Strain Name:
C57BL/6J-MtgxR8303Btlr/Mmmh
Stock Number:
067715-MU
Citation ID:
RRID:MMRRC_067715-MU
Other Names:
R8303 (G1)
Major Collection:

Strain Information

Arid4b
Name: AT-rich interaction domain 4B
Synonyms: Rbp1l1, 6330417L24Rik, RBBP1L1, 6720480E17Rik, SAP180, BRCAA1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 94246
Homologene: 12847
Pcm1
Name: pericentriolar material 1
Synonyms: C030044G17Rik, 9430077F19Rik, 2600002H09Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 18536
HGNC: HGNC:8727
Homologene: 4518
Ist1
Name: increased sodium tolerance 1 homolog (yeast)
Synonyms: 2400003C14Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 71955
Homologene: 8849
Erbin
Name: Erbb2 interacting protein
Synonyms: 1700028E05Rik, Erbb2ip, Erbin
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 59079
Homologene: 41282
Ddx54
Name: DEAD box helicase 54
Synonyms: DEAD (Asp-Glu-Ala-Asp) box polypeptide 54, APR-5, 2410015A15Rik, DP97
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71990
Homologene: 5590
Hmmr
Name: hyaluronan mediated motility receptor (RHAMM)
Synonyms: CD168, Rhamm
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15366
HGNC: HGNC:5012
Homologene: 8271
Smpd4
Name: sphingomyelin phosphodiesterase 4
Synonyms: neutral membrane (neutral sphingomyelinase-3), 4122402O22Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 77626
Homologene: 9813
Gapvd1
Name: GTPase activating protein and VPS9 domains 1
Synonyms: 4432404J10Rik, 2010005B09Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66691
Homologene: 32637
Arhgap32
Name: Rho GTPase activating protein 32
Synonyms: p200RhoGAP, PX-RICS, 3426406O18Rik, Grit, GC-GAP
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 330914
Homologene: 8812
Scaf8
Name: SR-related CTD-associated factor 8
Synonyms: A930036P18Rik, A630086M08Rik, Rbm16
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106583
VEGA: 17
Homologene: 8928
Ngdn
Name: neuroguidin, EIF4E binding protein
Synonyms: neuroguidin, Ngd, 1500001L15Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 68966
VEGA: 14
Homologene: 44286
Zzef1
Name: zinc finger, ZZ-type with EF hand domain 1
Synonyms: 8430405D05Rik, C130099L13Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 195018
Homologene: 9027
Arhgap42
Name: Rho GTPase activating protein 42
Synonyms: 9030420J04Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71544
Homologene: 28446
Umps
Name: uridine monophosphate synthetase
Synonyms: 1700095D23Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 22247
Homologene: 319
Cep135
Name: centrosomal protein 135
Synonyms: LOC381644, Cep4
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381644
Homologene: 45709
Card6
Name: caspase recruitment domain family, member 6
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239319
Homologene: 13067
Dsp
Name: desmoplakin
Synonyms: 5730453H04Rik, DP, rul, 2300002E22Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 109620
HGNC: HGNC:3052
Homologene: 37922
Vps13b
Name: vacuolar protein sorting 13B
Synonyms: Coh1, 2310042E16Rik, 1810042B05Rik, C330002D13Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 666173
VEGA: 15
HGNC: HGNC:2183
Homologene: 49516
Xpot
Name: exportin, tRNA (nuclear export receptor for tRNAs)
Synonyms: C79645, 1110004L07Rik, EXPORTIN-T
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 73192
VEGA: 10
Homologene: 38291
2810021J22Rik
Name: RIKEN cDNA 2810021J22 gene
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69944
Homologene: 138400
Lrrtm1
Name: leucine rich repeat transmembrane neuronal 1
Synonyms: 4632401D06Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 74342
Homologene: 41763
Arhgef3
Name: Rho guanine nucleotide exchange factor 3
Synonyms: C76747, 1200004I24Rik, 9830169H03Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 71704
VEGA: 14
HGNC: HGNC:683
Homologene: 41329
Pask
Name: PAS domain containing serine/threonine kinase
Synonyms: Paskin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 269224
Homologene: 9038
Ice1
Name: interactor of little elongation complex ELL subunit 1
Synonyms: BC018507
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218333
VEGA: 13
Homologene: 18902
Vps13a
Name: vacuolar protein sorting 13A
Synonyms: 4930543C13Rik, D330038K10Rik, 4930516E05Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 271564
VEGA: 19
HGNC: HGNC:1908
Homologene: 22068
Asxl3
Name: ASXL transcriptional regulator 3
Synonyms: D430002O22Rik, LOC381127, D930044O18Rik, C230079D11Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 211961
