Strain Name:
C57BL/6J-MtgxR7029Btlr/Mmmh
Stock Number:
045130-MU
Citation ID:
RRID:MMRRC_045130-MU
Other Names:
R7029 (G1)
Major Collection:

Strain Information

Kcnj10
Name: potassium inwardly-rectifying channel, subfamily J, member 10
Synonyms: Kir4.1, Kir1.2, BIRK-1, BIR10, Kir4.1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16513
HGNC: HGNC:6256
Homologene: 1689
Vcan
Name: versican
Synonyms: hdf, DPEAAE, heart defect, 5430420N07Rik, PG-M, Cspg2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 13003
HGNC: HGNC:2464
Homologene: 3228
Mga
Name: MAX gene associated
Synonyms: Mga, D030062C11Rik, C130042M01Rik, Mad5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 29808
Homologene: 49351
Zfp423
Name: zinc finger protein 423
Synonyms: Ebfaz, Roaz, Zfp104, ataxia1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 94187
Homologene: 9010
Neurl4
Name: neuralized E3 ubiquitin protein ligase 4
Synonyms: 0610025P10Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216860
Homologene: 13029
Psme4
Name: proteasome (prosome, macropain) activator subunit 4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 103554
Homologene: 113742
Sfpq
Name: splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)
Synonyms: 5730453G22Rik, D4Ertd314e, PSF, REP1, 9030402K04Rik, 1110004P21Rik, 2810416M14Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 71514
Homologene: 3714
Ell
Name: elongation factor RNA polymerase II
Synonyms: eleven-nineteen lysine-rich leukemia gene, Men, Ell1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 13716
Homologene: 4762
Vapa
Name: vesicle-associated membrane protein, associated protein A
Synonyms: VAP33, synaptobrevin-associated protein of 33kDa
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 30960
VEGA: 17
Homologene: 37824
Zfp35
Name: zinc finger protein 35
Synonyms: Zfp-35
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 22694
Homologene: 133081
Robo2
Name: roundabout guidance receptor 2
Synonyms: D230004I22Rik, 2600013A04Rik, 9430089E08Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 268902
Homologene: 43188
Ccn3
Name: cellular communication network factor 3
Synonyms: CCN3, C130088N23Rik, Nov
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 18133
HGNC: HGNC:7885
Homologene: 1884
Ticam1
Name: TIR domain containing adaptor molecule 1
Synonyms: Trif, TICAM-1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106759
Homologene: 8605
Lyn
Name: LYN proto-oncogene, Src family tyrosine kinase
Synonyms: Yamaguchi sarcoma viral (v-yes-1) oncogene homolog, Hck-2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17096
HGNC: HGNC:6735
Homologene: 55649
Srebf1
Name: sterol regulatory element binding transcription factor 1
Synonyms: SREBP-1a, ADD-1, SREBP-1c, SREBP1, bHLHd1, SREBP-1, SREBP1c
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20787
Homologene: 3079
Bach1
Name: BTB and CNC homology 1, basic leucine zipper transcription factor 1
Synonyms: 6230421P05Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 12013
HGNC: HGNC:935
Homologene: 916
Dna2
Name: DNA replication helicase/nuclease 2
Synonyms: E130315B21Rik, Dna2l
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 327762
HGNC: HGNC:2939
Homologene: 6124
Sh2d3c
Name: SH2 domain containing 3C
Synonyms: SH2-containing Eph receptor-binding protein 1, Nsp3, Shep1, Chat, Cas/HEF1-associated signal transducer
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 27387
Homologene: 69145
Spp1
Name: secreted phosphoprotein 1
Synonyms: bone sialoprotein 1, Spp-1, 44kDa bone phosphoprotein, 2ar, osteopontin, minopontin, Ric, Opn, BNSP, ETA-1, OP, osteopontin-like protein, Apl-1, Opnl
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20750
Homologene: 20156
Klhl1
Name: kelch-like 1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 93688
HGNC: HGNC:6352
Homologene: 56903
Epha3
Name: Eph receptor A3
Synonyms: Hek, End3, Hek4, Mek4, Tyro4, Cek4
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 13837
VEGA: 16
HGNC: HGNC:3387
Homologene: 21083
Def6
Name: differentially expressed in FDCP 6
Synonyms: IBP, 2410003F05Rik, IRF-4-binding protein, 6430538D02Rik, SLAT
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 23853
HGNC: HGNC:2760
Homologene: 11103
Adcy5
Name: adenylate cyclase 5
Synonyms: AC5
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224129
VEGA: 16
HGNC: HGNC:236
Homologene: 11213
Tie1
Name: tyrosine kinase with immunoglobulin-like and EGF-like domains 1
Synonyms: TIE, D430008P04Rik, tie-1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 21846
Homologene: 3957
Myh4
Name: myosin, heavy polypeptide 4, skeletal muscle
Synonyms: MyHC-IIb, Myhsf, MHC2B, Minmus, MYH-2B, Minimsc, MM
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17884
HGNC: HGNC:7574
Homologene: 123880
Gys1
