Strain Name:
C57BL/6J-MtgxR7175Btlr/Mmmh
Stock Number:
045231-MU
Citation ID:
RRID:MMRRC_045231-MU
Other Names:
R7175 (G1)
Major Collection:

Strain Information

Tle4
Name: transducin-like enhancer of split 4
Synonyms: 5730411M05Rik, Bce1, ESTM13, ESTM14, Grg4
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 21888
VEGA: 19
Homologene: 38259
Ank2
Name: ankyrin 2, brain
Synonyms: ankyrin B, Gm4392, Ankyrin-B, Ank-2, Ankyrin-2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 109676
HGNC: HGNC:493
Spns1
Name: SPNS lysolipid transporter 1, lysophospholipid
Synonyms: 2210013K02Rik, spinster homolog
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 73658
Homologene: 41530
Vps54
Name: VPS54 GARP complex subunit
Synonyms: 5330404P15Rik, Vps54l, wr, mSLP8
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 245944
Homologene: 5605
Sema4b
Name: sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
Synonyms: Semac, SemC
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20352
Homologene: 8426
Itsn1
Name: intersectin 1 (SH3 domain protein 1A)
Synonyms: Sh3p17, EHSH1, Intersectin-L, Ese1, Eh domain, SH3 domain regulator of endocytosis 1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 16443
HGNC: HGNC:6183
Homologene: 2277
Dcaf1
Name: DDB1 and CUL4 associated factor 1
Synonyms: Vprbp, B930007L02Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 321006
Homologene: 8805
Eif4g3
Name: eukaryotic translation initiation factor 4 gamma, 3
Synonyms: 1500002J22Rik, repro8, G1-419-52, eIF4GII, 4930523M17Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230861
HGNC: HGNC:3298
Homologene: 2789
Nfkb1
Name: nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
Synonyms: nuclear factor kappaB p50, NF-kappaB p50, NF kappaB1, p50 subunit of NF kappaB, p50/p105, NF-kappaB, p50
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18033
HGNC: HGNC:7794
Homologene: 2971
Fam91a1
Name: family with sequence similarity 91, member A1
Synonyms: D15Ertd621e
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 210998
VEGA: 15
Homologene: 13388
Vps35
Name: VPS35 retromer complex component
Synonyms: Mem3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 65114
Homologene: 6221
Fbxo38
Name: F-box protein 38
Synonyms: SP329, 6030410I24Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 107035
VEGA: 18
Homologene: 34526
Fer
Name: FER tyrosine kinase
Synonyms: Fert2, Fert, C330004K01Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14158
VEGA: 17
HGNC: HGNC:3655
Homologene: 74300
Zgrf1
Name: zinc finger, GRF-type containing 1
Synonyms: 4930422G04Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 71643
Homologene: 34708
Exosc5
Name: exosome component 5
Synonyms: D7Wsu180e
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 27998
Homologene: 5981
Afdn
Name: afadin, adherens junction formation factor
Synonyms: AF6, S-afadin, 5033403D15Rik, Afadin, I-afadin, Mllt4
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 17356
HGNC: HGNC:7137
Homologene: 21202
Mdn1
Name: midasin AAA ATPase 1
Synonyms: 4833432B22Rik, LOC213784, D4Abb1e
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100019
Homologene: 39689
Bdp1
Name: B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB
Synonyms: TFIIIB90, G630013P12Rik, TFC5, TAF3B1, B130055N23Rik, Tfnr, TFIIIB150
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 544971
Homologene: 34582
Hk2
Name: hexokinase 2
Synonyms: HKII
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 15277
HGNC: HGNC:4923
Homologene: 37273
Zzef1
Name: zinc finger, ZZ-type with EF hand domain 1
Synonyms: 8430405D05Rik, C130099L13Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 195018
Homologene: 9027
Zfp318
Name: zinc finger protein 318
Synonyms: TZF, 2610034E08Rik, D530032D06Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 57908
Homologene: 22808
Apob
Name: apolipoprotein B
Synonyms: apob-48, apob-100
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238055
HGNC: HGNC:603
Homologene: 328
Echdc2
Name: enoyl Coenzyme A hydratase domain containing 2
Synonyms: 2610009M20Rik, 1300017C12Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 52430
Homologene: 23088
Runx2
Name: runt related transcription factor 2
Synonyms: AML3, PEBP2aA, Pebpa2a, Osf2, Cbfa1, PEBP2 alpha A, polyomavirus enhancer binding factor 2 (PEBP2), SL3-3 enhancer factor 1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12393
Homologene: 68389
Fcrl5
Name: Fc receptor-like 5
Synonyms: BXMAS1-like protein 2, mBXMH2, Fcrh3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 329693
Homologene: 137404
Hectd4
