Strain Name:
C57BL/6J-MtgxR6898Btlr/Mmmh
Stock Number:
044992-MU
Citation ID:
RRID:MMRRC_044992-MU
Other Names:
R6898 (G1)
Major Collection:

Strain Information

Fn1
Name: fibronectin 1
Synonyms: Fn, Fn-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14268
HGNC: HGNC:3778
Homologene: 1533
Gnl3
Name: guanine nucleotide binding protein nucleolar 3
Synonyms: nucleostemin, NS
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 30877
VEGA: 14
Homologene: 56670
Fryl
Name: FRY like transcription coactivator
Synonyms: 2310004H21Rik, 9030227G01Rik, 2510002A14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 72313
Homologene: 103956
Setx
Name: senataxin
Synonyms: Als4, A930037J23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 269254
HGNC: HGNC:445
Homologene: 41003
Lima1
Name: LIM domain and actin binding 1
Synonyms: 3526402A12Rik, 1110021C24Rik, epithelial protein lost in neoplasm, EPLIN
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 65970
Homologene: 9484
St7
Name: suppression of tumorigenicity 7
Synonyms: SEN4, 9430001H04Rik, Fam4a2, RAY1, TSG7, HELG
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 64213
Homologene: 10185
Dsp
Name: desmoplakin
Synonyms: 5730453H04Rik, DP, rul, 2300002E22Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 109620
HGNC: HGNC:3052
Homologene: 37922
Ntng1
Name: netrin G1
Synonyms: A930010C08Rik, Lmnt1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 80883
Homologene: 8949
Snx11
Name: sorting nexin 11
Synonyms: A930041K09Rik, 4933439F10Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74479
Homologene: 12568
Papln
Name: papilin, proteoglycan-like sulfated glycoprotein
Synonyms: E030033C16Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 170721
Homologene: 71541
Dnhd1
Name: dynein heavy chain domain 1
Synonyms: 8030491N06Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 77505
Homologene: 131117
Gdpd3
Name: glycerophosphodiester phosphodiesterase domain containing 3
Synonyms: 1110015E22Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 68616
Homologene: 23441
Capns2
Name: calpain, small subunit 2
Synonyms: 30K-2, 2310005G05Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 69543
Homologene: 57167
Spocd1
Name: SPOC domain containing 1
Synonyms: OTTMUSG00000009522
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 622480
Homologene: 83439
Aplnr
Name: apelin receptor
Synonyms: msr/apj, apelin receptor, APJ, Agtrl1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 23796
HGNC: HGNC:339
Homologene: 3784
Cul9
Name: cullin 9
Synonyms: Parc, 1810035I07Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 78309
Homologene: 56696
Dscam
Name: DS cell adhesion molecule
Synonyms: Down syndrome cell adhesion molecule, 4932410A21Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 13508
HGNC: HGNC:3039
Homologene: 74393
Ankrd7
Name: ankyrin repeat domain 7
Synonyms: 4930532L20Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 75196
Homologene: 35506
Wnk2
Name: WNK lysine deficient protein kinase 2
Synonyms: X83337, ESTM15, 1810073P09Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 75607
Homologene: 19155
Specc1
Name: sperm antigen with calponin homology and coiled-coil domains 1
Synonyms: Cytsb, 2810012G08Rik, B230396K10Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 432572
Homologene: 45157
Stab1
Name: stabilin 1
Synonyms: MS-1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 192187
Homologene: 9035
Pitrm1
Name: pitrilysin metallepetidase 1
Synonyms: MP-1, 2310012C15Rik, PreP, Ntup1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 69617
VEGA: 13
Homologene: 5742
Or2y13
Name: olfactory receptor family 2 subfamily Y member 14
Synonyms: MOR256-56, Olfr1383, GA_x6K02T2QP88-5912627-5911692
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 404337
Homologene: 105344
Aoc1l2
Name: amine oxidase copper containing 1-like 2
Synonyms: 1600015I10Rik, Doxl1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 69761
HGNC: HGNC:80
Homologene: 79726
Hsd17b3
Name: hydroxysteroid (17-beta) dehydrogenase 3
Synonyms: 17(beta)HSD type 3
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 15487
VEGA: 13
HGNC: HGNC:5212
Homologene: 20089
Tcf21
Name: transcription factor 21
Synonyms: Pod1, epc, podocyte-expressed 1, epicardin, capsulin, bHLHa23, Pod-1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 21412
VEGA: 10
Homologene: 2414
Tmcc3
Name: transmembrane and coiled coil domains 3
Synonyms: A230066D03Rik, C630016B22Rik, LOC380656
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 319880
Homologene: 10792
Pramel22
Name: PRAME like 22
Synonyms: Gm13088
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 277668
Homologene: 129883
Osmr
Name: oncostatin M receptor
Synonyms: OSMRB
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 18414
