Strain Name:
C57BL/6J-MtgxR8141Btlr/Mmmh
Stock Number:
067569-MU
Citation ID:
RRID:MMRRC_067569-MU
Other Names:
R8141 (G1)
Major Collection:

Strain Information

Plcb4
Name: phospholipase C, beta 4
Synonyms: A930039J07Rik, C230058B11Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18798
HGNC: HGNC:9059
Homologene: 8471
Usp47
Name: ubiquitin specific peptidase 47
Synonyms: A630020C16Rik, 4930502N04Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74996
Homologene: 9929
Sf3b3
Name: splicing factor 3b, subunit 3
Synonyms: D8Ertd633e, 5730409A01Rik, 1810061H24Rik, SAP130, RSE1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 101943
Homologene: 6579
Rasal2
Name: RAS protein activator like 2
Synonyms: A330066M24Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226525
HGNC: HGNC:9874
Homologene: 35217
Kdm3b
Name: KDM3B lysine (K)-specific demethylase 3B
Synonyms: JHDM2B, Jmjd1b, 5830462I21Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 277250
VEGA: 18
HGNC: HGNC:1337
Homologene: 41145
Casr
Name: calcium-sensing receptor
Synonyms: CaR, Gprc2a, cation sensing receptor
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 12374
HGNC: HGNC:1514
Homologene: 332
Cpne6
Name: copine VI
Synonyms: neuronal copine
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12891
HGNC: HGNC:2319
Homologene: 81815
Lypd4
Name: Ly6/Plaur domain containing 4
Synonyms: 4933400F01Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232973
Homologene: 45458
Foxk1
Name: forkhead box K1
Synonyms: Mnf, A630048H08Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 17425
Homologene: 82414
Pnpla6
Name: patatin-like phospholipase domain containing 6
Synonyms: Nte, Swiss-cheese, MSws
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 50767
Homologene: 21333
Kirrel1
Name: kirre like nephrin family adhesion molecule 1
Synonyms: Kirrel, Kirrel1, 6720469N11Rik, Neph1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 170643
Homologene: 10089
1700017B05Rik
Name: RIKEN cDNA 1700017B05 gene
Synonyms: D9Ertd278e
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74211
VEGA: 9
Homologene: 19283
Zfyve26
Name: zinc finger, FYVE domain containing 26
Synonyms: 9330197E15Rik, A630028O16Rik, LOC380767
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 211978
VEGA: 12
Homologene: 9102
Pdgfra
Name: platelet derived growth factor receptor, alpha polypeptide
Synonyms: CD140a, Pdgfr-2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18595
HGNC: HGNC:8803
Homologene: 31361
Syne2
Name: spectrin repeat containing, nuclear envelope 2
Synonyms: nesprin-2, D12Ertd777e, diminished cone electroretinogram, Cpfl8, Nesp2g, dice, syne-2, 6820443O06Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 319565
Homologene: 56700
Fat3
Name: FAT atypical cadherin 3
Synonyms: D430038H04Rik, LOC234973, LOC382129, 9430076A06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270120
VEGA: 9
Homologene: 82252
Spocd1
Name: SPOC domain containing 1
Synonyms: OTTMUSG00000009522
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 622480
Homologene: 83439
Tamalin
Name: trafficking regulator and scaffold protein tamalin
Synonyms: tamalin, Grasp
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 56149
VEGA: 15
Homologene: 32442
Ttf1
Name: transcription termination factor, RNA polymerase I
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22130
Homologene: 137223
Sycp1
Name: synaptonemal complex protein 1
Synonyms: SCP1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20957
Homologene: 2389
Tmem63a
Name: transmembrane protein 63a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 208795
Homologene: 101673
Eln
Name: elastin
Synonyms: tropoelastin, E030024M20Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13717
HGNC: HGNC:3327
Lrrc37
Name: leucine rich repeat containing 37
Synonyms: Gm884, LOC380730
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380730
Homologene: 134511
Actn2
Name: actinin alpha 2
Synonyms: 1110008F24Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 11472
HGNC: HGNC:164
Homologene: 31016
Igsf10
Name: immunoglobulin superfamily, member 10
Synonyms: Adlican2, CMF608, 6530405F15Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242050
Homologene: 18712
Cfap251
Name: cilia and flagella associated protein 251
Synonyms: 4933428F06Rik, 4930415N18Rik, Wdr66
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269701
Homologene: 16964
Gpr87
Name: G protein-coupled receptor 87
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 84111
HGNC: HGNC:4538
Homologene: 13021
Ccm2l
Name: cerebral cavernous malformation 2-like
Synonyms: BC020535
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228788
Homologene: 130991
C1s1
Name: complement component 1, s subcomponent 1
Synonyms: C1s
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 50908
HGNC: HGNC:1247
Homologene: 1314
Usp13
Name: ubiquitin specific peptidase 13 (isopeptidase T-3)
Synonyms: 2700071E21Rik, IsoT-3, ISOT3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 72607
Homologene: 68372
Klra17
Name: killer cell lectin-like receptor, subfamily A, member 17
Synonyms: Ly-49Q, Ly49Q, Ly49q1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 170733
Nin
Name: ninein
Synonyms: 3110068G20Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 18080
Homologene: 40632
Pcdhb9
Name: protocadherin beta 9
Synonyms: Pcdhb4C, PcdhbI
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93880
HGNC: HGNC:8689
Homologene: 87124
Cdhr4
Name: cadherin-related family member 4
