Strain Name:
C57BL/6J-MtgxR8007Btlr/Mmmh
Stock Number:
046047-MU
Citation ID:
RRID:MMRRC_046047-MU
Other Names:
R8007 (G1)
Major Collection:

Strain Information

Ank2
Name: ankyrin 2, brain
Synonyms: ankyrin B, Gm4392, Ankyrin-B, Ank-2, Ankyrin-2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 109676
HGNC: HGNC:493
Cnmd
Name: chondromodulin
Synonyms: Bricd3, ChM-I, Chmd, Lect1, Chondromodulin 1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 16840
Homologene: 5095
Rtel1
Name: regulator of telomere elongation helicase 1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 269400
Homologene: 13168
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: b2b1625.2Clo, D230004K18Rik, Megalin, Gp330
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
Foxp1
Name: forkhead box P1
Synonyms: 3110052D19Rik, 4932443N09Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 108655
HGNC: HGNC:3823
Homologene: 13092
Gria4
Name: glutamate receptor, ionotropic, AMPA4 (alpha 4)
Synonyms: Glur4, spkw1, Gluralpha4, Glur-4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 14802
HGNC: HGNC:4574
Homologene: 20227
Anapc5
Name: anaphase-promoting complex subunit 5
Synonyms: 2510006G12Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 59008
Homologene: 41118
Tcf12
Name: transcription factor 12
Synonyms: HTF-4, REB, HTF4, HEBAlt, bHLHb20, ALF1, ME1, HEB
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 21406
Homologene: 40774
Tab1
Name: TGF-beta activated kinase 1/MAP3K7 binding protein 1
Synonyms: 2310012M03Rik, Tak1-binding protein 1, Map3k7ip1, b2b449Clo
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 66513
VEGA: 15
Homologene: 4461
Tcof1
Name: treacle ribosome biogenesis factor 1
Synonyms: treacle
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 21453
Homologene: 68049
Fasn
Name: fatty acid synthase
Synonyms: A630082H08Rik, FAS
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14104
HGNC: HGNC:3594
Homologene: 55800
Cenpf
Name: centromere protein F
Synonyms: mitosin, Lek1, 6530404A22Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 108000
HGNC: HGNC:1857
Homologene: 22969
Cc2d2a
Name: coiled-coil and C2 domain containing 2A
Synonyms: 5730509K17Rik, b2b1035Clo
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231214
Homologene: 18159
Samd7
Name: sterile alpha motif domain containing 7
Synonyms: 4930597A01Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 75953
Homologene: 18802
Dmxl2
Name: Dmx-like 2
Synonyms: E130119P06Rik, 6430411K14Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235380
HGNC: HGNC:2938
Homologene: 41022
Smarce1
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
Synonyms: BAF57, 5830412H02Rik, 9030408N19Rik, 2810417B20Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 57376
Homologene: 37727
Fgfr2
Name: fibroblast growth factor receptor 2
Synonyms: Fgfr-2, Fgfr2b, Fgfr-7, KGFRTr, Bek, svs, Fgfr7
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14183
HGNC: HGNC:3689
Homologene: 22566
Hnrnpul2
Name: heterogeneous nuclear ribonucleoprotein U-like 2
Synonyms: 1110031M08Rik, Hnrpul2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 68693
VEGA: 19
Homologene: 28583
Ibtk
Name: inhibitor of Bruton agammaglobulinemia tyrosine kinase
Synonyms: 5430411K16Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 108837
Homologene: 34661
Zfp142
Name: zinc finger protein 142
Synonyms: 9330177B18Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 77264
Homologene: 3723
Trp53inp1
Name: transformation related protein 53 inducible nuclear protein 1
Synonyms: Teap, Stinp, 2700057G22Rik, SIP18, SIP27, Tp53inp1, SIP
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 60599
Homologene: 11065
Clstn1
Name: calsyntenin 1
Synonyms: alcadein alpha, calsyntenin-1, 1810034E21Rik, Cst-1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 65945
Homologene: 8814
Slc25a38
Name: solute carrier family 25, member 38
Synonyms: appoptosin
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 208638
Homologene: 5553
Kcnd2
Name: potassium voltage-gated channel, Shal-related family, member 2
Synonyms: Kv4.2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16508
HGNC: HGNC:6238
Homologene: 40828
Acacb
Name: acetyl-Coenzyme A carboxylase beta
Synonyms: Accb, Acc2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100705
HGNC: HGNC:85
Homologene: 74382
Adtrp
Name: androgen dependent TFPI regulating protein
Synonyms: 9530008L14Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 109254
Homologene: 13107
Adgrv1
Name: adhesion G protein-coupled receptor V1
