Strain Name:
C57BL/6J-MtgxR7335Btlr/Mmmh
Stock Number:
045372-MU
Citation ID:
RRID:MMRRC_045372-MU
Other Names:
R7335 (G1)
Major Collection:

Strain Information

Hyal1
Name: hyaluronoglucosaminidase 1
Synonyms: Hyal-1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 15586
HGNC: HGNC:5320
Homologene: 5277
Herc3
Name: hect domain and RLD 3
Synonyms: 5730409F18Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 73998
HGNC: HGNC:4876
Homologene: 57095
Prkd3
Name: protein kinase D3
Synonyms: PKD3, 4930557O20Rik, Prkcn, 5730497N19Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 75292
HGNC: HGNC:9408
Homologene: 2055
Arpp21
Name: cyclic AMP-regulated phosphoprotein, 21
Synonyms: ARPP-21, D9Bwg1012e, Tarpp, R3hdm3, 0710001E13Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74100
Homologene: 32306
Dop1b
Name: DOP1 leucine zipper like protein B
Synonyms: 2610510B01Rik, 0610038M01Rik, Dopey2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 70028
VEGA: 16
HGNC: HGNC:1291
Homologene: 21068
Kdm5b
Name: lysine demethylase 5B
Synonyms: Rb-Bp2, 2210016I17Rik, Jarid1b, 2010009J12Rik, D1Ertd202e, Plu1, PLU-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 75605
Homologene: 48448
Suclg2
Name: succinate-Coenzyme A ligase, GDP-forming, beta subunit
Synonyms: D6Wsu120e
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20917
Homologene: 2854
Agrn
Name: agrin
Synonyms: nmf380, NMF380, Agrin
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11603
HGNC: HGNC:329
Homologene: 27907
Cenpc1
Name: centromere protein C1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12617
HGNC: HGNC:1854
Homologene: 1371
Tom1l2
Name: target of myb1-like 2 (chicken)
Synonyms: 2900016I08Rik, A730055F12Rik, myb1-like protein 2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216810
Homologene: 44901
Trit1
Name: tRNA isopentenyltransferase 1
Synonyms: 2310075G14Rik, MOD5
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 66966
Homologene: 7010
C2cd3
Name: C2 calcium-dependent domain containing 3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 277939
Homologene: 19524
Ptprj
Name: protein tyrosine phosphatase receptor type J
Synonyms: Byp, CD148, Scc1, DEP-1, Scc-1, RPTPJ
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19271
HGNC: HGNC:9673
Homologene: 2130
Ncam1
Name: neural cell adhesion molecule 1
Synonyms: E-NCAM, NCAM-180, NCAM-140, CD56, NCAM-120, NCAM-1, NCAM
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17967
HGNC: HGNC:7656
Homologene: 40754
Prox1
Name: prospero homeobox 1
Synonyms: A230003G05Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19130
HGNC: HGNC:9459
Homologene: 2069
Hs3st3a1
Name: heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
Synonyms: 3Ost3a
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15478
HGNC: HGNC:5196
Homologene: 88735
Magel2
Name: MAGE family member L2
Synonyms: ns7, NDNL1, nM15, Mage-l2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 27385
HGNC: HGNC:6814
Homologene: 8460
Smurf2
Name: SMAD specific E3 ubiquitin protein ligase 2
Synonyms: 2810411E22Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 66313
Homologene: 41490
Mtcl2
Name: microtubule crosslinking factor 2
Synonyms: 9830001H06Rik, D430036N24Rik, Soga1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 320706
Homologene: 52382
Sez6l
Name: seizure related 6 homolog like
Synonyms: Acig1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56747
Homologene: 10895
Cdh23
Name: cadherin related 23 (otocadherin)
Synonyms: nmf112, 4930542A03Rik, USH1D, sals, ahl, bob, mdfw, nmf252, nmf181
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 22295
Homologene: 11142
Pmaip1
Name: phorbol-12-myristate-13-acetate-induced protein 1
Synonyms: Noxa
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 58801
VEGA: 18
HGNC: HGNC:9108
Homologene: 75166
Hmcn2
Name: hemicentin 2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 665700
Homologene: 90772
Vav1
Name: vav 1 oncogene
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22324
