Strain Name:
C57BL/6J-MtgxR7843Btlr/Mmmh
Stock Number:
045897-MU
Citation ID:
RRID:MMRRC_045897-MU
Other Names:
R7843 (G1)
Major Collection:

Strain Information

Sptbn1
Name: spectrin beta, non-erythrocytic 1
Synonyms: 9930031C03Rik, brain spectrin, elf1, spectrin G, beta fodrin, Spnb2, non-erythrocytic, Spnb-2, elf3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20742
Homologene: 2354
Top1
Name: topoisomerase (DNA) I
Synonyms: D130064I21Rik, Top-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 21969
Homologene: 2467
Slc1a6
Name: solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
Synonyms: EAAT4
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 20513
VEGA: 10
Homologene: 21055
Chst5
Name: carbohydrate sulfotransferase 5
Synonyms: I-GlcNAc6ST, GST-4
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 56773
Homologene: 56927
Mast2
Name: microtubule associated serine/threonine kinase 2
Synonyms: MAST205, Mtssk
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17776
Homologene: 7428
Cep290
Name: centrosomal protein 290
Synonyms: Kiaa, b2b1454Clo, b2b1752Clo, Nphp6
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216274
VEGA: 10
Homologene: 77213
Setx
Name: senataxin
Synonyms: Als4, A930037J23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 269254
HGNC: HGNC:445
Homologene: 41003
Dvl2
Name: dishevelled segment polarity protein 2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 13543
HGNC: HGNC:3086
Homologene: 20927
Cstf1
Name: cleavage stimulation factor, 3' pre-RNA, subunit 1
Synonyms: 1700057K18Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67337
HGNC: HGNC:2483
Homologene: 1012
Blmh
Name: bleomycin hydrolase
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 104184
HGNC: HGNC:1059
Homologene: 330
Ccdc191
Name: coiled-coil domain containing 191
Synonyms: 2610015P09Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 212153
Homologene: 19484
Rps6ka5
Name: ribosomal protein S6 kinase, polypeptide 5
Synonyms: MSK1, 6330404E13Rik, 3110005L17Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 73086
VEGA: 12
Homologene: 48302
Ank3
Name: ankyrin 3, epithelial
Synonyms: Ank-3, AnkG, 2900054D09Rik, Ankyrin-3, Ankyrin-G
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11735
HGNC: HGNC:494
Homologene: 56908
Jam3
Name: junction adhesion molecule 3
Synonyms: Jcam3, JAM-3, JAM-C, 1110002N23Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 83964
Homologene: 11338
C6
Name: complement component 6
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12274
HGNC: HGNC:1339
Homologene: 47
Abcf1
Name: ATP-binding cassette, sub-family F member 1
Synonyms: Abc50, GCN20, D17Wsu166e
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224742
HGNC: HGNC:70
Homologene: 849
Muc2
Name: mucin 2
Synonyms: 2010015E03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17831
HGNC: HGNC:7512
Homologene: 136755
Chpf
Name: chondroitin polymerizing factor
Synonyms: D1Bwg1363e, 1700028N03Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74241
Homologene: 11574
Cenpe
Name: centromere protein E
Synonyms: Kif10, 312kDa, CENP-E, N-7 kinesin
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229841
HGNC: HGNC:1856
Homologene: 20429
Tenm3
Name: teneurin transmembrane protein 3
Synonyms: 2610100B16Rik, Odz3, Ten-m3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 23965
Homologene: 22673
Zfp984
Name: zinc finger protein 984
Synonyms: Gm13157
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100041677
Homologene: 133076
Slc9a1
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 1
Synonyms: antiporter, Apnh, Nhe-1, Nhe1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 20544
Homologene: 20660
Lrrc4c
Name: leucine rich repeat containing 4C
Synonyms: 6430556C10Rik, netrin g1 ligand, NGL-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241568
Homologene: 18696
Ern2
Name: endoplasmic reticulum to nucleus signalling 2
Synonyms: Ire1b
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 26918
Homologene: 22687
Mep1b
Name: meprin 1 beta
Synonyms: Mep-1b, meprin beta
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 17288
VEGA: 18
HGNC: HGNC:7020
Homologene: 48382
Or8b1c
Name: olfactory receptor family 8 subfamily B member 1C
Synonyms: GA_x6K02T2PVTD-32165709-32166641, Olfr905, MOR167-1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258800
VEGA: 9
Homologene: 110524
Dscam
Name: DS cell adhesion molecule
Synonyms: Down syndrome cell adhesion molecule, 4932410A21Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 13508
HGNC: HGNC:3039
Homologene: 74393
Ampd3
Name: adenosine monophosphate deaminase 3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11717
