Strain Name:
C57BL/6J-MtgxR8082Btlr/Mmmh
Stock Number:
067515-MU
Citation ID:
RRID:MMRRC_067515-MU
Other Names:
R8082 (G1)
Major Collection:

Strain Information

Shprh
Name: SNF2 histone linker PHD RING helicase
Synonyms: D230017O13Rik, 2610103K11Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 268281
Homologene: 6489
Met
Name: met proto-oncogene
Synonyms: HGF receptor, Par4, c-Met
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 17295
HGNC: HGNC:7029
Homologene: 206
Fam3c
Name: FAM3 metabolism regulating signaling molecule C
Synonyms: D6Wsu176e, Ilei, Fam3c
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 27999
Homologene: 8926
Lars1
Name: leucyl-tRNA synthetase 1
Synonyms: 2310045K21Rik, Lars, 3110009L02Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 107045
VEGA: 18
HGNC: HGNC:6512
Homologene: 7083
Gid4
Name: GID complex subunit 4, VID24 homolog
Synonyms: 4933439F18Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 66771
Homologene: 5971
Hic2
Name: hypermethylated in cancer 2
Synonyms: HRG22
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 58180
Homologene: 9020
Sorbs1
Name: sorbin and SH3 domain containing 1
Synonyms: Sh3d5, Ponsin, c-Cbl-associated protein, CAP, 9530001P15Rik, 2310065E01Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 20411
VEGA: 19
Homologene: 83252
4921524J17Rik
Name: RIKEN cDNA 4921524J17 gene
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66714
Homologene: 12014
Polr3b
Name: polymerase (RNA) III (DNA directed) polypeptide B
Synonyms: A330032P03Rik, 2700078H01Rik, RPC2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70428
VEGA: 10
Homologene: 6981
Bicd2
Name: BICD cargo adaptor 2
Synonyms: 0610027D24Rik, 1110005D12Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 76895
VEGA: 13
Homologene: 9070
Rims2
Name: regulating synaptic membrane exocytosis 2
Synonyms: RIM2, Syt3-rs, 2810036I15Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 116838
VEGA: 15
Homologene: 81639
Ccdc141
Name: coiled-coil domain containing 141
Synonyms: ENSMUSG00000075261, 2610301F02Rik, CAMDI
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 545428
Homologene: 52149
Ecpas
Name: Ecm29 proteasome adaptor and scaffold
Synonyms: AI314180
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230249
Homologene: 6056
Polr1b
Name: polymerase (RNA) I polypeptide B
Synonyms: RPA116, D630020H17Rik, RPA2, Rpo1-2, 128kDa
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20017
Homologene: 7133
Tuba1a
Name: tubulin, alpha 1A
Synonyms: Tuba-1, Talpha1 alpha-tubulin, Tuba1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 22142
Homologene: 68498
Mtfr2
Name: mitochondrial fission regulator 2
Synonyms: Fam54a, 2610016C23Rik, 4933412C16Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71804
VEGA: 10
Homologene: 69441
2700049A03Rik
Name: RIKEN cDNA 2700049A03 gene
Synonyms: Ta3, talpid3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 76967
Homologene: 8839
Cep152
Name: centrosomal protein 152
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99100
Homologene: 37159
Dync2i1
Name: dynein 2 intermediate chain 1
Synonyms: Wdr60, D430033N04Rik, Dync2l1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217935
VEGA: 12
Homologene: 23067
Kel
Name: Kell blood group
Synonyms: CD238
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 23925
HGNC: HGNC:6308
Homologene: 362
Mcoln1
Name: mucolipin 1
Synonyms: TRPML1, 2210015I05Rik, mucolipidin
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 94178
Homologene: 10744
Lgals1
Name: lectin, galactose binding, soluble 1
Synonyms: Gal-1, galectin-1, Lect14, Galbp, L14
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16852
VEGA: 15
HGNC: HGNC:6561
Homologene: 7399
Izumo1r
Name: IZUMO1 receptor, JUNO
Synonyms: Juno, Folr4, 0910001L11Rik, Folbp3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 64931
Homologene: 11283
AAdacl4fm3
Name: AADACL4 family member 3
Synonyms: Gm13178
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 546849
Homologene: 82586
Lrrc37a
Name: leucine rich repeat containing 37A
Synonyms: LOC237954
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237954
Homologene: 138824
Or51k1
