Strain Name:
C57BL/6J-MtgxR8120Btlr/Mmmh
Stock Number:
067549-MU
Citation ID:
RRID:MMRRC_067549-MU
Other Names:
R8120 (G1)
Major Collection:

Strain Information

Nae1
Name: NEDD8 activating enzyme E1 subunit 1
Synonyms: Appbp1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234664
HGNC: HGNC:621
Homologene: 68370
Hgf
Name: hepatocyte growth factor
Synonyms: scatter factor, NK2, NK1, C230052L06Rik, HGF/SF, SF/HGF
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 15234
HGNC: HGNC:4893
Homologene: 503
Abca12
Name: ATP-binding cassette, sub-family A member 12
Synonyms: 4833417A11Rik, 4832428G11Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74591
Homologene: 45441
Fryl
Name: FRY like transcription coactivator
Synonyms: 9030227G01Rik, 2310004H21Rik, 2510002A14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 72313
Homologene: 103956
Uba2
Name: ubiquitin-like modifier activating enzyme 2
Synonyms: Arx, anthracycline-associated resistance, SAE2, UBA2, Sumo-1 activating enzyme subunit 2, Uble1b
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 50995
Homologene: 4018
Abcc8
Name: ATP-binding cassette, sub-family C member 8
Synonyms: Sur, D930031B21Rik, SUR1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20927
HGNC: HGNC:59
Homologene: 68048
Pde1b
Name: phosphodiesterase 1B, Ca2+-calmodulin dependent
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 18574
VEGA: 15
HGNC: HGNC:8775
Homologene: 37370
Cdc5l
Name: cell division cycle 5-like
Synonyms: 1200002I02Rik, PCDC5RP
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 71702
VEGA: 17
HGNC: HGNC:1743
Homologene: 13291
Stk38l
Name: serine/threonine kinase 38 like
Synonyms: 4930473A22Rik, Ndr2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232533
Homologene: 56299
Vangl1
Name: VANGL planar cell polarity 1
Synonyms: mStbm, stbm, Lpp2, KITENIN
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229658
Homologene: 44540
Prr12
Name: proline rich 12
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233210
Homologene: 18957
Brwd1
Name: bromodomain and WD repeat domain containing 1
Synonyms: Wdr9, repro5, 5330419I02Rik, G1-403-16, D530019K20Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 93871
Homologene: 23130
Rtf1
Name: RTF1, Paf1/RNA polymerase II complex component
Synonyms: 2900005O08Rik, 6530416A09Rik, Gtl7
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 76246
Homologene: 133868
Washc3
Name: WASH complex subunit 3
Synonyms: Ccdc53, 2900091E11Rik, 5730495F03Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67282
Homologene: 9364
Nars1
Name: asparaginyl-tRNA synthetase 1
Synonyms: Nars, ASNRS
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 70223
VEGA: 18
HGNC: HGNC:7643
Homologene: 68404
Tceanc2
Name: transcription elongation factor A (SII) N-terminal and central domain containing 2
Synonyms: Tdeanc2, 6330404A07Rik, 2210012G02Rik, 2210010B22Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 66526
Homologene: 11984
Dgcr2
Name: DiGeorge syndrome critical region gene 2
Synonyms: DGS-C, Sez12, Lan, Idd, Dgcr2, Dgsc, 9930034O06Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 13356
HGNC: HGNC:2845
Homologene: 31292
Limk2
Name: LIM domain kinase 2
Synonyms: Limk2a, LIM kinase 2, A930024P04Rik, whe, Limk2b
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16886
HGNC: HGNC:6614
Homologene: 55911
Farsb
Name: phenylalanyl-tRNA synthetase, beta subunit
Synonyms: Farsl, Frsb, PheRS alpha, Farslb
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 23874
Homologene: 4160
Pcnx3
Name: pecanex homolog 3
Synonyms: Pcnxl3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 104401
Homologene: 17000
Zfp386
Name: zinc finger protein 386 (Kruppel-like)
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 56220
Homologene: 51668
Dhodh
Name: dihydroorotate dehydrogenase
Synonyms: 2810417D19Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 56749
HGNC: HGNC:2867
Homologene: 1043
Cubn
Name: cubilin
Synonyms: intrinsic factor-cobalamin receptor, D2Wsu88e