Homologene: 3961
Fsip2
Name: fibrous sheath-interacting protein 2
Synonyms: OTTMUSG00000013335
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241516
Homologene: 110349
Nynrin
Name: NYN domain and retroviral integrase containing
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 277154
VEGA: 14
Homologene: 19483
Pak5
Name: p21 (RAC1) activated kinase 5
Synonyms: Pak7, Pak5, 2900083L08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241656
Homologene: 22211
Mapk4
Name: mitogen-activated protein kinase 4
Synonyms: Erk3-related, p63Mapk, A330097D03Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225724
HGNC: HGNC:6878
Homologene: 2058
Fras1
Name: Fraser extracellular matrix complex subunit 1
Synonyms: E130113P14Rik, bl
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231470
Homologene: 23516
Adamts2
Name: ADAM metallopeptidase with thrombospondin type 1 motif 2
Synonyms: a disintegrin and metalloproteinase with thrombospondin repeats, procollagen N-proteinase, ADAM-TS2, hPCPNI
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216725
HGNC: HGNC:218
Homologene: 8597
Stac3
Name: SH3 and cysteine rich domain 3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237611
Homologene: 17039
Slco3a1
Name: solute carrier organic anion transporter family, member 3a1
Synonyms: Anr1, OATP-D, 5830414C08Rik, Slc21a11, MJAM
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 108116
Homologene: 40862
Skint2
Name: selection and upkeep of intraepithelial T cells 2
Synonyms: B7S3, OTTMUSG00000008540
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329919
Homologene: 136741
Bmal2
Name: basic helix-loop-helix ARNT like 2
Synonyms: bHLHe6, 4632430A05Rik, Arntl2, MOP9
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 272322
Homologene: 10609
Cacna1i
Name: calcium channel, voltage-dependent, alpha 1I subunit
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239556
HGNC: HGNC:1396
Homologene: 69331
Cd101
Name: CD101 antigen
Synonyms: Igsf2, LOC381460
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 630146
HGNC: HGNC:5949
Homologene: 3142
Vmn2r82
Name: vomeronasal 2, receptor 82
Synonyms: EG624845
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 624845
Homologene: 83483
Rp1l1
Name: retinitis pigmentosa 1 homolog like 1
Synonyms: Dcdc4, Rp1hl1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 271209
VEGA: 14
Homologene: 105870
Col6a4
Name: collagen, type VI, alpha 4
Synonyms: Dvwa, EG235580, Vwa6, 1110001D15Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 68553
Homologene: 130754
Zfp735
Name: zinc finger protein 735
Synonyms: 1700012C15Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76390
Homologene: 88945
Hnf4g
Name: hepatocyte nuclear factor 4, gamma
Synonyms: NR2A2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 30942
HGNC: HGNC:5026
Homologene: 37886
Iqcc
Name: IQ motif containing C
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230767
Homologene: 49526
Lgals4
Name: lectin, galactose binding, soluble 4
Synonyms: galectin-4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16855
HGNC: HGNC:6565
Homologene: 21239
Adcy6
Name: adenylate cyclase 6
Synonyms: AC6
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 11512
VEGA: 15
HGNC: HGNC:237
Homologene: 22400
Tas2r118
Name: taste receptor, type 2, member 118
Synonyms: mt2r40, mGR18, Tas2r18, T2R18
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 387347
Homologene: 9660
Pcdhb15
Name: protocadherin beta 15
Synonyms: PcdhbO, Pcdhb7
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93886
HGNC: HGNC:8692
Homologene: 32429
Slc22a22
Name: solute carrier family 22 (organic cation transporter), member 22
Synonyms: BC026439, OAT-PG
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 210463
Homologene: 18166
Sgcg
Name: sarcoglycan, gamma (dystrophin-associated glycoprotein)
Synonyms: 5430420E18Rik, gamma-SG
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 24053
Homologene: 194
Lmtk3
Name: lemur tyrosine kinase 3
