Strain Name:
C57BL/6J-MtgxR7012Btlr/Mmmh
Stock Number:
045113-MU
Citation ID:
RRID:MMRRC_045113-MU
Other Names:
R7012 (G1)
Major Collection:

Strain Information

Sez6
Name: seizure related gene 6
Synonyms: sez-6, D11Bhm177e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20370
Homologene: 10948
Dock5
Name: dedicator of cytokinesis 5
Synonyms: rlc, 1110060D06Rik, lr2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 68813
VEGA: 14
Homologene: 57016
Birc5
Name: baculoviral IAP repeat-containing 5
Synonyms: TIAP, survivin, Api4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11799
HGNC: HGNC:593
Homologene: 37450
Setd2
Name: SET domain containing 2
Synonyms: KMT3A, 4921524K10Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235626
Homologene: 56493
Tyw1
Name: tRNA-yW synthesizing protein 1 homolog (S. cerevisiae)
Synonyms: Rsafd1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100929
Homologene: 7068
Sbno2
Name: strawberry notch 2
Synonyms: Stno
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216161
VEGA: 10
Homologene: 8981
Git1
Name: GIT ArfGAP 1
Synonyms: p95Cat, Cat-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216963
HGNC: HGNC:4272
Homologene: 32204
Zfp472
Name: zinc finger protein 472
Synonyms: Krim-1A, Krim-1B, Krim-1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224691
Homologene: 77422
Sh3d19
Name: SH3 domain protein D19
Synonyms: Kryn
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 27059
Homologene: 19064
Rab5c
Name: RAB5C, member RAS oncogene family
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19345
HGNC: HGNC:9785
Homologene: 55533
Adcy4
Name: adenylate cyclase 4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 104110
VEGA: 14
HGNC: HGNC:235
Homologene: 23149
Muc16
Name: mucin 16
Synonyms: 1110008I14Rik, LOC385009, Gm21044
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 73732
Homologene: 141193
Ap1b1
Name: adaptor protein complex AP-1, beta 1 subunit
Synonyms: b2b1660Clo, Adtb1, beta-prime adaptin
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11764
HGNC: HGNC:554
Homologene: 21972
Dbr1
Name: debranching RNA lariats 1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 83703
Homologene: 9428
Tbc1d32
Name: TBC1 domain family, member 32
Synonyms: C6orf170, b2b2284Clo, D630037F22Rik, Bromi
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 544696
VEGA: 10
Homologene: 51889
Cngb1
Name: cyclic nucleotide gated channel beta 1
Synonyms: BC016201, Cngb1, Cngb1b
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 333329
HGNC: HGNC:2151
Homologene: 136420
Stag3
Name: STAG3 cohesin complex component
Synonyms: SA-2, stromalin 3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 50878
Homologene: 40844
Clcn1
Name: chloride channel, voltage-sensitive 1
Synonyms: Clc1, SMCC1, Clc-1, nmf355, NMF355
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12723
HGNC: HGNC:2019
Homologene: 63
Pclo
Name: piccolo (presynaptic cytomatrix protein)
Synonyms: Pico, Acz
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 26875
Homologene: 69111
Slco1a6
Name: solute carrier organic anion transporter family, member 1a6
Synonyms: organic anion-transporting polypeptide, Oatp-5, Slc21a13, 4930422F19Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 28254
Homologene: 23416
Fhad1
Name: forkhead-associated phosphopeptide binding domain 1
Synonyms: 2900090M10Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329977
Homologene: 77947
Lysmd4
Name: LysM, putative peptidoglycan-binding, domain containing 4
Synonyms: 4930506D23Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 75099
Homologene: 45123
Ttll9
Name: tubulin tyrosine ligase-like family, member 9
Synonyms: 4930509O20Rik, 1700016F23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74711
Homologene: 41769
Trim60
Name: tripartite motif-containing 60
Synonyms: 2czf45, Rnf33
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234329
Homologene: 51876
Phlpp2
Name: PH domain and leucine rich repeat protein phosphatase 2
Synonyms: Phlppl, C130044A18Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244650
Homologene: 71015
Greb1l
Name: growth regulation by estrogen in breast cancer-like
Synonyms: mKIAA4095, AK220484
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 381157
Homologene: 73393
Vmn2r98
Name: vomeronasal 2, receptor 98
Synonyms: EG224552
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224552
Homologene: 115024
Col6a2
Name: collagen, type VI, alpha 2
Synonyms: Col6a-2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 12834
HGNC: HGNC:2212
Homologene: 1392
F13b
Name: coagulation factor XIII, beta subunit
Synonyms: Cf-13b, Cf13b
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14060
HGNC: HGNC:3534
Homologene: 1512
Rxfp2
Name: relaxin/insulin-like family peptide receptor 2
Synonyms: LGR8, Gpr106, Great
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 140498
Homologene: 15402
Adss1
Name: adenylosuccinate synthase 1
Synonyms: Adssl1, Adss
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 11565
VEGA: 12
Homologene: 111992
Adgrb1
Name: adhesion G protein-coupled receptor B1
Synonyms: B830018M07Rik, Bai1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 107831
