Strain Name:
C57BL/6J-MtgxR6785Btlr/Mmmh
Stock Number:
044899-MU
Citation ID:
RRID:MMRRC_044899-MU
Other Names:
R6785 (G1)
Major Collection:

Strain Information

Fasl
Name: Fas ligand
Synonyms: APT1LG1, CD178, Tnfsf6, Fas-L, Fasl, CD95L
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14103
Homologene: 533
Tead4
Name: TEA domain family member 4
Synonyms: Tcf13r1, ETFR-2a, Rtef1, Tefr1a, Etfr2, Tefr, Tef3, TEF-3, TEAD-4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 21679
Homologene: 74463
Ppp6c
Name: protein phosphatase 6, catalytic subunit
Synonyms: 2310003C10Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67857
HGNC: HGNC:9323
Homologene: 68273
Ndnf
Name: neuron-derived neurotrophic factor
Synonyms: epidermacan, A930038C07Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 68169
Homologene: 11593
Coa4
Name: cytochrome c oxidase assembly factor 4
Synonyms: Chchd8, 5330414O08Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 68185
Homologene: 9567
Nfkb1
Name: nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
Synonyms: NF-kappaB p50, p50 subunit of NF kappaB, nuclear factor kappaB p50, p50, NF kappaB1, NF-kappaB, p50/p105
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18033
HGNC: HGNC:7794
Homologene: 2971
Fbxw8
Name: F-box and WD-40 domain protein 8
Synonyms: FBW6, 4930438M06Rik, FBXO29, Fbx29, FBW8
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231672
Homologene: 17731
Snrnp200
Name: small nuclear ribonucleoprotein 200 (U5)
Synonyms: HELIC2, U5-200KD, A330064G03Rik, Ascc3l1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 320632
Homologene: 5859
Tfdp1
Name: transcription factor Dp 1
Synonyms: Dp1, Drtf1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 21781
Homologene: 38276
Prrc2c
Name: proline-rich coiled-coil 2C
Synonyms: 9630039I18Rik, 1810043M20Rik, Bat2l2, Bat2d
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226562
Homologene: 41015
Katnb1
Name: katanin p80 (WD40-containing) subunit B 1
Synonyms: KAT, 2410003J24Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 74187
HGNC: HGNC:6217
Homologene: 4302
Rab11fip3
Name: RAB11 family interacting protein 3 (class II)
Synonyms: D030060O14Rik, Rab11-FIP3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 215445
Homologene: 49396
Tex2
Name: testis expressed gene 2
Synonyms: Def-5, Taz4, 4930568E07Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 21763
Homologene: 32414
Setdb1
Name: SET domain, bifurcated 1
Synonyms: ESET, KMT1E
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 84505
Homologene: 32157
Dync1h1
Name: dynein cytoplasmic 1 heavy chain 1
Synonyms: Swl, Dnchc1, 9930018I23Rik, Dnec1, dynein heavy chain, retrograde transport, MAP1C, Loa
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13424
HGNC: HGNC:2961
Homologene: 1053
Herc1
Name: HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
Synonyms: tbl, D130015N03Rik, 2810449H11Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235439
HGNC: HGNC:4867
Homologene: 31207
Abi1
Name: abl interactor 1
Synonyms: E3B1, Ssh3bp1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11308
Homologene: 38053
Hnrnpd
Name: heterogeneous nuclear ribonucleoprotein D
Synonyms: Hnrpd, Auf1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 11991
HGNC: HGNC:5036
Homologene: 22410
Mier2
Name: MIER family member 2
Synonyms: 2700087H15Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70427
Homologene: 18941
Scube2
Name: signal peptide, CUB domain, EGF-like 2
Synonyms: 4932442O19Rik, Cegf1, ICRFP703B1614Q5.1, ICRFP703N2430Q5.1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 56788
Homologene: 36383
Mybbp1a
Name: MYB binding protein (P160) 1a
Synonyms: p160MBP, p67MBP
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18432
HGNC: HGNC:7546
Homologene: 40954
Hspg2
Name: perlecan (heparan sulfate proteoglycan 2)
Synonyms: Pcn, perlecan, per, Plc
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 15530
HGNC: HGNC:5273
Homologene: 68473
Rai1
Name: retinoic acid induced 1
Synonyms: Gt1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19377
HGNC: HGNC:9834
Homologene: 7508
Ryr1
Name: ryanodine receptor 1, skeletal muscle
Synonyms: Ryr, calcium release channel isoform 1, skrr
