Strain Name:
C57BL/6J-MtgxR7540Btlr/Mmmh
Stock Number:
045612-MU
Citation ID:
RRID:MMRRC_045612-MU
Other Names:
R7540 (G1)
Major Collection:

Strain Information

Itga8
Name: integrin alpha 8
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241226
HGNC: HGNC:6144
Homologene: 37396
Neurog3
Name: neurogenin 3
Synonyms: Atoh5, ngn3, bHLHa7, Math4B
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11925
VEGA: 10
Homologene: 40692
Ank2
Name: ankyrin 2, brain
Synonyms: ankyrin B, Gm4392, Ankyrin-B, Ank-2, Ankyrin-2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 109676
HGNC: HGNC:493
Nub1
Name: negative regulator of ubiquitin-like proteins 1
Synonyms: NY-REN-18, BS4, 4931404D21Rik, 6330412F12Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 53312
Homologene: 41108
Zfp423
Name: zinc finger protein 423
Synonyms: Ebfaz, Roaz, Zfp104, ataxia1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 94187
Homologene: 9010
Zmym1
Name: zinc finger, MYM domain containing 1
Synonyms: 5830412B09Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68310
Homologene: 32904
Tti1
Name: TELO2 interacting protein 1
Synonyms: 2610036D13Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 75425
Homologene: 40969
Tg
Name: thyroglobulin
Synonyms: Tgn
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 21819
Homologene: 2430
Zfp160
Name: zinc finger protein 160
Synonyms: 6720480D16Rik, 6720480D16Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224585
VEGA: 17
Homologene: 137372
Iws1
Name: IWS1, SUPT6 interacting protein
Synonyms: 1700069O15Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 73473
Homologene: 134421
C3
Name: complement component 3
Synonyms: Plp, complement factor 3, acylation stimulating protein
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12266
HGNC: HGNC:1318
Homologene: 68031
Hspg2
Name: perlecan (heparan sulfate proteoglycan 2)
Synonyms: Plc, perlecan, Pcn, per
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 15530
HGNC: HGNC:5273
Homologene: 68473
Tmco1
Name: transmembrane and coiled-coil domains 1
Synonyms: 1190006A08Rik, ESTM39, 4930403O06Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 68944
Homologene: 10384
Zfyve26
Name: zinc finger, FYVE domain containing 26
Synonyms: 9330197E15Rik, A630028O16Rik, LOC380767
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 211978
VEGA: 12
Homologene: 9102
Slmap
Name: sarcolemma associated protein
Synonyms: D330001L02Rik, Slap, Miranda
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 83997
Homologene: 31428
Gemin5
Name: gem nuclear organelle associated protein 5
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216766
Homologene: 9155
Bpifb1
Name: BPI fold containing family B, member 1
Synonyms: U46068, von Ebner minor salivary protein, LPlunc1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228801
Homologene: 50047
Prkcb
Name: protein kinase C, beta
Synonyms: Prkcb2, PKC-Beta, A130082F03Rik, Prkcb1, Pkcb
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18751
HGNC: HGNC:9395
Homologene: 56424
Ush1g
Name: USH1 protein network component sans
Synonyms: Sans, js
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16470
Homologene: 56113
Mboat4
Name: membrane bound O-acyltransferase domain containing 4
Synonyms: GOAT, LOC234155
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234155
Homologene: 19272
Ghr
Name: growth hormone receptor
Synonyms: GHBP, GHR/BP
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 14600
HGNC: HGNC:4263
Homologene: 134
Mroh7
Name: maestro heat-like repeat family member 7
Synonyms: Gm1027, Heatr8, LOC381538
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 381538
Homologene: 19633
Kctd19
Name: potassium channel tetramerisation domain containing 19
Synonyms: 4922504H04Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 279499
Homologene: 18630
Pus7
Name: pseudouridylate synthase 7
Synonyms: C330017I15Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 78697
Homologene: 6998
Tubgcp6
Name: tubulin, gamma complex component 6
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 328580
Homologene: 32477
Man2c1
Name: mannosidase, alpha, class 2C, member 1
Synonyms: 1110025H24Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 73744
HGNC: HGNC:6827
Homologene: 4887
Irs1
Name: insulin receptor substrate 1
Synonyms: G972R, IRS-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16367
HGNC: HGNC:6125
Homologene: 4049
Meis3
Name: Meis homeobox 3
Synonyms: Mrg2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17537
Homologene: 7425
Osbp2
Name: oxysterol binding protein 2
Synonyms: C630001G20Rik, ORP-4, OSBPL1, 1700095P05Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74309
HGNC: HGNC:8504
Homologene: 75303
Dgkb
Name: diacylglycerol kinase, beta
Synonyms: DGK-beta, C630029D13Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217480
VEGA: 12
HGNC: HGNC:2850
Homologene: 37875
Zdhhc8
Name: zinc finger, DHHC domain containing 8
Synonyms: E330009O14Rik, Op53c05, D16H22S1738E
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 27801
VEGA: 16
Homologene: 8363
Pcdh8
Name: protocadherin 8
Synonyms: 1700080P15Rik, Papc
