Strain Name:
C57BL/6J-MtgxR7109Btlr/Mmmh
Stock Number:
045201-MU
Citation ID:
RRID:MMRRC_045201-MU
Other Names:
R7109 (G1)
Major Collection:

Strain Information

Wwp2
Name: WW domain containing E3 ubiquitin protein ligase 2
Synonyms: 1300010O06Rik, AIP2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66894
Homologene: 48490
Camsap3
Name: calmodulin regulated spectrin-associated protein family, member 3
Synonyms: Nezha, 2310057J16Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 69697
Homologene: 18966
Pcnt
Name: pericentrin (kendrin)
Synonyms: m275Asp, Pcnt2, m239Asp
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 18541
VEGA: 10
Anapc1
Name: anaphase promoting complex subunit 1
Synonyms: tsg24, 2610021O03Rik, Apc1, Mcpr
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17222
Homologene: 7414
Eif2ak4
Name: eukaryotic translation initiation factor 2 alpha kinase 4
Synonyms: GCN2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 27103
Homologene: 40891
Rsf1
Name: remodeling and spacing factor 1
Synonyms: Hbxap, p325, XAP8, C030033M12Rik, 4832420A03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233532
Homologene: 41142
Wasl
Name: WASP like actin nucleation promoting factor
Synonyms: Wiskott-Aldrich syndrome-like (human), 2900021I12Rik, 3110031I02Rik, N-WASP
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 73178
Homologene: 135996
Stip1
Name: stress-induced phosphoprotein 1
Synonyms: p60, Hsp70/Hsp90 organizing protein, Hop, IEF SSP 3521, STI1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 20867
VEGA: 19
Homologene: 4965
Herc1
Name: HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
Synonyms: 2810449H11Rik, D130015N03Rik, tbl
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235439
HGNC: HGNC:4867
Homologene: 31207
Lrrk2
Name: leucine-rich repeat kinase 2
Synonyms: cI-46, 9330188B09Rik, D630001M17Rik, 4921513O20Rik, LOC381026
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 66725
Homologene: 18982
Podxl2
Name: podocalyxin-like 2
Synonyms: D130074J02Rik, Endoglycan, PODLX2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 319655
Homologene: 9254
Trappc3
Name: trafficking protein particle complex 3
Synonyms: 1110058K12Rik, Bet3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 27096
Homologene: 6399
Klc1
Name: kinesin light chain 1
Synonyms: Kns2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 16593
HGNC: HGNC:6387
Homologene: 4056
Fam193a
Name: family with sequence homology 193, member A
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231128
Homologene: 2746
Pah
Name: phenylalanine hydroxylase
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 18478
HGNC: HGNC:8582
Homologene: 234
C1qtnf9
Name: C1q and tumor necrosis factor related protein 9
Synonyms: CTRP9, 9130217G22Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239126
Homologene: 18679
Epha6
Name: Eph receptor A6
Synonyms: m-ehk2, Hek12, Ehk2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 13840
Homologene: 56396
Plod2
Name: procollagen lysine, 2-oxoglutarate 5-dioxygenase 2
Synonyms: LH2, D530025C14Rik, Plod-2, lysyl hydroxylase 2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 26432
HGNC: HGNC:9082
Homologene: 22681
Synrg
Name: synergin, gamma
Synonyms: L71-5, Ap1gbp1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217030
HGNC: HGNC:557
Homologene: 105680
Copb2
Name: COPI coat complex subunit beta 2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 50797
HGNC: HGNC:2232
Homologene: 3499
Cenpk
Name: centromere protein K
Synonyms: C530004N04Rik, Solt, B130045K24Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 60411
VEGA: 13
Homologene: 11035
Dennd1a
Name: DENN domain containing 1A
Synonyms: 6030446I19Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227801
Homologene: 17141
Szt2
Name: SZT2 subunit of KICSTOR complex
