Strain Name:
C57BL/6J-MtgxR7191Btlr/Mmmh
Stock Number:
045274-MU
Citation ID:
RRID:MMRRC_045274-MU
Other Names:
R7191 (G1)
Major Collection:

Strain Information

Ank2
Name: ankyrin 2, brain
Synonyms: ankyrin B, Gm4392, Ankyrin-B, Ank-2, Ankyrin-2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 109676
HGNC: HGNC:493
Gria2
Name: glutamate receptor, ionotropic, AMPA2 (alpha 2)
Synonyms: GluA2, Glur2, GluR2, GluR-B, Glur-2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14800
HGNC: HGNC:4572
Homologene: 20225
Gcg
Name: glucagon
Synonyms: glucagon-like peptide I, GLP-1, Glu, PPG
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14526
HGNC: HGNC:4191
Homologene: 1553
Nrcam
Name: neuronal cell adhesion molecule
Synonyms: C030017F07Rik, Bravo, C130076O07Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 319504
VEGA: 12
HGNC: HGNC:7994
Homologene: 21041
Traip
Name: TRAF-interacting protein
Synonyms: Trip
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22036
Homologene: 31343
Fryl
Name: FRY like transcription coactivator
Synonyms: 2310004H21Rik, 9030227G01Rik, 2510002A14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 72313
Homologene: 103956
Cyp39a1
Name: cytochrome P450, family 39, subfamily a, polypeptide 1
Synonyms: oxysterol 7-alpha-hydroxylase
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 56050
VEGA: 17
Homologene: 9580
Nup35
Name: nucleoporin 35
Synonyms: 5330402E05Rik, 2310006I24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 69482
Homologene: 44517
Samd4b
Name: sterile alpha motif domain containing 4B
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233033
Homologene: 35268
Tbck
Name: TBC1 domain containing kinase
Synonyms: 1700120J03Rik, A630047E20Rik, C030007I09Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 271981
Homologene: 13221
Fam83h
Name: family with sequence similarity 83, member H
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105732
VEGA: 15
Homologene: 15890
Smyd5
Name: SET and MYND domain containing 5
Synonyms: NN8-4AG, Rai15, Rrg1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232187
Homologene: 6143
Gpr4
Name: G protein-coupled receptor 4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 319197
HGNC: HGNC:4497
Homologene: 3867
Dmbt1
Name: deleted in malignant brain tumors 1
Synonyms: Crpd, vomeroglandin, gp300, CRP-[a], MUCLIN, ebnerin, hensin, CRP-[b]
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12945
HGNC: HGNC:2926
Homologene: 68990
Ptprc
Name: protein tyrosine phosphatase receptor type C
Synonyms: CD45, T200, Ly-5, Lyt-4, B220
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19264
HGNC: HGNC:9666
Homologene: 2126
Zfp277
Name: zinc finger protein 277
Synonyms: NIRF4, 2410017E24Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 246196
VEGA: 12
Homologene: 11087
Gprc5c
Name: G protein-coupled receptor, family C, group 5, member C
Synonyms: 3200002M13Rik, 1110028I06Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70355
Homologene: 11099
Trpv4
Name: transient receptor potential cation channel, subfamily V, member 4
Synonyms: VR-OAC, VRL-2, VROAC, Trp12, OTRPC4, 0610033B08Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 63873
Homologene: 11003
Mpzl3
Name: myelin protein zero-like 3
Synonyms: A530065I17Rik, rc, ruf, 5430427F17Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 319742
Homologene: 18867
Nudcd2
Name: NudC domain containing 2
Synonyms: 2700047N05Rik, D11Ertd603e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 52653
Homologene: 12094
Arap1
Name: ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
Synonyms: 2410002L19Rik, Centd2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 69710
Homologene: 12326
Clp1