Name: HECT domain E3 ubiquitin protein ligase 4
Synonyms: Gm15800
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269700
Homologene: 28297
Trpa1
Name: transient receptor potential cation channel, subfamily A, member 1
Synonyms: ANKTM1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 277328
HGNC: HGNC:497
Homologene: 7189
Pik3ap1
Name: phosphoinositide-3-kinase adaptor protein 1
Synonyms: BCAP, 1810044J04Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 83490
VEGA: 19
Homologene: 12848
Alox12e
Name: arachidonate lipoxygenase, epidermal
Synonyms: e-LOX1, Alox12-ps2, Alox12-ps1, 8-LOX, Aloxe
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11685
Homologene: 105868
Epha3
Name: Eph receptor A3
Synonyms: Hek, End3, Hek4, Mek4, Tyro4, Cek4
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 13837
VEGA: 16
HGNC: HGNC:3387
Homologene: 21083
Gm11639
Name: predicted gene 11639
Synonyms: Gm11639, Efcab15
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 105242472
Dnah9
Name: dynein, axonemal, heavy chain 9
Synonyms: Dnahc9, D11Ertd686e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237806
HGNC: HGNC:2953
Homologene: 20357
Slc20a1
Name: solute carrier family 20, member 1
Synonyms: Glvr-1, Glvr1, PiT-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20515
Homologene: 38049
Gpr158
Name: G protein-coupled receptor 158
Synonyms: 5330427M13Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241263
Homologene: 19381
Zxdc
Name: ZXD family zinc finger C
Synonyms: B930086F11Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 80292
Homologene: 82340
Abcb5
Name: ATP-binding cassette, sub-family B member 5
Synonyms: 9230106F14Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 77706
HGNC: HGNC:46
Homologene: 83488
Spata31h1
Name: SPATA31 subfamily H member 1
Synonyms: 4932415D10Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 102635990
VEGA: 10
Homologene: 82476
Cpb1
Name: carboxypeptidase B1
Synonyms: 1810063F02Rik, 0910001A18Rik, 2210008M23Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 76703
HGNC: HGNC:2299
Homologene: 68127
Speg
Name: SPEG complex locus
Synonyms: D1Bwg1450e, BPEG, Apeg1, SPEG, SPEGalpha, SPEGbeta
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 11790
Homologene: 55619
Usp13
Name: ubiquitin specific peptidase 13 (isopeptidase T-3)
Synonyms: 2700071E21Rik, IsoT-3, ISOT3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 72607
Homologene: 68372
Eml6
Name: echinoderm microtubule associated protein like 6
Synonyms: 2900083P10Rik, C230094A16Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237711
Homologene: 104282
Ccs
Name: copper chaperone for superoxide dismutase
Synonyms: Ccsd, CCS
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 12460
VEGA: 19
HGNC: HGNC:1613
Homologene: 3762
Trim50
Name: tripartite motif-containing 50
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 215061
Homologene: 14548
Inhca
Name: inhibitor of carbonic anhydrase
Synonyms: mICA, 1300017J02Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71775
Homologene: 826
Rasgrf1
Name: RAS protein-specific guanine nucleotide-releasing factor 1
Synonyms: Grfbeta, CDC25, Grf1, CDC25Mm
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 19417
HGNC: HGNC:9875
Homologene: 74972
Lztr1
Name: leucine-zipper-like transcriptional regulator, 1
Synonyms: TCFL2, 1200003E21Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 66863
HGNC: HGNC:6742
Homologene: 4925
Otulinl
Name: OTU deubiquitinase with linear linkage specificity like
Synonyms: Fam105a
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223433
VEGA: 15
Homologene: 41302
Dhcr7
Name: 7-dehydrocholesterol reductase
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13360
HGNC: HGNC:2860
Homologene: 1042
Vmn1r35
Name: vomeronasal 1 receptor 35
Synonyms: V1rc12
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 171185
Homologene: 110800
Prdm13
Name: PR domain containing 13
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230025
Homologene: 11000
Or2g7
Name: olfactory receptor family 2 subfamily G member 7
Synonyms: GA_x6K02T2PSCP-2515350-2516303, MOR256-19, Olfr130
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258480
Homologene: 105876
Zfp62
Name: zinc finger protein 62
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 22720
Homologene: 40686
Cd200
Name: CD200 molecule
Synonyms: Mox2, MRC OX-2, OX2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 17470
HGNC: HGNC:7203
Homologene: 4344
Gzmg
Name: granzyme G
Synonyms: Ctla-7, Ctla7
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 14944
VEGA: 14
Homologene: 133275
Rergl
