Strain Name:
C57BL/6J-MtgxR8166Btlr/Mmmh
Stock Number:
067592-MU
Citation ID:
RRID:MMRRC_067592-MU
Other Names:
R8166 (G1)
Major Collection:

Strain Information

Vcan
Name: versican
Synonyms: hdf, DPEAAE, heart defect, 5430420N07Rik, PG-M, Cspg2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 13003
HGNC: HGNC:2464
Homologene: 3228
Rictor
Name: RPTOR independent companion of MTOR, complex 2
Synonyms: 4921505C17Rik, 6030405M08Rik, D530039E11Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 78757
VEGA: 15
Homologene: 34317
Mtif3
Name: mitochondrial translational initiation factor 3
Synonyms: 2810012L14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 76366
Homologene: 49927
Suclg1
Name: succinate-CoA ligase, GDP-forming, alpha subunit
Synonyms: Sucla1, 1500000I01Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 56451
Homologene: 55785
Ncapg2
Name: non-SMC condensin II complex, subunit G2
Synonyms: Luzp5, Mtb, 5830426I05Rik, mCAP-G2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 76044
VEGA: 12
Homologene: 9820
Bmpr1a
Name: bone morphogenetic protein receptor, type 1A
Synonyms: 1110037I22Rik, ALK3, Bmpr, BMPR-IA
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12166
HGNC: HGNC:1076
Homologene: 20911
Sall1
Name: spalt like transcription factor 1
Synonyms: Msal-3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 58198
Homologene: 2230
Rsf1
Name: remodeling and spacing factor 1
Synonyms: Hbxap, p325, XAP8, C030033M12Rik, 4832420A03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233532
Homologene: 41142
Nasp
Name: nuclear autoantigenic sperm protein (histone-binding)
Synonyms: 5033430J04Rik, Nasp-T, D4Ertd767e, Epcs32
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 50927
HGNC: HGNC:7644
Homologene: 133894
Kctd9
Name: potassium channel tetramerisation domain containing 9
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105440
Homologene: 9754
N4bp2
Name: NEDD4 binding protein 2
Synonyms: LOC386488, LOC333789, B3bp
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 333789
Homologene: 32396
Aqr
Name: aquarius
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11834
Homologene: 7629
Bmpr2
Name: bone morphogenetic protein receptor type 2
Synonyms: BMPR-II, BMPRII, BMP-2, 2610024H22Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12168
HGNC: HGNC:1078
Homologene: 929
Efs
Name: embryonal Fyn-associated substrate
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 13644
VEGA: 14
Homologene: 4284
Pum2
Name: pumilio RNA-binding family member 2
Synonyms: Pumm2, 5730503J23Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 80913
Homologene: 69183
Amph
Name: amphiphysin
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218038
HGNC: HGNC:471
Homologene: 121585
Dync2h1
Name: dynein cytoplasmic 2 heavy chain 1
Synonyms: Dnchc2, m152Asp, m407Asp, b2b414Clo, D030010H02Rik, D330044F14Rik, 4432416O06Rik, DHC1b, DHC2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 110350
HGNC: HGNC:2962
Homologene: 14468
Eif5b
Name: eukaryotic translation initiation factor 5B
Synonyms: IF2, A030003E17Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226982
Homologene: 134613
Med20
Name: mediator complex subunit 20
Synonyms: 2410115I17Rik, Trfp, 1110011O05Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 56771
Homologene: 3158
Clec4f
Name: C-type lectin domain family 4, member f
Synonyms: Clecsf13, D18063, kupffer cell receptor
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 51811
Homologene: 9630
Wdr72
Name: WD repeat domain 72
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 546144
Homologene: 52326
Atp10a
Name: ATPase, class V, type 10A
Synonyms: pfatp, Atp10c
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11982
Homologene: 56461
Tarbp1
Name: TAR RNA binding protein 1
Synonyms: Gm17296
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 212728
Homologene: 38082
Hipk1
