Strain Name:
C57BL/6J-MtgxR7760Btlr/Mmmh
Stock Number:
045816-MU
Citation ID:
RRID:MMRRC_045816-MU
Other Names:
R7760 (G1)
Major Collection:

Strain Information

Wnt3
Name: wingless-type MMTV integration site family, member 3
Synonyms: Int-4, Wnt-3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 22415
Homologene: 22527
Ppp5c
Name: protein phosphatase 5, catalytic subunit
Synonyms: ANP receptor, PP5
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 19060
HGNC: HGNC:9322
Homologene: 4550
Slc6a5
Name: solute carrier family 6 (neurotransmitter transporter, glycine), member 5
Synonyms: Glyt2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 104245
Homologene: 37901
Tlk2
Name: tousled-like kinase 2 (Arabidopsis)
Synonyms: 4933403M19Rik, PKUalpha, protein kinase U-alpha
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 24086
Homologene: 4993
Gatad2b
Name: GATA zinc finger domain containing 2B
Synonyms: p66beta, C430014D17Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229542
Homologene: 32484
Wac
Name: WW domain containing adaptor with coiled-coil
Synonyms: Wwp4, 1110067P07Rik, A230035H12Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225131
Homologene: 41148
Senp7
Name: SUMO1/sentrin specific peptidase 7
Synonyms: 2900036C23Rik, 2810413I22Rik, 2410152H17Rik, 6030449K19Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 66315
Homologene: 10778
Tom1l2
Name: target of myb1-like 2 (chicken)
Synonyms: 2900016I08Rik, A730055F12Rik, myb1-like protein 2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216810
Homologene: 44901
Pdcd11
Name: programmed cell death 11
Synonyms: 1110021I22Rik, ALG-4
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18572
VEGA: 19
Homologene: 74968
Elp1
Name: elongator complex protein 1
Synonyms: C78473, Ikbkap, IKAP, 3110040G09Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230233
HGNC: HGNC:5959
Homologene: 2699
Smc5
Name: structural maintenance of chromosomes 5
Synonyms: Smc5l1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226026
VEGA: 19
Homologene: 41009
Ctr9
Name: CTR9 homolog, Paf1/RNA polymerase II complex component
Synonyms: Tsp, Sh2bp1, Tsbp
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22083
Homologene: 40668
Golga3
Name: golgin A3
Synonyms: 5430416E01Rik, G1-499-14, repro27, Mea-2, Mea2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269682
HGNC: HGNC:4426
Homologene: 4308
Pigr
Name: polymeric immunoglobulin receptor
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18703
HGNC: HGNC:8968
Homologene: 1984
Anxa11
Name: annexin A11
Synonyms: A830099O17Rik, Anx11
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 11744
HGNC: HGNC:535
Homologene: 22759
Nfatc3
Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3
Synonyms: D8Ertd281e, NFAT4, NFATx
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 18021
HGNC: HGNC:7777
Homologene: 27827
Grpel1
Name: GrpE-like 1, mitochondrial
Synonyms: mt-GrpE#1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 17713
Homologene: 6992
Nipbl
Name: NIPBL cohesin loading factor
Synonyms: 4933421G18Rik, 4921518A06Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 71175
VEGA: 15
Homologene: 15850
Sec31a
Name: SEC31 homolog A, COPII coat complex component
Synonyms: Sec31l1, 1810024J13Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 69162
Homologene: 42056
Clec4d
Name: C-type lectin domain family 4, member d
Synonyms: mMCL, Mpcl, Clecsf8, mcl
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 17474
Homologene: 7844
Capg
Name: capping actin protein, gelsolin like
Synonyms: gCap39, mbh1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12332
HGNC: HGNC:1474
Homologene: 37523
Ldb3
Name: LIM domain binding 3
Synonyms: cypher, ZASP
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 24131