Synonyms: Cdh29, 1700021K14Rik, D330022A01Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 69398
Homologene: 82362
Llgl1
Name: LLGL1 scribble cell polarity complex component
Synonyms: Lgl1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16897
HGNC: HGNC:6628
Homologene: 31220
Iqub
Name: IQ motif and ubiquitin domain containing
Synonyms: Trs4, 4932408B21Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 214704
Homologene: 44790
Or6n2
Name: olfactory receptor family 6 subfamily N member 2
Synonyms: Olfr430, MOR105-5P, GA_x6K02T2P20D-21108443-21107490
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 258713
Homologene: 17362
Pacsin1
Name: protein kinase C and casein kinase substrate in neurons 1
Synonyms: Syndapin I, A830061D09Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 23969
HGNC: HGNC:8570
Homologene: 22674
Cyp2f2
Name: cytochrome P450, family 2, subfamily f, polypeptide 2
Synonyms: Cyp2f
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13107
Homologene: 73898
Ptpn22
Name: protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
Synonyms: 70zpep, Ptpn8
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 19260
HGNC: HGNC:9652
Homologene: 7498
Prss41
Name: serine protease 41
Synonyms: 4931440B09Rik, Tessp1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 71003
Homologene: 28091
Arl14epl
Name: ADP-ribosylation factor-like 14 effector protein-like
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 381142
VEGA: 18
Homologene: 85362
Oog2
Name: oogenesin 2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 381570
Homologene: 77858
Celf3
Name: CUGBP, Elav-like family member 3
Synonyms: BRUNOL1, Tnrc4, ERDA4, CAGH4, 4930415M08Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 78784
Homologene: 48510
Ptgr3
Name: prostaglandin reductase 3
Synonyms: Zadh2, Pthr3, C530046K17Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225791
VEGA: 18
Homologene: 38387
4930438A08Rik
Name: RIKEN cDNA 4930438A08 gene
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 73988
Homologene: 104884
Prlhr
Name: prolactin releasing hormone receptor
Synonyms: Gpr10, PrRPR, GR3, LOC226278
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226278
VEGA: 19
HGNC: HGNC:4464
Homologene: 3134
Bend7
Name: BEN domain containing 7
Synonyms: E130319B15Rik, 1110017O21Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 209645
Homologene: 17660
Ska1
Name: spindle and kinetochore associated complex subunit 1
Synonyms: 2810433K01Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 66468
VEGA: 18
Homologene: 11975
Syf2
Name: SYF2 homolog, RNA splicing factor (S. cerevisiae)
Synonyms: mp29, 1110018L13Rik, D4Bwg1551e, Cbpin, Gcipip, p29, Ntc31
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68592
Homologene: 5993
Ifi204
Name: interferon activated gene 204
Synonyms: p204
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 15951
Homologene: 115929
Fam53b
Name: family with sequence similarity 53, member B
Synonyms: A930008G19Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 77938
Homologene: 8776
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 157,164,670 bp
  • A to G, chromosome 1 at 173,755,623 bp
  • T to C, chromosome 1 at 174,069,922 bp
  • A to G, chromosome 1 at 180,974,211 bp
  • T to C, chromosome 2 at 4,752,825 bp
  • C to T, chromosome 2 at 29,067,226 bp
  • T to C, chromosome 2 at 135,939,249 bp
  • T to C, chromosome 2 at 153,070,871 bp
  • T to C, chromosome 3 at 32,894,876 bp
  • A to G, chromosome 3 at 59,179,599 bp
  • A to G, chromosome 3 at 59,330,528 bp
  • C to T, chromosome 3 at 87,086,428 bp
  • C to A, chromosome 3 at 94,488,543 bp
  • G to T, chromosome 3 at 102,935,569 bp
  • A to G, chromosome 3 at 103,886,327 bp
  • A to C, chromosome 4 at 129,929,704 bp
  • C to T, chromosome 4 at 134,936,871 bp
  • T to C, chromosome 4 at 144,194,207 bp
  • T to C, chromosome 5 at 75,177,726 bp
  • T to G, chromosome 5 at 123,286,430 bp
  • CTCCAGCTCCGAT to C, chromosome 5 at 134,729,149 bp
  • A to G, chromosome 5 at 142,453,961 bp
  • T to A, chromosome 6 at 24,491,609 bp
  • A to T, chromosome 6 at 124,531,362 bp
  • T to C, chromosome 6 at 129,872,329 bp
  • A to T, chromosome 7 at 24,864,829 bp
  • G to A, chromosome 7 at 27,129,253 bp
  • A to G, chromosome 7 at 112,053,265 bp
  • A to C, chromosome 7 at 132,760,029 bp
  • T to C, chromosome 8 at 3,521,384 bp
  • A to C, chromosome 8 at 110,820,851 bp
  • T to A, chromosome 9 at 15,997,066 bp
  • T to C, chromosome 9 at 57,258,405 bp
  • G to A, chromosome 9 at 107,996,792 bp
  • A to G, chromosome 11 at 58,286,585 bp
  • G to C, chromosome 11 at 60,710,316 bp
  • T to C, chromosome 11 at 103,621,029 bp
  • A to G, chromosome 12 at 70,030,021 bp
  • A to G, chromosome 12 at 76,061,668 bp
  • A to T, chromosome 12 at 79,268,557 bp
  • T to C, chromosome 13 at 12,288,630 bp
  • T to C, chromosome 14 at 55,512,609 bp
  • T to A, chromosome 15 at 101,231,909 bp
  • T to C, chromosome 16 at 36,494,811 bp
  • G to A, chromosome 17 at 23,837,633 bp
  • G to T, chromosome 17 at 27,707,060 bp
  • A to T, chromosome 18 at 34,828,546 bp
  • T to A, chromosome 18 at 37,402,308 bp
  • C to A, chromosome 18 at 46,926,343 bp
  • T to C, chromosome 18 at 74,206,836 bp
  • T to C, chromosome 18 at 84,094,526 bp
  • C to G, chromosome 19 at 60,467,309 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8141 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067569-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.