Strain Name:
C57BL/6J-MtgxR7531Btlr/Mmmh
Stock Number:
045603-MU
Citation ID:
RRID:MMRRC_045603-MU
Other Names:
R7531 (G1)
Major Collection:

Strain Information

Kit
Name: KIT proto-oncogene receptor tyrosine kinase
Synonyms: SOW3, Dominant white spotting, c-KIT, Steel Factor Receptor, CD117, belly-spot, Tr-kit, Gsfsow3, Gsfsco5, SCO1, SCO5, Gsfsco1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 16590
HGNC: HGNC:6342
Homologene: 187
Npy1r
Name: neuropeptide Y receptor Y1
Synonyms: Y1-R, Npyr
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 18166
HGNC: HGNC:7956
Homologene: 700
Abca12
Name: ATP-binding cassette, sub-family A member 12
Synonyms: 4833417A11Rik, 4832428G11Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74591
Homologene: 45441
Hcn4
Name: hyperpolarization-activated, cyclic nucleotide-gated K+ 4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 330953
VEGA: 9
Homologene: 3997
Tm9sf2
Name: transmembrane 9 superfamily member 2
Synonyms: P76, D14Ertd64e, 1500001N15Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 68059
Homologene: 21004
Agrn
Name: agrin
Synonyms: nmf380, NMF380, Agrin
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11603
HGNC: HGNC:329
Homologene: 27907
Arfgap2
Name: ADP-ribosylation factor GTPase activating protein 2
Synonyms: Zfp289, 2310032E02Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 77038
Homologene: 8735
Hectd1
Name: HECT domain E3 ubiquitin protein ligase 1
Synonyms: b2b327Clo, opm, A630086P08Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 207304
VEGA: 12
Homologene: 9115
Bpgm
Name: 2,3-bisphosphoglycerate mutase
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12183
HGNC: HGNC:1093
Homologene: 55599
Fam114a2
Name: family with sequence similarity 114, member A2
Synonyms: 9030624B09Rik, 1810073G14Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67726
HGNC: HGNC:1333
Homologene: 10270
Lepr
Name: leptin receptor
Synonyms: OB-RGRP, Leprb, leptin receptor gene-related protein, LEPROT, Obr, obl, Modb1, obese-like
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16847
HGNC: HGNC:6554
Homologene: 1731
Ror1
Name: receptor tyrosine kinase-like orphan receptor 1
Synonyms: Ntrkr1, 2810404D04Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 26563
Homologene: 3675
Acsf2
Name: acyl-CoA synthetase family member 2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 264895
Homologene: 23519
Clec4e
Name: C-type lectin domain family 4, member e
Synonyms: Mincle, Clecsf9
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 56619
Homologene: 22809
Pcmt1
Name: protein-L-isoaspartate (D-aspartate) O-methyltransferase 1
Synonyms: PIMT, protein carboxyl methyltransferase
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 18537
HGNC: HGNC:8728
Homologene: 135759
Tax1bp1
Name: Tax1 (human T cell leukemia virus type I) binding protein 1
Synonyms: D6Ertd404e, 1200003J11Rik, 1700069J21Rik, T6BP, TXBP151, D6Ertd772e
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 52440
Homologene: 4395
Naa35
Name: N(alpha)-acetyltransferase 35, NatC auxiliary subunit
Synonyms: Mak10, C030004C14Rik, A330021G12Rik, A330027C19Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 78689
Homologene: 5781
Ddx11
Name: DEAD/H box helicase 11
Synonyms: 4732462I11Rik, CHLR1, essa15a, KRG2, CHL1, DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 320209
VEGA: 17
Homologene: 68973
Scn4a
Name: sodium channel, voltage-gated, type IV, alpha
Synonyms: Nav1.4, SkM1, mH2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 110880
Homologene: 283
Hmcn1
Name: hemicentin 1
Synonyms: LOC240793, EG545370
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 545370
Homologene: 23741
Depdc1a
Name: DEP domain containing 1a
Synonyms: 5830484J08Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 76131
Homologene: 9834
Dhx36
Name: DEAH-box helicase 36
