Strain Name:
C57BL/6J-MtgxR8122Btlr/Mmmh
Stock Number:
067551-MU
Citation ID:
RRID:MMRRC_067551-MU
Other Names:
R8122 (G1)
Major Collection:

Strain Information

Slc12a6
Name: solute carrier family 12, member 6
Synonyms: KCC3, gaxp
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 107723
Homologene: 21069
Evl
Name: Ena-vasodilator stimulated phosphoprotein
Synonyms: b2b2600Clo
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 14026
VEGA: 12
Homologene: 56752
Csrnp1
Name: cysteine-serine-rich nuclear protein 1
Synonyms: taip-3, CSRNP-1, Axud1, 4931429D10Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 215418
VEGA: 9
Homologene: 13196
Syt3
Name: synaptotagmin III
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20981
Homologene: 9617
Eif4g2
Name: eukaryotic translation initiation factor 4, gamma 2
Synonyms: E130105L11Rik, Natm1, DAP-5, Nat1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13690
HGNC: HGNC:3297
Homologene: 37477
Polk
Name: polymerase (DNA directed), kappa
Synonyms: Dinb1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 27015
VEGA: 13
HGNC: HGNC:9183
Homologene: 32140
Top2a
Name: topoisomerase (DNA) II alpha
Synonyms: DNA Topoisomerase II alpha, Top-2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 21973
Homologene: 830
Bptf
Name: bromodomain PHD finger transcription factor
Synonyms: 9430093H17Rik, Falz
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 207165
HGNC: HGNC:3581
Homologene: 114397
Prom1
Name: prominin 1
Synonyms: Prom-1, Prom, AC133, 4932416E19Rik, CD133
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19126
HGNC: HGNC:9454
Homologene: 4390
Cit
Name: citron
Synonyms: citron kinase, Cit-k, CRIK-SK, C030025P15Rik, citron-N
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12704
HGNC: HGNC:1985
Homologene: 21404
Scfd1
Name: Sec1 family domain containing 1
Synonyms: RA410, STXBP1L2, 3110021P21Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 76983
VEGA: 12
Homologene: 5650
Kcnn2
Name: potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
Synonyms: SK2, fri, bc, small conductance calcium-activated potassium channel 2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 140492
HGNC: HGNC:6291
Homologene: 135651
C1qtnf6
Name: C1q and tumor necrosis factor related protein 6
Synonyms: CTRP6, 2810036M19Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 72709
Homologene: 12481
Tmem183a
Name: transmembrane protein 183A
Synonyms: 1300007B12Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 57439
Homologene: 10757
Trub1
Name: TruB pseudouridine (psi) synthase family member 1
Synonyms: 9030425C13Rik, 2610009I02Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 72133
VEGA: 19
Homologene: 34714
Sag
Name: S-antigen, retina and pineal gland (arrestin)
Synonyms: arrestin 1, Arr1, A930001K18Rik, rod arrestin, visual arrestin 1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20215
Homologene: 455
Scn4a
Name: sodium channel, voltage-gated, type IV, alpha
Synonyms: Nav1.4, SkM1, mH2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 110880
Homologene: 283
Lama2
Name: laminin, alpha 2
Synonyms: merosin, mer
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16773
HGNC: HGNC:6482
Homologene: 37306
Mroh7
Name: maestro heat-like repeat family member 7
Synonyms: Gm1027, Heatr8, LOC381538
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 381538
Homologene: 19633
Cspg4b
Name: chondroitin sulfate proteoglycan 4B
Synonyms: BC067074
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 408066
Pkhd1
Name: polycystic kidney and hepatic disease 1
Synonyms: tigmin, FPC
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241035
HGNC: HGNC:9016
Homologene: 16336
Arhgap20
Name: Rho GTPase activating protein 20
Synonyms: 6530403F17Rik, A530023E23Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244867
Homologene: 18938
Wdr17
Name: WD repeat domain 17
Synonyms: 3010002I12Rik, B230207L18Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244484
Homologene: 12460
Dgkg
Name: diacylglycerol kinase, gamma
Synonyms: 2900055E17Rik, E430001K23Rik, Dagk3
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 110197
HGNC: HGNC:2853
Homologene: 1029
Adgrv1
Name: adhesion G protein-coupled receptor V1
Synonyms: Mgr1, Mass1, Gpr98, VLGR1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 110789
Homologene: 19815
Dbt
Name: dihydrolipoamide branched chain transacylase E2
Synonyms: dihydrolipoyllysine-residue (2-methylpropanoyl)transferase, D3Wsu60e, BCKAD E2, dihydrolipoyl transacylase
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 13171
HGNC: HGNC:2698
Homologene: 1444
Ahnak2
Name: AHNAK nucleoprotein 2
Synonyms: LOC382643
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 100041194
Homologene: 131081
Or8g35
Name: olfactory receptor family 8 subfamily G member 35
Synonyms: MOR171-34, MOR171-50, GA_x6K02T2PVTD-33167297-33166353, Olfr955
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258242
VEGA: 9
Homologene: 133698
St6gal1
Name: beta galactoside alpha 2,6 sialyltransferase 1
