Strain Name:
C57BL/6J-MtgxR8362Btlr/Mmmh
Stock Number:
067808-MU
Citation ID:
RRID:MMRRC_067808-MU
Other Names:
R8362 (G1)
Major Collection:

Strain Information

Gria2
Name: glutamate receptor, ionotropic, AMPA2 (alpha 2)
Synonyms: GluA2, Glur2, GluR2, GluR-B, Glur-2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14800
HGNC: HGNC:4572
Homologene: 20225
Rbms1
Name: RNA binding motif, single stranded interacting protein 1
Synonyms: YC1, MSSP-2, MSSP-3, 2600014B10Rik, MSSP-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56878
HGNC: HGNC:9907
Homologene: 9640
Nudt5
Name: nudix hydrolase 5
Synonyms: nudix (nucleoside diphosphate linked moiety X)-type motif 5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 53893
HGNC: HGNC:8052
Homologene: 5388
Ascc3
Name: activating signal cointegrator 1 complex subunit 3
Synonyms: B630009I04Rik, Helic1, ASC1p200
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 77987
VEGA: 10
Homologene: 4973
Ankrd11
Name: ankyrin repeat domain 11
Synonyms: 9530048I21Rik, Yod, 3010027A04Rik, 2410104C19Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 77087
Homologene: 69134
Zc3h13
Name: zinc finger CCCH type containing 13
Synonyms: 4930570G11Rik, C87618, 3110050K21Rik, 2600010B19Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 67302
VEGA: 14
Dop1a
Name: DOP1 leucine zipper like protein A
Synonyms: D9Ertd809e, Dopey1, B130005I07Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320615
Homologene: 26645
Zfp516
Name: zinc finger protein 516
Synonyms: Zfp26l, C330029B10Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 329003
VEGA: 18
Homologene: 37122
Polr1a
Name: polymerase (RNA) I polypeptide A
Synonyms: Rpo1-4, 3010014K16Rik, RPA194, 194kDa, mRPA1, 2900087K15Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20019
Homologene: 7033
Lrrfip1
Name: leucine rich repeat (in FLII) interacting protein 1
Synonyms: Fliiap1, FLAP (FLI LRR associated protein)
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16978
HGNC: HGNC:6702
Homologene: 48301
Abr
Name: active BCR-related gene
Synonyms: 6330400K15Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 109934
HGNC: HGNC:81
Homologene: 11081
Stt3b
Name: STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae)
Synonyms: 1300006C19Rik, Simp
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 68292
VEGA: 9
Homologene: 7387
Amotl1
Name: angiomotin-like 1
Synonyms: 2310067L22Rik, 4932416D09Rik, JEAP, 2310010G08Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 75723
Homologene: 43977
Cpt1a
Name: carnitine palmitoyltransferase 1a, liver
Synonyms: L-CPT I, Cpt1, CPTI
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 12894
VEGA: 19
HGNC: HGNC:2328
Homologene: 1413
Rasal1
Name: RAS protein activator like 1 (GAP1 like)
Synonyms: MRASAL
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19415
HGNC: HGNC:9873
Homologene: 3423
Spg11
Name: SPG11, spatacsin vesicle trafficking associated
Synonyms: spastic paraplegia 11, 6030465E24Rik, C530005A01Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 214585
Homologene: 41614
Homer1
Name: homer scaffolding protein 1
Synonyms: PSD-Zip45, Ves-1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 26556
Homologene: 3155
H13
Name: histocompatibility 13
Synonyms: Spp, 1200006O09Rik, H-13, Hm13, 5031424B04Rik, 4930443L17Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14950
Homologene: 7749
Qser1
Name: glutamine and serine rich 1
Synonyms: 4732486I23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99003
Homologene: 11710
Ska3
Name: spindle and kinetochore associated complex subunit 3
Synonyms: F630043A04Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219114
VEGA: 14
Homologene: 124284
Khdc3
Name: KH domain containing 3, subcortical maternal complex member
Synonyms: ecat1, FILIA, 2410004A20Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 66991
Homologene: 49842
Clec4b1
Name: C-type lectin domain family 4, member b1