Name: olfactory receptor family 51 subfamily K member 1
Synonyms: Olfr639, MOR12-1, GA_x6K02T2PBJ9-6747143-6746193
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259088
Homologene: 17497
Calcrl
Name: calcitonin receptor-like
Synonyms: CRLR
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 54598
Homologene: 21179
Mrc1
Name: mannose receptor, C type 1
Synonyms: MR, CD206
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17533
HGNC: HGNC:7228
Homologene: 37622
Ints15
Name: integrator complex subunit 15
Synonyms: E130309D02Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231868
Homologene: 11445
Ankrd34c
Name: ankyrin repeat domain 34C
Synonyms: B230218L05Rik, LOC330998
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 330998
Homologene: 19814
Pcdh10
Name: protocadherin 10
Synonyms: 6430521D13Rik, OL-pc, 6430703F07Rik, Olpc
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18526
Homologene: 74967
Mink1
Name: misshapen-like kinase 1 (zebrafish)
Synonyms: Map4k6, MINK, Misshapen/NIKs-related kinase, Ysk2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 50932
Homologene: 56762
Lgsn
Name: lengsin, lens protein with glutamine synthetase domain
Synonyms: Gluld1, lengsin, Lgs
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 266744
Homologene: 9569
Otog
Name: otogelin
Synonyms: Otgn
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18419
HGNC: HGNC:8516
Homologene: 8421
Naip6
Name: NLR family, apoptosis inhibitory protein 6
Synonyms: Naip-rs4, Birc1f, Naip-rs4A
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17952
HGNC: HGNC:7634
Homologene: 113589
Tm7sf2
Name: transmembrane 7 superfamily member 2
Synonyms: 3110041O18Rik, ANG1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 73166
Homologene: 68305
Col6a6
Name: collagen, type VI, alpha 6
Synonyms: E330026B02Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 245026
Homologene: 18260
Cgn
Name: cingulin
Synonyms: 6330408J11Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 70737
Homologene: 41394
Cspg4
Name: chondroitin sulfate proteoglycan 4
Synonyms: Cspg4a, AN2, 4732461B14Rik, NG2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 121021
VEGA: 9
HGNC: HGNC:2466
Homologene: 20445
Myo5c
Name: myosin VC
Synonyms: 9130003O20Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 208943
VEGA: 9
HGNC: HGNC:7604
Homologene: 135711
Sipa1l2
Name: signal-induced proliferation-associated 1 like 2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244668
Homologene: 18956
Cntnap5b
Name: contactin associated protein-like 5B
Synonyms: Caspr5-2, C230078M14Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241175
Homologene: 104295
Cadps2
Name: Ca2+-dependent activator protein for secretion 2
Synonyms: cpd2, A230044C21Rik, Caps2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 320405
Homologene: 23060
Fam83f
Name: family with sequence similarity 83, member F
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 213956
VEGA: 15
Homologene: 16313
Or5ac20
Name: olfactory receptor family 5 subfamily AC member 20
Synonyms: GA_x54KRFPKG5P-55498766-55497843, Olfr202, MOR182-1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 258997
Homologene: 138323
Dsc2
Name: desmocollin 2
Synonyms: Dsc2a, Dsc2b
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13506
HGNC: HGNC:3036
Homologene: 8397
Sry
Name: sex determining region of Chr Y
Synonyms: Tdf, Tdy
Type: Gene
Species: Mouse
Chromosome: Y
NCBI: 21674
Spata31e5
Name: spermatogenesis associated 31 subfamily E member 5
Synonyms: Gm597, LOC210962
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 210962
Tekt3
Name: tektin 3
Synonyms: 4933407G07Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71062
Homologene: 12896
Emilin3
Name: elastin microfibril interfacer 3
Synonyms: EMILIN-T, 1110013O17Rik, Emilin5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 280635
Homologene: 18817
Amd1
Name: S-adenosylmethionine decarboxylase 1
Synonyms: Amd-1, AdoMetDC, SAMDC
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11702
VEGA: 10
HGNC: HGNC:457
Homologene: 1235
Ilvbl
Name: ilvB (bacterial acetolactate synthase)-like
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216136
VEGA: 10
HGNC: HGNC:6041