Name: CLP1, cleavage and polyadenylation factor I subunit
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 98985
Homologene: 4975
Actmap
Name: actin maturation protease
Synonyms: BC024978
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 414069
Homologene: 45689
Trim29
Name: tripartite motif-containing 29
Synonyms: 1110047J21Rik, 4732461M22Rik, 2810431N19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 72169
VEGA: 9
Homologene: 8100
Dchs1
Name: dachsous cadherin related 1
Synonyms: C130033F22Rik, 3110041P15Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233651
Homologene: 2771
Pkhd1
Name: polycystic kidney and hepatic disease 1
Synonyms: tigmin, FPC
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241035
HGNC: HGNC:9016
Homologene: 16336
Mipol1
Name: mirror-image polydactyly 1
Synonyms: 6030439O22Rik, D12Ertd19e, 1700081O04Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 73490
Homologene: 16340
Dock10
Name: dedicator of cytokinesis 10
Synonyms: A630054M16Rik, Zizimin3, Jr5, Jr4, ZIZ3, 9330153B10Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 210293
Homologene: 45952
Fras1
Name: Fraser extracellular matrix complex subunit 1
Synonyms: E130113P14Rik, bl
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231470
Homologene: 23516
Syde2
Name: synapse defective 1, Rho GTPase, homolog 2 (C. elegans)
Synonyms: C430017H16Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 214804
Homologene: 19035
Gne
Name: glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
Synonyms: 2310066H07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 50798
Homologene: 3996
Krt81
Name: keratin 81
Synonyms: Krt2-19
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 64818
VEGA: 15
HGNC: HGNC:6458
Homologene: 55645
Kin
Name: Kin17 DNA and RNA binding protein
Synonyms: antigenic determinant of rec-A protein, Kin17
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16588
HGNC: HGNC:6327
Homologene: 8196
Hid1
Name: HID1 domain containing
Synonyms: C630004H02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217310
Homologene: 12737
Olfml3
Name: olfactomedin-like 3
Synonyms: 2810002E22Rik, mONT3, ONT3, HNOEL-iso
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99543
Homologene: 10613
Lypd11
Name: Ly6/PLAUR domain containing 11
Synonyms: Gm4763
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 210155
Cfh
Name: complement component factor h
Synonyms: Mud-1, Sas-1, Sas1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12628
HGNC: HGNC:4883
Homologene: 20086
Krt16
Name: keratin 16
Synonyms: Krt1-16, K16
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16666
HGNC: HGNC:6423
Homologene: 21145
Lrrc34
Name: leucine rich repeat containing 34
Synonyms: Spata34, 1700007J06Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 71827
Homologene: 27419
Get1
Name: guided entry of tail-anchored proteins factor 1
Synonyms: Wrb, C030018G21Rik, 5530402J05Rik, Chd5
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 71446
Homologene: 37945
Usp36
Name: ubiquitin specific peptidase 36
Synonyms: 2700002L06Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 72344
Homologene: 11828
Vmn2r97
Name: vomeronasal 2, receptor 97
Synonyms: EG627367
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627367
Homologene: 115024
Iigp1c
Name: interferon inducible GTPase 1C
Synonyms: Gm4951
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240327
Vmn2r51
Name: vomeronasal 2, receptor 51
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100042921
Homologene: 113703
Or5p56
Name: olfactory receptor family 5 subfamily P member 56
Synonyms: GA_x6K02T2PBJ9-10319672-10320604, Olfr477, MOR204-1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258928