Name: glycogen synthase 1, muscle
Synonyms: Gys3, MGS
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14936
HGNC: HGNC:4706
Homologene: 113557
Whamm
Name: WAS protein homolog associated with actin, golgi membranes and microtubules
Synonyms: Whdc1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 434204
Homologene: 45851
Zdhhc14
Name: zinc finger, DHHC domain containing 14
Synonyms: B530001K09Rik, New1cp
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224454
VEGA: 17
Homologene: 62301
1700034J05Rik
Name: RIKEN cDNA 1700034J05 gene
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 73344
Homologene: 53485
Abhd4
Name: abhydrolase domain containing 4
Synonyms: 1110035H23Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105501
Homologene: 56937
Pcdhb15
Name: protocadherin beta 15
Synonyms: PcdhbO, Pcdhb7
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93886
HGNC: HGNC:8692
Homologene: 32429
Ppm1l
Name: protein phosphatase 1 (formerly 2C)-like
Synonyms: 5930404J21Rik, PP2C-epsilon, Pp2ce
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242083
Homologene: 33158
Srrm4
Name: serine/arginine repetitive matrix 4
Synonyms: bv, nSR100, 1500001A10Rik, flopsy, B230202K19Rik, fp
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 68955
Homologene: 49869
Zfp874b
Name: zinc finger protein 874b
Synonyms: 9630025I21Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 408067
Homologene: 135597
Scrn2
Name: secernin 2
Synonyms: SES2, D11Moh48
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217140
Homologene: 26698
Entrep2
Name: endosomal transmembrane epsin interactor 2
Synonyms: 5730507A09Rik, Fam189a1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 70638
Homologene: 77705
Reep2
Name: receptor accessory protein 2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225362
VEGA: 18
Homologene: 41146
Brox
Name: BRO1 domain and CAAX motif containing
Synonyms: 0610010K06Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71678
Homologene: 13499
Mrgpra3
Name: MAS-related GPR, member A3
Synonyms: MrgA3, G protein-coupled receptor
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233222
Homologene: 131159
Habp4
Name: hyaluronic acid binding protein 4
Synonyms: 4933413D03Rik, 4933428J01Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 56541
VEGA: 13
Homologene: 8615
Pomc
Name: pro-opiomelanocortin-alpha
Synonyms: beta-endorphin, gamma-melanocyte stimulating hormone, beta-melanocyte stimulating hormone, gamma-MSH, beta-MSH, BE, alpha-melanocyte stimulating hormone, alphaMSH, alpha-MSH, adrenal corticotropic hormone, ACTH, POMC, Pomc-1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 18976
VEGA: 12
HGNC: HGNC:9201
Homologene: 723
Iqcn
Name: IQ motif containing N
Synonyms: Gm16486
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 637079
Homologene: 141171
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 172,368,996 bp
  • G to A, chromosome 1 at 183,284,186 bp
  • T to C, chromosome 2 at 32,754,569 bp
  • A to G, chromosome 2 at 119,923,550 bp
  • C to A, chromosome 3 at 69,553,066 bp
  • A to G, chromosome 4 at 3,782,996 bp
  • T to C, chromosome 4 at 118,484,626 bp
  • G to A, chromosome 4 at 127,029,882 bp
  • A to G, chromosome 5 at 104,439,301 bp
  • T to A, chromosome 5 at 116,444,792 bp
  • T to C, chromosome 6 at 146,952,343 bp
  • A to G, chromosome 7 at 45,439,584 bp
  • G to T, chromosome 7 at 47,589,542 bp
  • T to A, chromosome 7 at 64,759,327 bp
  • A to G, chromosome 7 at 81,591,826 bp
  • G to A, chromosome 8 at 70,579,229 bp
  • G to T, chromosome 8 at 70,708,862 bp
  • C to A, chromosome 8 at 87,688,066 bp
  • T to C, chromosome 10 at 62,963,994 bp
  • A to G, chromosome 11 at 30,772,474 bp
  • T to C, chromosome 11 at 60,206,984 bp
  • T to C, chromosome 11 at 67,246,425 bp
  • T to A, chromosome 11 at 69,910,736 bp
  • T to A, chromosome 11 at 97,030,436 bp
  • A to G, chromosome 12 at 3,960,146 bp
  • A to T, chromosome 13 at 64,162,125 bp
  • T to C, chromosome 13 at 67,474,273 bp
  • C to T, chromosome 13 at 89,690,241 bp
  • T to A, chromosome 14 at 54,262,707 bp
  • T to A, chromosome 14 at 96,518,196 bp
  • A to G, chromosome 15 at 54,747,775 bp
  • A to G, chromosome 16 at 35,299,648 bp
  • T to A, chromosome 16 at 63,773,335 bp
  • T to G, chromosome 16 at 73,948,337 bp
  • G to A, chromosome 16 at 87,719,291 bp
  • A to G, chromosome 17 at 5,647,911 bp
  • A to G, chromosome 17 at 28,225,969 bp
  • A to T, chromosome 17 at 56,271,154 bp
  • G to A, chromosome 17 at 65,582,591 bp
  • T to A, chromosome 18 at 24,003,526 bp
  • A to G, chromosome 18 at 34,845,289 bp
  • T to A, chromosome 18 at 37,475,568 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7029 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045130-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.