Homologene: 68532
Ndufs3
Name: NADH:ubiquinone oxidoreductase core subunit S3
Synonyms: 0610010M09Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68349
HGNC: HGNC:7710
Homologene: 3346
Taar8b
Name: trace amine-associated receptor 8B
Synonyms: LOC382348
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 382348
Homologene: 77586
Or5g9
Name: olfactory receptor family 5 subfamily G member 9
Synonyms: GA_x6K02T2Q125-47195323-47196267, MOR175-3, Olfr1009
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258565
Homologene: 17297
Fgfbp1
Name: fibroblast growth factor binding protein 1
Synonyms: FGF-BP
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14181
Homologene: 3766
Or9g8
Name: olfactory receptor family 9 subfamily G member 8
Synonyms: MOR213-5, Olfr1014, GA_x6K02T2Q125-47255337-47256254
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258562
Homologene: 83447
Slc43a1
Name: solute carrier family 43, member 1
Synonyms: 2610016F07Rik, PB39, Pov1, Lat3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 72401
HGNC: HGNC:9225
Homologene: 2688
Klf15
Name: Kruppel-like transcription factor 15
Synonyms: CKLF, 1810013I09Rik, hlb444, KKLF
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 66277
Homologene: 8553
H3c13
Name: H3 clustered histone 13
Synonyms: Hist2h3b, H3-616
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 319154
Homologene: 136775
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 28,777,498 bp
  • C to T, chromosome 1 at 31,204,192 bp
  • T to A, chromosome 1 at 100,379,216 bp
  • T to C, chromosome 2 at 14,248,960 bp
  • T to C, chromosome 2 at 77,124,244 bp
  • T to C, chromosome 2 at 84,370,442 bp
  • C to T, chromosome 2 at 84,856,900 bp
  • T to C, chromosome 2 at 85,721,480 bp
  • T to A, chromosome 2 at 85,776,700 bp
  • T to C, chromosome 2 at 90,894,864 bp
  • T to C, chromosome 2 at 125,586,393 bp
  • A to G, chromosome 2 at 129,115,732 bp
  • A to C, chromosome 2 at 160,908,146 bp
  • A to T, chromosome 3 at 45,381,744 bp
  • A to G, chromosome 3 at 94,763,061 bp
  • C to A, chromosome 3 at 96,268,993 bp
  • G to A, chromosome 4 at 58,807,852 bp
  • A to C, chromosome 4 at 144,715,327 bp
  • T to C, chromosome 5 at 43,979,279 bp
  • T to C, chromosome 5 at 143,311,852 bp
  • G to A, chromosome 6 at 17,492,313 bp
  • T to A, chromosome 6 at 22,343,304 bp
  • T to A, chromosome 6 at 23,323,314 bp
  • T to A, chromosome 6 at 41,703,490 bp
  • T to C, chromosome 6 at 90,466,484 bp
  • C to T, chromosome 7 at 46,289,719 bp
  • T to A, chromosome 7 at 104,012,690 bp
  • T to A, chromosome 8 at 3,507,420 bp
  • G to A, chromosome 8 at 85,409,839 bp
  • T to C, chromosome 8 at 125,491,809 bp
  • T to A, chromosome 9 at 14,894,077 bp
  • A to G, chromosome 9 at 56,885,893 bp
  • G to A, chromosome 9 at 75,275,511 bp
  • C to A, chromosome 9 at 89,728,715 bp
  • T to A, chromosome 9 at 105,783,930 bp
  • T to A, chromosome 10 at 11,151,811 bp
  • C to T, chromosome 10 at 20,353,389 bp
  • T to A, chromosome 10 at 24,091,891 bp
  • A to G, chromosome 10 at 40,290,512 bp
  • C to T, chromosome 10 at 78,584,153 bp
  • T to C, chromosome 10 at 84,656,063 bp
  • A to G, chromosome 11 at 60,436,447 bp
  • T to G, chromosome 11 at 63,070,230 bp
  • T to A, chromosome 11 at 70,613,277 bp
  • T to A, chromosome 11 at 103,457,422 bp
  • T to C, chromosome 12 at 71,142,121 bp
  • T to A, chromosome 12 at 116,213,507 bp
  • C to T, chromosome 13 at 49,379,053 bp
  • C to A, chromosome 13 at 100,300,401 bp
  • T to C, chromosome 13 at 100,300,453 bp
  • G to T, chromosome 15 at 39,476,523 bp
  • C to T, chromosome 15 at 78,930,101 bp
  • T to C, chromosome 15 at 80,689,918 bp
  • C to T, chromosome 15 at 98,950,861 bp
  • A to G, chromosome 16 at 17,258,699 bp
  • T to C, chromosome 16 at 59,284,387 bp
  • C to T, chromosome 18 at 20,032,274 bp
  • T to A, chromosome 18 at 42,244,910 bp
  • A to G, chromosome 19 at 6,066,321 bp
  • T to C, chromosome 19 at 40,365,083 bp
  • T to A, chromosome Y at 2,662,589 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8082 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067515-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.