Name: homeodomain interacting protein kinase 1
Synonyms: 1110062K04Rik, Myak
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 15257
Homologene: 56483
Naip2
Name: NLR family, apoptosis inhibitory protein 2
Synonyms: Naip-rs6, Naip2, Birc1b
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17948
HGNC: HGNC:7634
Homologene: 136092
Actrt3
Name: actin related protein T3
Synonyms: 1700119I24Rik, Arpm1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 76652
Homologene: 13038
Kcnh4
Name: potassium voltage-gated channel, subfamily H (eag-related), member 4
Synonyms: BEC2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380728
HGNC: HGNC:6253
Homologene: 8180
Ttc22
Name: tetratricopeptide repeat domain 22
Synonyms: 4732467L16Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230576
Homologene: 89253
Ogdhl
Name: oxoglutarate dehydrogenase-like
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239017
VEGA: 14
Homologene: 56801
Cadm2
Name: cell adhesion molecule 2
Synonyms: Igsf4d, 2900078E11Rik, A830029E02Rik, Necl3, SynCAM2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239857
Homologene: 17705
Tshz2
Name: teashirt zinc finger family member 2
Synonyms: 2900073F20Rik, Tsh2, Mtsh2, Sdccag33l, Zfp218, teashirt2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228911
Homologene: 35258
Vmn2r105
Name: vomeronasal 2, receptor 105
Synonyms: EG627743
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627743
Homologene: 129680
Acad9
Name: acyl-Coenzyme A dehydrogenase family, member 9
Synonyms: NPD002, 2600017P15Rik, C630012L17Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229211
Homologene: 8539
Flnc
Name: filamin C, gamma
Synonyms: 1110055E19Rik, actin binding protein 280, Fln2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 68794
HGNC: HGNC:3756
Homologene: 37481
Zfp518b
Name: zinc finger protein 518B
Synonyms: 6820424L24Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100515
Homologene: 19115
Vmn1r68
Name: vomeronasal 1 receptor 68
Synonyms: Gm6898
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 628580
Homologene: 120153
Lats1
Name: large tumor suppressor
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16798
VEGA: 10
HGNC: HGNC:6514
Homologene: 55843
Scg2
Name: secretogranin II
Synonyms: SgII, Chgc
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20254
Homologene: 2591
Vmn2r96
Name: vomeronasal 2, receptor 96
Synonyms: EG433070
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 433070
P3h2
Name: prolyl 3-hydroxylase 2
Synonyms: Leprel1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 210530
Homologene: 10062
Pnpt1
Name: polyribonucleotide nucleotidyltransferase 1
Synonyms: PNPase, polynucleotide phosphorylase, 1200003F12Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71701
Homologene: 12404
Nipsnap1
Name: nipsnap homolog 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18082
HGNC: HGNC:7827
Homologene: 2695
Or5p66
Name: olfactory receptor family 5 subfamily P member 66
Synonyms: MOR204-17, GA_x6K02T2PBJ9-10617173-10616229, Olfr490
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258491
Homologene: 73955
Ccdc102a
Name: coiled-coil domain containing 102A
Synonyms: LOC234582
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234582
Homologene: 13240
Msantd4
Name: Myb/SANT-like DNA-binding domain containing 4 with coiled-coils
Synonyms: 8430410K20Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 78100
Homologene: 34935
Nsmce1
Name: NSE1 homolog, SMC5-SMC6 complex component
Synonyms: 2510027N19Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67711
Homologene: 41672
Rps6ka4
Name: ribosomal protein S6 kinase, polypeptide 4
Synonyms: 90kDa, MSK2, 1110069D02Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 56613
VEGA: 19
Homologene: 69288
Entrep2
Name: endosomal transmembrane epsin interactor 2
Synonyms: 5730507A09Rik, Fam189a1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 70638
