Strain Name:
C57BL/6J-MtgxR8197Btlr/Mmmh
Stock Number:
067620-MU
Citation ID:
RRID:MMRRC_067620-MU
Other Names:
R8197 (G1)
Major Collection:

Strain Information

B4galt5
Name: UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 5
Synonyms: 9430078I07Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56336
HGNC: HGNC:928
Homologene: 3507
Pdyn
Name: prodynorphin
Synonyms: Dyn
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18610
HGNC: HGNC:8820
Homologene: 10321
Rps6ka1
Name: ribosomal protein S6 kinase polypeptide 1
Synonyms: Rsk1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 20111
Homologene: 55703
Rsf1
Name: remodeling and spacing factor 1
Synonyms: Hbxap, p325, XAP8, C030033M12Rik, 4832420A03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233532
Homologene: 41142
Myo9b
Name: myosin IXb
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 17925
HGNC: HGNC:7609
Homologene: 3058
Bub1
Name: BUB1, mitotic checkpoint serine/threonine kinase
Synonyms: Bub1a, D2Xrf87
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12235
HGNC: HGNC:1148
Homologene: 37910
Supt16
Name: SPT16, facilitates chromatin remodeling subunit
Synonyms: Cdc68, Spt16, Fact140, Supt16h
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 114741
VEGA: 14
Homologene: 5207
Ncapd3
Name: non-SMC condensin II complex, subunit D3
Synonyms: 2810487N22Rik, B130055D15Rik, 4632407J06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 78658
VEGA: 9
Homologene: 41021
Scube2
Name: signal peptide, CUB domain, EGF-like 2
Synonyms: Cegf1, ICRFP703N2430Q5.1, 4932442O19Rik, ICRFP703B1614Q5.1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 56788
Homologene: 36383
Iqsec3
Name: IQ motif and Sec7 domain 3
Synonyms: synarfGEF, BRAG3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243621
Homologene: 46091
Kcnip2
Name: Kv channel-interacting protein 2
Synonyms: KChIP2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 80906
Homologene: 23710
Scyl2
Name: SCY1-like 2 (S. cerevisiae)
Synonyms: CVAK104, D10Ertd802e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 213326
Homologene: 13349
Aars1
Name: alanyl-tRNA synthetase 1
Synonyms: Aars
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234734
HGNC: HGNC:20
Homologene: 1213
Lrrtm3
Name: leucine rich repeat transmembrane neuronal 3
Synonyms: 9630044H04Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216028
Homologene: 37110
Edrf1
Name: erythroid differentiation regulatory factor 1
Synonyms: 2700050L05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 214764
Homologene: 27985
Pde4d
Name: phosphodiesterase 4D, cAMP specific
Synonyms: dunce, Dpde3, 9630011N22Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238871
HGNC: HGNC:8783
Itgae
Name: integrin alpha E, epithelial-associated
Synonyms: CD103, alpha-E1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16407
HGNC: HGNC:6147
Homologene: 113560
Sec31b
Name: SEC31 homolog B, COPII coat complex component
Synonyms: LOC240667, Sec31l2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 240667
Homologene: 56708
Dnah14
Name: dynein, axonemal, heavy chain 14
Synonyms: LOC381311, Gm980, A230079K17Rik, Dnahc14
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240960
HGNC: HGNC:2945
Homologene: 90078
Cntnap4
Name: contactin associated protein-like 4
Synonyms: Caspr4, E130114F09Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 170571
Homologene: 24912
Anxa3
Name: annexin A3
Synonyms: Anx3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 11745
HGNC: HGNC:541
Homologene: 68445
Or8b54
Name: olfactory receptor family 8 subfamily B member 54
Synonyms: MOR165-8, Olfr921, GA_x6K02T2PVTD-32478047-32478988
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258778
VEGA: 9
Homologene: 128138
Cdk5rap3
Name: CDK5 regulatory subunit associated protein 3
Synonyms: OK/SW-cl.114, MST016, C53, IC53, HSF-27, 1810007E24Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 80280
Homologene: 12718
Serpinb6d
Name: serine (or cysteine) peptidase inhibitor, clade B, member 6d
Synonyms: Gm11390, SPI3D
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238568
HGNC: HGNC:8950
Vmn2r111
Name: vomeronasal 2, receptor 111
Synonyms: EG210876
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 210876
Homologene: 86604
Or5h18
Name: olfactory receptor family 5 subfamily H member 18
Synonyms: Olfr186, GA_x54KRFPKG5P-55257214-55256285, MOR183-9
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 258318
Homologene: 133671
Skint6
Name: selection and upkeep of intraepithelial T cells 6
Synonyms: OTTMUSG00000008519
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230622
Homologene: 135888
Gm13941
Name: predicted gene 13941
Type: Gene
Species: Mouse
Chromosome: 2
Abca6
Name: ATP-binding cassette, sub-family A member 6
Synonyms: 6330565N06Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76184
HGNC: HGNC:36
Homologene: 71264
Adra2b
Name: adrenergic receptor, alpha 2b
Synonyms: a2b-AR, alpha2B, [a]2B, Adra-2b
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11552
HGNC: HGNC:282
Homologene: 553
Gys1
Name: glycogen synthase 1, muscle
Synonyms: Gys3, MGS