HGNC: HGNC:8507
Homologene: 2972
Eif4a3l1
Name: eukaryotic translation initiation factor 4A3 like 1
Synonyms: Gm8994, B020013A22Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 668137
Sgce
Name: sarcoglycan, epsilon
Synonyms: e-SG
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20392
Homologene: 31205
Serinc2
Name: serine incorporator 2
Synonyms: 2310004K20Rik, Tde2l, TDE2, FKSG84
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230779
Homologene: 27797
Crocc2
Name: ciliary rootlet coiled-coil, rootletin family member 2
Synonyms: LOC381284, E030010N08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 381284
Homologene: 141152
Vps16
Name: VSP16 CORVET/HOPS core subunit
Synonyms: 1810074M16Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 80743
Homologene: 7116
Toe1
Name: target of EGR1, member 1 (nuclear)
Synonyms: 4930584N22Rik, 4933424D16Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68276
Homologene: 11823
Col25a1
Name: collagen, type XXV, alpha 1
Synonyms: 2700062B08Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 77018
Homologene: 57111
Tgfbr3l
Name: transforming growth factor, beta receptor III-like
Synonyms: Gm14378, LOC100039590
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 100044509
Homologene: 130375
Nfu1
Name: NFU1 iron-sulfur cluster scaffold
Synonyms: CGI-33, 0610006G17Rik, Hirip5
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 56748
Homologene: 6369
Pramel7
Name: PRAME like 7
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 347712
Homologene: 87261
Emc9
Name: ER membrane protein complex subunit 9
Synonyms: Fam158a, Cgi112, 1500005A01Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 85308
Homologene: 41095
Spata6l
Name: spermatogenesis associated 6 like
Synonyms: 4430402I18Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 381218
Homologene: 128454
Gpt2
Name: glutamic pyruvate transaminase (alanine aminotransferase) 2
Synonyms: ALT2, 4631422C05Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 108682
Homologene: 68832
Tgfb2
Name: transforming growth factor, beta 2
Synonyms: Tgf-beta2, Tgfb-2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 21808
Homologene: 2432
Noto
Name: notochord homeobox
Synonyms: MmNot, tc, Flh, Not
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 384452
Homologene: 53496
Or4a70
Name: olfactory receptor family 4 subfamily A member 70
Synonyms: MOR231-5, GA_x6K02T2Q125-50937307-50936387, Olfr1242
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258970
Homologene: 27316
Eppk1
Name: epiplakin 1
Synonyms: EPPK, EPIPL1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223650
VEGA: 15
Homologene: 20006
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 71,600,413 bp
  • T to C, chromosome 1 at 93,215,582 bp
  • T to A, chromosome 1 at 186,632,500 bp
  • T to C, chromosome 2 at 29,148,108 bp
  • A to T, chromosome 2 at 85,139,811 bp
  • T to C, chromosome 2 at 87,489,726 bp
  • C to T, chromosome 2 at 89,494,250 bp
  • T to C, chromosome 2 at 130,437,681 bp
  • T to C, chromosome 3 at 109,872,218 bp
  • T to C, chromosome 3 at 130,584,728 bp
  • A to G, chromosome 4 at 116,807,474 bp
  • A to G, chromosome 4 at 129,956,512 bp
  • A to T, chromosome 4 at 130,255,442 bp
  • A to T, chromosome 4 at 143,655,483 bp
  • A to T, chromosome 5 at 73,022,142 bp
  • A to T, chromosome 6 at 4,689,666 bp
  • T to A, chromosome 6 at 17,854,946 bp
  • G to T, chromosome 6 at 18,868,101 bp
  • A to T, chromosome 6 at 48,931,041 bp
  • A to G, chromosome 6 at 85,427,960 bp
  • G to A, chromosome 6 at 87,017,052 bp
  • T to A, chromosome 6 at 136,328,619 bp
  • T to C, chromosome 7 at 105,687,377 bp
  • C to A, chromosome 7 at 126,771,029 bp
  • A to G, chromosome 8 at 4,250,365 bp
  • G to A, chromosome 8 at 85,518,052 bp
  • T to C, chromosome 8 at 92,901,977 bp
  • T to C, chromosome 10 at 22,819,504 bp
  • A to G, chromosome 10 at 94,551,172 bp
  • G to A, chromosome 11 at 49,523,709 bp
  • G to A, chromosome 11 at 62,118,336 bp
  • G to A, chromosome 11 at 96,769,062 bp
  • A to G, chromosome 12 at 83,777,460 bp
  • T to C, chromosome 13 at 6,555,459 bp
  • A to G, chromosome 13 at 38,192,217 bp
  • G to T, chromosome 13 at 49,071,081 bp
  • T to C, chromosome 13 at 64,059,525 bp
  • A to T, chromosome 14 at 31,013,179 bp
  • C to T, chromosome 14 at 31,158,963 bp
  • A to G, chromosome 14 at 55,584,910 bp
  • C to A, chromosome 15 at 6,815,883 bp
  • A to C, chromosome 15 at 76,111,926 bp
  • T to C, chromosome 15 at 99,781,267 bp
  • A to T, chromosome 16 at 96,829,900 bp
  • C to A, chromosome 17 at 46,511,026 bp
  • T to G, chromosome 19 at 28,944,288 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6898 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044992-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.