Synonyms: Mgr1, Mass1, Gpr98, VLGR1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 110789
Homologene: 19815
Col6a3
Name: collagen, type VI, alpha 3
Synonyms: Col6a-3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12835
HGNC: HGNC:2213
Homologene: 37917
Exoc7
Name: exocyst complex component 7
Synonyms: 70kDa, sec70, Exo70
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 53413
Homologene: 41019
Ctss
Name: cathepsin S
Synonyms: Cat S
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 13040
HGNC: HGNC:2545
Homologene: 20867
Ppargc1b
Name: peroxisome proliferative activated receptor, gamma, coactivator 1 beta
Synonyms: 4631412G21Rik, PGC-1beta/ERRL1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 170826
Homologene: 15776
A2m
Name: alpha-2-macroglobulin
Synonyms: A2mp
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232345
HGNC: HGNC:7
Homologene: 37248
Chtf18
Name: CTF18, chromosome transmission fidelity factor 18
Synonyms: CTF18, 6030457M03Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 214901
Homologene: 32532
F12
Name: coagulation factor XII (Hageman factor)
Synonyms: FXII
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 58992
HGNC: HGNC:3530
Homologene: 425
Skint10
Name: selection and upkeep of intraepithelial T cells 10
Synonyms: A030001H23Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230613
Homologene: 136292
Nebl
Name: nebulette
Synonyms: D830029A09Rik, A630080F05Rik, 1200007O21Rik, Lnebl
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74103
Homologene: 128431
Adgre4
Name: adhesion G protein-coupled receptor E4
Synonyms: D17Ertd479e, Emr4, Gpr127, FIRE, EGF-TM7
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 52614
VEGA: 17
Homologene: 64640
Corin
Name: corin, serine peptidase
Synonyms: Lrp4
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 53419
Homologene: 4804
Ly6g2
Name: lymphocyte antigen 6 family member G2
Synonyms: BC025446
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223631
Kcnj2
Name: potassium inwardly-rectifying channel, subfamily J, member 2
Synonyms: Kcnf1, IRK1, Kir2.1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16518
HGNC: HGNC:6263
Homologene: 20249
Pappa2
Name: pappalysin 2
Synonyms: pregnancy-associated plasma protein-E, pregnancy-associated plasma preproprotein-A2, placenta-specific 3, PLAC3, PAPP-A2, Pappe
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 23850
Homologene: 10661
Rtl1
Name: retrotransposon Gaglike 1
Synonyms: Mart1, Mor1, Mar
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 353326
VEGA: 12
Homologene: 120261
Plch2
Name: phospholipase C, eta 2
Synonyms: A930027K05Rik, PLCeta2, Plcl4
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269615
Homologene: 85172
Matn2
Name: matrilin 2
Synonyms: Crtm2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 17181
VEGA: 15
HGNC: HGNC:6908
Homologene: 20538
F13b
Name: coagulation factor XIII, beta subunit
Synonyms: Cf-13b, Cf13b
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14060
HGNC: HGNC:3534
Homologene: 1512
Cacna2d4
Name: calcium channel, voltage-dependent, alpha 2/delta subunit 4
Synonyms: 5730412N02Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 319734
Homologene: 26544
A430033K04Rik
Name: RIKEN cDNA A430033K04 gene
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243308
Homologene: 65621
Nudt19
Name: nudix hydrolase 19
Synonyms: RP2-r, D7RP2e, D7Rp2, D7Rp2-r, D7Rp2-s, RP2-s, nudix (nucleoside diphosphate linked moiety X)-type motif 19, androgen regulated gene RP2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 110959
Homologene: 13211
Serpinb9e
Name: serine (or cysteine) peptidase inhibitor, clade B, member 9e
Synonyms: NK26, Spi14, ovalbumin
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20710
HGNC: HGNC:8955
Homologene: 69093
Stmn4
Name: stathmin-like 4
Synonyms: RB3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 56471
Homologene: 10496
Ip6k2
Name: inositol hexaphosphate kinase 2
Synonyms: Ihpk2, 1500005N04Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 76500
Homologene: 56929
Stt3a
Name: STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae)
Synonyms: Itm1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 16430
HGNC: HGNC:6172
Homologene: 40617
Vmn2r14
Name: vomeronasal 2, receptor 14
Synonyms: EG231591
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231591
Homologene: 129606
Pacrg
Name: PARK2 co-regulated
Synonyms: 1700008H23Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 69310
Homologene: 16212
Or4a68
Name: olfactory receptor family 4 subfamily A member 68