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20190
Homologene: 68069
Prrg2
Name: proline-rich Gla (G-carboxyglutamic acid) polypeptide 2
Synonyms: 2510041M06Rik, 1600014G02Rik, N4WBP1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 65116
HGNC: HGNC:9470
Homologene: 735
Cfap74
Name: cilia and flagella associated protein 74
Synonyms: 2010015L04Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 544678
Homologene: 129584
Adamtsl3
Name: ADAMTS-like 3
Synonyms: punctin-2, 9230119C12Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 269959
Homologene: 18912
Ttn
Name: titin
Synonyms: mdm, D830007G01Rik, shru, 1100001C23Rik, D330041I19Rik, 2310057K23Rik, 2310036G12Rik, 2310074I15Rik, L56, connectin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Mboat7
Name: membrane bound O-acyltransferase domain containing 7
Synonyms: Leng4, Lpiat1, mBB1, 5730589L02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 77582
Homologene: 11510
Gen1
Name: GEN1, Holliday junction 5' flap endonuclease
Synonyms: 5830483C08Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 209334
VEGA: 12
Homologene: 35313
Trim80
Name: tripartite motif-containing 80
Synonyms: 4933422H20Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 432613
Homologene: 46325
H2-M9
Name: histocompatibility 2, M region locus 9
Synonyms: M9
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14997
Homologene: 110792
Kif21a
Name: kinesin family member 21A
Synonyms: N-5 kinesin
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16564
VEGA: 15
Homologene: 56761
Crybg1
Name: crystallin beta-gamma domain containing 1
Synonyms: Aim1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11630
HGNC: HGNC:356
Homologene: 18168
Igsf10
Name: immunoglobulin superfamily, member 10
Synonyms: Adlican2, CMF608, 6530405F15Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242050
Homologene: 18712
Shoc1
Name: shortage in chiasmata 1
Synonyms: LOC242489, Gm426, Mzip2, AI481877
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100155
Homologene: 79783
Acad12
Name: acyl-Coenzyme A dehydrogenase family, member 12
Synonyms: 9330129D05Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 338350
Espnl
Name: espin-like
Synonyms: LOC227357
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227357
Homologene: 77795
Thsd7b
Name: thrombospondin, type I, domain containing 7B
Synonyms: 1700074E13Rik, D130067I03Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 210417
Homologene: 18180
Tssk4
Name: testis-specific serine kinase 4
Synonyms: 4933424F08Rik, 1700020B19Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 71099
VEGA: 14
Homologene: 57078
Zfp267
Name: zinc finger protein 267
Synonyms: D3Ertd254e
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 241944
Homologene: 117700
Aldh18a1
Name: aldehyde dehydrogenase 18 family, member A1
Synonyms: 2810433K04Rik, Pycs
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 56454
HGNC: HGNC:9722
Homologene: 2142
Nostrin
Name: nitric oxide synthase trafficker
Synonyms: mDaIP2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 329416
Homologene: 43142
Lcn2
Name: lipocalin 2
Synonyms: neu-related lipocalin, 24p3, NGAL, NRL
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16819
HGNC: HGNC:6526
Homologene: 4064
Itih3
Name: inter-alpha trypsin inhibitor, heavy chain 3
Synonyms: Intin3, Itih-3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 16426
HGNC: HGNC:6168
Homologene: 1669
Vmn1r177
Name: vomeronasal 1 receptor 177
Synonyms: V1rd12
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 384572
Homologene: 122945
H6pd
Name: hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
Synonyms: G6pd1, Gpd-1, Gpd1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100198
HGNC: HGNC:4795
Homologene: 48275
Slfn3
Name: schlafen 3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20557
Homologene: 133236
Or1j10
Name: olfactory receptor family 1 subfamily J member 10
Synonyms: GA_x6K02T2NLDC-33070879-33071799, Olfr338, MOR136-5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258949
Homologene: 133647
Or8k35
Name: olfactory receptor family 8 subfamily K member 35
Synonyms: Olfr1082, MOR192-4_p, GA_x6K02T2Q125-48079993-48079157
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 404473