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 65969
HGNC: HGNC:2548
Homologene: 37434
Tub
Name: TUB bipartite transcription factor
Synonyms: rd5, tub
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22141
Homologene: 31147
Ttn
Name: titin
Synonyms: mdm, D830007G01Rik, shru, 1100001C23Rik, D330041I19Rik, 2310057K23Rik, 2310036G12Rik, 2310074I15Rik, L56, connectin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Dnah6
Name: dynein, axonemal, heavy chain 6
Synonyms: A730004I20Rik, Dnahc6
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330355
HGNC: HGNC:2951
Homologene: 15221
Ptchd3
Name: patched domain containing 3
Synonyms: 4933440L20Rik, 4930451E13Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74675
Homologene: 111041
Aadacl4
Name: arylacetamide deacetylase like 4
Synonyms: Gm13177
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 435815
Homologene: 82530
Or6z5
Name: olfactory receptor family 6 subfamily Z member 5
Synonyms: MOR103-6, GA_x6K02T2QGBW-3203957-3204898, Olfr1346
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258918
Homologene: 74134
Dnai4
Name: dynein axonemal intermediate chain 4
Synonyms: Wdr78
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242584
Homologene: 11702
Pde4dip
Name: phosphodiesterase 4D interacting protein (myomegalin)
Synonyms: D130016K21Rik, Usmg4, D3Bwg1078e, 4732458A06Rik, 9430063L05Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 83679
Homologene: 66961
Tpk1
Name: thiamine pyrophosphokinase
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 29807
Homologene: 6960
Ablim1
Name: actin-binding LIM protein 1
Synonyms: 4833406P10Rik, 2610209L21Rik, abLIM-L, abLIM-M, abLIM-S, 9330196J19Rik, Limab1, 2210411C18Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226251
HGNC: HGNC:78
Homologene: 40994
Zfp217
Name: zinc finger protein 217
Synonyms: 4933431C08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228913
Homologene: 4757
Als2cl
Name: ALS2 C-terminal like
Synonyms: mRn.49018, D930044G19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235633
Homologene: 17152
Acte1
Name: actin, epsilon 1
Synonyms: Gm498, LOC244239
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 102636989
Homologene: 131918
Arhgef26
Name: Rho guanine nucleotide exchange factor 26
Synonyms: 4631416L12Rik, 8430436L14Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 622434
Homologene: 9204
Garin4
Name: golgi associated RAB2 interactor family member 4
Synonyms: Fam71a, 4933417M04Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 619288
Homologene: 77474
Zfp267
Name: zinc finger protein 267
Synonyms: D3Ertd254e
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 241944
Homologene: 117700
Or10j3
Name: olfactory receptor family 10 subfamily J member 3B
Synonyms: GA_x6K02T2R7CC-643715-642847, Olfr218, MOR267-3, Olfr1405-ps1, GA_x6K02SYWG4P-534-1100, MOR267-3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 258880
Homologene: 105155
Sardh
Name: sarcosine dehydrogenase
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 192166
Homologene: 5149
Itga2b
Name: integrin alpha 2b
Synonyms: GpIIb, alphaIIb, platelet glycoprotein IIb, CD41, GP IIb
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16399
HGNC: HGNC:6138
Homologene: 37304
Tead2
Name: TEA domain family member 2
Synonyms: TEAD-2, Etdf, TEF-4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 21677
Homologene: 19662
Odr4
Name: odr4 GPCR localization factor homolog
Synonyms: BC003331, 1810053E15Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226499
Homologene: 41202
Zw10
Name: zw10 kinetochore protein
Synonyms: 6330566F14Rik, MmZw10
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 26951
VEGA: 9
Homologene: 37959
Gpcpd1
Name: glycerophosphocholine phosphodiesterase 1
Synonyms: 2310004G06Rik, Prei4, 2310032D16Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74182
Homologene: 10478
Rusc1
Name: RUN and SH3 domain containing 1
Synonyms: 2210403N08Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 72296
Homologene: 75028