Synonyms: GA_x6K02T2Q125-50883183-50882239, Olfr1240, MOR231-8
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258804
Homologene: 121591
Lgi2
Name: leucine-rich repeat LGI family, member 2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 246316
Homologene: 10048
Ldlrad1
Name: low density lipoprotein receptor class A domain containing 1
Synonyms: OTTMUSG00000008594
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 546840
Homologene: 54473
Or12k8
Name: olfactory receptor family 12 subfamily K member 8
Synonyms: MOR159-3, GA_x6K02T2NLDC-33777519-33776551, Olfr361
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258365
Homologene: 27142
Krtap4-21
Name: keratin associated protein 4-21
Synonyms: Gm11569
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 670472
Homologene: 124486
Or4k42
Name: olfactory receptor family 4 subfamily K member 42
Synonyms: Olfr1290, MOR248-9, GA_x6K02T2Q125-72541649-72540711
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 257662
Homologene: 74248
Mocs2
Name: molybdenum cofactor synthesis 2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17434
HGNC: HGNC:7193
Homologene: 32193
Yae1d1
Name: Yae1 domain containing 1
Synonyms: 1600012F09Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 67008
VEGA: 13
Homologene: 10615
Or10u4
Name: olfactory receptor family 10 subfamily U member 4
Synonyms: Olfr819, GA_x6K02T2PULF-11644164-11643823, MOR265-2_p
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 100043200
Homologene: 73929
Pcdhga7
Name: protocadherin gamma subfamily A, 7
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93715
HGNC: HGNC:8705
Homologene: 36377
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 74,571,496 bp
  • A to C, chromosome 1 at 90,777,457 bp
  • A to G, chromosome 1 at 139,506,942 bp
  • A to G, chromosome 1 at 158,782,304 bp
  • G to A, chromosome 1 at 189,646,947 bp
  • T to A, chromosome 2 at 17,370,489 bp
  • T to A, chromosome 2 at 37,084,843 bp
  • T to C, chromosome 2 at 69,506,505 bp
  • C to T, chromosome 2 at 89,440,340 bp
  • A to T, chromosome 2 at 111,489,723 bp
  • T to A, chromosome 2 at 181,334,974 bp
  • T to A, chromosome 3 at 30,758,382 bp
  • A to T, chromosome 3 at 95,550,154 bp
  • G to C, chromosome 3 at 126,936,447 bp
  • T to C, chromosome 4 at 11,164,525 bp
  • G to A, chromosome 4 at 107,209,491 bp
  • A to G, chromosome 4 at 112,711,668 bp
  • T to C, chromosome 4 at 149,631,848 bp
  • A to G, chromosome 4 at 155,002,831 bp
  • T to A, chromosome 5 at 43,706,100 bp
  • C to A, chromosome 5 at 52,566,033 bp
  • T to C, chromosome 5 at 72,316,103 bp
  • A to T, chromosome 5 at 109,220,458 bp
  • A to G, chromosome 5 at 114,218,874 bp
  • T to C, chromosome 5 at 122,791,900 bp
  • T to C, chromosome 5 at 138,646,639 bp
  • G to A, chromosome 6 at 21,217,074 bp
  • A to T, chromosome 6 at 98,941,634 bp
  • C to T, chromosome 6 at 119,312,444 bp
  • T to A, chromosome 6 at 121,670,886 bp
  • A to G, chromosome 7 at 35,555,620 bp
  • A to T, chromosome 7 at 130,163,989 bp
  • T to C, chromosome 9 at 4,503,740 bp
  • G to C, chromosome 9 at 36,741,769 bp
  • G to A, chromosome 9 at 54,383,691 bp
  • G to C, chromosome 9 at 71,934,623 bp
  • A to T, chromosome 9 at 85,690,717 bp
  • T to C, chromosome 9 at 108,805,756 bp
  • T to A, chromosome 9 at 120,122,142 bp
  • T to A, chromosome 10 at 129,965,875 bp
  • G to C, chromosome 11 at 99,225,050 bp
  • A to G, chromosome 11 at 99,798,862 bp
  • A to C, chromosome 11 at 111,073,058 bp
  • C to T, chromosome 11 at 116,306,639 bp
  • A to G, chromosome 11 at 120,809,527 bp
  • T to C, chromosome 12 at 109,591,626 bp
  • G to A, chromosome 13 at 17,989,744 bp
  • A to G, chromosome 13 at 33,251,622 bp
  • A to T, chromosome 13 at 41,816,231 bp
  • A to G, chromosome 13 at 55,418,452 bp
  • A to G, chromosome 13 at 81,283,466 bp
  • T to A, chromosome 13 at 114,820,873 bp
  • T to G, chromosome 14 at 66,355,583 bp
  • A to T, chromosome 14 at 79,637,966 bp
  • A to T, chromosome 15 at 34,426,169 bp
  • A to G, chromosome 15 at 75,216,703 bp
  • G to A, chromosome 15 at 80,158,768 bp
  • A to G, chromosome 17 at 10,840,032 bp
  • A to G, chromosome 17 at 25,725,534 bp
  • A to T, chromosome 17 at 55,814,233 bp
  • A to T, chromosome 18 at 37,716,893 bp
  • G to C, chromosome 18 at 60,829,051 bp
  • A to T, chromosome 18 at 61,310,494 bp
  • T to A, chromosome 19 at 8,820,815 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8007 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
046047-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.