Strain Name:
C57BL/6J-MtgxR8023Btlr/Mmmh
Stock Number:
067462-MU
Citation ID:
RRID:MMRRC_067462-MU
Other Names:
R8023 (G1)
Major Collection:

Strain Information

Tln2
Name: talin 2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 70549
VEGA: 9
Homologene: 56692
Tiparp
Name: TCDD-inducible poly(ADP-ribose) polymerase
Synonyms: DDF1, PARP-7, PARP7
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99929
Homologene: 9167
Ptpn3
Name: protein tyrosine phosphatase, non-receptor type 3
Synonyms: 9530011I20Rik, PTPCL, PTP-H1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 545622
HGNC: HGNC:9655
Homologene: 74451
Rps6ka1
Name: ribosomal protein S6 kinase polypeptide 1
Synonyms: Rsk1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 20111
Homologene: 55703
Pds5a
Name: PDS5 cohesin associated factor A
Synonyms: 9030416H16Rik, E230024D05Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71521
Homologene: 22877
Zfp462
Name: zinc finger protein 462
Synonyms: 9430078C22Rik, Gt4-2, Zfpip
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242466
Homologene: 41430
Sall1
Name: spalt like transcription factor 1
Synonyms: Msal-3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 58198
Homologene: 2230
Txlna
Name: taxilin alpha
Synonyms: Txln, IL14, 2600010N21Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 109658
Homologene: 14062
Cux1
Name: cut-like homeobox 1
Synonyms: CDP, Cutl1, Cux, Cux-1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13047
HGNC: HGNC:2557
Slu7
Name: SLU7 splicing factor homolog (S. cerevisiae)
Synonyms: D3Bwg0878e, D11Ertd730e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 193116
Homologene: 4690
Hk2
Name: hexokinase 2
Synonyms: HKII
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 15277
HGNC: HGNC:4923
Homologene: 37273
Satb2
Name: special AT-rich sequence binding protein 2
Synonyms: BAP002
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 212712
Homologene: 32249
Ncam1
Name: neural cell adhesion molecule 1
Synonyms: E-NCAM, NCAM-180, NCAM-140, CD56, NCAM-120, NCAM-1, NCAM
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17967
HGNC: HGNC:7656
Homologene: 40754
Acsbg2
Name: acyl-CoA synthetase bubblegum family member 2
Synonyms: Bgr
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 328845
Homologene: 57133
Grhl3
Name: grainyhead like transcription factor 3
Synonyms: Get1, ct, Som
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230824
Homologene: 18864
Ttf2
Name: transcription termination factor, RNA polymerase II
Synonyms: 4632434F22Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74044
Homologene: 37826
Hibch
Name: 3-hydroxyisobutyryl-Coenzyme A hydrolase
Synonyms: HIBYL-COA-H, 2610509I15Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227095
HGNC: HGNC:4908
Homologene: 5607
Zfc3h1
Name: zinc finger, C3H1-type containing
Synonyms: Psrc2, Ccdc131
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216345
Homologene: 17017
Col1a2
Name: collagen, type I, alpha 2
Synonyms: Cola2, Cola-2, Col1a-2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12843
HGNC: HGNC:2198
Homologene: 69
Ttn
Name: titin
Synonyms: shru, L56, mdm, connectin, D330041I19Rik, 2310057K23Rik, 2310074I15Rik, 2310036G12Rik, D830007G01Rik, 1100001C23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Itpr2
Name: inositol 1,4,5-triphosphate receptor 2
Synonyms: Ip3r2, Itpr5
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16439
HGNC: HGNC:6181
Homologene: 37593
Ptprq
Name: protein tyrosine phosphatase receptor type Q
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237523
HGNC: HGNC:9679
Homologene: 83557
Or51k1
Name: olfactory receptor family 51 subfamily K member 1
Synonyms: Olfr639, MOR12-1, GA_x6K02T2PBJ9-6747143-6746193
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259088
Homologene: 17497
Sis
Name: sucrase isomaltase
Synonyms: sucrase-isomaltase, 2010204N08Rik, Si-s
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 69983
Homologene: 37424
Prr29
Name: proline rich 29
Synonyms: 2310007L24Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 75573
Homologene: 130357
Hpd
Name: 4-hydroxyphenylpyruvic acid dioxygenase
Synonyms: Laf, Fla, Flp, Hppd
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 15445
HGNC: HGNC:5147
Homologene: 1620
Heg1
Name: heart development protein with EGF-like domains 1
Synonyms: 4632417D23Rik, 9530025L16Rik, 5530401I02Rik, LOC268884
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 77446
Homologene: 35276
Il6ra
Name: interleukin 6 receptor, alpha
Synonyms: Il6r, CD126, IL-6 receptor alpha chain, IL-6R
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 16194
HGNC: HGNC:6019
Homologene: 474
Slc6a20a
Name: solute carrier family 6 (neurotransmitter transporter), member 20A
Synonyms: Xtrp3s1, A730081N20Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102680
Homologene: 10625
Acte1
Name: actin, epsilon 1
Synonyms: Gm498, LOC244239
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 102636989
Homologene: 131918
Ranbp6
Name: RAN binding protein 6
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 240614
HGNC: HGNC:9851
Homologene: 18935
Fndc7
Name: fibronectin type III domain containing 7