Homologene: 104285
Plekhf1
Name: pleckstrin homology domain containing, family F (with FYVE domain) member 1
Synonyms: LAPF, 1810013P09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72287
Homologene: 11516
Pdpr
Name: pyruvate dehydrogenase phosphatase regulatory subunit
Synonyms: 4930402E16Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 319518
Homologene: 9948
Acss2
Name: acyl-CoA synthetase short-chain family member 2
Synonyms: Acas2, AceCS1, ACAS, Acas1, Acs1, acetyl-CoA synthetase 1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 60525
Homologene: 6469
Krtap5-20
Name: keratin associated protein 5-20
Synonyms: Gm4559
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100043627
VEGA: 7
Slc35f3
Name: solute carrier family 35, member F3
Synonyms: B230375D17Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 210027
Homologene: 62481
Lce1l
Name: late cornified envelope 1L
Synonyms: 1110008K04Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 73730
Lmf2
Name: lipase maturation factor 2
Synonyms: Tmem153, Tmem112b
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105847
VEGA: 15
Homologene: 11251
Vmn2r40
Name: vomeronasal 2, receptor 40
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100042781
Homologene: 113703
B020011L13Rik
Name: RIKEN cDNA B020011L13 gene
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 547097
Homologene: 140625
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 91,322,221 bp
  • A to G, chromosome 1 at 117,801,069 bp
  • T to C, chromosome 1 at 129,430,907 bp
  • T to A, chromosome 1 at 161,781,835 bp
  • T to C, chromosome 1 at 162,709,101 bp
  • A to G, chromosome 2 at 22,953,467 bp
  • C to T, chromosome 2 at 32,387,027 bp
  • A to G, chromosome 2 at 36,376,842 bp
  • C to A, chromosome 2 at 36,376,951 bp
  • A to T, chromosome 2 at 39,197,581 bp
  • A to G, chromosome 2 at 69,183,927 bp
  • T to C, chromosome 2 at 76,711,495 bp
  • A to T, chromosome 2 at 76,747,944 bp
  • T to A, chromosome 2 at 86,594,421 bp
  • T to A, chromosome 2 at 127,229,165 bp
  • T to C, chromosome 2 at 155,560,685 bp
  • T to A, chromosome 3 at 36,165,452 bp
  • G to T, chromosome 3 at 59,319,244 bp
  • A to T, chromosome 3 at 92,850,193 bp
  • C to A, chromosome 3 at 95,326,401 bp
  • C to A, chromosome 3 at 135,615,303 bp
  • T to C, chromosome 4 at 59,049,066 bp
  • T to C, chromosome 4 at 137,508,398 bp
  • C to T, chromosome 4 at 149,982,790 bp
  • T to A, chromosome 4 at 155,454,024 bp
  • C to A, chromosome 5 at 99,978,424 bp
  • T to C, chromosome 5 at 118,092,689 bp
  • T to C, chromosome 5 at 121,609,845 bp
  • C to A, chromosome 6 at 65,703,063 bp
  • T to A, chromosome 6 at 128,242,481 bp
  • A to G, chromosome 7 at 3,685,836 bp
  • T to A, chromosome 7 at 8,908,204 bp
  • A to G, chromosome 7 at 23,866,137 bp
  • G to T, chromosome 7 at 29,064,874 bp
  • G to A, chromosome 7 at 38,222,064 bp
  • A to G, chromosome 7 at 45,060,225 bp
  • A to G, chromosome 7 at 82,522,004 bp
  • G to A, chromosome 7 at 100,539,253 bp
  • A to G, chromosome 7 at 109,810,617 bp
  • A to G, chromosome 7 at 142,274,108 bp
  • C to T, chromosome 8 at 13,370,485 bp
  • G to T, chromosome 8 at 13,377,233 bp
  • T to C, chromosome 8 at 95,095,642 bp
  • C to A, chromosome 8 at 111,124,611 bp
  • T to C, chromosome 8 at 126,394,459 bp
  • TCCC to TCC, chromosome 9 at 66,501,188 bp
  • T to C, chromosome 10 at 43,999,171 bp
  • T to C, chromosome 10 at 79,544,713 bp
  • A to G, chromosome 11 at 60,188,794 bp
  • T to C, chromosome 11 at 72,447,566 bp
  • A to T, chromosome 11 at 83,214,601 bp
  • A to C, chromosome 11 at 106,533,950 bp
  • T to C, chromosome 11 at 115,441,201 bp
  • A to G, chromosome 12 at 11,262,530 bp
  • G to A, chromosome 12 at 110,629,679 bp
  • C to T, chromosome 14 at 30,912,615 bp
  • T to A, chromosome 14 at 55,650,475 bp
  • A to T, chromosome 15 at 89,352,033 bp
  • A to T, chromosome 15 at 90,935,730 bp
  • T to G, chromosome 17 at 25,991,718 bp
  • T to C, chromosome 17 at 36,642,233 bp
  • A to G, chromosome 19 at 40,568,344 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6785 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044899-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.