hydroxytryptamine (serotonin) receptor 5B
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 15564
Homologene: 74951
Cacna1g
Name: calcium channel, voltage-dependent, T type, alpha 1G subunit
Synonyms: Cav3.1d, a1G
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12291
HGNC: HGNC:1394
Homologene: 22544
Esco2
Name: establishment of sister chromatid cohesion N-acetyltransferase 2
Synonyms: D030072L07Rik, 2410004I17Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 71988
Homologene: 12432
Foxp1
Name: forkhead box P1
Synonyms: 4932443N09Rik, 3110052D19Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 108655
HGNC: HGNC:3823
Homologene: 13092
Ano1
Name: anoctamin 1, calcium activated chloride channel
Synonyms: Tmem16a
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101772
Homologene: 75079
Arl5b
Name: ADP-ribosylation factor-like 5B
Synonyms: 4930587A11Rik, Arl8
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 75869
Homologene: 101695
Bbx
Name: bobby sox HMG box containing
Synonyms: 5530401J07Rik, 5730403O13Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 70508
Homologene: 10634
Ankrd17
Name: ankyrin repeat domain 17
Synonyms: 4933425K22Rik, Gtar, A130069E23Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 81702
Homologene: 82403
Dot1l
Name: DOT1 like histone lysine methyltransferase
Synonyms: mDot1, KMT4
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 208266
Homologene: 32779
Pi4ka
Name: phosphatidylinositol 4-kinase alpha
Synonyms: Pik4ca
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224020
HGNC: HGNC:8983
Homologene: 11171
Ralgapb
Name: Ral GTPase activating protein, beta subunit (non-catalytic)
Synonyms: B230339M05Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228850
Homologene: 10666
Ric8b
Name: RIC8 guanine nucleotide exchange factor B
Synonyms: Ric-8, Ric-8b
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237422
VEGA: 10
Homologene: 23080
Arhgap42
Name: Rho GTPase activating protein 42
Synonyms: 9030420J04Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71544
Homologene: 28446
Wwc2
Name: WW, C2 and coiled-coil domain containing 2
Synonyms: D8Ertd594e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 52357
Homologene: 32618
Chd2
Name: chromodomain helicase DNA binding protein 2
Synonyms: 2810040A01Rik, 5630401D06Rik, 2810013C04Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244059
HGNC: HGNC:1917
Homologene: 37462
Atp5mc3
Name: ATP synthase membrane subunit c locus 3
Synonyms: Atp5g3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228033
HGNC: HGNC:843
Homologene: 133873
Hhip
Name: Hedgehog-interacting protein
Synonyms: Hip, Hhip1, Hip1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 15245
Homologene: 32469
Slc12a7
Name: solute carrier family 12, member 7
Synonyms: Kcc4
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20499
VEGA: 13
Homologene: 21312
Tenm3
Name: teneurin transmembrane protein 3
Synonyms: 2610100B16Rik, Ten-m3, Odz3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 23965
Homologene: 22673
Cntrl
Name: centriolin
Synonyms: IB3/5, Cep110, 6720467O09Rik, Ma2a8, b2b1468Clo, Cep1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 26920
HGNC: HGNC:1858
Homologene: 38260
Zfp975
Name: zinc finger protein 975
Synonyms: Gm5595
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 434179
Homologene: 134004
Zfp345
Name: zinc finger protein 345
Synonyms: OTTMUSG00000015743
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 545471
Homologene: 134546
Gtf3c2
Name: general transcription factor IIIC, polypeptide 2, beta
Synonyms: 1300004C11Rik, TFIIIC-BETA, 2610510G03Rik, TFIIIC110
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71752
HGNC: HGNC:4665
Homologene: 37490
Dnah5
Name: dynein, axonemal, heavy chain 5