Synonyms: DCAR, 1810046I24Rik, DCARbeta, mDcar2, 1810046I24Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 69810
Homologene: 130350
Flywch1
Name: FLYWCH-type zinc finger 1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224613
VEGA: 17
Homologene: 72130
Cdc42bpa
Name: CDC42 binding protein kinase alpha
Synonyms: A930014J19Rik, DMPK-like
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226751
HGNC: HGNC:1737
Homologene: 55765
Spata31
Name: spermatogenesis associated 31
Synonyms: Fam75a, 4930458L03Rik, Spata31a
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 78124
Homologene: 84621
Ush2a
Name: usherin
Synonyms: MUSH2A, LOC269160, Ush2a, A930037M10Rik, A930011D15Rik, LOC381317, Ushrn
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22283
Homologene: 66151
Dnah12
Name: dynein, axonemal, heavy chain 12
Synonyms: Dnahc12, HL19, DLP12, LOC380889, Dnahc7l, 4921531P07Rik, Hdhc3, DHC3, HL-19
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 110083
HGNC: HGNC:2943
Homologene: 56821
Tprg1l
Name: transformation related protein 63 regulated 1 like
Synonyms: Tprgl, mover, 1200015A19Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67808
Homologene: 12192
Lrrc37
Name: leucine rich repeat containing 37
Synonyms: Gm884, LOC380730
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380730
Homologene: 134511
Abcb1b
Name: ATP-binding cassette, sub-family B member 1B
Synonyms: mdr, Mdr1b, Mdr1, Pgy-1, Abcb1, Pgy1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18669
HGNC: HGNC:40
Homologene: 69084
Tnxb
Name: tenascin XB
Synonyms: Tnx, TN-MHC
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 81877
Homologene: 49589
Srgap1
Name: SLIT-ROBO Rho GTPase activating protein 1
Synonyms: 4930572H05Rik, Arhgap13
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 117600
Homologene: 56898
Morc2b
Name: microrchidia 2B
Synonyms: 4932411A10Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240069
Homologene: 18615
Ptprt
Name: protein tyrosine phosphatase receptor type T
Synonyms: RPTPrho
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19281
HGNC: HGNC:9682
Homologene: 56924
Vmn2r93
Name: vomeronasal 2, receptor 93
Synonyms: EG627132
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627132
Homologene: 129750
Megf8
Name: multiple EGF-like-domains 8
Synonyms: b2b288Clo, b2b1702Clo, m687Ddg, Egfl4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 269878
HGNC: HGNC:3233
Homologene: 15988
Zfp623
Name: zinc finger protein 623
Synonyms: 2610029D06Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 78834
VEGA: 15
Homologene: 15994
Hecw2
Name: HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
Synonyms: A730039N16Rik, D030049F17Rik, Nedl2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329152
Homologene: 66192
Pcnx1
Name: pecanex 1
Synonyms: Pcnx, 3526401J03Rik, 2900024E21Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 54604
VEGA: 12
Homologene: 40997
Or6c211
Name: olfactory receptor family 6 subfamily C member 211
Synonyms: GA_x6K02T2PULF-11349138-11348182, Olfr801, MOR110-10
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258282
Homologene: 138306
Slc26a4
Name: solute carrier family 26, member 4
Synonyms: Pds, pendrin
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 23985
VEGA: 12
HGNC: HGNC:8818
Homologene: 20132
Hars2
Name: histidyl-tRNA synthetase 2
Synonyms: HARSR, 4631412B19Rik, Harsl, HO3
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 70791
HGNC: HGNC:4817
Homologene: 40819
Smg8
Name: SMG8 nonsense mediated mRNA decay factor
Synonyms: smg-8 homolog, nonsense mediated mRNA decay factor (C. elegans), 1200011M11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74133
Homologene: 32393
Itga2b
Name: integrin alpha 2b
Synonyms: GpIIb, alphaIIb, CD41, GP IIb, platelet glycoprotein IIb
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16399
HGNC: HGNC:6138
Homologene: 37304
Alcam