Synonyms: Siat1, ST6Gal I, St6Gal-I
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 20440
Homologene: 2281
Cyp2d11
Name: cytochrome P450, family 2, subfamily d, polypeptide 11
Synonyms: Cyp2d, P450-2D
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 545123
VEGA: 15
Homologene: 86099
Gpr158
Name: G protein-coupled receptor 158
Synonyms: 5330427M13Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241263
Homologene: 19381
Shank1
Name: SH3 and multiple ankyrin repeat domains 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243961
Homologene: 22949
Capn13
Name: calpain 13
Synonyms: LOC381122
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 381122
VEGA: 17
Homologene: 27026
Pld2
Name: phospholipase D2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18806
HGNC: HGNC:9068
Homologene: 55672
AW551984
Name: expressed sequence AW551984
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244810
HGNC: HGNC:6658
Acsbg3
Name: acyl-CoA synthetase bubblegum family member 3
Synonyms: 1700061G19Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 78625
Homologene: 28378
Loxl3
Name: lysyl oxidase-like 3
Synonyms: Lor2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16950
Homologene: 56591
Ube2j1
Name: ubiquitin-conjugating enzyme E2J 1
Synonyms: 0710008M05Rik, Ncube, Ubc6p, 1110030I22Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56228
Homologene: 41090
Ttll13
Name: tubulin tyrosine ligase-like family, member 13
Synonyms: 1700111A04Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 269954
Homologene: 136186
Or2y1f
Name: olfactory receptor family 2 subfamily Y member 1F
Synonyms: MOR256-25, GA_x6K02T2QP88-6141322-6140387, Olfr1392
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258462
Homologene: 81347
Amer2
Name: APC membrane recruitment 2
Synonyms: 2600011E07Rik, Fam123a, Amer2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 72125
VEGA: 14
Homologene: 45141
Asah1
Name: N-acylsphingosine amidohydrolase 1
Synonyms: 2310081N20Rik, acid ceramidase
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11886
HGNC: HGNC:735
Homologene: 10504
Taar8c
Name: trace amine-associated receptor 8C
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 494546
Homologene: 77586
Ppl
Name: periplakin
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 19041
VEGA: 16
HGNC: HGNC:9273
Homologene: 2026
Cd6
Name: CD6 antigen
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 12511
HGNC: HGNC:1691
Homologene: 4893
Mab21l1
Name: mab-21-like 1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 17116
HGNC: HGNC:6757
Homologene: 36183
Abat
Name: 4-aminobutyrate aminotransferase
Synonyms: GABA-T, 9630038C02Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 268860
HGNC: HGNC:23
Homologene: 542
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 20,562,458 bp
  • A to G, chromosome 1 at 87,834,567 bp
  • A to T, chromosome 1 at 134,354,765 bp
  • A to T, chromosome 2 at 21,826,863 bp
  • A to G, chromosome 2 at 112,266,822 bp
  • A to T, chromosome 3 at 55,783,484 bp
  • T to A, chromosome 3 at 116,520,242 bp
  • T to G, chromosome 4 at 33,045,145 bp
  • T to C, chromosome 4 at 106,702,529 bp
  • T to C, chromosome 5 at 44,012,953 bp
  • T to C, chromosome 5 at 115,969,010 bp
  • T to A, chromosome 6 at 83,049,259 bp
  • G to T, chromosome 7 at 44,333,591 bp
  • A to G, chromosome 7 at 44,395,729 bp
  • T to A, chromosome 7 at 80,259,469 bp
  • T to C, chromosome 7 at 111,078,553 bp
  • T to C, chromosome 8 at 41,343,730 bp
  • A to G, chromosome 8 at 54,664,976 bp
  • A to G, chromosome 9 at 39,470,526 bp
  • T to A, chromosome 9 at 39,599,369 bp
  • A to G, chromosome 9 at 51,849,993 bp
  • T to C, chromosome 9 at 119,973,207 bp
  • C to T, chromosome 10 at 24,101,209 bp
  • G to A, chromosome 10 at 27,054,596 bp
  • C to A, chromosome 11 at 49,293,574 bp
  • T to A, chromosome 11 at 70,541,433 bp
  • T to C, chromosome 11 at 98,999,167 bp
  • A to G, chromosome 11 at 106,330,331 bp
  • C to A, chromosome 11 at 107,036,591 bp
  • T to A, chromosome 12 at 51,433,269 bp
  • C to T, chromosome 12 at 108,681,524 bp
  • T to C, chromosome 12 at 112,776,076 bp
  • A to G, chromosome 13 at 81,270,918 bp
  • A to T, chromosome 13 at 81,440,225 bp
  • A to T, chromosome 13 at 96,483,783 bp
  • A to T, chromosome 13 at 113,318,908 bp
  • A to T, chromosome 14 at 60,379,342 bp
  • T to C, chromosome 15 at 78,527,246 bp
  • T to A, chromosome 15 at 82,392,543 bp
  • C to T, chromosome 16 at 5,088,861 bp
  • A to G, chromosome 16 at 8,615,897 bp
  • A to C, chromosome 16 at 22,566,545 bp
  • A to G, chromosome 16 at 23,354,894 bp
  • T to A, chromosome 17 at 56,886,670 bp
  • T to A, chromosome 17 at 73,367,210 bp
  • T to G, chromosome 18 at 45,676,938 bp
  • A to G, chromosome 19 at 10,792,867 bp
  • G to T, chromosome 19 at 57,485,131 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8122 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067551-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.