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 18530
HGNC: HGNC:8660
Homologene: 1943
Plin4
Name: perilipin 4
Synonyms: S3-12
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 57435
Homologene: 69311
Pcsk7
Name: proprotein convertase subtilisin/kexin type 7
Synonyms: SPC7
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 18554
VEGA: 9
HGNC: HGNC:8748
Homologene: 37955
Naaa
Name: N-acylethanolamine acid amidase
Synonyms: Asahl, 2210023K21Rik, 3830414F09Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 67111
HGNC: HGNC:736
Homologene: 8686
Fmn1
Name: formin 1
Synonyms: Fmn, formin-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14260
HGNC: HGNC:3768
Homologene: 121778
Gpr161
Name: G protein-coupled receptor 161
Synonyms: vl, LOC240888
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240888
Homologene: 17824
Rmnd1
Name: required for meiotic nuclear division 1 homolog
Synonyms: 0610042C05Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 66084
Homologene: 5675
Or2t47
Name: olfactory receptor family 2 subfamily T member 47
Synonyms: Olfr328, MOR275-2, GA_x6K02T2NKPP-873285-874217
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258495
Homologene: 133015
Or6c207
Name: olfactory receptor family 6 subfamily C member 207
Synonyms: MOR114-9, GA_x6K02T2PULF-10955551-10954616, Olfr777
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258537
Homologene: 27203
Foxb1
Name: forkhead box B1
Synonyms: Foxb1a, TWH, C43, Hfh-e5.1, Fkh5, Foxb1b, Mf3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 64290
VEGA: 9
HGNC: HGNC:3799
Homologene: 8138
Adgrg7
Name: adhesion G protein-coupled receptor G7
Synonyms: 9130020O16Rik, Gpr128
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239853
Homologene: 13115
Adamts8
Name: ADAM metallopeptidase with thrombospondin type 1 motif 8
Synonyms: METH-2, METH2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 30806
HGNC: HGNC:224
Homologene: 5108
Krtap12-23
Name: keratin associated protein 12-23
Synonyms: Gm10272
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16697
VEGA: 10
4930516K23Rik
Name: RIKEN cDNA 4930516K23 gene
Type: Gene
Species: Mouse
Chromosome: 7
Sytl3
Name: synaptotagmin-like 3
Synonyms: Slp3, Slp3-b, Slp3-a
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 83672
Homologene: 12855
Or3a1c
Name: olfactory receptor family 3 subfamily A member 1C
Synonyms: MOR255-4, GA_x6K02T2P1NL-4307199-4308146, Olfr402
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258703
HGNC: HGNC:8282
Homologene: 1915
Myl6b
Name: myosin, light polypeptide 6B
Synonyms: 5730437E04Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216459
VEGA: 10
Homologene: 86887
Msantd5f2
Name: Myb/SANT DNA binding domain containing 5 family member 2
Synonyms: Gm11239
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 101055863
Homologene: 128423
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 82,288,002 bp
  • G to A, chromosome 1 at 165,318,835 bp
  • A to G, chromosome 1 at 167,326,003 bp
  • T to A, chromosome 2 at 12,111,037 bp
  • A to G, chromosome 2 at 113,529,310 bp
  • G to A, chromosome 2 at 154,213,111 bp
  • G to A, chromosome 2 at 158,007,996 bp
  • C to T, chromosome 3 at 126,988,159 bp
  • C to T, chromosome 4 at 73,668,411 bp
  • G to T, chromosome 4 at 106,720,398 bp
  • A to T, chromosome 4 at 127,048,757 bp
  • T to A, chromosome 4 at 137,541,440 bp
  • G to A, chromosome 5 at 23,760,246 bp
  • T to G, chromosome 5 at 24,701,529 bp
  • T to A, chromosome 5 at 92,263,724 bp
  • C to A, chromosome 7 at 16,177,493 bp
  • T to C, chromosome 7 at 104,059,263 bp
  • G to A, chromosome 7 at 122,568,134 bp
  • T to A, chromosome 8 at 34,124,024 bp
  • A to T, chromosome 8 at 87,688,067 bp
  • G to T, chromosome 8 at 105,386,935 bp
  • A to G, chromosome 9 at 30,959,064 bp
  • G to T, chromosome 9 at 45,927,673 bp
  • G to A, chromosome 9 at 57,140,275 bp
  • G to A, chromosome 9 at 69,759,859 bp
  • A to G, chromosome 10 at 4,403,989 bp
  • T to G, chromosome 10 at 62,133,977 bp
  • A to C, chromosome 10 at 77,706,626 bp
  • T to A, chromosome 10 at 128,496,280 bp
  • A to T, chromosome 10 at 129,269,134 bp
  • T to C, chromosome 11 at 3,717,944 bp
  • C to T, chromosome 11 at 58,130,402 bp
  • C to A, chromosome 11 at 58,551,631 bp
  • A to T, chromosome 11 at 74,155,588 bp
  • T to C, chromosome 11 at 115,318,573 bp
  • A to T, chromosome 12 at 37,981,790 bp
  • A to T, chromosome 12 at 79,268,676 bp
  • T to C, chromosome 14 at 26,460,191 bp
  • A to T, chromosome 14 at 79,771,103 bp
  • T to A, chromosome 15 at 3,319,914 bp
  • A to G, chromosome 15 at 66,689,927 bp
  • G to T, chromosome 15 at 89,102,323 bp
  • A to G, chromosome 16 at 18,227,810 bp
  • G to A, chromosome 16 at 56,750,429 bp
  • T to C, chromosome 17 at 6,681,947 bp
  • T to A, chromosome 17 at 21,025,660 bp
  • G to A, chromosome 17 at 56,104,883 bp
  • A to G, chromosome 17 at 57,206,220 bp
  • T to A, chromosome 18 at 32,080,483 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7540 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045612-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.