Synonyms: seaizure threshold 2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230676
Homologene: 49413
Ncoa1
Name: nuclear receptor coactivator 1
Synonyms: KAT13A, bHLHe74, SRC-1, SRC-a/NCoA-1, steroid receptor coactivator-1, SRC1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 17977
VEGA: 12
HGNC: HGNC:7668
Homologene: 7859
Scn1a
Name: sodium channel, voltage-gated, type I, alpha
Synonyms: Nav1.1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20265
Homologene: 21375
Adamtsl3
Name: ADAMTS-like 3
Synonyms: punctin-2, 9230119C12Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 269959
Homologene: 18912
Ppp1r3a
Name: protein phosphatase 1, regulatory subunit 3A
Synonyms: GM, RGL
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 140491
HGNC: HGNC:9291
Homologene: 48124
Ush2a
Name: usherin
Synonyms: MUSH2A, LOC269160, Ush2a, A930037M10Rik, A930011D15Rik, LOC381317, Ushrn
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22283
Homologene: 66151
Or51a6
Name: olfactory receptor family 51 subfamily A member 6
Synonyms: GA_x6K02T2PBJ9-5666843-5665908, Olfr575, MOR8-1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259118
Homologene: 122786
Mbd3l1
Name: methyl-CpG binding domain protein 3-like 1
Synonyms: 1700095H13Rik, 1700070G05Rik, Mbd3l
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 73503
VEGA: 9
Homologene: 12502
Slc22a21
Name: solute carrier family 22 (organic cation transporter), member 21
Synonyms: Slc22a9, Octn3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 56517
Homologene: 137336
Nlrp2
Name: NLR family, pyrin domain containing 2
Synonyms: E330007A02Rik, Nalp2, Pan1, Nbs1, PYPAF2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232827
Homologene: 56789
Jakmip1
Name: janus kinase and microtubule interacting protein 1
Synonyms: Gababrbp, Marlin-1, 5830437M04Rik, C330021K24Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 76071
Homologene: 90789
Insr
Name: insulin receptor
Synonyms: 4932439J01Rik, IR, D630014A15Rik, IR-A, IR-B, CD220
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16337
HGNC: HGNC:6091
Homologene: 20090
Rasal3
Name: RAS protein activator like 3
Synonyms: A430107D22Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 320484
Homologene: 18901
Tulp4
Name: TUB like protein 4
Synonyms: 2210038L17Rik, 1110057P05Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 68842
Homologene: 32467
Mrps2
Name: mitochondrial ribosomal protein S2
Synonyms: 1500019M10Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 118451
Homologene: 99837
Ndst2
Name: N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
Synonyms: glucosaminyl N-deacetylase/N-sulphotransferase-2, [Heparan sulfate]-glucosamine N-sulfotransferase, Mndns
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 17423
VEGA: 14
HGNC: HGNC:7681
Homologene: 20803
Or5p1
Name: olfactory receptor family 5 subfamily P member 1
Synonyms: GA_x6K02T2PBJ9-10646917-10647849, MOR204-11, Olfr491
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258731
Homologene: 128150
Abtb2
Name: ankyrin repeat and BTB domain containing 2
Synonyms: BPOZ-2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99382
Homologene: 15904
Bst2
Name: bone marrow stromal cell antigen 2
Synonyms: C87040, 2310015I10Rik, Bst-2, GREG
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 69550
HGNC: HGNC:1119
Homologene: 138472
Alcam
Name: activated leukocyte cell adhesion molecule
Synonyms: SC1, DM-GRASP, MuSC, BEN, CD166
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 11658
HGNC: HGNC:400
Homologene: 1229
4921509C19Rik
Name: RIKEN cDNA 4921509C19 gene
Synonyms: LOC381389
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 381393
Homologene: 72396
Or7g16
Name: olfactory receptor family 7 subfamily G member 16
Synonyms: MOR149-1, GA_x6K02T2PVTD-12559294-12558356, Olfr828
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258598
HGNC: HGNC:8466