Homologene: 19371
Smad3
Name: SMAD family member 3
Synonyms: Madh3, Smad 3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17127
HGNC: HGNC:6769
Homologene: 55937
Sycp2l
Name: synaptonemal complex protein 2-like
Synonyms: EG621792, Gm40956, LOC218175
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 637277
Homologene: 52882
Fsip2
Name: fibrous sheath-interacting protein 2
Synonyms: OTTMUSG00000013335
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241516
Homologene: 110349
Nxpe5
Name: neurexophilin and PC-esterase domain family, member 5
Synonyms: BC055004, Fam55 related
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381680
Homologene: 134143
Kif21a
Name: kinesin family member 21A
Synonyms: N-5 kinesin
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16564
VEGA: 15
Homologene: 56761
Ttc41
Name: tetratricopeptide repeat domain 41
Synonyms: Gnn, BC030307
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 103220
VEGA: 10
Homologene: 52968
Cfap251
Name: cilia and flagella associated protein 251
Synonyms: 4933428F06Rik, 4930415N18Rik, Wdr66
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269701
Homologene: 16964
Dclre1a
Name: DNA cross-link repair 1A
Synonyms: SNM1, 2810043H12Rik, mSNM1, SMN1a
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 55947
Homologene: 8920
Or1j18
Name: olfactory receptor family 1 subfamily J member 18
Synonyms: Olfr347, MOR136-9, GA_x6K02T2NLDC-33428755-33429693
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258945
Homologene: 51790
Nol4
Name: nucleolar protein 4
Synonyms: 4930568N03Rik, LOC383304, 1700013J13Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 319211
HGNC: HGNC:7870
Homologene: 36142
Cyp4a12a
Name: cytochrome P450, family 4, subfamily a, polypeptide 12a
Synonyms: Cyp4a12
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 277753
Homologene: 134044
Cfap52
Name: cilia and flagella associated protein 52
Synonyms: 1700019F09Rik, Wdr16, 4933417B11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71860
Homologene: 12416
Vmn2r94
Name: vomeronasal 2, receptor 94
Synonyms: EG665227
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 665227
Homologene: 129751
Or8g30
Name: olfactory receptor family 8 subfamily G member 30
Synonyms: MOR171-45, Olfr948, MOR171-51, GA_x6K02T2PVTD-33016899-33015934
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 257912
VEGA: 9
HGNC: HGNC:8484
Homologene: 79377
Cbr1
Name: carbonyl reductase 1
Synonyms: CR
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 12408
HGNC: HGNC:1548
Homologene: 37524
Tmem143
Name: transmembrane protein 143
Synonyms: 2310076O21Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 70209
Homologene: 10105
Aass
Name: aminoadipate-semialdehyde synthase
Synonyms: Lorsdh, LOR/SDH
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 30956
Homologene: 4212
Cntnap5b
Name: contactin associated protein-like 5B
Synonyms: Caspr5-2, C230078M14Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241175
Homologene: 104295
Zfp422
Name: zinc finger protein 422
Synonyms: KOX15, 2900028O21Rik, Krox-26, Krox25, Krox-25-2, Krox26
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 67255
Homologene: 5067
Aars2
Name: alanyl-tRNA synthetase 2, mitochondrial
Synonyms: Aarsl
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224805
VEGA: 17
Homologene: 56897
Cfap43
Name: cilia and flagella associated protein 43
Synonyms: 4632415N18Rik, D19Ertd652e, 4930428C11Rik, Wdr96, 4930463G05Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 100048534
Homologene: 36425
Elovl4
Name: ELOVL fatty acid elongase 4
Synonyms: elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 83603
Homologene: 41488
Nup50l
Name: nucleoporin 50 like
Synonyms: 1700123L14Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 78482
HGNC: HGNC:8065
Vmn2r65
Name: vomeronasal 2, receptor 65
Synonyms: ENSMUSG00000070600
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100009609
Gpc5
Name: glypican 5
Synonyms: A230034F01Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 103978
HGNC: HGNC:4453
Homologene: 3285
Gbp9
Name: guanylate-binding protein 9
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 236573
Homologene: 128731
Itga3
Name: integrin alpha 3
Synonyms: VLA-3 alpha 3, alpha3-integrin
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16400
HGNC: HGNC:6139
Homologene: 21129
Hlx
Name: H2.0-like homeobox
Synonyms: Hlx1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 15284
HGNC: HGNC:4978
Homologene: 7363
Or8d1
