Strain Name:
C57BL/6J-MtgxR8323Btlr/Mmmh
Stock Number:
067724-MU
Citation ID:
RRID:MMRRC_067724-MU
Other Names:
R8323 (G1)
Major Collection:

Strain Information

Igfbp2
Name: insulin-like growth factor binding protein 2
Synonyms: Igfbp-2, IGFBP-2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16008
HGNC: HGNC:5471
Homologene: 499
Gtf2h3
Name: general transcription factor IIH, polypeptide 3
Synonyms: 34kDa, 5033417D07Rik, D5Ertd679e, BTF2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 209357
HGNC: HGNC:4657
Homologene: 1160
Zdbf2
Name: zinc finger, DBF-type containing 2
Synonyms: 4930431J08Rik, 9330107J05Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 73884
Homologene: 52868
Rnf111
Name: ring finger 111
Synonyms: Arkadia
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 93836
VEGA: 9
Homologene: 9741
Psme4
Name: proteasome (prosome, macropain) activator subunit 4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 103554
Homologene: 113742
Kif11
Name: kinesin family member 11
Synonyms: Kifl1, Eg5, Knsl1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 16551
VEGA: 19
HGNC: HGNC:6388
Homologene: 3322
Sacm1l
Name: SAC1 suppressor of actin mutations 1-like (yeast)
Synonyms: Sac1p, SAC1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 83493
VEGA: 9
Homologene: 6320
Tmem104
Name: transmembrane protein 104
Synonyms: C630005D06Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 320534
Homologene: 9802
Nsf
Name: N-ethylmaleimide sensitive fusion protein
Synonyms: N-ethylmaleimide sensitive factor, SKD2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18195
HGNC: HGNC:8016
Homologene: 4502
Braf
Name: Braf transforming gene
Synonyms: Braf2, Braf-2, 9930012E13Rik, D6Ertd631e
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 109880
HGNC: HGNC:1097
Homologene: 3197
Trim24
Name: tripartite motif-containing 24
Synonyms: Tif1a, TIF1alpha, D430004I05Rik, A130082H20Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 21848
Homologene: 20830
Heatr5a
Name: HEAT repeat containing 5A
Synonyms: D930036F22Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 320487
VEGA: 12
Homologene: 19635
Fam193b
Name: family with sequence similarity 193, member B
Synonyms: IRIZIO
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 212483
VEGA: 13
Homologene: 130095
Lrrc28
Name: leucine rich repeat containing 28
Synonyms: 2310058O11Rik, 2210012C09Rik, 1300004K21Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67867
Homologene: 16944
Dsp
Name: desmoplakin
Synonyms: 5730453H04Rik, DP, rul, 2300002E22Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 109620
HGNC: HGNC:3052
Homologene: 37922
Scn10a
Name: sodium channel, voltage-gated, type X, alpha
Synonyms: Nav1.8
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20264
VEGA: 9
Homologene: 21300
Osbpl9
Name: oxysterol binding protein-like 9
Synonyms: 2600011I06Rik, ORP-9
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100273
Homologene: 69380
Hspg2
Name: perlecan (heparan sulfate proteoglycan 2)
Synonyms: Plc, perlecan, Pcn, per
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 15530
HGNC: HGNC:5273
Homologene: 68473
Rb1
Name: RB transcriptional corepressor 1
Synonyms: Rb-1, pRb, Rb, retinoblastoma 1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 19645
HGNC: HGNC:9884
Homologene: 272
Tmem170
Name: transmembrane protein 170
Synonyms: D8Bwg1414e, 9030409E16Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66817
Homologene: 12040
Cep295
Name: centrosomal protein 295
Synonyms: LOC382128, 5830418K08Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 319675
Homologene: 27936
Csmd1
Name: CUB and Sushi multiple domains 1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 94109
Homologene: 69536
Scin
Name: scinderin
Synonyms: adseverin
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20259
Homologene: 36296
Ms4a10
Name: membrane-spanning 4-domains, subfamily A, member 10
Synonyms: 2010001N17Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 69826
Homologene: 11355
Spata31
Name: spermatogenesis associated 31
Synonyms: Fam75a, 4930458L03Rik, Spata31a
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 78124
Homologene: 84621
Dnah14
Name: dynein, axonemal, heavy chain 14
Synonyms: LOC381311, Gm980, A230079K17Rik, Dnahc14
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240960
HGNC: HGNC:2945
Homologene: 90078
Snapc4
Name: small nuclear RNA activating complex, polypeptide 4
Synonyms: 5730436L13Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227644
Homologene: 2321
Cfap206
Name: cilia and flagella associated protein 206