Homologene: 77705
Irx5
Name: Iroquois homeobox 5
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 54352
Homologene: 38105
Prxl2c
Name: peroxiredoxin like 2C
Synonyms: Aaed1, 1110018J18Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 66129
VEGA: 13
Homologene: 7192
Alx1
Name: ALX homeobox 1
Synonyms: Cart1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216285
HGNC: HGNC:1494
Homologene: 5075
Gm13030
Name: predicted gene 13030
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 105734733
Ighv8-9
Name: immunoglobulin heavy variable V8-9
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 432709
Igkv8-34
Name: immunoglobulin kappa variable 8-34
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 620126
HGNC: HGNC:5834
Trgc1
Name: T cell receptor gamma, constant 1
Synonyms: Tcrg-C1, Gm17004, Cgamma1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 107573
AI607873
Name:
Type: Gene
Species: Mouse
Chromosome: 1
Dchs2
Name: dachsous cadherin related 2
Synonyms: LOC229459
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 100534287
Gm17190
Name: predicted gene 17190
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 100417936
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 38,048,820 bp
  • A to T, chromosome 1 at 59,867,581 bp
  • T to A, chromosome 1 at 79,435,583 bp
  • C to A, chromosome 1 at 173,729,600 bp
  • A to C, chromosome 1 at 173,729,938 bp
  • T to A, chromosome 2 at 114,113,325 bp
  • C to A, chromosome 2 at 169,883,655 bp
  • A to G, chromosome 3 at 30,598,525 bp
  • T to C, chromosome 3 at 36,090,083 bp
  • T to A, chromosome 3 at 83,354,333 bp
  • T to C, chromosome 3 at 103,778,173 bp
  • G to A, chromosome 4 at 106,634,476 bp
  • A to T, chromosome 4 at 116,610,915 bp
  • A to T, chromosome 4 at 138,871,222 bp
  • C to A, chromosome 5 at 38,674,495 bp
  • T to G, chromosome 5 at 65,820,312 bp
  • T to C, chromosome 5 at 146,959,242 bp
  • A to C, chromosome 6 at 29,433,732 bp
  • A to G, chromosome 6 at 70,044,635 bp
  • T to A, chromosome 6 at 73,260,572 bp
  • G to T, chromosome 6 at 83,652,642 bp
  • A to T, chromosome 7 at 10,527,961 bp
  • A to T, chromosome 7 at 58,807,522 bp
  • A to G, chromosome 7 at 64,759,405 bp
  • G to GACGGCGGCA, chromosome 7 at 97,579,909 bp
  • A to G, chromosome 7 at 108,286,697 bp
  • A to G, chromosome 7 at 125,471,147 bp
  • T to C, chromosome 8 at 89,028,518 bp
  • T to A, chromosome 8 at 92,360,084 bp
  • C to A, chromosome 8 at 94,913,316 bp
  • T to G, chromosome 8 at 126,427,128 bp
  • A to T, chromosome 9 at 4,384,095 bp
  • T to A, chromosome 9 at 7,129,089 bp
  • G to A, chromosome 9 at 74,213,328 bp
  • A to G, chromosome 10 at 7,702,116 bp
  • T to A, chromosome 10 at 103,009,363 bp
  • A to G, chromosome 11 at 4,884,057 bp
  • A to G, chromosome 11 at 29,156,875 bp
  • A to G, chromosome 11 at 100,741,886 bp
  • G to A, chromosome 12 at 8,721,739 bp
  • G to T, chromosome 12 at 115,468,592 bp
  • T to G, chromosome 12 at 116,412,416 bp
  • G to T, chromosome 13 at 18,948,490 bp
  • A to G, chromosome 13 at 19,216,602 bp
  • A to T, chromosome 13 at 64,309,107 bp
  • A to G, chromosome 13 at 89,692,736 bp
  • A to C, chromosome 13 at 96,082,634 bp
  • T to C, chromosome 13 at 100,162,007 bp
  • G to A, chromosome 14 at 32,337,806 bp
  • A to C, chromosome 14 at 34,425,069 bp
  • C to T, chromosome 14 at 54,920,620 bp
  • G to A, chromosome 14 at 67,729,692 bp
  • G to A, chromosome 15 at 6,769,334 bp
  • T to C, chromosome 16 at 25,992,822 bp
  • A to G, chromosome 16 at 66,953,309 bp
  • T to C, chromosome 17 at 18,582,482 bp
  • A to T, chromosome 17 at 20,208,642 bp
  • A to G, chromosome 17 at 47,613,102 bp
  • G to A, chromosome 19 at 6,837,443 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8166 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067592-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.