Name: olfactory receptor family 8 subfamily D member 1
Synonyms: Olfr26, MOR171-9, MTPCR09, GA_x6K02T2PVTD-32550930-32551856
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 18324
VEGA: 9
HGNC: HGNC:8481
Homologene: 79676
Cyp4f37
Name: cytochrome P450, family 4, subfamily f, polypeptide 37
Synonyms: Gm9705
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 677156
VEGA: 17
Homologene: 135840
Or4c11c
Name: olfactory receptor family 4 subfamily C member 11C
Synonyms: MOR230-3, Olfr1205, Olfr1203, MOR230-1, GA_x6K02T2Q125-50304328-50305251, GA_x6K02T2Q125-50336588-50337313
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258898
Homologene: 81567
Rasa4
Name: RAS p21 protein activator 4
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 54153
Homologene: 5080
Zfp319
Name: zinc finger protein 319
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 79233
Homologene: 11548
R3hdml
Name: R3H domain containing-like
Synonyms: OTTMUSG00000001070
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 100043899
Homologene: 45608
Bid
Name: BH3 interacting domain death agonist
Synonyms: 2700049M22Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12122
HGNC: HGNC:1050
Homologene: 923
Tas2r107
Name: taste receptor, type 2, member 107
Synonyms: STC 5-1, mt2r43, T2R4, T2R07, Tas2r7, mGR06
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 387342
Homologene: 137369
Pdrg1
Name: p53 and DNA damage regulated 1
Synonyms: 1110004D19Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68559
Homologene: 12779
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 93,320,564 bp
  • T to C, chromosome 1 at 100,141,297 bp
  • A to G, chromosome 1 at 184,727,708 bp
  • G to A, chromosome 2 at 34,712,200 bp
  • A to G, chromosome 2 at 36,734,455 bp
  • A to G, chromosome 2 at 82,988,380 bp
  • G to A, chromosome 2 at 88,831,289 bp
  • A to T, chromosome 2 at 153,009,667 bp
  • T to G, chromosome 2 at 163,499,912 bp
  • A to G, chromosome 4 at 115,328,933 bp
  • T to C, chromosome 5 at 76,611,728 bp
  • T to C, chromosome 5 at 105,081,305 bp
  • T to C, chromosome 5 at 120,621,790 bp
  • T to A, chromosome 5 at 123,322,587 bp
  • G to A, chromosome 5 at 136,089,381 bp
  • G to A, chromosome 5 at 138,241,002 bp
  • T to C, chromosome 6 at 23,092,368 bp
  • A to G, chromosome 6 at 77,244,679 bp
  • T to C, chromosome 6 at 96,165,721 bp
  • T to A, chromosome 6 at 116,626,651 bp
  • T to C, chromosome 6 at 120,900,239 bp
  • T to C, chromosome 6 at 131,659,622 bp
  • T to A, chromosome 7 at 45,916,570 bp
  • C to A, chromosome 7 at 84,940,183 bp
  • C to T, chromosome 7 at 103,250,816 bp
  • G to A, chromosome 7 at 103,418,182 bp
  • A to G, chromosome 8 at 41,283,721 bp
  • A to T, chromosome 8 at 95,329,137 bp
  • T to C, chromosome 8 at 109,683,780 bp
  • A to T, chromosome 9 at 9,009,326 bp
  • A to G, chromosome 9 at 32,260,909 bp
  • A to C, chromosome 9 at 38,855,541 bp
  • A to C, chromosome 9 at 39,319,393 bp
  • G to T, chromosome 9 at 63,667,478 bp
  • A to T, chromosome 9 at 83,788,267 bp
  • A to T, chromosome 10 at 86,719,630 bp
  • A to T, chromosome 10 at 121,611,500 bp
  • G to A, chromosome 11 at 40,721,672 bp
  • T to A, chromosome 11 at 58,880,140 bp
  • T to A, chromosome 11 at 67,939,795 bp
  • T to C, chromosome 11 at 72,917,189 bp
  • T to C, chromosome 11 at 95,062,640 bp
  • A to G, chromosome 13 at 14,120,223 bp
  • A to G, chromosome 13 at 38,197,343 bp
  • G to C, chromosome 13 at 41,129,799 bp
  • A to T, chromosome 13 at 70,606,407 bp
  • A to C, chromosome 13 at 103,830,186 bp
  • T to C, chromosome 14 at 27,394,138 bp
  • A to T, chromosome 14 at 55,023,145 bp
  • T to A, chromosome 14 at 115,428,255 bp
  • T to C, chromosome 15 at 5,105,365 bp
  • C to T, chromosome 15 at 35,639,917 bp
  • A to T, chromosome 15 at 76,189,266 bp
  • T to C, chromosome 15 at 90,971,196 bp
  • T to A, chromosome 16 at 17,639,331 bp
  • A to G, chromosome 16 at 33,963,870 bp
  • T to C, chromosome 16 at 93,610,017 bp
  • T to C, chromosome 17 at 3,148,552 bp
  • A to G, chromosome 17 at 18,244,171 bp
  • G to A, chromosome 17 at 32,634,178 bp
  • T to C, chromosome 17 at 45,507,597 bp
  • C to T, chromosome 18 at 22,524,416 bp
  • G to A, chromosome 18 at 23,040,174 bp
  • T to C, chromosome 19 at 16,616,906 bp
  • T to A, chromosome 19 at 47,765,835 bp
  • A to G, chromosome 19 at 56,542,689 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8303 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067715-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.