Synonyms: 1700003M02Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 69329
Homologene: 18713
Zfp943
Name: zinc finger prtoein 943
Synonyms: 4930432O21Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74670
Homologene: 134342
Csmd3
Name: CUB and Sushi multiple domains 3
Synonyms: 4930500N14Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239420
Homologene: 65982
Tdrd5
Name: tudor domain containing 5
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 214575
Homologene: 18312
Myo1h
Name: myosin 1H
Synonyms: 4631401O15Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231646
Homologene: 82639
Plcl1
Name: phospholipase C-like 1
Synonyms: C230017K02Rik, PLC-L, PRIP-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227120
HGNC: HGNC:9063
Homologene: 38155
Cfap251
Name: cilia and flagella associated protein 251
Synonyms: 4933428F06Rik, 4930415N18Rik, Wdr66
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269701
Homologene: 16964
Fbxw10
Name: F-box and WD-40 domain protein 10
Synonyms: SM2SH2, SM25H2, Fbw10
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 213980
Homologene: 32757
Or2w6
Name: olfactory receptor family 2 subfamily W member 6
Synonyms: MOR256-12, GA_x6K02T2QHY8-11577590-11578528, Olfr1361
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 258534
Homologene: 88362
Pcdhb8
Name: protocadherin beta 8
Synonyms: Pcdhb5C, PcdhbH
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93879
HGNC: HGNC:8690
Homologene: 89038
Slc51a
Name: solute carrier family 51, alpha subunit
Synonyms: OSTalpha, Osta, D630035O19Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 106407
Homologene: 44941
Or1e30
Name: olfactory receptor family 1 subfamily E member 30
Synonyms: MOR135-26, Olfr390, GA_x6K02T2P1NL-3938806-3939741
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258344
Homologene: 115483
Nrap
Name: nebulin-related anchoring protein
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18175
HGNC: HGNC:7988
Homologene: 4499
Zfp944
Name: zinc finger protein 944
Synonyms: 6330416L07Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 319615
VEGA: 17
Homologene: 133237
H2-T24
Name: histocompatibility 2, T region locus 24
Synonyms: H-2T24
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 15042
Homologene: 69019
Spdya
Name: speedy/RINGO cell cycle regulator family, member A
Synonyms: 4921517J08Rik, speedy A1, speedy A2, speedy/ringo, 4930548B21Rik, Spdy1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 70891
Homologene: 16357
Wdhd1
Name: WD repeat and HMG-box DNA binding protein 1
Synonyms: AND-1, D630024B06Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 218973
Homologene: 56019
Dcbld2
Name: discoidin, CUB and LCCL domain containing 2
Synonyms: CLCP1, 1700055P21Rik, Esdn
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 73379
Homologene: 12499
Gm1110
Name: predicted gene 1110
Synonyms: LOC382064
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 382064
VEGA: 9
Homologene: 78608
A3galt2
Name: alpha 1,3-galactosyltransferase 2
Synonyms: LOC215493, iGb3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 215493
Homologene: 16326
Fdps
Name: farnesyl diphosphate synthetase
Synonyms: Fdpsl1, 6030492I17Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 110196
HGNC: HGNC:3631
Homologene: 1519
Sardh
Name: sarcosine dehydrogenase
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 192166
Homologene: 5149
Ccdc57
Name: coiled-coil domain containing 57
Synonyms: 4933434G05Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71276
Homologene: 52351
Pcdhb15
Name: protocadherin beta 15
Synonyms: PcdhbO, Pcdhb7
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93886
HGNC: HGNC:8692
Homologene: 32429
Galk2
Name: galactokinase 2
Synonyms: 2810017M24Rik, Gk2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 69976
HGNC: HGNC:4119
Homologene: 13654
Vmn2r96
Name: vomeronasal 2, receptor 96
Synonyms: EG433070
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 433070
Prss3
Name: serine protease 3
Synonyms: MTG, Try3, Tb, TRY4, mesotrypsin
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 22073
Homologene: 88408
Cldn13
Name: claudin 13
Synonyms: 2500004B14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 57255
HGNC: HGNC:2046
Uap1
Name: UDP-N-acetylglucosamine pyrophosphorylase 1
Synonyms: ESTM38, AGX1, SPAG2, AgX
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 107652
Homologene: 2342
Lyg1
Name: lysozyme G-like 1
Synonyms: 2300002O18Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 69541
Homologene: 18376
Sele