Synonyms: Dnahc5, b2b3491Clo, b2b1565Clo, b2b1154Clo, b2b1537Clo, Mdnah5, b2b1134Clo
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 110082
HGNC: HGNC:2950
Homologene: 1048
Ptprd
Name: protein tyrosine phosphatase receptor type D
Synonyms: 3000002J10Rik, 1110002J03Rik, B230219D21Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 19266
HGNC: HGNC:9668
Sorcs1
Name: sortilin-related VPS10 domain containing receptor 1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 58178
Homologene: 10967
Ush2a
Name: usherin
Synonyms: MUSH2A, LOC269160, Ush2a, A930037M10Rik, A930011D15Rik, LOC381317, Ushrn
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22283
Homologene: 66151
Loxhd1
Name: lipoxygenase homology domains 1
Synonyms: 1700096C21Rik, sba
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240411
Mrc1
Name: mannose receptor, C type 1
Synonyms: MR, CD206
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17533
HGNC: HGNC:7228
Homologene: 37622
Gm10985
Name: predicted gene 10985
Type: Gene
Species: Mouse
Chromosome: 3
Cep162
Name: centrosomal protein 162
Synonyms: 4922501C03Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 382090
Homologene: 8930
Ifi206
Name: interferon activated gene 206
Synonyms: Gm4955, Pyblhin-C
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 102639543
HGNC: HGNC:5395
Homologene: 115929
Vmn2r73
Name: vomeronasal 2, receptor 73
Synonyms: EG620928
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 620928
Homologene: 115466
Mical2
Name: microtubule associated monooxygenase, calponin and LIM domain containing 2
Synonyms: Ebitein1, 5330438E18Rik, Micalcl, 4921517J23Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 320878
Homologene: 8760
Zfp217
Name: zinc finger protein 217
Synonyms: 4933431C08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228913
Homologene: 4757
Abca14
Name: ATP-binding cassette, sub-family A member 14
Synonyms: 4930539G24Rik, 1700110B15Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67928
Homologene: 86128
Akt3
Name: thymoma viral proto-oncogene 3
Synonyms: D930002M15Rik, Nmf350, PKB gamma
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 23797
HGNC: HGNC:393
Homologene: 55904
Tnrc18
Name: trinucleotide repeat containing 18
Synonyms: EG381742, Zfp469
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231861
Homologene: 45603
Or52a24
Name: olfactory receptor family 52 subfamily A member 24
Synonyms: MOR22-4P, Olfr1526-ps1, MOR22-1, Olfr628, MOR22-4P, GA_x6K02T2PBJ9-6457667-6458617
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259159
Homologene: 8420
Or5p63
Name: olfactory receptor family 5 subfamily P member 63
Synonyms: MOR204-31P, MOR204-29P, GA_x6K02T2PBJ9-10541702-10540758, Olfr1538-ps1, Olfr487, MOR204-31P
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258042
Homologene: 110483
Or5p70
Name: olfactory receptor family 5 subfamily P member 70
Synonyms: MOR204-37, Olfr495, GA_x6K02T2PBJ9-10725148-10726140
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258361
Homologene: 133600
H3c2
Name: H3 clustered histone 2
Synonyms: H3-53, Hist1h3b
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 319150
Homologene: 134491
Dcaf7
Name: DDB1 and CUL4 associated factor 7
Synonyms: Wdr68, 2610037L01Rik, 1700012F10Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71833
Homologene: 55930
Abcc3
Name: ATP-binding cassette, sub-family C member 3
Synonyms: MRP3, 1700019L09Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76408
HGNC: HGNC:54
Homologene: 68364
Ccdc63
Name: coiled-coil domain containing 63
Synonyms: 4921511C16Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 330188
Homologene: 45136
Spata13
Name: spermatogenesis associated 13
Synonyms: ESTM11
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219140
Homologene: 19482
Or4g16
