Strain Name:
C57BL/6J-MtgxR7142Btlr/Mmmh
Stock Number:
045250-MU
Citation ID:
RRID:MMRRC_045250-MU
Other Names:
R7142 (G1)
Major Collection:

Strain Information

Cdh3
Name: cadherin 3
Synonyms: P-cadherin, Pcad, Cadp
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12560
HGNC: HGNC:1762
Homologene: 20425
Wsb1
Name: WD repeat and SOCS box-containing 1
Synonyms: 2700038M07Rik, 1110056B13Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 78889
Homologene: 9218
Aldh1l1
Name: aldehyde dehydrogenase 1 family, member L1
Synonyms: 1810048F20Rik, Fthfd
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 107747
HGNC: HGNC:3978
Homologene: 122031
Rgs14
Name: regulator of G-protein signaling 14
Synonyms: Rap1/rap2 interacting protein
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 51791
HGNC: HGNC:9996
Homologene: 4735
Gtf2i
Name: general transcription factor II I
Synonyms: BAP-135, 6030441I21Rik, TFII-I
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14886
HGNC: HGNC:4659
Homologene: 7748
Wnk1
Name: WNK lysine deficient protein kinase 1
Synonyms: Hsn2, Prkwnk1, 6430573H23Rik, EG406236
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232341
Homologene: 14253
Grhl2
Name: grainyhead like transcription factor 2
Synonyms: BOM, clft3, grainyheadlike, Tcfcp2l3, 0610015A08Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 252973
HGNC: HGNC:2799
Homologene: 32616
Drosha
Name: drosha, ribonuclease type III
Synonyms: Etohi2, Rnasen, 1110013A17Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 14000
Homologene: 8293
Foxo3
Name: forkhead box O3
Synonyms: Foxo3a, Fkhr2, FKHRL1, 1110048B16Rik, 2010203A17Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 56484
Homologene: 31039
Chmp2b
Name: charged multivesicular body protein 2B
Synonyms: 1190006E07Rik, chromatin modifying protein 2B
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 68942
VEGA: 16
Homologene: 8534
Abca1
Name: ATP-binding cassette, sub-family A member 1
Synonyms: ABC1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11303
HGNC: HGNC:29
Homologene: 21130
Adgrl1
Name: adhesion G protein-coupled receptor L1
Synonyms: Lphn1, lectomedin-2, Lec2, 2900070I05Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 330814
Homologene: 8951
Dnah7a
Name: dynein, axonemal, heavy chain 7A
Synonyms: Dnahc7, LOC381341, Dnahc7a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 627872
Homologene: 41287
Cpt1a
Name: carnitine palmitoyltransferase 1a, liver
Synonyms: L-CPT I, Cpt1, CPTI
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 12894
VEGA: 19
HGNC: HGNC:2328
Homologene: 1413
Mxra8
Name: matrix-remodelling associated 8
Synonyms: DICAM, 1200013A08Rik, Asp3, limitrin
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 74761
HGNC: HGNC:7542
Homologene: 11500
P3h1
Name: prolyl 3-hydroxylase 1
Synonyms: Leprecan, Gros1, 2410024C15Rik, Lepre1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56401
Homologene: 10509
Ston2
Name: stonin 2
Synonyms: 4933401N24Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 108800
Homologene: 84338
2610008E11Rik
Name: RIKEN cDNA 2610008E11 gene
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 72128
Homologene: 86705
Wrnip1
Name: Werner helicase interacting protein 1
Synonyms: 4833444L21Rik, WHIP
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 78903
Homologene: 10592
Invs
Name: inversin
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16348
Homologene: 7786
Trpc6
Name: transient receptor potential cation channel, subfamily C, member 6
Synonyms: Trrp6, mtrp6
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22068
VEGA: 9
Homologene: 37944
Mboat4
Name: membrane bound O-acyltransferase domain containing 4
Synonyms: GOAT, LOC234155
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234155
Homologene: 19272
Akap6
Name: A kinase anchor protein 6
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238161
VEGA: 12
HGNC: HGNC:376
Homologene: 3157
Ercc5
Name: excision repair cross-complementing rodent repair deficiency, complementation group 5
Synonyms: Xpg
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22592
HGNC: HGNC:3437
Homologene: 133551
Sec14l2
Name: SEC14-like lipid binding 2
Synonyms: 1300013M05Rik, tap, Spf
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67815
Homologene: 8245
Nlrp1b
Name: NLR family, pyrin domain containing 1B
Synonyms: Nalp1b
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 637515
Homologene: 19080
Mcoln2
Name: mucolipin 2
