Strain Name:
C57BL/6J-MtgxR7961Btlr/Mmmh
Stock Number:
046005-MU
Citation ID:
RRID:MMRRC_046005-MU
Other Names:
R7961 (G1)
Major Collection:

Strain Information

Nrp2
Name: neuropilin 2
Synonyms: Npn2, NP-2, 1110048P06Rik, NP2, Npn-2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18187
HGNC: HGNC:8005
Homologene: 2875
Ntrk3
Name: neurotrophic tyrosine kinase, receptor, type 3
Synonyms: TrkC
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18213
HGNC: HGNC:8033
Homologene: 49183
Neurod4
Name: neurogenic differentiation 4
Synonyms: MATH-3, bHLHa4, Atoh3, Math3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11923
VEGA: 10
Homologene: 7234
Dock1
Name: dedicator of cytokinesis 1
Synonyms: Dock180, b2b3190Clo, 9130006G06Rik, D630004B07Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330662
HGNC: HGNC:2987
Homologene: 55575
Sgsm1
Name: small G protein signaling modulator 1
Synonyms: 2410098H20Rik, D5Bwg1524e, Rutbc2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 52850
Homologene: 64485
Dyrk3
Name: dual-specificity tyrosine phosphorylation regulated kinase 3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226419
HGNC: HGNC:3094
Homologene: 55762
Tnks2
Name: tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
Synonyms: 5430432P15Rik, Parp5b
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 74493
Homologene: 11890
Usp25
Name: ubiquitin specific peptidase 25
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 30940
VEGA: 16
Homologene: 8374
Pspc1
Name: paraspeckle protein 1
Synonyms: 5730470C09Rik, PSP1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 66645
Homologene: 10108
Tep1
Name: telomerase associated protein 1
Synonyms: Tp1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 21745
VEGA: 14
Homologene: 5157
Clcc1
Name: chloride channel CLIC-like 1
Synonyms: Mclc
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229725
Homologene: 9032
Nkiras2
Name: NFKB inhibitor interacting Ras-like protein 2
Synonyms: 2410003M04Rik, KBRAS2, 4930527H08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71966
Homologene: 9738
Lpcat1
Name: lysophosphatidylcholine acyltransferase 1
Synonyms: LPCAT, rd11, Aytl2, 2900035H07Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 210992
Homologene: 9871
Pikfyve
Name: phosphoinositide kinase, FYVE type zinc finger containing
Synonyms: Pip5k3, PipkIII, 5230400C17Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18711
Homologene: 32115
Cntnap1
Name: contactin associated protein-like 1
Synonyms: Nrxn4, p190, NCP1, shm, paranodin, Caspr
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 53321
HGNC: HGNC:8011
Homologene: 2693
Satb2
Name: special AT-rich sequence binding protein 2
Synonyms: BAP002
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 212712
Homologene: 32249
Icam5
Name: intercellular adhesion molecule 5, telencephalin
Synonyms: TLN, CD50, Tlcn, Icam3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 15898
VEGA: 9
HGNC: HGNC:5348
Homologene: 2447
Serinc5
Name: serine incorporator 5
Synonyms: AIGP3, A130038L21Rik, TPO1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218442
VEGA: 13
Homologene: 65246
Rbm33
Name: RNA binding motif protein 33
Synonyms: 3200001K10Rik, 6430512A10Rik, Prr8
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381626
Homologene: 137386
Zfp60
Name: zinc finger protein 60
Synonyms: 6330516O17Rik, Mfg-3, Mfg3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22718
Homologene: 137228
Ccng1
Name: cyclin G1
Synonyms: cyclin G
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12450
HGNC: HGNC:1592
Homologene: 2995
Dmrt1
Name: doublesex and mab-3 related transcription factor 1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 50796
HGNC: HGNC:2934
Homologene: 9280
Smad3
Name: SMAD family member 3
Synonyms: Madh3, Smad 3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17127
HGNC: HGNC:6769
Homologene: 55937
Idh2
Name: isocitrate dehydrogenase 2 (NADP+), mitochondrial
Synonyms: IDPm, Idh-2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 269951
HGNC: HGNC:5383
Homologene: 37590
Vmn1r28
Name: vomeronasal 1 receptor 28
Synonyms: V1rc25
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 171198
Homologene: 138094
Sntg1
Name: syntrophin, gamma 1
Synonyms: G1SYN, SYN4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71096
Homologene: 56834
Trpm5
Name: transient receptor potential cation channel, subfamily M, member 5
Synonyms: Ltrpc5, Mtr1, 9430099A16Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 56843
Homologene: 22818
Krt71
Name: keratin 71
Synonyms: mK6irs, Krt2-6g, Cu, Ca, mK6irs1, Cal4
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 56735
Homologene: 88864
Or4c35
Name: olfactory receptor family 4 subfamily C member 35
Synonyms: GA_x6K02T2Q125-51409740-51410672, MOR232-2, Olfr1260
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258983
Homologene: 17455
Abcb1b
Name: ATP-binding cassette, sub-family B member 1B
Synonyms: mdr, Mdr1b, Mdr1, Pgy-1, Abcb1, Pgy1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18669
HGNC: HGNC:40
Homologene: 69084
Dmrt3
Name: doublesex and mab-3 related transcription factor 3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 240590
VEGA: 19