Smpdl3a
Name: sphingomyelin phosphodiesterase, acid-like 3A
Synonyms: ASML3A, 0610010C24Rik, ASM3A
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 57319
Homologene: 4886
Slc17a9
Name: solute carrier family 17, member 9
Synonyms: 1700019H03Rik, Vnut
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228993
Homologene: 76562
Itpripl2
Name: inositol 1,4,5-triphosphate receptor interacting protein-like 2
Synonyms: E030018N11Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 319622
Homologene: 45882
Cfhr1
Name: complement factor H-related 1
Synonyms: Cfhl1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 50702
Homologene: 55632
Gpr171
Name: G protein-coupled receptor 171
Synonyms: H963, F730001G15Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229323
Homologene: 36330
Wipf1
Name: WAS/WASL interacting protein family, member 1
Synonyms: Waspip, D2Ertd120e, WIP
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 215280
Homologene: 86891
Psmc2
Name: proteasome (prosome, macropain) 26S subunit, ATPase 2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19181
HGNC: HGNC:9548
Homologene: 2096
Hcar1
Name: hydrocarboxylic acid receptor 1
Synonyms: Gpr81
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243270
HGNC: HGNC:4532
Homologene: 13060
Spo11
Name: SPO11 initiator of meiotic double stranded breaks
Synonyms: Spo11a, Spo11b
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 26972
Homologene: 6059
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 71,259,381 bp
  • A to T, chromosome 1 at 78,462,838 bp
  • T to C, chromosome 1 at 139,547,845 bp
  • T to C, chromosome 1 at 150,384,426 bp
  • C to T, chromosome 1 at 173,203,935 bp
  • T to G, chromosome 1 at 191,162,825 bp
  • A to T, chromosome 2 at 13,331,660 bp
  • A to G, chromosome 2 at 27,218,851 bp
  • G to A, chromosome 2 at 73,437,535 bp
  • T to C, chromosome 2 at 76,763,491 bp
  • A to G, chromosome 2 at 119,701,121 bp
  • C to T, chromosome 2 at 132,554,023 bp
  • G to A, chromosome 2 at 170,119,651 bp
  • G to T, chromosome 2 at 172,985,458 bp
  • G to A, chromosome 2 at 180,732,515 bp
  • A to T, chromosome 3 at 36,164,491 bp
  • T to A, chromosome 3 at 59,097,985 bp
  • A to T, chromosome 3 at 62,341,375 bp
  • C to A, chromosome 3 at 89,089,206 bp
  • T to A, chromosome 3 at 97,706,938 bp
  • T to A, chromosome 3 at 102,163,442 bp
  • G to A, chromosome 4 at 103,066,334 bp
  • A to T, chromosome 4 at 107,177,632 bp
  • A to T, chromosome 4 at 144,622,890 bp
  • T to A, chromosome 5 at 16,613,781 bp
  • T to C, chromosome 5 at 21,800,568 bp
  • T to C, chromosome 5 at 73,071,184 bp
  • C to A, chromosome 5 at 123,879,005 bp
  • A to G, chromosome 6 at 43,468,996 bp
  • G to A, chromosome 6 at 73,025,786 bp
  • A to G, chromosome 6 at 146,758,601 bp
  • A to T, chromosome 7 at 6,474,120 bp
  • A to T, chromosome 7 at 34,168,387 bp
  • A to G, chromosome 7 at 45,034,742 bp
  • A to T, chromosome 7 at 45,216,328 bp
  • T to C, chromosome 7 at 46,136,684 bp
  • T to A, chromosome 7 at 109,025,596 bp
  • G to T, chromosome 7 at 118,490,285 bp
  • A to G, chromosome 7 at 143,871,787 bp
  • A to T, chromosome 8 at 104,519,635 bp
  • G to A, chromosome 8 at 109,601,425 bp
  • A to T, chromosome 9 at 49,074,113 bp
  • A to C, chromosome 9 at 110,885,392 bp
  • A to T, chromosome 10 at 57,807,451 bp
  • G to A, chromosome 10 at 88,201,297 bp
  • C to T, chromosome 11 at 3,348,589 bp
  • A to T, chromosome 11 at 102,469,542 bp
  • A to T, chromosome 11 at 121,842,208 bp
  • C to T, chromosome 12 at 116,054,953 bp
  • A to G, chromosome 15 at 103,522,097 bp
  • A to T, chromosome 16 at 17,857,319 bp
  • A to C, chromosome 16 at 96,019,449 bp
  • T to C, chromosome 17 at 45,407,870 bp
  • T to C, chromosome 18 at 64,504,351 bp
  • C to T, chromosome 19 at 5,667,546 bp
  • C to T, chromosome 19 at 57,046,928 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8120 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067549-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.