Synonyms: AATYK3, Aatyk3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 381983
Homologene: 79449
Ptpn22
Name: protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
Synonyms: 70zpep, Ptpn8
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 19260
HGNC: HGNC:9652
Homologene: 7498
Cyp2c67
Name: cytochrome P450, family 2, subfamily c, polypeptide 67
Synonyms: C730004C24Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 545288
Homologene: 74936
Pde6h
Name: phosphodiesterase 6H, cGMP-specific, cone, gamma
Synonyms: A930033D18Rik, PDEgamma
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 78600
HGNC: HGNC:8790
Homologene: 4522
Duoxa2
Name: dual oxidase maturation factor 2
Synonyms: Nip2, 9030623N16Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66811
Homologene: 57037
Ighv1-19
Name: immunoglobulin heavy variable V1-19
Synonyms: Gm16855
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 382692
C1rb
Name: complement component 1, r subcomponent B
Synonyms: Gm8551, mC1rB
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 667277
HGNC: HGNC:1246
Homologene: 1313
Catspere2
Name: cation channel sperm associated auxiliary subunit epsilon 2
Synonyms: EG545391, Gm30473, Gm16432
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 545391
Gm3402
Name: predicted gene 3402
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100041548
Homologene: 86127
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 134,560,439 bp
  • A to G, chromosome 1 at 178,098,508 bp
  • T to A, chromosome 1 at 190,161,845 bp
  • T to C, chromosome 2 at 31,392,157 bp
  • C to A, chromosome 2 at 82,983,118 bp
  • G to T, chromosome 2 at 90,440,782 bp
  • A to T, chromosome 2 at 122,301,340 bp
  • T to C, chromosome 2 at 136,098,299 bp
  • T to C, chromosome 2 at 157,031,005 bp
  • A to G, chromosome 3 at 3,652,864 bp
  • C to G, chromosome 3 at 101,018,729 bp
  • T to A, chromosome 3 at 103,886,019 bp
  • C to T, chromosome 4 at 112,624,218 bp
  • T to C, chromosome 4 at 123,016,779 bp
  • T to A, chromosome 4 at 129,616,708 bp
  • A to G, chromosome 4 at 156,176,532 bp
  • C to A, chromosome 5 at 86,034,353 bp
  • A to G, chromosome 5 at 96,736,970 bp
  • G to T, chromosome 5 at 112,576,812 bp
  • T to C, chromosome 5 at 146,515,233 bp
  • C to T, chromosome 6 at 23,969,750 bp
  • T to A, chromosome 6 at 58,876,788 bp
  • T to A, chromosome 6 at 95,566,460 bp
  • G to A, chromosome 6 at 95,566,463 bp
  • A to T, chromosome 6 at 124,575,279 bp
  • T to C, chromosome 6 at 136,963,213 bp
  • A to G, chromosome 6 at 146,809,719 bp
  • T to C, chromosome 7 at 28,841,146 bp
  • C to T, chromosome 7 at 45,795,157 bp
  • A to T, chromosome 7 at 62,380,776 bp
  • A to G, chromosome 7 at 74,284,342 bp
  • T to C, chromosome 7 at 100,422,603 bp
  • A to G, chromosome 9 at 49,506,911 bp
  • G to A, chromosome 9 at 106,076,892 bp
  • G to T, chromosome 9 at 107,579,160 bp
  • A to T, chromosome 9 at 112,176,251 bp
  • T to C, chromosome 10 at 60,305,116 bp
  • T to C, chromosome 10 at 79,378,888 bp
  • T to A, chromosome 10 at 127,504,900 bp
  • A to G, chromosome 11 at 50,602,266 bp
  • T to G, chromosome 11 at 60,245,165 bp
  • A to G, chromosome 11 at 64,520,337 bp
  • T to A, chromosome 11 at 73,711,553 bp
  • A to T, chromosome 11 at 106,846,085 bp
  • A to G, chromosome 12 at 114,708,951 bp
  • A to T, chromosome 14 at 55,863,914 bp
  • T to A, chromosome 14 at 61,240,367 bp
  • A to G, chromosome 14 at 64,031,998 bp
  • A to T, chromosome 15 at 57,263,375 bp
  • T to G, chromosome 15 at 80,375,575 bp
  • G to T, chromosome 15 at 98,603,876 bp
  • A to G, chromosome 16 at 93,747,508 bp
  • G to A, chromosome 17 at 57,296,720 bp
  • A to G, chromosome 17 at 78,954,566 bp
  • A to G, chromosome 18 at 37,474,336 bp
  • T to C, chromosome 18 at 66,458,814 bp
  • A to T, chromosome 18 at 73,937,267 bp
  • A to T, chromosome 19 at 39,640,007 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7335 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045372-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.