Homologene: 133690
Cfap221
Name: cilia and flagella associated protein 221
Synonyms: Gm101, Pcdp1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226356
Homologene: 88578
Zfp764
Name: zinc finger protein 764
Synonyms: 8030466O12Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233893
Homologene: 62158
Rdm1
Name: RAD52 motif 1
Synonyms: Rad52b, 2410008M22Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 66599
Homologene: 11992
Cchcr1
Name: coiled-coil alpha-helical rod protein 1
Synonyms: Hcr
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240084
Homologene: 10396
Pm20d2
Name: peptidase M20 domain containing 2
Synonyms: LOC242377, Acy1l2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242377
Homologene: 19025
Or4d10
Name: olfactory receptor family 4 subfamily D member 10
Synonyms: MOR239-7, GA_x6K02T2RE5P-2433425-2432490, Olfr1425
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258155
Homologene: 17398
Pdxk
Name: pyridoxal (pyridoxine, vitamin B6) kinase
Synonyms: 2310036D04Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216134
HGNC: HGNC:8819
Homologene: 2731
Zfp51
Name: zinc finger protein 51
Synonyms: Zfp-51, zfec12
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22709
VEGA: 17
Homologene: 134003
Ikbip
Name: IKBKB interacting protein
Synonyms: 1200009F10Rik, 1700023M03Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67454
Homologene: 12138
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 119,925,571 bp
  • T to A, chromosome 1 at 188,381,484 bp
  • T to A, chromosome 2 at 28,468,246 bp
  • T to A, chromosome 2 at 38,048,792 bp
  • T to C, chromosome 2 at 66,350,942 bp
  • T to C, chromosome 2 at 103,715,515 bp
  • C to T, chromosome 2 at 118,405,051 bp
  • A to G, chromosome 2 at 128,674,602 bp
  • T to G, chromosome 2 at 151,473,753 bp
  • A to T, chromosome 4 at 33,187,186 bp
  • A to G, chromosome 4 at 118,375,479 bp
  • A to G, chromosome 4 at 126,273,933 bp
  • C to A, chromosome 5 at 34,465,821 bp
  • C to T, chromosome 5 at 37,174,765 bp
  • A to T, chromosome 6 at 14,719,236 bp
  • G to A, chromosome 6 at 24,633,187 bp
  • C to T, chromosome 6 at 88,843,584 bp
  • A to G, chromosome 7 at 5,328,617 bp
  • C to T, chromosome 7 at 82,611,861 bp
  • CG to CGACGGCGGGG, chromosome 7 at 97,579,908 bp
  • A to T, chromosome 7 at 102,955,253 bp
  • A to G, chromosome 7 at 108,317,752 bp
  • A to G, chromosome 7 at 127,404,715 bp
  • A to G, chromosome 8 at 3,258,481 bp
  • A to G, chromosome 8 at 3,598,087 bp
  • A to G, chromosome 8 at 71,537,282 bp
  • A to G, chromosome 8 at 107,483,356 bp
  • G to T, chromosome 9 at 18,484,914 bp
  • A to T, chromosome 9 at 18,815,608 bp
  • A to T, chromosome 9 at 66,481,889 bp
  • T to C, chromosome 9 at 92,573,597 bp
  • T to A, chromosome 9 at 98,581,280 bp
  • T to G, chromosome 10 at 76,369,904 bp
  • T to A, chromosome 10 at 78,446,976 bp
  • T to C, chromosome 10 at 87,570,286 bp
  • C to A, chromosome 10 at 91,083,228 bp
  • A to G, chromosome 11 at 53,979,503 bp
  • C to A, chromosome 11 at 84,039,672 bp
  • A to G, chromosome 11 at 101,633,828 bp
  • G to A, chromosome 12 at 4,322,978 bp
  • A to G, chromosome 12 at 111,776,865 bp
  • A to G, chromosome 13 at 104,230,748 bp
  • G to T, chromosome 14 at 20,729,843 bp
  • G to C, chromosome 14 at 60,779,570 bp
  • T to A, chromosome 15 at 91,764,782 bp
  • T to A, chromosome 16 at 52,276,829 bp
  • C to A, chromosome 16 at 59,682,668 bp
  • C to T, chromosome 17 at 6,231,780 bp
  • A to G, chromosome 17 at 21,463,569 bp
  • A to G, chromosome 17 at 32,392,709 bp
  • T to A, chromosome 17 at 35,517,941 bp
  • C to T, chromosome 19 at 7,021,810 bp
  • A to G, chromosome 19 at 12,074,212 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7109 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045201-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.