HGNC: HGNC:470
Homologene: 408
Wdr64
Name: WD repeat domain 64
Synonyms: 4930511H01Rik, 4930415O10Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 75820
Homologene: 51634
Dclk1
Name: doublecortin-like kinase 1
Synonyms: Click-I, 1700113D08Rik, Dcl, DCLK, CPG16, Dcamkl1, 2810480F11Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 13175
HGNC: HGNC:2700
Homologene: 130530
Eif2ak2
Name: eukaryotic translation initiation factor 2-alpha kinase 2
Synonyms: Tik, IFN-induced and double-stranded RNA-activated kinase, eIF-2 alpha, Prkr, eIF-2 alpha, 4732414G15Rik, IFN- type I-induced and dsRNA-activated kinase, 2310047A08Rik, dsRNA-activated kinase, Pkr
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 19106
HGNC: HGNC:9437
Homologene: 48134
Vwce
Name: von Willebrand factor C and EGF domains
Synonyms: 1300015B04Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 71768
VEGA: 19
Homologene: 17651
Tsbp1
Name: testis expressed basic protein 1
Synonyms: BC051142
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 407788
Homologene: 128168
Slc5a3
Name: solute carrier family 5 (inositol transporters), member 3
Synonyms: Smit1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 53881
Homologene: 31412
Gpatch1
Name: G patch domain containing 1
Synonyms: Gpatc1, 1300003A17Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67471
Homologene: 41217
Vmn2r72
Name: vomeronasal 2, receptor 72
Synonyms: EG244114, Vmn2r72-ps
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244114
Homologene: 115466
F13a1
Name: coagulation factor XIII, A1 subunit
Synonyms: 1200014I03Rik, Factor XIIIA
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 74145
VEGA: 13
HGNC: HGNC:3531
Homologene: 20077
Pla2r1
Name: phospholipase A2 receptor 1
Synonyms: PLA2-I receptor, Pla2g1br, M-type receptor
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18779
HGNC: HGNC:9042
Homologene: 32016
Vmn2r53
Name: vomeronasal 2, receptor 53
Synonyms: EG637908
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 637908
Homologene: 104040
Man2a2
Name: mannosidase 2, alpha 2
Synonyms: MX, 4931438M07Rik, alpha mannosidase IIx, 1700052O22Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 140481
HGNC: HGNC:6825
Homologene: 55954
Klhdc7a
Name: kelch domain containing 7A
Synonyms: B230308G19Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242721
Homologene: 17567
Cers5
Name: ceramide synthase 5
Synonyms: 2310081H14Rik, Lass5, CerS5, Trh4
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 71949
Homologene: 23634
Gcc2
Name: GRIP and coiled-coil domain containing 2
Synonyms: 2600014C01Rik, 0610043A03Rik, 2210420P05Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70297
Homologene: 45639
Tnni3k
Name: TNNI3 interacting kinase
Synonyms: D830019J24Rik, Cark
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 435766
Homologene: 41084
Elovl4
Name: ELOVL fatty acid elongase 4
Synonyms: elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 83603
Homologene: 41488
Vmn2r60
Name: vomeronasal 2, receptor 60
Synonyms: Casr-rs3, Gprc2a-rs3, EG637898
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 637898
Homologene: 129683
Trabd
Name: TraB domain containing
Synonyms: 5730502D15Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 67976
Homologene: 36427
D7Ertd443e
Name: DNA segment, Chr 7, ERATO Doi 443, expressed
Synonyms: 4933400E14Rik, Fats
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71007
Homologene: 18998
Ccdc74a
Name: coiled-coil domain containing 74A
Synonyms: 2310015A05Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 72315
Homologene: 82592
Haus6
Name: HAUS augmin-like complex, subunit 6
Synonyms: D4Ertd27e, 6230416J20Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230376
Homologene: 9760
Usp36
Name: ubiquitin specific peptidase 36
Synonyms: 2700002L06Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 72344
Homologene: 11828
Adamtsl5
Name: ADAMTS-like 5
Synonyms: Thsd6, 2010109H09Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 66548
Homologene: 19803
Or5b109
Name: olfactory receptor family 5 subfamily B member 109
Synonyms: Olfr1463, GA_x6K02T2RE5P-3560863-3561795, MOR202-29P
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258120
HGNC: HGNC:8324
Homologene: 133886
Ppil6
Name: peptidylprolyl isomerase (cyclophilin)-like 6
Synonyms: 2900084F20Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 73075
VEGA: 10
Homologene: 52155
Bcl11a
Name: BCL11 transcription factor A
Synonyms: Evi9b, 2810047E18Rik, D930021L15Rik, CTIP1, COUP-TF interacting protein 1, Evi9a, Evi9, mouse myeloid leukemia gene, Evi9c
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14025
Homologene: 11284