Synonyms: RHAU, Ddx36, 2810407E23Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 72162
Homologene: 6356
Fcgbpl1
Name: Fc fragment of IgG binding protein like 1
Synonyms: 9530053A07Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 319482
Homologene: 130055
Rin2
Name: Ras and Rab interactor 2
Synonyms: 4632403N06Rik, RASSF4, 2010003K16Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74030
Homologene: 32430
Aldh9a1
Name: aldehyde dehydrogenase 9, subfamily A1
Synonyms: TMABA-DH, ESTM40
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 56752
HGNC: HGNC:412
Homologene: 55483
Prg4
Name: proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein)
Synonyms: SZP, MSF, DOL54, lubricin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 96875
HGNC: HGNC:9364
Homologene: 137352
Sema3a
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
Synonyms: semaphorin III, Semad, collapsin-1, SemD, sema III
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20346
Homologene: 31358
Adam25
Name: ADAM metallopeptidase domain 25
Synonyms: testase 2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 23793
HGNC: HGNC:199
Homologene: 128364
Lmod3
Name: leiomodin 3 (fetal)
Synonyms: 5430424A14Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 320502
HGNC: HGNC:6649
Homologene: 28097
Flg2
Name: filaggrin family member 2
Synonyms: EG229574
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229574
Homologene: 134146
Rsl1
Name: regulator of sex limited protein 1
Synonyms: rslcan-9
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 380855
Homologene: 110878
Abcg3
Name: ATP binding cassette subfamily G member 3
Synonyms: Abcp2, Mxr2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 27405
HGNC: HGNC:74
Homologene: 86845
Tesc
Name: tescalcin
Synonyms: TE-1, 1010001A17Rik, 2410011K10Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 57816
Homologene: 75158
Usp4
Name: ubiquitin specific peptidase 4 (proto-oncogene)
Synonyms: F730026I20Rik, Unp
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22258
Homologene: 20716
Unc45b
Name: unc-45 myosin chaperone B
Synonyms: Cmya4, D230041A13Rik, UNC45
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217012
Homologene: 14666
Nr1h3
Name: nuclear receptor subfamily 1, group H, member 3
Synonyms: LXR alpha, Unr1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22259
HGNC: HGNC:7966
Homologene: 21165
Or5p79
Name: olfactory receptor family 5 subfamily P member 79
Synonyms: MOR204-7, GA_x6K02T2PBJ9-10951546-10952496, Olfr507
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258738
Homologene: 27249
Vmn1r10
Name: vomeronasal 1 receptor 10
Synonyms: V1rc1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 113858
Homologene: 76459
Zfyve16
Name: zinc finger, FYVE domain containing 16
Synonyms: B130024H06Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218441
Homologene: 8826
Brinp2
Name: bone morphogenic protein/retinoic acid inducible neural-specific 2
Synonyms: Fam5b, 6430517E21Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240843
Homologene: 10905
Marchf1
Name: membrane associated ring-CH-type finger 1
Synonyms: 2900024D24Rik, March1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 72925
Homologene: 113749
Asb7
Name: ankyrin repeat and SOCS box-containing 7
Synonyms: D030055C23Rik, Asb-7
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 117589
Homologene: 34130
Glb1l3
Name: galactosidase, beta 1 like 3
Synonyms: 4921509F24Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 70893
Homologene: 72240
Hyal6
Name: hyaluronoglucosaminidase 6
Synonyms: 4932701A20Rik, Hyal-ps1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 74409
HGNC: HGNC:5324
Homologene: 78028
Cry2
Name: cryptochrome circadian regulator 2
Synonyms: D130054K12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12953
HGNC: HGNC:2385
Homologene: 56466
Dcxr
Name: dicarbonyl L-xylulose reductase
Synonyms: 1810027P18Rik, 0610038K04Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67880