Homologene: 27246
Tas2r105
Name: taste receptor, type 2, member 105
Synonyms: Tas2r5, T2R05, T2r5, T2R9, mt2r5, mGR05
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 57252
Homologene: 69307
Scgn
Name: secretagogin, EF-hand calcium binding protein
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 214189
Homologene: 5088
Jakmip3
Name: janus kinase and microtubule interacting protein 3
Synonyms: 6330417G02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74004
Homologene: 90425
Ccdc82
Name: coiled-coil domain containing 82
Synonyms: 2310043N13Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 66396
VEGA: 9
Homologene: 11678
2510009E07Rik
Name: RIKEN cDNA 2510009E07 gene
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 72190
VEGA: 16
Homologene: 78167
Rdh16
Name: retinol dehydrogenase 16
Synonyms: CRAD1, cis-retinol/androgen dehydrogenase 1, Rdh6
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19683
Homologene: 129514
Slfn14
Name: schlafen 14
Synonyms: LOC237890, Slfn14-ps
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237890
Homologene: 19082
Zfp987
Name: zinc finger protein 987
Synonyms: Gm13051, OTTMUSG00000010104
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 626316
Homologene: 133076
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 20,558,719 bp
  • A to G, chromosome 1 at 80,540,331 bp
  • T to A, chromosome 1 at 138,101,044 bp
  • A to C, chromosome 1 at 140,112,567 bp
  • G to A, chromosome 2 at 10,091,793 bp
  • C to G, chromosome 2 at 62,476,839 bp
  • A to T, chromosome 2 at 80,658,379 bp
  • A to T, chromosome 2 at 84,724,146 bp
  • C to T, chromosome 3 at 30,624,878 bp
  • C to A, chromosome 3 at 80,732,085 bp
  • T to C, chromosome 3 at 103,735,860 bp
  • T to A, chromosome 3 at 126,946,392 bp
  • T to C, chromosome 3 at 132,737,555 bp
  • T to C, chromosome 3 at 146,002,358 bp
  • T to C, chromosome 4 at 44,040,266 bp
  • A to G, chromosome 4 at 146,121,903 bp
  • T to C, chromosome 5 at 73,072,912 bp
  • A to G, chromosome 5 at 96,614,912 bp
  • T to C, chromosome 5 at 114,633,140 bp
  • T to C, chromosome 6 at 85,440,111 bp
  • T to C, chromosome 6 at 131,686,982 bp
  • T to A, chromosome 7 at 10,100,553 bp
  • T to C, chromosome 7 at 19,223,230 bp
  • C to T, chromosome 7 at 24,723,334 bp
  • G to A, chromosome 7 at 27,201,123 bp
  • C to A, chromosome 7 at 28,414,261 bp
  • T to C, chromosome 7 at 101,384,992 bp
  • G to A, chromosome 7 at 105,765,439 bp
  • G to A, chromosome 7 at 107,990,646 bp
  • A to T, chromosome 7 at 131,044,520 bp
  • G to A, chromosome 7 at 138,989,528 bp
  • C to T, chromosome 9 at 13,252,472 bp
  • A to G, chromosome 9 at 43,311,609 bp
  • T to G, chromosome 9 at 45,055,244 bp
  • A to G, chromosome 9 at 107,970,017 bp
  • A to G, chromosome 10 at 127,813,418 bp
  • C to T, chromosome 11 at 40,736,603 bp
  • T to C, chromosome 11 at 83,276,749 bp
  • T to C, chromosome 11 at 100,246,658 bp
  • C to T, chromosome 11 at 114,868,617 bp
  • T to C, chromosome 11 at 115,348,469 bp
  • C to T, chromosome 11 at 118,268,834 bp
  • A to T, chromosome 12 at 40,329,562 bp
  • A to G, chromosome 12 at 44,572,244 bp
  • A to G, chromosome 12 at 57,457,066 bp
  • A to G, chromosome 13 at 23,981,493 bp
  • C to T, chromosome 15 at 76,003,037 bp
  • T to C, chromosome 15 at 101,460,229 bp
  • T to A, chromosome 16 at 21,653,564 bp
  • A to G, chromosome 16 at 96,151,945 bp
  • A to G, chromosome 17 at 18,930,286 bp
  • G to A, chromosome 17 at 43,731,019 bp
  • A to T, chromosome 18 at 60,246,257 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7191 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045274-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.