Name: activated leukocyte cell adhesion molecule
Synonyms: SC1, DM-GRASP, MuSC, BEN, CD166
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 11658
HGNC: HGNC:400
Homologene: 1229
Vmn2r60
Name: vomeronasal 2, receptor 60
Synonyms: Casr-rs3, Gprc2a-rs3, EG637898
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 637898
Homologene: 129683
Slc25a24
Name: solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 24
Synonyms: 2610016M12Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229731
Homologene: 92693
Fndc1
Name: fibronectin type III domain containing 1
Synonyms: 1110027O12Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 68655
Vmn2r81
Name: vomeronasal 2, receptor 81
Synonyms: pheromone recepter, V2rf2, EC1-VR2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216144
Homologene: 83483
Paqr5
Name: progestin and adipoQ receptor family member V
Synonyms: 0610010I15Rik, mPRg
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74090
Homologene: 9788
Gabra1
Name: gamma-aminobutyric acid type A receptor subunit alpha 1
Synonyms: GABAA alpha 1, GABAAR alpha1, Gabra-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14394
HGNC: HGNC:4075
Homologene: 629
1810009A15Rik
Name: RIKEN cDNA 1810009A15 gene
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 66276
Homologene: 84408
Ivd
Name: isovaleryl coenzyme A dehydrogenase
Synonyms: 1300016K07Rik, 6720455E18Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56357
HGNC: HGNC:6186
Homologene: 1676
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 54,040,491 bp
  • T to A, chromosome 1 at 91,053,701 bp
  • C to T, chromosome 1 at 180,162,125 bp
  • G to A, chromosome 1 at 188,957,453 bp
  • A to G, chromosome 2 at 5,853,511 bp
  • C to T, chromosome 2 at 60,962,739 bp
  • A to G, chromosome 2 at 104,789,901 bp
  • T to A, chromosome 2 at 118,877,941 bp
  • G to T, chromosome 2 at 122,118,361 bp
  • T to A, chromosome 2 at 152,686,391 bp
  • A to T, chromosome 2 at 161,551,747 bp
  • T to C, chromosome 3 at 80,707,890 bp
  • T to A, chromosome 3 at 109,158,562 bp
  • G to C, chromosome 4 at 154,160,358 bp
  • A to T, chromosome 5 at 8,798,758 bp
  • C to T, chromosome 5 at 120,675,420 bp
  • T to C, chromosome 6 at 71,964,667 bp
  • T to C, chromosome 6 at 123,050,643 bp
  • C to A, chromosome 7 at 25,340,518 bp
  • T to A, chromosome 7 at 42,195,530 bp
  • A to T, chromosome 8 at 122,892,058 bp
  • G to A, chromosome 9 at 14,644,922 bp
  • A to T, chromosome 9 at 61,972,663 bp
  • A to T, chromosome 9 at 73,103,566 bp
  • G to A, chromosome 9 at 86,513,888 bp
  • A to G, chromosome 9 at 115,254,920 bp
  • A to C, chromosome 10 at 50,642,596 bp
  • T to A, chromosome 10 at 79,267,449 bp
  • A to G, chromosome 10 at 121,855,478 bp
  • G to T, chromosome 10 at 129,670,231 bp
  • G to T, chromosome 11 at 42,176,004 bp
  • A to T, chromosome 11 at 76,479,128 bp
  • A to T, chromosome 11 at 87,078,055 bp
  • T to A, chromosome 11 at 102,461,363 bp
  • A to G, chromosome 11 at 103,615,337 bp
  • C to T, chromosome 12 at 31,544,507 bp
  • A to C, chromosome 12 at 81,967,056 bp
  • A to G, chromosome 13 at 64,922,230 bp
  • T to A, chromosome 13 at 93,366,289 bp
  • T to A, chromosome 14 at 26,854,831 bp
  • T to C, chromosome 14 at 57,816,648 bp
  • C to A, chromosome 14 at 75,324,469 bp
  • T to C, chromosome 15 at 75,947,639 bp
  • A to T, chromosome 16 at 52,295,024 bp
  • A to G, chromosome 17 at 7,782,375 bp
  • G to A, chromosome 17 at 18,326,091 bp
  • G to T, chromosome 17 at 23,756,708 bp
  • G to T, chromosome 17 at 33,138,321 bp
  • A to G, chromosome 17 at 34,712,972 bp
  • T to A, chromosome 18 at 36,790,175 bp
  • T to C, chromosome 18 at 82,986,894 bp
  • C to T, chromosome 19 at 3,370,744 bp
  • T to A, chromosome 19 at 8,890,031 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8362 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067808-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.