Name: RERG/RAS-like
Synonyms: EG632971
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 632971
Homologene: 41583
Or1a1
Name: olfactory receptor family 1 subfamily A member 1
Synonyms: Olfr403, GA_x6K02T2P1NL-4348188-4349129, MOR125-5_p, IA7
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 404316
Homologene: 8219
Or52e19
Name: olfactory receptor family 52 subfamily E member 19
Synonyms: ENSMUSG00000073953, Olfr596-ps1, Gm15117, GA_x6K02T2PBJ9-6019769-6019943, Olfr596
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100041187
Homologene: 121535
Csn3
Name: casein kappa
Synonyms: Csnk, CSN10
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12994
HGNC: HGNC:2446
Homologene: 3818
Anks6
Name: ankyrin repeat and sterile alpha motif domain containing 6
Synonyms: 2210417J20Rik, Samd6, b2b1801.1Clo, LOC269533, SamCystin
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 75691
Homologene: 19545
Zfp319
Name: zinc finger protein 319
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 79233
Homologene: 11548
Pate1
Name: prostate and testis expressed 1
Synonyms: Gm17252
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 100312987
Homologene: 89136
Cirbp
Name: cold inducible RNA binding protein
Synonyms: Cirp
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 12696
HGNC: HGNC:1982
Homologene: 980
Pcdhgc4
Name: protocadherin gamma subfamily C, 4
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93707
HGNC: HGNC:8717
Homologene: 110932
Or1p1b
Name: olfactory receptor family 1 subfamily P member 1B
Synonyms: GA_x6K02T2P1NL-4385196-4386167, Olfr404-ps1, MOR133-5P
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 257920
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 14,893,207 bp
  • A to G, chromosome 1 at 75,422,490 bp
  • A to G, chromosome 2 at 21,368,302 bp
  • T to G, chromosome 2 at 129,210,742 bp
  • A to G, chromosome 3 at 20,263,763 bp
  • C to T, chromosome 3 at 32,917,608 bp
  • T to C, chromosome 3 at 87,446,338 bp
  • A to T, chromosome 3 at 126,946,941 bp
  • T to C, chromosome 3 at 127,563,590 bp
  • A to T, chromosome 3 at 135,613,990 bp
  • A to T, chromosome 4 at 21,679,473 bp
  • A to G, chromosome 4 at 32,694,634 bp
  • T to C, chromosome 4 at 47,046,268 bp
  • C to A, chromosome 4 at 108,174,169 bp
  • A to G, chromosome 4 at 138,126,215 bp
  • C to T, chromosome 5 at 87,929,727 bp
  • C to T, chromosome 5 at 121,273,629 bp
  • T to A, chromosome 5 at 135,353,297 bp
  • A to T, chromosome 6 at 66,678,922 bp
  • T to A, chromosome 6 at 82,734,849 bp
  • A to G, chromosome 6 at 90,369,663 bp
  • A to G, chromosome 6 at 139,496,535 bp
  • G to A, chromosome 7 at 25,664,369 bp
  • T to A, chromosome 7 at 80,198,654 bp
  • T to C, chromosome 7 at 103,309,847 bp
  • T to C, chromosome 7 at 126,373,789 bp
  • C to T, chromosome 7 at 143,845,490 bp
  • A to T, chromosome 8 at 85,263,560 bp
  • C to A, chromosome 8 at 95,328,782 bp
  • T to G, chromosome 9 at 35,685,112 bp
  • T to A, chromosome 9 at 89,980,749 bp
  • A to G, chromosome 9 at 103,251,789 bp
  • A to T, chromosome 9 at 106,858,576 bp
  • T to C, chromosome 10 at 80,170,463 bp
  • T to A, chromosome 10 at 82,286,749 bp
  • T to C, chromosome 11 at 21,315,028 bp
  • T to A, chromosome 11 at 29,784,231 bp
  • C to T, chromosome 11 at 49,216,753 bp
  • T to A, chromosome 11 at 66,133,637 bp
  • T to C, chromosome 11 at 70,319,708 bp
  • T to C, chromosome 11 at 72,851,901 bp
  • T to A, chromosome 11 at 74,196,178 bp
  • T to C, chromosome 11 at 74,239,977 bp
  • T to C, chromosome 11 at 104,947,411 bp
  • A to C, chromosome 12 at 8,007,034 bp
  • G to A, chromosome 12 at 118,867,876 bp
  • C to A, chromosome 13 at 100,049,970 bp
  • C to T, chromosome 14 at 56,159,522 bp
  • A to C, chromosome 15 at 27,658,288 bp
  • A to T, chromosome 15 at 58,430,678 bp
  • G to T, chromosome 16 at 17,523,031 bp
  • T to C, chromosome 16 at 45,400,215 bp
  • C to T, chromosome 16 at 63,583,500 bp
  • T to C, chromosome 16 at 91,868,050 bp
  • T to C, chromosome 17 at 13,888,607 bp
  • T to A, chromosome 17 at 38,067,479 bp
  • G to A, chromosome 17 at 44,814,192 bp
  • T to A, chromosome 17 at 46,386,848 bp
  • T to A, chromosome 17 at 63,924,095 bp
  • T to C, chromosome 18 at 37,816,371 bp
  • A to C, chromosome 18 at 62,515,473 bp
  • T to A, chromosome 19 at 4,833,362 bp
  • A to T, chromosome 19 at 14,451,707 bp
  • T to C, chromosome 19 at 41,287,490 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7175 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045231-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.