Meig1
Name: meiosis expressed gene 1
Synonyms: Meg1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 104362
Homologene: 56414
Or1ad1
Name: olfactory receptor family 1 subfamily AD member 1
Synonyms: Olfr1377, MOR129-1, GA_x6K02T2QP88-4453480-4452557
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258913
Homologene: 64929
Oaf
Name: out at first homolog
Synonyms: D9Ucla1, D130038B21Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102644
VEGA: 9
Homologene: 14334
Gnpda1
Name: glucosamine-6-phosphate deaminase 1
Synonyms: oscillin, Gnpi, glucose-6-phosphate isomerase, Gnp1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 26384
HGNC: HGNC:4417
Homologene: 38054
Nkx2-3
Name: NK2 homeobox 3
Synonyms: tinman, Nkx2.3, Nkx-2.3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18089
HGNC: HGNC:7836
Homologene: 17061
Adam1b
Name: a disintegrin and metallopeptidase domain 1b
Synonyms: PH-30 alpha, Ftna, fertilin alpha
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 280667
Homologene: 136485
Umad1
Name: UMAP1-MVP12 associated (UMA) domain containing 1
Synonyms: Gm16039
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 100036521
Cpn1
Name: carboxypeptidase N, polypeptide 1
Synonyms: 50 kDa, CPN, 0610011F20Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 93721
HGNC: HGNC:2312
Homologene: 1002
Zdhhc4
Name: zinc finger, DHHC domain containing 4
Synonyms: 2900029I10Rik, 1810021D01Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 72881
Homologene: 10006
Hcfc1r1
Name: host cell factor C1 regulator 1 (XPO1-dependent)
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 353502
Homologene: 9901
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 75,478,287 bp
  • C to A, chromosome 1 at 175,812,102 bp
  • T to A, chromosome 2 at 3,409,211 bp
  • T to A, chromosome 2 at 29,173,569 bp
  • T to G, chromosome 2 at 60,447,475 bp
  • A to T, chromosome 2 at 97,630,213 bp
  • T to C, chromosome 2 at 160,714,256 bp
  • T to C, chromosome 2 at 172,378,000 bp
  • T to A, chromosome 3 at 55,255,877 bp
  • T to A, chromosome 3 at 135,232,959 bp
  • T to A, chromosome 3 at 155,038,524 bp
  • T to C, chromosome 4 at 86,586,341 bp
  • G to T, chromosome 4 at 116,353,011 bp
  • T to C, chromosome 4 at 133,370,442 bp
  • A to T, chromosome 4 at 139,966,844 bp
  • A to T, chromosome 4 at 147,757,708 bp
  • A to T, chromosome 5 at 121,501,437 bp
  • A to T, chromosome 5 at 143,320,276 bp
  • G to A, chromosome 6 at 8,401,140 bp
  • A to G, chromosome 7 at 12,582,099 bp
  • G to T, chromosome 7 at 35,281,454 bp
  • A to T, chromosome 7 at 42,195,087 bp
  • G to C, chromosome 7 at 80,368,865 bp
  • G to A, chromosome 7 at 85,749,630 bp
  • A to G, chromosome 7 at 110,791,188 bp
  • A to G, chromosome 7 at 122,173,708 bp
  • A to C, chromosome 7 at 134,349,095 bp
  • T to G, chromosome 7 at 141,695,419 bp
  • T to A, chromosome 8 at 48,229,111 bp
  • C to A, chromosome 8 at 111,890,572 bp
  • T to C, chromosome 9 at 27,106,416 bp
  • T to C, chromosome 9 at 38,472,947 bp
  • G to A, chromosome 9 at 43,222,780 bp
  • T to C, chromosome 9 at 83,788,271 bp
  • C to T, chromosome 10 at 41,501,866 bp
  • C to A, chromosome 10 at 58,268,021 bp
  • A to T, chromosome 10 at 69,986,958 bp
  • A to T, chromosome 10 at 78,796,260 bp
  • A to G, chromosome 10 at 80,342,923 bp
  • G to T, chromosome 10 at 100,516,188 bp
  • A to G, chromosome 11 at 24,164,831 bp
  • A to G, chromosome 11 at 30,154,320 bp
  • A to T, chromosome 11 at 50,985,018 bp
  • A to G, chromosome 11 at 70,008,786 bp
  • A to G, chromosome 11 at 76,946,313 bp
  • T to C, chromosome 11 at 118,285,965 bp
  • T to C, chromosome 12 at 100,553,149 bp
  • A to G, chromosome 12 at 115,193,863 bp
  • A to T, chromosome 13 at 37,025,771 bp
  • T to A, chromosome 15 at 4,808,404 bp
  • A to G, chromosome 15 at 89,081,954 bp
  • A to T, chromosome 15 at 99,772,331 bp
  • C to G, chromosome 16 at 17,646,749 bp
  • T to A, chromosome 16 at 43,959,336 bp
  • T to A, chromosome 16 at 92,079,019 bp
  • C to T, chromosome 16 at 96,825,630 bp
  • G to T, chromosome 17 at 23,674,656 bp
  • C to T, chromosome 17 at 34,449,824 bp
  • T to C, chromosome 17 at 35,959,243 bp
  • T to A, chromosome 17 at 78,868,774 bp
  • G to T, chromosome 18 at 21,095,053 bp
  • A to T, chromosome 18 at 38,328,899 bp
  • T to A, chromosome 19 at 10,664,283 bp
  • A to T, chromosome 19 at 13,234,537 bp
  • C to A, chromosome 19 at 43,614,882 bp
  • T to A, chromosome 19 at 43,986,158 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7843 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045897-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.