Strain Name:
C57BL/6J-MtgxR8119Btlr/Mmmh
Stock Number:
067548-MU
Citation ID:
RRID:MMRRC_067548-MU
Other Names:
R8119 (G1)
Major Collection:

Strain Information

Smarca4
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
Synonyms: SW1/SNF, Brg1, b2b508.1Clo, b2b692Clo, SNF2beta
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20586
Homologene: 135927
Trmt9b
Name: tRNA methyltransferase 9B
Synonyms: 6430573F11Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 319582
Homologene: 35306
Lypd2
Name: Ly6/Plaur domain containing 2
Synonyms: 0610005K03Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 68311
Homologene: 19022
Amigo1
Name: adhesion molecule with Ig like domain 1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229715
Homologene: 46421
Rictor
Name: RPTOR independent companion of MTOR, complex 2
Synonyms: 4921505C17Rik, D530039E11Rik, 6030405M08Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 78757
VEGA: 15
Homologene: 34317
Smarcad1
Name: SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
Synonyms: Etl1, D6Pas1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 13990
Homologene: 5301
Zranb2
Name: zinc finger, RAN-binding domain containing 2
Synonyms: Zis, Zfp265, Znf265
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 53861
Ints3
Name: integrator complex subunit 3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229543
Homologene: 11309
Nsrp1
Name: nuclear speckle regulatory protein 1
Synonyms: NSpr70, Ccdc55
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237859
Homologene: 134095
Wwox
Name: WW domain-containing oxidoreductase
Synonyms: 9030416C10Rik, WOX1, 5330426P09Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 80707
Homologene: 56334
Nav2
Name: neuron navigator 2
Synonyms: Rainb1, POMFIL2, Unc53H2, HELAD1, 5330421F07Rik, RAINB2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 78286
Homologene: 52330
Taf2
Name: TATA-box binding protein associated factor 2
Synonyms: 4732460C16Rik, TAF2B, TAFII150, 150kDa, CIF150
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 319944
VEGA: 15
Homologene: 31137
Dgkd
Name: diacylglycerol kinase, delta
Synonyms: dgkd-2, DGKdelta
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227333
HGNC: HGNC:2851
Homologene: 100054
Ash1l
Name: ASH1 like histone lysine methyltransferase
Synonyms: 8030453L17Rik, E430018P19Rik, chromatin remodeling factor, KMT2H
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 192195
Homologene: 10225
Map3k1
Name: mitogen-activated protein kinase kinase kinase 1
Synonyms: Mekk, MEKK1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 26401
HGNC: HGNC:6848
Homologene: 8056
Fndc3b
Name: fibronectin type III domain containing 3B
Synonyms: 1600019O04Rik, fad104
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 72007
Homologene: 11244
Trpm4
Name: transient receptor potential cation channel, subfamily M, member 4
Synonyms: TRPM4B, 1110030C19Rik, LTRPC4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 68667
Homologene: 23033
Nipbl
Name: NIPBL cohesin loading factor
Synonyms: 4933421G18Rik, 4921518A06Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 71175
VEGA: 15
Homologene: 15850
Kctd10
Name: potassium channel tetramerisation domain containing 10
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 330171
Homologene: 32652
Prss22
Name: serine protease 22
Synonyms: SP001LA, BSSP-4, 4733401N09Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 70835
VEGA: 17
Homologene: 23344
Csmd1
Name: CUB and Sushi multiple domains 1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 94109
Homologene: 69536
Ttll5
Name: tubulin tyrosine ligase-like family, member 5
Synonyms: STAMP, 4930556H18Rik, 2310009M18Rik, 1700048H13Rik, D630041K24Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 320244
Homologene: 9013
Ptprd
Name: protein tyrosine phosphatase receptor type D
Synonyms: 3000002J10Rik, 1110002J03Rik, B230219D21Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 19266
HGNC: HGNC:9668
Mcc
Name: mutated in colorectal cancers
Synonyms: D18Ertd451e
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 328949
HGNC: HGNC:6935
Homologene: 20539
Usp40
Name: ubiquitin specific peptidase 40
Synonyms: B230215L03Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227334
Homologene: 32400
Slx4
Name: SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)
Synonyms: D16Bwg1016e, Btbd12
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 52864
Homologene: 23770
Ankar
Name: ankyrin and armadillo repeat containing
Synonyms: 4932422E22Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 319695
Homologene: 85163
Zfp770
Name: zinc finger protein 770
Synonyms: 6430601A21Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228491
Homologene: 82354
Abca6
Name: ATP-binding cassette, sub-family A member 6
Synonyms: 6330565N06Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76184
HGNC: HGNC:36
Homologene: 71264
Fam20b
Name: FAM20B, glycosaminoglycan xylosylkinase
Synonyms: C530043G21Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 215015
Homologene: 8909
Zfp217
Name: zinc finger protein 217
Synonyms: 4933431C08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228913
Homologene: 4757
Atrnl1
Name: attractin like 1
Synonyms: Alp
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226255