Homologene: 10935
Nubpl
Name: nucleotide binding protein-like
Synonyms: 2410170E07Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 76826
Homologene: 11854
Bckdha
Name: branched chain ketoacid dehydrogenase E1, alpha polypeptide
Synonyms: BCKAD E1[a]
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12039
HGNC: HGNC:986
Homologene: 569
Engase
Name: endo-beta-N-acetylglucosaminidase
Synonyms: D230014K01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217364
Homologene: 13666
Kcna5
Name: potassium voltage-gated channel, shaker-related subfamily, member 5
Synonyms: Kv1.5
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16493
HGNC: HGNC:6224
Homologene: 1683
Or5d41
Name: olfactory receptor family 5 subfamily D member 41
Synonyms: MOR174-12, Olfr1170, GA_x6K02T2Q125-49709783-49708833
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258525
Homologene: 138307
Or4k48
Name: olfactory receptor family 4 subfamily K member 48
Synonyms: MOR248-6, GA_x6K02T2Q125-72697413-72696475, Olfr1298
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258888
Homologene: 121521
Loxl3
Name: lysyl oxidase-like 3
Synonyms: Lor2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16950
Homologene: 56591
Mia2
Name: MIA SH3 domain ER export factor 2
Synonyms: Mgea, Ctage5, Mgea6, MEA6, D12Bwg0579e
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 338320
Homologene: 137655
Tmem200a
Name: transmembrane protein 200A
Synonyms: C030003D03Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 77220
VEGA: 10
Homologene: 14175
Polm
Name: polymerase (DNA directed), mu
Synonyms: B230309I03Rik, Tdt-N
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 54125
HGNC: HGNC:9185
Homologene: 41170
Pcsk1
Name: proprotein convertase subtilisin/kexin type 1
Synonyms: SPC3, prohormone convertase 1/3, Nec1, Nec-1, Phpp-1, PC1, PC3
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18548
HGNC: HGNC:8743
Homologene: 379
Ppcs
Name: phosphopantothenoylcysteine synthetase
Synonyms: 6330579B17Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 106564
Homologene: 6173
Cenpn
Name: centromere protein N
Synonyms: 2610510J17Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 72155
Homologene: 12450
Ubqln3
Name: ubiquilin 3
Synonyms: 4933400K24Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244178
Homologene: 9700
Ciart
Name: circadian associated repressor of transcription
Synonyms: Gm129, LOC229599
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229599
Homologene: 79670
Krtap5-4
Name: keratin associated protein 5-4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 50775
Odf1
Name: outer dense fiber of sperm tails 1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 18285
HGNC: HGNC:8113
Homologene: 7456
Trav14d-3-dv8
Name: T cell receptor alpha variable 14D-3-DV8
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 634322
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 8,363,570 bp
  • A to G, chromosome 1 at 56,871,758 bp
  • C to T, chromosome 1 at 62,745,408 bp
  • A to G, chromosome 1 at 65,255,134 bp
  • A to G, chromosome 1 at 131,136,258 bp
  • C to A, chromosome 2 at 88,224,689 bp
  • A to G, chromosome 2 at 89,977,787 bp
  • G to A, chromosome 2 at 111,645,937 bp
  • A to G, chromosome 3 at 95,881,317 bp
  • A to G, chromosome 3 at 108,661,458 bp
  • A to T, chromosome 4 at 119,419,065 bp
  • T to A, chromosome 5 at 8,828,870 bp
  • G to A, chromosome 5 at 28,394,608 bp
  • T to C, chromosome 5 at 93,636,684 bp
  • T to C, chromosome 5 at 113,282,644 bp
  • T to C, chromosome 6 at 58,265,193 bp
  • T to C, chromosome 6 at 83,050,809 bp
  • A to G, chromosome 6 at 126,533,554 bp
  • G to A, chromosome 7 at 25,631,478 bp
  • G to A, chromosome 7 at 27,748,456 bp
  • T to A, chromosome 7 at 78,453,328 bp
  • T to C, chromosome 7 at 80,098,253 bp
  • T to A, chromosome 7 at 104,142,590 bp
  • T to A, chromosome 7 at 134,745,057 bp
  • C to T, chromosome 7 at 142,303,934 bp
  • T to C, chromosome 7 at 143,080,369 bp
  • C to A, chromosome 8 at 116,937,237 bp
  • T to C, chromosome 9 at 21,038,755 bp
  • G to A, chromosome 9 at 63,650,282 bp
  • A to G, chromosome 10 at 25,994,006 bp
  • A to T, chromosome 10 at 130,270,487 bp
  • T to C, chromosome 11 at 5,830,155 bp
  • G to A, chromosome 11 at 40,751,269 bp
  • A to T, chromosome 11 at 100,619,802 bp
  • G to A, chromosome 11 at 101,178,295 bp
  • A to G, chromosome 11 at 118,486,860 bp
  • T to A, chromosome 12 at 52,181,297 bp
  • T to A, chromosome 12 at 59,159,639 bp
  • C to T, chromosome 13 at 73,511,379 bp
  • T to C, chromosome 13 at 75,126,839 bp
  • T to C, chromosome 13 at 92,661,191 bp
  • A to G, chromosome 14 at 50,824,230 bp
  • A to C, chromosome 14 at 53,078,767 bp
  • G to A, chromosome 14 at 56,771,847 bp
  • A to G, chromosome 15 at 38,226,596 bp
  • T to C, chromosome 15 at 101,735,442 bp
  • A to G, chromosome 16 at 77,059,262 bp
  • C to T, chromosome 18 at 90,591,759 bp
  • T to A, chromosome 19 at 25,545,881 bp
  • T to C, chromosome 19 at 25,610,908 bp
  • T to A, chromosome 19 at 36,852,501 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7961 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
046005-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.