VEGA: 14
Homologene: 134626
Tarbp1
Name: TAR RNA binding protein 1
Synonyms: Gm17296
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 212728
Homologene: 38082
Muc6
Name: mucin 6, gastric
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 353328
HGNC: HGNC:7517
Homologene: 18768
Or2t6
Name: olfactory receptor family 2 subfamily T member 6
Synonyms: Olfr720, GA_x6K02T2PLTE-6544896-6543946, MOR274-2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258387
Homologene: 74036
Man2c1
Name: mannosidase, alpha, class 2C, member 1
Synonyms: 1110025H24Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 73744
HGNC: HGNC:6827
Homologene: 4887
Plcb2
Name: phospholipase C, beta 2
Synonyms: B230205M18Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18796
HGNC: HGNC:9055
Homologene: 20957
Gm19410
Name: predicted gene, 19410
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 100502846
Homologene: 132117
Tnxb
Name: tenascin XB
Synonyms: Tnx, TN-MHC
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 81877
Homologene: 49589
Trmt1l
Name: tRNA methyltransferase 1 like
Synonyms: 1190005F20Rik, Trm1-like
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98685
Homologene: 12801
Ngef
Name: neuronal guanine nucleotide exchange factor
Synonyms: ephexin, Tims2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 53972
HGNC: HGNC:7807
Homologene: 75120
Greb1
Name: gene regulated by estrogen in breast cancer protein
Synonyms: 5730583K22Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 268527
Homologene: 8780
Elfn2
Name: leucine rich repeat and fibronectin type III, extracellular 2
Synonyms: Lrrc62
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 207393
VEGA: 15
Homologene: 18835
Fbrs
Name: fibrosin
Synonyms: Fbs1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14123
Homologene: 79554
Dnah7b
Name: dynein, axonemal, heavy chain 7B
Synonyms: Dnahc7b, LOC227058
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227058
Homologene: 41287
Arl6
Name: ADP-ribosylation factor-like 6
Synonyms: 1110018H24Rik, BBS3, 2210411E14Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 56297
Homologene: 12960
Dmwd
Name: dystrophia myotonica-containing WD repeat motif
Synonyms: 59, DMR-N9, Dm9
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13401
HGNC: HGNC:2936
Homologene: 22559
Zfp948
Name: zinc finger protein 948
Synonyms: BC049807
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 381066
VEGA: 17
Arg1
Name: arginase, liver
Synonyms: AI, PGIF, Arg-1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11846
VEGA: 10
HGNC: HGNC:663
Homologene: 29
Efcab5
Name: EF-hand calcium binding domain 5
Synonyms: 4930563A03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 319634
Homologene: 63366
Esrp2
Name: epithelial splicing regulatory protein 2
Synonyms: Rbm35b, 9530027K23Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 77411
Homologene: 32617
Ceacam1
Name: CEA cell adhesion molecule 1
Synonyms: MHVR1, Bgp1, Cea1, Hv2, C-CAM, Cea7, Cea-7, CD66a, Mhv-1, Cea-1, Bgp, Hv-2, mmCGM1, mCEA1, mmCGM2, Cc1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 26365
Homologene: 128630
Rnf7l
Name: ring finger protein 7 like
Synonyms: Gm7075
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 631906
VEGA: 10
Pbx4
Name: pre B cell leukemia homeobox 4
Synonyms: 2410015M21Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 80720
Homologene: 57027
Rtkn2
Name: rhotekin 2
Synonyms: RTKN2, B130039D23Rik, Plekhk1, Mbf
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 170799
Homologene: 17065
Slc7a9
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 9
Synonyms: CSNU3, bo, + amino acid transporter, bo, +AT
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 30962
Homologene: 56668
Mblac2
Name: metallo-beta-lactamase domain containing 2