VEGA: 19
Homologene: 45809
Vmn2r74
Name: vomeronasal 2, receptor 74
Synonyms: EG546980
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 546980
Homologene: 115466
Slc25a35
Name: solute carrier family 25, member 35
Synonyms: 1810012H11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71998
Homologene: 6343
Ngp
Name: neutrophilic granule protein
Synonyms: clone B6, bectenecin, myeloid granule protein
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 18054
Homologene: 49180
Cfh
Name: complement component factor h
Synonyms: Sas1, Sas-1, Mud-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12628
HGNC: HGNC:4883
Homologene: 20086
Pbld2
Name: phenazine biosynthesis-like protein domain containing 2
Synonyms: 3110049J23Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67307
Mocs1
Name: molybdenum cofactor synthesis 1
Synonyms: 3110045D15Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 56738
HGNC: HGNC:7190
Homologene: 4343
Caln1
Name: calneuron 1
Synonyms: Cabp8, 9630012C17Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 140904
Homologene: 10966
Abcd2
Name: ATP-binding cassette, sub-family D member 2
Synonyms: ABC39, ALDR, ALDL1, adrenoleukodystrophy related
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 26874
VEGA: 15
HGNC: HGNC:66
Homologene: 55873
Apol7e
Name: apolipoprotein L 7e
Synonyms: ENSMUSG00000071716
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 666348
VEGA: 15
HGNC: HGNC:619
Homologene: 40940
Ftdc1
Name: ferritin domain containing 1
Synonyms: LOC328695, Gm813, LOC385656
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 328695
VEGA: 16
Or52n20
Name: olfactory receptor family 52 subfamily N member 20
Synonyms: GA_x6K02T2PBJ9-7298889-7299857, MOR34-4, Olfr659
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259052
Homologene: 74118
Or4f47
Name: olfactory receptor family 4 subfamily F member 47
Synonyms: GA_x6K02T2Q125-73188162-73189112, MOR245-4, Olfr1317
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258440
Homologene: 71983
Or2y16
Name: olfactory receptor family 2 subfamily Y member 16
Synonyms: GA_x6K02T2QP88-5991012-5990077, MOR256-28, Olfr1388
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258459
Homologene: 74258
Cldn23
Name: claudin 23
Synonyms: 2310014B08Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 71908
Homologene: 12421
Cfap54
Name: cilia and flagella associated protein 54
Synonyms: LOC380653, Gm872, 4930485B16Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 380654
Homologene: 133438
Ttc6
Name: tetratricopeptide repeat domain 6
Synonyms: EG639426, AU024163, 4921506M07Rik, Gm9813, LOC217602
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 70846
Homologene: 78002
Zscan4-ps3
Name: zinc finger and SCAN domain containing 4, pseudogene 3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100043042
Trav8d-1
Name: T cell receptor alpha variable 8D-1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 667476
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 72,647,001 bp
  • A to T, chromosome 1 at 87,917,967 bp
  • G to T, chromosome 1 at 87,967,678 bp
  • A to C, chromosome 1 at 140,120,015 bp
  • T to G, chromosome 1 at 156,690,502 bp
  • T to A, chromosome 2 at 112,142,563 bp
  • G to A, chromosome 2 at 114,197,027 bp
  • G to A, chromosome 2 at 170,119,651 bp
  • A to T, chromosome 3 at 27,451,344 bp
  • G to A, chromosome 3 at 89,035,427 bp
  • C to T, chromosome 3 at 90,392,300 bp
  • T to C, chromosome 3 at 108,187,536 bp
  • A to G, chromosome 3 at 157,536,332 bp
  • G to T, chromosome 4 at 76,129,026 bp
  • A to G, chromosome 5 at 114,367,255 bp
  • A to G, chromosome 5 at 130,822,984 bp
  • T to C, chromosome 6 at 65,094,319 bp
  • A to G, chromosome 7 at 11,610,340 bp
  • A to T, chromosome 7 at 45,327,128 bp
  • A to G, chromosome 7 at 49,453,484 bp
  • T to C, chromosome 7 at 85,961,482 bp
  • A to T, chromosome 7 at 104,670,854 bp
  • A to G, chromosome 8 at 17,027,294 bp
  • A to G, chromosome 8 at 35,825,902 bp
  • G to A, chromosome 8 at 36,498,422 bp
  • T to C, chromosome 8 at 114,706,368 bp
  • T to C, chromosome 9 at 21,647,626 bp
  • A to G, chromosome 9 at 110,422,353 bp
  • A to T, chromosome 10 at 63,053,877 bp
  • T to C, chromosome 10 at 92,868,810 bp
  • A to T, chromosome 11 at 49,444,126 bp
  • T to C, chromosome 11 at 68,971,972 bp
  • A to G, chromosome 11 at 77,048,351 bp
  • T to C, chromosome 11 at 110,197,104 bp
  • A to T, chromosome 12 at 57,705,643 bp
  • C to A, chromosome 12 at 86,020,548 bp
  • T to C, chromosome 13 at 111,772,622 bp
  • A to T, chromosome 14 at 52,778,968 bp
  • C to T, chromosome 15 at 6,772,154 bp
  • C to T, chromosome 15 at 8,359,212 bp
  • T to C, chromosome 15 at 55,031,130 bp
  • A to G, chromosome 15 at 74,733,032 bp
  • T to C, chromosome 15 at 77,717,756 bp
  • T to C, chromosome 15 at 91,148,994 bp
  • A to T, chromosome 16 at 3,985,272 bp
  • C to A, chromosome 16 at 58,616,848 bp
  • T to A, chromosome 17 at 23,994,727 bp
  • C to T, chromosome 17 at 49,449,519 bp
  • C to T, chromosome 18 at 44,468,433 bp
  • A to G, chromosome 19 at 57,642,463 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8119 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067548-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.