Synonyms: E230011A21Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 320181
Homologene: 18551
Tcn2
Name: transcobalamin 2
Synonyms: Tcn-2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 21452
Homologene: 303
Agbl4
Name: ATP/GTP binding protein-like 4
Synonyms: 4931433A01Rik, 4930578N11Rik, Ccp6
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 78933
Homologene: 84880
Mpz
Name: myelin protein zero
Synonyms: P0, Mpp
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17528
HGNC: HGNC:7225
Homologene: 445
Vmn2r16
Name: vomeronasal 2, receptor 16
Synonyms: EG384220
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 384220
Homologene: 104825
Or7e178
Name: olfactory receptor family 7 subfamily E member 178
Synonyms: MTPCR34, Olfr18, GA_x6K02T2PVTD-14054886-14053957, MOR145-1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 18315
HGNC: HGNC:8396
Homologene: 138313
Or4c31
Name: olfactory receptor family 4 subfamily C member 31
Synonyms: GA_x6K02T2Q125-49948903-49949814, Olfr1183, MOR230-6
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258522
Homologene: 128125
Vmn2r76
Name: vomeronasal 2, receptor 76
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 675969
Homologene: 104330
Il34
Name: interleukin 34
Synonyms: 2010004A03Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 76527
Homologene: 12648
Fam24b
Name: family with sequence similarity 24 member B
Synonyms: 1700007K09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 69318
Homologene: 78032
Ndufs2
Name: NADH:ubiquinone oxidoreductase core subunit S2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226646
HGNC: HGNC:7708
Homologene: 56659
Tbx6
Name: T-box 6
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 21389
Homologene: 3389
Slc1a7
Name: solute carrier family 1 (glutamate transporter), member 7
Synonyms: EAAT5, A930031E15Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242607
Homologene: 21327
Med24
Name: mediator complex subunit 24
Synonyms: DRIP100, Trap100, Gse2, Pparb2, R75526, D11Ertd307e, Thrap4, 100kDa
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 23989
Homologene: 40795
Ccnc
Name: cyclin C
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 51813
HGNC: HGNC:1581
Homologene: 3803
Card9
Name: caspase recruitment domain family, member 9
Synonyms: LOC332579
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 332579
Homologene: 14150
Obox2
Name: oocyte specific homeobox 2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 246792
Homologene: 44937
Zfp189
Name: zinc finger protein 189
Synonyms: C430015I23Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230162
Homologene: 20737
H2ac20
Name: H2A clustered histone 20
Synonyms: H2a-613b, Hist2h2ac
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 319176
HGNC: HGNC:4738
Homologene: 128596
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 52,860,038 bp
  • T to C, chromosome 1 at 56,891,231 bp
  • A to G, chromosome 1 at 171,160,033 bp
  • A to T, chromosome 1 at 171,236,694 bp
  • T to C, chromosome 2 at 26,357,315 bp
  • A to G, chromosome 2 at 76,939,220 bp
  • A to G, chromosome 2 at 88,461,678 bp
  • A to G, chromosome 3 at 65,531,803 bp
  • T to A, chromosome 3 at 72,952,480 bp
  • A to G, chromosome 3 at 89,912,953 bp
  • A to G, chromosome 3 at 96,220,790 bp
  • T to C, chromosome 3 at 100,956,255 bp
  • C to T, chromosome 3 at 108,867,145 bp
  • T to C, chromosome 4 at 21,747,578 bp
  • G to A, chromosome 4 at 49,530,312 bp
  • G to A, chromosome 4 at 55,073,106 bp
  • G to C, chromosome 4 at 57,248,688 bp
  • G to A, chromosome 4 at 108,012,276 bp
  • T to A, chromosome 4 at 111,617,148 bp
  • A to T, chromosome 4 at 129,639,485 bp
  • A to T, chromosome 4 at 133,867,195 bp
  • A to G, chromosome 4 at 135,550,329 bp
  • A to T, chromosome 5 at 65,637,898 bp
  • C to T, chromosome 5 at 109,340,406 bp
  • A to G, chromosome 5 at 123,176,234 bp
  • T to A, chromosome 5 at 136,373,397 bp
  • T to G, chromosome 6 at 4,533,847 bp
  • T to A, chromosome 6 at 82,728,809 bp
  • A to G, chromosome 6 at 146,187,490 bp
  • A to G, chromosome 7 at 15,397,220 bp
  • A to G, chromosome 7 at 86,229,820 bp
  • A to G, chromosome 7 at 104,011,799 bp
  • C to T, chromosome 7 at 126,782,859 bp
  • A to C, chromosome 7 at 131,326,140 bp
  • T to C, chromosome 7 at 143,891,791 bp
  • A to G, chromosome 8 at 89,032,543 bp
  • C to T, chromosome 8 at 110,742,652 bp
  • C to T, chromosome 9 at 20,314,249 bp
  • C to A, chromosome 9 at 49,509,757 bp
  • A to G, chromosome 9 at 67,224,064 bp
  • T to C, chromosome 9 at 123,660,592 bp
  • G to A, chromosome 10 at 107,652,616 bp
  • T to A, chromosome 10 at 115,420,648 bp
  • A to T, chromosome 11 at 3,927,579 bp
  • G to A, chromosome 11 at 43,446,148 bp
  • A to G, chromosome 11 at 98,718,495 bp
  • A to G, chromosome 11 at 106,376,273 bp
  • G to A, chromosome 13 at 62,369,869 bp
  • T to A, chromosome 16 at 33,730,525 bp
  • A to G, chromosome 17 at 56,845,448 bp
  • T to C, chromosome 19 at 29,811,822 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8023 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067462-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.