Strain Name:
C57BL/6J-MtgxR6990Btlr/Mmmh
Stock Number:
045096-MU
Citation ID:
RRID:MMRRC_045096-MU
Other Names:
R6990 (G1)
Major Collection:

Strain Information

Sall4
Name: spalt like transcription factor 4
Synonyms: Tex20, 5730441M18Rik, C330011P20Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99377
Homologene: 10716
Tyrp1
Name: tyrosinase-related protein 1
Synonyms: TRP1, TRP-1, Oca3, isa, Tyrp
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 22178
Homologene: 464
Chd7
Name: chromodomain helicase DNA binding protein 7
Synonyms: Todo, Gena 52, GENA 60, Dz, Cycn, Cyn, Obt, Mt, Whi, GENA 47, A730019I05Rik, Lda, Flo, Edy, WBE1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 320790
Homologene: 19067
Pde1c
Name: phosphodiesterase 1C
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 18575
HGNC: HGNC:8776
Homologene: 3682
Dnmt1
Name: DNA methyltransferase 1
Synonyms: Cxxc9, Dnmt1o, MommeD2, MTase
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 13433
VEGA: 9
HGNC: HGNC:2976
Homologene: 124071
Bltp3b
Name: bridge-like lipid transfer protein family member 3B
Synonyms: 4930506D01Rik, Uhrf1bp1l, E030041M21Rik, 2010319N22Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 75089
VEGA: 10
Homologene: 12590
Arap2
Name: ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
Synonyms: Centd1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 212285
Homologene: 9064
Tbc1d5
Name: TBC1 domain family, member 5
Synonyms: 1600014N05Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 72238
VEGA: 17
Homologene: 8834
Nf2
Name: neurofibromin 2
Synonyms: merlin, moesin-ezrin-radixin-like protein, schwannomin
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18016
HGNC: HGNC:7773
Homologene: 2180
Ucn3
Name: urocortin 3
Synonyms: Urocortin III
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 83428
VEGA: 13
Homologene: 49959
Oga
Name: O-GlcNAcase
Synonyms: 2810009A20Rik, Mgea5, 5830447M11Rik, Hy5, 4833427O07Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 76055
VEGA: 19
HGNC: HGNC:7056
Homologene: 8154
Uchl1
Name: ubiquitin carboxy-terminal hydrolase L1
Synonyms: PGP 9.5, PGP9.5
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22223
Homologene: 37894
Camta1
Name: calmodulin binding transcription activator 1
Synonyms: 1810059M14Rik, 2310058O09Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100072
Homologene: 18942
Bcr
Name: BCR activator of RhoGEF and GTPase
Synonyms: 5133400C09Rik, breakpoint cluster region
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 110279
VEGA: 10
HGNC: HGNC:1014
Homologene: 3192
2610008E11Rik
Name: RIKEN cDNA 2610008E11 gene
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 72128
Homologene: 86705
Zfp157
Name: zinc finger protein 157
Synonyms: A630094N24Rik, 2610020C11Rik, Roma
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 72154
Homologene: 57009
Fam13b
Name: family with sequence similarity 13, member B
Synonyms: 2610024E20Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225358
VEGA: 18
HGNC: HGNC:1335
Homologene: 9585
Abca16
Name: ATP-binding cassette, sub-family A member 16
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233810
Homologene: 132942
Peg10
Name: paternally expressed 10
Synonyms: HB-1, Edr, MyEF-3 like, MEF3L, Mart2, Rtl2, MyEF-3, Mar2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 170676
Homologene: 116067
Ppp2cb
Name: protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform
Synonyms: D8Ertd766e, PP2Ac
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 19053
HGNC: HGNC:9300
Homologene: 37889
Astn2
Name: astrotactin 2
Synonyms: Astnl, 1d8
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56079
Homologene: 77850
Mroh2b
Name: maestro heat-like repeat family member 2B
Synonyms: 4930455B06Rik, Heatr7b2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223825
VEGA: 15
Homologene: 128807
Tmem63a
Name: transmembrane protein 63a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 208795
Homologene: 101673
Vmn2r2
Name: vomeronasal 2, receptor 2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 100125586
Homologene: 129753
Krt86
Name: keratin 86
Synonyms: MHb4, Khb4, Krt2-10, Krt2-11
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16679
VEGA: 15
HGNC: HGNC:6463
Homologene: 1717
Xcr1
Name: chemokine (C motif) receptor 1
Synonyms: C motif-1/lymphotactin receptor, Ccxcr1, GPR5, XCR1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 23832
HGNC: HGNC:1625
Homologene: 21095
Myo1h
Name: myosin 1H
Synonyms: 4631401O15Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231646
Homologene: 82639