Name: selectin, endothelial cell
Synonyms: E-selectin, CD62E, Elam
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20339
Homologene: 389
Catsperb
Name: cation channel sperm associated auxiliary subunit beta
Synonyms: 4932415G16Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 271036
VEGA: 12
Homologene: 81904
Gm340
Name: predicted gene 340
Synonyms: LOC381224
Type: Gene
Species: Mouse
Chromosome: 19
Slc22a28
Name: solute carrier family 22, member 28
Synonyms: Gm5631
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 434674
VEGA: 19
Homologene: 77136
Slc17a1
Name: solute carrier family 17 (sodium phosphate), member 1
Synonyms: Npt1, NAPI-1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20504
Homologene: 48324
Slc2a10
Name: solute carrier family 2 (facilitated glucose transporter), member 10
Synonyms: Glut10
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 170441
Homologene: 38551
Nmnat3
Name: nicotinamide nucleotide adenylyltransferase 3
Synonyms: PNAT3, 4933408N02Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74080
Homologene: 39772
Zfp747l1
Name: zinc finger protein 747 like 1
Synonyms: 9130019O22Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 78921
Homologene: 118005
Gm3727
Name: predicted gene 3727
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 102632113
Homologene: 115686
Igkv17-127
Name: immunoglobulin kappa variable 17-127
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243433
HGNC: HGNC:5835
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 37,949,937 bp
  • T to A, chromosome 1 at 55,697,736 bp
  • G to A, chromosome 1 at 63,302,914 bp
  • C to T, chromosome 1 at 72,849,621 bp
  • T to C, chromosome 1 at 156,267,262 bp
  • G to A, chromosome 1 at 164,051,638 bp
  • A to G, chromosome 1 at 170,151,066 bp
  • A to G, chromosome 1 at 181,704,544 bp
  • T to C, chromosome 2 at 26,364,699 bp
  • C to T, chromosome 2 at 27,235,564 bp
  • C to T, chromosome 2 at 125,866,378 bp
  • T to A, chromosome 2 at 165,514,751 bp
  • G to T, chromosome 3 at 89,095,389 bp
  • C to T, chromosome 4 at 34,719,647 bp
  • A to G, chromosome 4 at 109,107,922 bp
  • T to C, chromosome 4 at 128,755,558 bp
  • C to G, chromosome 4 at 137,518,979 bp
  • A to G, chromosome 5 at 114,342,139 bp
  • A to G, chromosome 5 at 123,297,525 bp
  • A to G, chromosome 5 at 124,582,471 bp
  • A to G, chromosome 5 at 134,914,974 bp
  • G to T, chromosome 6 at 37,915,298 bp
  • T to C, chromosome 6 at 39,643,124 bp
  • A to G, chromosome 6 at 41,374,324 bp
  • A to G, chromosome 6 at 67,861,514 bp
  • G to T, chromosome 7 at 67,595,707 bp
  • A to T, chromosome 7 at 127,384,449 bp
  • G to T, chromosome 8 at 17,216,735 bp
  • A to T, chromosome 8 at 111,876,521 bp
  • G to T, chromosome 9 at 15,338,233 bp
  • T to A, chromosome 9 at 15,353,061 bp
  • A to G, chromosome 9 at 26,902,423 bp
  • T to A, chromosome 9 at 70,475,922 bp
  • T to C, chromosome 9 at 98,410,223 bp
  • C to A, chromosome 9 at 119,609,396 bp
  • T to C, chromosome 9 at 123,548,922 bp
  • T to A, chromosome 11 at 30,843,532 bp
  • G to A, chromosome 11 at 62,876,680 bp
  • A to T, chromosome 11 at 73,786,940 bp
  • C to A, chromosome 11 at 103,928,839 bp
  • T to C, chromosome 11 at 115,243,373 bp
  • G to T, chromosome 11 at 120,897,924 bp
  • T to C, chromosome 12 at 40,079,682 bp
  • C to T, chromosome 12 at 51,955,506 bp
  • A to C, chromosome 12 at 101,409,399 bp
  • T to A, chromosome 13 at 21,659,132 bp
  • C to A, chromosome 13 at 23,887,999 bp
  • C to T, chromosome 13 at 38,172,830 bp
  • A to T, chromosome 13 at 55,554,410 bp
  • C to A, chromosome 13 at 64,922,251 bp
  • C to T, chromosome 14 at 7,261,693 bp
  • A to T, chromosome 14 at 47,274,795 bp
  • A to G, chromosome 14 at 73,265,583 bp
  • T to C, chromosome 15 at 47,698,151 bp
  • A to G, chromosome 16 at 32,476,379 bp
  • T to A, chromosome 16 at 58,463,110 bp
  • A to T, chromosome 17 at 18,582,761 bp
  • A to G, chromosome 17 at 21,992,782 bp
  • A to T, chromosome 17 at 22,339,254 bp
  • T to A, chromosome 17 at 36,017,539 bp
  • A to G, chromosome 17 at 71,588,592 bp
  • T to A, chromosome 18 at 37,355,423 bp
  • A to C, chromosome 18 at 37,475,662 bp
  • T to A, chromosome 19 at 8,131,424 bp
  • G to A, chromosome 19 at 10,962,999 bp
  • T to A, chromosome 19 at 37,384,244 bp
  • T to C, chromosome 19 at 41,583,597 bp
  • T to C, chromosome 19 at 56,389,823 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8323 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067724-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.