Synonyms: mucolipidin 2, 3300002C04Rik, TRPML2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 68279
Homologene: 12258
Skint5
Name: selection and upkeep of intraepithelial T cells 5
Synonyms: OTTMUSG00000008560
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242627
Homologene: 135888
Lrp4
Name: low density lipoprotein receptor-related protein 4
Synonyms: mdig, 6430526J12Rik, Megf7
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228357
HGNC: HGNC:6696
Homologene: 17964
Fbxo44
Name: F-box protein 44
Synonyms: Fbxo6a, FBX30, Fbx6a, FBG3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230903
Homologene: 13232
Usp35
Name: ubiquitin specific peptidase 35
Synonyms: LOC244144, LOC381901
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244144
Homologene: 35459
Hal
Name: histidine ammonia lyase
Synonyms: histidase, Hsd
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 15109
HGNC: HGNC:4806
Homologene: 68229
Il17a
Name: interleukin 17A
Synonyms: Ctla8, IL-17A, Ctla-8, Il17
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16171
HGNC: HGNC:5981
Homologene: 1651
Cd93
Name: CD93 antigen
Synonyms: C1qr1, C1qrp, Ly68, AA4.1, 6030404G09Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17064
Homologene: 7823
Psd2
Name: pleckstrin and Sec7 domain containing 2
Synonyms: EFA6C, 6330404E20Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 74002
Homologene: 12522
Abca14
Name: ATP-binding cassette, sub-family A member 14
Synonyms: 1700110B15Rik, 4930539G24Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67928
Homologene: 86128
Vmn1r178
Name: vomeronasal 1 receptor 178
Synonyms: LOC232959, V1rd13
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232959
Homologene: 104166
Pkn1
Name: protein kinase N1
Synonyms: PRK1, Stk3, Prkcl1, Pkn, F730027O18Rik, PAK1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 320795
HGNC: HGNC:9405
Homologene: 48130
Caskin2
Name: CASK-interacting protein 2
Synonyms: 1600028L06Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 140721
Homologene: 32485
Cacna1e
Name: calcium channel, voltage-dependent, R type, alpha 1E subunit
Synonyms: alpha1E, Cchra1, Cav2.3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12290
HGNC: HGNC:1392
Homologene: 20185
Ofcc1
Name: orofacial cleft 1 candidate 1
Synonyms: Opo, ojoplano
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218165
VEGA: 13
Homologene: 125376
Phldb2
Name: pleckstrin homology like domain, family B, member 2
Synonyms: C820004H04Rik, LL5b, LL5beta
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 208177
Homologene: 17100
Fam163b
Name: family with sequence similarity 163, member B
Synonyms: C630035N08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 109349
Homologene: 106097
Ctsk
Name: cathepsin K
Synonyms: Cat K, catK
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 13038
HGNC: HGNC:2536
Homologene: 68053
Or5l13
Name: olfactory receptor family 5 subfamily L member 13
Synonyms: MOR174-3, GA_x6K02T2Q125-49433499-49432537, Olfr1156
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258814
HGNC: HGNC:8351
Homologene: 72031
Gpc5
Name: glypican 5
Synonyms: A230034F01Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 103978
HGNC: HGNC:4453
Homologene: 3285
D6Ertd527e
Name: DNA segment, Chr 6, ERATO Doi 527, expressed
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 52372
Ccdc85a
Name: coiled-coil domain containing 85A
Synonyms: E030025D05Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216613
Homologene: 65605
Cyp3a44
Name: cytochrome P450, family 3, subfamily a, polypeptide 44
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 337924
HGNC: HGNC:2638
Homologene: 133568
Otud4
Name: OTU domain containing 4
Synonyms: D8Ertd69e, 4930431L18Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 73945
Homologene: 35370
Gnal
Name: guanine nucleotide binding protein, alpha stimulating, olfactory type
Synonyms: Golf, 2610011C15Rik, Gna10, Galphaolf, G alpha 10, 9630020G10Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 14680
VEGA: 18
HGNC: HGNC:4388
Homologene: 68222
Tmem132b
Name: transmembrane protein 132B
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 208151
Homologene: 28135
Mgat5
Name: mannoside acetylglucosaminyltransferase 5
Synonyms: GlcNAc-TV, beta1,6N-acetylglucosaminyltransferase V, 4930471A21Rik, 5330407H02Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 107895
HGNC: HGNC:7049
Homologene: 1808
Kng1
Name: kininogen 1
Synonyms: L-kininogen, H-kininigen
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 16644
HGNC: HGNC:6383