HGNC: HGNC:943
Homologene: 1287
Slc43a3
Name: solute carrier family 43, member 3
Synonyms: SEEEG-1, Eeg1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 58207
Homologene: 40925
Itih4
Name: inter alpha-trypsin inhibitor, heavy chain 4
Synonyms: Itih-4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 16427
HGNC: HGNC:6169
Homologene: 1670
Usp16
Name: ubiquitin specific peptidase 16
Synonyms: 1200004E02Rik, UBP-M, 2810483I07Rik, 6330514E22Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74112
Homologene: 38183
Tmem132b
Name: transmembrane protein 132B
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 208151
Homologene: 28135
Vmn2r97
Name: vomeronasal 2, receptor 97
Synonyms: EG627367
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627367
Homologene: 115024
Cntn6
Name: contactin 6
Synonyms: NB-3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 53870
HGNC: HGNC:2176
Homologene: 8702
Or2y1g
Name: olfactory receptor family 2 subfamily Y member 1G
Synonyms: Olfr1393, GA_x6K02T2QP88-6154577-6153642, MOR256-24, MOR256-67_i
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258463
Homologene: 81347
Apold1
Name: apolipoprotein L domain containing 1
Synonyms: LOC381823
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 381823
Homologene: 12781
Ston1
Name: stonin 1
Synonyms: 4921524J06Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 77057
Homologene: 122152
Or5t16
Name: olfactory receptor family 5 subfamily T member 16
Synonyms: Olfr1101, MOR179-3, GA_x6K02T2Q125-48475870-48474938
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258584
Homologene: 74087
Lin28a
Name: lin-28 homolog A
Synonyms: Tex17, Lin-28, Lin28a, Lin28
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 83557
Homologene: 32592
Lipt1
Name: lipoyltransferase 1
Synonyms: EG623661
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 623661
Homologene: 50569
Tssk5
Name: testis-specific serine kinase 5
Synonyms: 1700091F14Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 73542
VEGA: 15
Homologene: 18832
Cops5
Name: COP9 signalosome subunit 5
Synonyms: CSN5, COP9 complex S5, Jab1, JUN activation binding protein, Sgn5
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 26754
HGNC: HGNC:2240
Homologene: 55992
Acox3
Name: acyl-Coenzyme A oxidase 3, pristanoyl
Synonyms: pristanoyl-CoA oxidase, EST-s59, PCOX
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 80911
HGNC: HGNC:121
Homologene: 37792
Or6e1
Name: olfactory receptor family 6 subfamily E member 1
Synonyms: IC6, GA_x6K02T2QVSB-39745261-39746202, Olfr49, MOR118-1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 18348
Homologene: 106373
Or13c9
Name: olfactory receptor family 13 subfamily C member 9
Synonyms: GA_x6K02T2N78B-7060274-7061225, Olfr271, MOR262-3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 258856
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 10,030,665 bp
  • T to C, chromosome 1 at 37,875,979 bp
  • A to G, chromosome 1 at 139,516,358 bp
  • T to C, chromosome 2 at 84,946,969 bp
  • A to T, chromosome 2 at 86,988,707 bp
  • T to C, chromosome 2 at 153,003,062 bp
  • A to G, chromosome 3 at 86,085,013 bp
  • A to G, chromosome 4 at 52,936,193 bp
  • A to G, chromosome 4 at 134,018,729 bp
  • CGG to CG, chromosome 4 at 141,918,291 bp
  • G to A, chromosome 5 at 14,750,479 bp
  • T to C, chromosome 5 at 35,612,087 bp
  • T to A, chromosome 5 at 125,698,590 bp
  • T to G, chromosome 5 at 130,277,730 bp
  • T to A, chromosome 5 at 138,297,609 bp
  • T to C, chromosome 5 at 150,081,194 bp
  • G to A, chromosome 6 at 42,290,608 bp
  • T to A, chromosome 6 at 104,726,262 bp
  • A to G, chromosome 6 at 104,774,480 bp
  • G to A, chromosome 6 at 134,984,044 bp
  • T to C, chromosome 6 at 142,086,561 bp
  • A to G, chromosome 7 at 67,226,017 bp
  • A to G, chromosome 8 at 65,000,391 bp
  • T to A, chromosome 8 at 95,257,955 bp
  • T to A, chromosome 8 at 109,876,854 bp
  • T to C, chromosome 9 at 18,495,618 bp
  • T to A, chromosome 9 at 99,583,321 bp
  • T to A, chromosome 9 at 110,547,683 bp
  • A to T, chromosome 10 at 56,224,724 bp
  • A to T, chromosome 10 at 76,614,677 bp
  • A to T, chromosome 10 at 80,069,518 bp
  • T to G, chromosome 11 at 5,030,963 bp
  • A to T, chromosome 11 at 49,280,996 bp
  • T to C, chromosome 11 at 77,499,780 bp
  • A to G, chromosome 11 at 77,977,795 bp
  • G to A, chromosome 11 at 100,719,963 bp
  • A to G, chromosome 11 at 117,849,436 bp
  • A to G, chromosome 12 at 112,634,236 bp
  • A to G, chromosome 14 at 30,890,749 bp
  • A to G, chromosome 14 at 54,282,217 bp
  • C to T, chromosome 14 at 55,779,919 bp
  • A to C, chromosome 14 at 67,822,586 bp
  • A to G, chromosome 15 at 74,529,901 bp
  • A to C, chromosome 15 at 76,373,545 bp
  • T to C, chromosome 16 at 87,458,744 bp
  • T to C, chromosome 17 at 18,947,494 bp
  • A to G, chromosome 17 at 19,066,268 bp
  • T to G, chromosome 17 at 32,977,246 bp
  • T to C, chromosome 17 at 88,635,985 bp
  • G to T, chromosome 18 at 10,529,707 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7012 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045113-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.