Homologene: 22964
Keap1
Name: kelch-like ECH-associated protein 1
Synonyms: INrf2, ring canal protein
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 50868
Homologene: 8184
Pate2
Name: prostate and testis expressed 2
Synonyms: LOC330921, mANLP1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 330921
Homologene: 86016
Aspa
Name: aspartoacylase
Synonyms: Acy-2, aspartoacylase, Acy2, nur7, small lethargic
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11484
HGNC: HGNC:756
Homologene: 33
Aqp5
Name: aquaporin 5
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 11830
VEGA: 15
HGNC: HGNC:638
Homologene: 20398
Smpd5
Name: sphingomyelin phosphodiesterase 5
Synonyms: Gm10345
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 100503915
Homologene: 132205
Crisp3
Name: cysteine-rich secretory protein 3
Synonyms: Aeg2, CRISP-3, SGP28, CRS3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 11572
Homologene: 135665
Gramd2a
Name: GRAM domain containing 2A
Synonyms: Gramd2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 546134
Homologene: 52791
Krtap5-3
Name: keratin associated protein 5-3
Synonyms: A030007E19Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 77215
Gm45844
Name: predicted gene 45844
Type: Gene
Species: Mouse
Chromosome: 7
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 71,247,173 bp
  • T to G, chromosome 1 at 150,455,035 bp
  • A to T, chromosome 1 at 150,686,780 bp
  • A to G, chromosome 1 at 158,266,572 bp
  • G to A, chromosome 1 at 167,350,326 bp
  • C to T, chromosome 2 at 91,184,394 bp
  • T to A, chromosome 2 at 91,273,744 bp
  • A to G, chromosome 2 at 92,413,005 bp
  • T to G, chromosome 2 at 145,858,499 bp
  • T to C, chromosome 3 at 62,484,968 bp
  • A to T, chromosome 3 at 93,200,870 bp
  • A to C, chromosome 3 at 159,522,639 bp
  • T to A, chromosome 4 at 88,691,286 bp
  • T to A, chromosome 4 at 100,441,191 bp
  • T to A, chromosome 4 at 101,752,175 bp
  • A to T, chromosome 4 at 156,169,804 bp
  • T to C, chromosome 5 at 13,565,838 bp
  • T to C, chromosome 5 at 75,607,040 bp
  • A to G, chromosome 5 at 104,977,641 bp
  • A to T, chromosome 5 at 118,059,458 bp
  • A to T, chromosome 6 at 24,740,787 bp
  • A to G, chromosome 6 at 34,504,288 bp
  • A to T, chromosome 6 at 52,746,697 bp
  • T to A, chromosome 6 at 57,113,939 bp
  • A to T, chromosome 6 at 97,248,442 bp
  • A to G, chromosome 6 at 123,285,574 bp
  • T to C, chromosome 7 at 7,240,186 bp
  • T to C, chromosome 7 at 28,140,231 bp
  • T to C, chromosome 7 at 66,679,136 bp
  • T to A, chromosome 7 at 108,622,062 bp
  • T to A, chromosome 7 at 142,202,205 bp
  • T to A, chromosome 8 at 40,753,877 bp
  • C to G, chromosome 8 at 66,386,337 bp
  • C to A, chromosome 8 at 66,704,894 bp
  • A to G, chromosome 9 at 21,237,327 bp
  • T to C, chromosome 9 at 26,853,654 bp
  • A to G, chromosome 9 at 35,670,712 bp
  • A to G, chromosome 9 at 58,860,137 bp
  • A to T, chromosome 9 at 59,709,910 bp
  • T to A, chromosome 9 at 108,372,680 bp
  • A to G, chromosome 10 at 7,680,605 bp
  • A to G, chromosome 11 at 57,513,716 bp
  • G to A, chromosome 11 at 73,313,525 bp
  • A to G, chromosome 11 at 82,929,012 bp
  • G to T, chromosome 11 at 94,573,231 bp
  • A to G, chromosome 11 at 106,348,697 bp
  • A to G, chromosome 11 at 120,727,006 bp
  • C to T, chromosome 12 at 51,806,367 bp
  • A to T, chromosome 13 at 59,617,941 bp
  • T to A, chromosome 13 at 67,176,502 bp
  • A to G, chromosome 13 at 92,522,965 bp
  • T to C, chromosome 14 at 122,142,412 bp
  • T to C, chromosome 15 at 76,296,339 bp
  • T to C, chromosome 15 at 99,591,299 bp
  • A to G, chromosome 17 at 40,234,738 bp
  • A to T, chromosome 17 at 66,138,219 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7531 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045603-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.