Homologene: 88343
Tmem106b
Name: transmembrane protein 106B
Synonyms: 2310036D22Rik, 5830455K21Rik, 6430519M21Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 71900
Homologene: 56806
Eif3j2
Name: eukaryotic translation initiation factor 3, subunit J2
Synonyms: Gm9781
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 100042807
HGNC: HGNC:3270
Homologene: 37845
Unc93a2
Name: unc-93 homolog A2
Synonyms: Gm9992
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 667055
VEGA: 17
Homologene: 10356
Pde2a
Name: phosphodiesterase 2A, cGMP-stimulated
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 207728
HGNC: HGNC:8777
Homologene: 1952
Cypt4
Name: cysteine-rich perinuclear theca 4
Synonyms: Ckt1r2, 1700009B20Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235067
VEGA: 9
Septin12
Name: septin 12
Synonyms: 4933413B09Rik, Sept12, 1700028G04Rik, Septin12
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 71089
VEGA: 16
Homologene: 69435
Hmx2
Name: H6 homeobox 2
Synonyms: Nkx5-2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 15372
HGNC: HGNC:5018
Homologene: 24625
Mri1
Name: methylthioribose-1-phosphate isomerase 1
Synonyms: 2410018C20Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 67873
Homologene: 7160
Psg29
Name: pregnancy-specific beta-1-glycoprotein 29
Synonyms: cea17
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 114872
Homologene: 83380
Tmie
Name: transmembrane inner ear
Synonyms: Mm.87012, 5131400L21Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20776
Homologene: 17155
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 20,732,103 bp
  • A to G, chromosome 1 at 44,174,214 bp
  • A to T, chromosome 1 at 53,413,768 bp
  • A to T, chromosome 1 at 127,412,187 bp
  • G to T, chromosome 1 at 154,412,484 bp
  • C to T, chromosome 2 at 27,113,555 bp
  • T to C, chromosome 2 at 87,949,712 bp
  • T to A, chromosome 2 at 91,494,994 bp
  • C to T, chromosome 2 at 148,441,805 bp
  • G to A, chromosome 3 at 95,506,948 bp
  • G to A, chromosome 3 at 146,183,569 bp
  • T to A, chromosome 4 at 48,407,696 bp
  • T to A, chromosome 4 at 53,082,050 bp
  • A to T, chromosome 4 at 113,571,594 bp
  • T to A, chromosome 4 at 119,247,161 bp
  • C to T, chromosome 4 at 148,158,812 bp
  • A to T, chromosome 4 at 155,843,062 bp
  • G to A, chromosome 5 at 125,622,673 bp
  • C to A, chromosome 5 at 134,244,851 bp
  • A to G, chromosome 5 at 145,777,961 bp
  • A to G, chromosome 6 at 13,081,565 bp
  • C to G, chromosome 6 at 87,111,524 bp
  • G to A, chromosome 6 at 90,563,416 bp
  • T to A, chromosome 6 at 119,949,279 bp
  • A to G, chromosome 7 at 17,210,621 bp
  • A to G, chromosome 7 at 23,893,610 bp
  • A to G, chromosome 7 at 97,311,547 bp
  • A to T, chromosome 7 at 101,504,650 bp
  • G to C, chromosome 7 at 120,251,183 bp
  • T to C, chromosome 7 at 131,555,736 bp
  • A to G, chromosome 8 at 34,120,137 bp
  • T to A, chromosome 8 at 79,672,762 bp
  • T to C, chromosome 8 at 83,693,967 bp
  • C to T, chromosome 8 at 83,937,200 bp
  • C to A, chromosome 8 at 84,257,124 bp
  • G to A, chromosome 8 at 106,545,228 bp
  • A to T, chromosome 9 at 8,653,016 bp
  • C to T, chromosome 9 at 24,625,444 bp
  • A to T, chromosome 9 at 110,870,681 bp
  • T to C, chromosome 10 at 42,274,595 bp
  • T to A, chromosome 10 at 79,067,612 bp
  • A to T, chromosome 10 at 81,720,206 bp
  • T to C, chromosome 10 at 93,500,651 bp
  • T to C, chromosome 11 at 4,098,379 bp
  • A to T, chromosome 11 at 28,577,192 bp
  • T to A, chromosome 11 at 71,172,075 bp
  • T to C, chromosome 11 at 79,250,988 bp
  • A to G, chromosome 11 at 115,806,736 bp
  • T to G, chromosome 12 at 52,887,364 bp
  • A to G, chromosome 12 at 91,647,235 bp
  • C to A, chromosome 13 at 32,802,633 bp
  • T to C, chromosome 13 at 40,004,062 bp
  • T to C, chromosome 13 at 55,379,604 bp
  • T to A, chromosome 14 at 115,417,203 bp
  • A to T, chromosome 15 at 12,924,146 bp
  • A to T, chromosome 15 at 37,279,582 bp
  • T to C, chromosome 16 at 4,988,362 bp
  • T to A, chromosome 16 at 23,079,420 bp
  • G to A, chromosome 16 at 45,757,176 bp
  • G to A, chromosome 16 at 65,546,908 bp
  • G to A, chromosome 17 at 7,376,622 bp
  • A to G, chromosome 18 at 35,980,044 bp
  • T to C, chromosome 18 at 43,477,400 bp
  • C to T, chromosome 18 at 67,218,528 bp
  • T to C, chromosome 19 at 3,375,100 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7142 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045250-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.