Name: olfactory receptor family 4 subfamily G member 16
Synonyms: GA_x6K02T2Q125-72357646-72358581, MOR245-12, Olfr1279
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258388
Homologene: 121520
Vmn2r107
Name: vomeronasal 2, receptor 107
Synonyms: V2r6
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22312
Homologene: 129750
Tmem232
Name: transmembrane protein 232
Synonyms: LOC381107, E130009J12Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 381107
VEGA: 17
Homologene: 54378
Sdc2
Name: syndecan 2
Synonyms: Synd2, Hspg1, 4833414L08Rik, fibroglycan
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 15529
Homologene: 2253
Tll1
Name: tolloid-like
Synonyms: Tll-1, b2b2476Clo
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 21892
Homologene: 49202
Tada1
Name: transcriptional adaptor 1
Synonyms: Tada1l, 2900026B15Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 27878
Homologene: 41793
Gfi1
Name: growth factor independent 1 transcription repressor
Synonyms: Gfi-1, Pal-1, Pal1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14581
HGNC: HGNC:4237
Homologene: 3854
Gm5113
Name: predicted gene 5113
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330503
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 121,510,498 bp
  • A to G, chromosome 1 at 166,389,972 bp
  • A to G, chromosome 1 at 173,481,357 bp
  • A to T, chromosome 1 at 177,050,190 bp
  • A to G, chromosome 1 at 188,356,834 bp
  • T to C, chromosome 2 at 14,261,337 bp
  • A to G, chromosome 2 at 15,073,182 bp
  • T to G, chromosome 2 at 35,170,646 bp
  • C to T, chromosome 2 at 73,909,328 bp
  • A to G, chromosome 2 at 111,306,745 bp
  • T to C, chromosome 2 at 150,473,354 bp
  • G to A, chromosome 2 at 158,436,566 bp
  • T to C, chromosome 2 at 170,116,258 bp
  • TTCTCTCTCTCTCTCTCT to TTCTCTCTCTCTCTCT, chromosome 3 at 53,845,205 bp
  • T to C, chromosome 3 at 90,456,253 bp
  • T to C, chromosome 4 at 76,325,140 bp
  • A to C, chromosome 5 at 31,169,836 bp
  • T to C, chromosome 5 at 90,254,738 bp
  • A to T, chromosome 5 at 107,725,953 bp
  • A to T, chromosome 5 at 122,111,014 bp
  • T to C, chromosome 5 at 142,787,308 bp
  • T to C, chromosome 6 at 98,930,145 bp
  • G to A, chromosome 7 at 30,178,753 bp
  • A to C, chromosome 7 at 42,662,030 bp
  • G to A, chromosome 7 at 73,475,379 bp
  • A to G, chromosome 7 at 85,870,355 bp
  • A to G, chromosome 7 at 103,732,342 bp
  • T to C, chromosome 7 at 108,212,463 bp
  • T to G, chromosome 7 at 108,395,537 bp
  • A to G, chromosome 7 at 112,346,761 bp
  • C to T, chromosome 7 at 120,248,085 bp
  • G to A, chromosome 7 at 144,621,687 bp
  • A to G, chromosome 8 at 47,900,791 bp
  • A to G, chromosome 8 at 48,646,256 bp
  • A to G, chromosome 8 at 64,071,281 bp
  • T to C, chromosome 8 at 80,051,604 bp
  • T to A, chromosome 9 at 9,115,720 bp
  • A to T, chromosome 9 at 87,211,684 bp
  • C to T, chromosome 10 at 80,789,390 bp
  • T to C, chromosome 10 at 84,947,527 bp
  • A to T, chromosome 11 at 94,358,950 bp
  • A to G, chromosome 11 at 94,459,550 bp
  • A to G, chromosome 11 at 106,054,755 bp
  • T to C, chromosome 13 at 23,752,410 bp
  • T to A, chromosome 13 at 73,798,969 bp
  • G to T, chromosome 14 at 60,691,463 bp
  • T to C, chromosome 14 at 65,820,016 bp
  • T to A, chromosome 15 at 28,449,156 bp
  • C to A, chromosome 15 at 33,028,135 bp
  • T to A, chromosome 16 at 17,325,988 bp
  • A to G, chromosome 16 at 17,376,982 bp
  • T to C, chromosome 16 at 50,200,565 bp
  • T to C, chromosome 17 at 20,356,879 bp
  • T to C, chromosome 17 at 65,500,124 bp
  • T to A, chromosome 18 at 77,431,177 bp
  • G to T, chromosome 19 at 50,176,122 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6782 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044896-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.