Synonyms: 2900024O10Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 72852
VEGA: 13
Homologene: 15174
Spaca3
Name: sperm acrosome associated 3
Synonyms: SLLP1, 1700025M08Rik, ALLP17
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 75622
Homologene: 18365
Fbxl21
Name: F-box and leucine-rich repeat protein 21
Synonyms: FBL3B, FBXL3B, Psttm, D630045D17Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 213311
Homologene: 78724
Taco1
Name: translational activator of mitochondrially encoded cytochrome c oxidase I
Synonyms: Ccdc44, 2310066I18Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70207
Homologene: 39079
Pcdhgb5
Name: protocadherin gamma subfamily B, 5
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93702
HGNC: HGNC:8712
Homologene: 55773
Trav6-4
Name: T cell receptor alpha variable 6-4
Synonyms: Gm13945
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 100126463
Gm6882
Name: predicted gene 6882
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 628475
Traj46
Name: T cell receptor alpha joining 46
Synonyms: Gm16928
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 100124342
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 46,201,253 bp
  • T to C, chromosome 1 at 87,540,773 bp
  • A to T, chromosome 1 at 130,846,631 bp
  • C to T, chromosome 1 at 151,442,674 bp
  • T to C, chromosome 2 at 118,711,388 bp
  • C to T, chromosome 3 at 90,354,469 bp
  • A to G, chromosome 4 at 56,790,892 bp
  • G to T, chromosome 5 at 36,470,642 bp
  • A to G, chromosome 5 at 100,392,628 bp
  • A to G, chromosome 5 at 110,205,850 bp
  • A to G, chromosome 6 at 72,557,786 bp
  • A to G, chromosome 6 at 123,270,341 bp
  • A to G, chromosome 7 at 17,006,349 bp
  • C to T, chromosome 7 at 19,080,735 bp
  • T to A, chromosome 7 at 21,427,484 bp
  • T to A, chromosome 7 at 25,472,025 bp
  • T to C, chromosome 7 at 35,457,075 bp
  • T to C, chromosome 7 at 49,946,617 bp
  • T to G, chromosome 7 at 111,046,601 bp
  • T to C, chromosome 7 at 127,489,400 bp
  • T to A, chromosome 7 at 141,651,057 bp
  • T to A, chromosome 8 at 35,802,337 bp
  • C to A, chromosome 8 at 69,832,795 bp
  • A to G, chromosome 8 at 106,108,341 bp
  • T to A, chromosome 8 at 106,133,470 bp
  • C to T, chromosome 8 at 126,452,807 bp
  • T to C, chromosome 9 at 57,139,363 bp
  • T to G, chromosome 10 at 24,927,463 bp
  • T to C, chromosome 10 at 63,421,537 bp
  • T to G, chromosome 10 at 68,005,609 bp
  • T to C, chromosome 11 at 60,274,965 bp
  • T to A, chromosome 11 at 77,151,926 bp
  • T to A, chromosome 11 at 80,864,563 bp
  • T to A, chromosome 11 at 103,811,440 bp
  • T to C, chromosome 11 at 105,279,167 bp
  • T to A, chromosome 11 at 106,073,112 bp
  • T to C, chromosome 12 at 16,723,416 bp
  • T to A, chromosome 12 at 113,702,175 bp
  • T to C, chromosome 13 at 56,526,934 bp
  • C to T, chromosome 13 at 56,537,003 bp
  • G to T, chromosome 13 at 81,711,877 bp
  • T to C, chromosome 14 at 14,175,905 bp
  • C to T, chromosome 14 at 25,872,827 bp
  • T to A, chromosome 14 at 34,542,503 bp
  • T to A, chromosome 14 at 53,454,646 bp
  • A to T, chromosome 14 at 54,172,356 bp
  • T to G, chromosome 14 at 54,172,357 bp
  • T to C, chromosome 15 at 8,358,702 bp
  • C to T, chromosome 15 at 78,673,841 bp
  • A to T, chromosome 16 at 56,139,079 bp
  • T to C, chromosome 16 at 59,618,806 bp
  • T to C, chromosome 17 at 21,588,366 bp
  • A to T, chromosome 17 at 34,712,937 bp
  • T to A, chromosome 18 at 7,921,913 bp
  • A to G, chromosome 18 at 37,731,637 bp
  • A to C, chromosome 19 at 23,235,890 bp
  • G to A, chromosome 19 at 47,113,198 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7760 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045816-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.