Or11l3
Name: olfactory receptor family 11 subfamily L member 3
Synonyms: Olfr323, GA_x6K02T2NKPP-794386-795357, MOR107-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258373
Homologene: 64865
Slc7a14
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 14
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 241919
Homologene: 76320
Or4p18
Name: olfactory receptor family 4 subfamily P member 18
Synonyms: Olfr1179, MOR225-2, GA_x6K02T2Q125-49890854-49889931
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258919
Homologene: 74070
Zbtb26
Name: zinc finger and BTB domain containing 26
Synonyms: A630026F21Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 320633
Homologene: 10853
Bap1
Name: Brca1 associated protein 1
Synonyms: 2300006C11Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 104416
HGNC: HGNC:950
Homologene: 3421
Pga5
Name: pepsinogen 5, group I
Synonyms: Pepf, 1110035E17Rik, pepsinogen A5
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 58803
VEGA: 19
Homologene: 105932
Vmn2r96
Name: vomeronasal 2, receptor 96
Synonyms: EG433070
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 433070
Trpt1
Name: tRNA phosphotransferase 1
Synonyms: Tpt1h, EST-MNCb3719, TPT1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107328
VEGA: 19
Homologene: 12878
Pira2
Name: paired-Ig-like receptor A2
Synonyms: 6M23
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18725
Homologene: 134028
Nr1h4
Name: nuclear receptor subfamily 1, group H, member 4
Synonyms: FXR, Fxr, RIP14, Rxrip14, HRR1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 20186
HGNC: HGNC:7967
Homologene: 3760
Zfp850
Name: zinc finger protein 850
Synonyms: C130069I09Rik, Gm4636
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100043772
Spns2
Name: SPNS lysolipid transporter 2, sphingosine-1-phosphate
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216892
Homologene: 71040
Speer4b
Name: spermatogenesis associated glutamate (E)-rich protein 4B
Synonyms: 1700081O22Rik, SPEER-4B
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 73526
Homologene: 69402
Ms4a7
Name: membrane-spanning 4-domains, subfamily A, member 7
Synonyms: CD20l4, CFFMA, A430103C15Rik, 9130422I10Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 109225
Homologene: 10922
Krtap2-20
Name: keratin associated protein 2-20
Synonyms: Gm11562
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 100502803
Homologene: 136079
Wdr54
Name: WD repeat domain 54
Synonyms: 1700030E05Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 75659
Homologene: 11382
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 180,961,121 bp
  • T to C, chromosome 2 at 37,436,545 bp
  • A to G, chromosome 2 at 88,402,295 bp
  • T to C, chromosome 2 at 168,755,070 bp
  • G to A, chromosome 3 at 31,223,579 bp
  • T to G, chromosome 3 at 64,117,187 bp
  • A to T, chromosome 4 at 8,844,525 bp
  • G to T, chromosome 4 at 65,992,303 bp
  • T to C, chromosome 4 at 80,835,437 bp
  • A to G, chromosome 4 at 151,145,044 bp
  • A to T, chromosome 5 at 27,497,078 bp
  • A to G, chromosome 5 at 62,676,517 bp
  • A to G, chromosome 5 at 66,682,475 bp
  • T to C, chromosome 5 at 114,330,160 bp
  • T to G, chromosome 5 at 138,456,510 bp
  • T to TCCA, chromosome 6 at 4,756,451 bp
  • C to G, chromosome 6 at 56,442,035 bp
  • A to C, chromosome 6 at 83,155,647 bp
  • T to A, chromosome 7 at 3,841,068 bp
  • A to T, chromosome 7 at 27,990,376 bp
  • A to G, chromosome 7 at 120,527,727 bp
  • A to G, chromosome 8 at 33,619,133 bp
  • A to T, chromosome 9 at 20,915,814 bp
  • A to G, chromosome 9 at 123,856,235 bp
  • G to A, chromosome 10 at 75,131,036 bp
  • T to G, chromosome 10 at 79,067,091 bp
  • T to C, chromosome 10 at 89,454,930 bp
  • A to G, chromosome 10 at 89,806,117 bp
  • T to C, chromosome 11 at 4,799,944 bp
  • T to C, chromosome 11 at 58,625,458 bp
  • T to C, chromosome 11 at 72,489,621 bp
  • T to A, chromosome 11 at 99,619,991 bp
  • C to T, chromosome 13 at 3,941,295 bp
  • A to G, chromosome 14 at 31,255,651 bp
  • A to G, chromosome 15 at 4,912,802 bp
  • A to G, chromosome 15 at 101,473,833 bp
  • T to A, chromosome 17 at 18,583,820 bp
  • A to T, chromosome 17 at 50,968,232 bp
  • A to G, chromosome 18 at 34,497,447 bp
  • A to G, chromosome 19 at 6,998,315 bp
  • A to T, chromosome 19 at 10,669,415 bp
  • A to T, chromosome 19 at 11,333,241 bp
  • G to A, chromosome 19 at 45,767,476 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6990 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045096-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.