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14936
HGNC: HGNC:4706
Homologene: 113557
Adamts18
Name: ADAM metallopeptidase with thrombospondin type 1 motif 18
Synonyms: E130314N14Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 208936
Homologene: 65241
Qrich2
Name: glutamine rich 2
Synonyms: LOC217341
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217341
Homologene: 12951
Zfp959
Name: zinc finger protein 959
Synonyms: BC011426
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224893
Homologene: 138295
Mast1
Name: microtubule associated serine/threonine kinase 1
Synonyms: 9430008B02Rik, SAST170, SAST
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 56527
Homologene: 10543
Hrh4
Name: histamine receptor H4
Synonyms: H4R
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225192
VEGA: 18
Homologene: 11002
Kndc1
Name: kinase non-catalytic C-lobe domain (KIND) containing 1
Synonyms: 2410012C07Rik, very-kind, VKIND, B830014K08Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76484
Homologene: 45138
Fhl4
Name: four and a half LIM domains 4
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14202
VEGA: 10
Nab1
Name: Ngfi-A binding protein 1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17936
HGNC: HGNC:7626
Homologene: 4352
Ccdc185
Name: coiled-coil domain containing 185
Synonyms: 4922505E12Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 433386
Homologene: 17631
Dpp4
Name: dipeptidylpeptidase 4
Synonyms: Dpp-4, THAM, Cd26
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13482
HGNC: HGNC:3009
Homologene: 3279
Tmem114
Name: transmembrane protein 114
Synonyms: 4930511J11Rik, Cldn26
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74720
VEGA: 16
Homologene: 12583
Gsdmd
Name: gasdermin D
Synonyms: DF5L, Gsdmdc1, Dfna5l, M2-4, 1810036L03Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 69146
VEGA: 15
Homologene: 12299
Igfals
Name: insulin-like growth factor binding protein, acid labile subunit
Synonyms: ALS, Albs
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 16005
VEGA: 17
HGNC: HGNC:5468
Homologene: 37987
Vmn1r125
Name: vomeronasal 1 receptor 125
Synonyms: Gm8519
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 667215
Homologene: 104166
Fabp9
Name: fatty acid binding protein 9, testis
Synonyms: 1700007P10Rik, Tlbp
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 21884
HGNC: HGNC:3563
Homologene: 40776
Igkv5-37
Name: immunoglobulin kappa variable 5-37
Synonyms: IgVk 23-37, LOC384417
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 384417
Crygc
Name: crystallin, gamma C
Synonyms: Cryg-5
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12966
HGNC: HGNC:2410
Homologene: 36281
3010026O09Rik
Name:
Type: Gene
Species: Mouse
Chromosome: 11
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 52,489,968 bp
  • T to C, chromosome 1 at 65,073,206 bp
  • A to G, chromosome 1 at 181,690,101 bp
  • G to T, chromosome 1 at 182,748,759 bp
  • T to C, chromosome 2 at 62,372,827 bp
  • T to C, chromosome 2 at 111,096,576 bp
  • A to T, chromosome 2 at 127,364,658 bp
  • G to T, chromosome 2 at 127,801,257 bp
  • C to T, chromosome 2 at 129,688,357 bp
  • A to T, chromosome 2 at 150,267,657 bp
  • T to A, chromosome 2 at 167,302,103 bp
  • T to G, chromosome 3 at 10,194,827 bp
  • T to G, chromosome 4 at 112,894,843 bp
  • T to C, chromosome 4 at 133,865,362 bp
  • A to G, chromosome 5 at 96,834,792 bp
  • A to G, chromosome 6 at 69,963,857 bp
  • A to G, chromosome 6 at 121,413,012 bp
  • G to A, chromosome 7 at 21,272,926 bp
  • A to G, chromosome 7 at 45,442,924 bp
  • CGGCGGCGG to CGGCGGCGGGGGCGGCGG, chromosome 7 at 97,579,914 bp
  • T to A, chromosome 7 at 109,808,477 bp
  • T to A, chromosome 7 at 133,647,359 bp
  • A to G, chromosome 7 at 139,913,531 bp
  • T to C, chromosome 8 at 71,290,963 bp
  • T to A, chromosome 8 at 84,912,821 bp
  • T to A, chromosome 8 at 111,053,996 bp
  • T to A, chromosome 8 at 112,570,225 bp
  • G to T, chromosome 8 at 113,754,595 bp
  • C to A, chromosome 9 at 27,086,033 bp
  • G to A, chromosome 9 at 38,775,281 bp
  • T to A, chromosome 10 at 64,088,516 bp
  • T to A, chromosome 10 at 85,098,237 bp
  • T to C, chromosome 10 at 89,662,366 bp
  • A to G, chromosome 11 at 50,199,780 bp
  • G to A, chromosome 11 at 73,120,384 bp
  • A to G, chromosome 11 at 96,916,149 bp
  • A to C, chromosome 11 at 110,211,815 bp
  • CACCTGCTTGCAACACACCAGGCTGAACTGGACCT to CACCT, chromosome 11 at 116,457,035 bp
  • T to C, chromosome 13 at 33,667,605 bp
  • T to A, chromosome 13 at 109,948,336 bp
  • G to A, chromosome 14 at 52,174,085 bp
  • T to C, chromosome 15 at 75,864,337 bp
  • T to C, chromosome 16 at 8,409,652 bp
  • T to A, chromosome 16 at 59,027,085 bp
  • T to C, chromosome 17 at 22,559,051 bp
  • A to G, chromosome 17 at 24,880,304 bp
  • A to T, chromosome 17 at 55,897,677 bp
  • A to G, chromosome 18 at 13,021,929 bp
  • T to G, chromosome 19 at 44,524,516 bp
  • T to C, chromosome 19 at 45,794,291 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8197 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067620-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.