Strain Name:
C57BL/6J-MtgxR8459Btlr/Mmmh
Stock Number:
067836-MU
Citation ID:
RRID:MMRRC_067836-MU
Other Names:
R8459 (G1)
Major Collection:

Strain Information

Cdk17
Name: cyclin dependent kinase 17
Synonyms: 6430598J10Rik, Pctk2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237459
VEGA: 10
HGNC: HGNC:8750
Homologene: 55666
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Aclp7, trabeculin alpha, Acf7
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11426
Homologene: 136191
Ep400
Name: E1A binding protein p400
Synonyms: 1700020J09Rik, p400, mDomino
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75560
Homologene: 38779
Phip
Name: pleckstrin homology domain interacting protein
Synonyms: Wdr11, 2810004D21Rik, 4632404O06Rik, Ndrp
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 83946
Homologene: 41209
Syne1
Name: spectrin repeat containing, nuclear envelope 1
Synonyms: enaptin165, nesprin-1, A330049M09Rik, C130039F11Rik, SYNE-1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 64009
VEGA: 10
Homologene: 52329
Mbnl1
Name: muscleblind like splicing regulator 1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 56758
HGNC: HGNC:6923
Homologene: 23186
Ecpas
Name: Ecm29 proteasome adaptor and scaffold
Synonyms: AI314180
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230249
Homologene: 6056
Dnah8
Name: dynein, axonemal, heavy chain 8
Synonyms: Hst6.7b, Dnahc8, P1-Loop
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13417
VEGA: 17
HGNC: HGNC:2952
Homologene: 1049
Ank1
Name: ankyrin 1, erythroid
Synonyms: pale, Ank-1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11733
HGNC: HGNC:492
Homologene: 55427
Fsip2
Name: fibrous sheath-interacting protein 2
Synonyms: OTTMUSG00000013335
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241516
Homologene: 110349
Madd
Name: MAP-kinase activating death domain
Synonyms: Rab3 GEP, 9630059K23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228355
HGNC: HGNC:6766
Homologene: 14249
Skint5
Name: selection and upkeep of intraepithelial T cells 5
Synonyms: OTTMUSG00000008560
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242627
Homologene: 135888
Vmn1r50
Name: vomeronasal 1 receptor 50
Synonyms: VN2, V1rb1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 113852
Homologene: 113975
Or5h17
Name: olfactory receptor family 5 subfamily H member 17
Synonyms: MOR183-2, Olfr183, GA_x54KRFPKG5P-55229158-55230087
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 258478
Homologene: 27178
Hal
Name: histidine ammonia lyase
Synonyms: histidase, Hsd
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 15109
HGNC: HGNC:4806
Homologene: 68229
Dpp7
Name: dipeptidylpeptidase 7
Synonyms: QPP
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 83768
Homologene: 22748
Bpifb9a
Name: BPI fold containing family B, member 9A
Synonyms: vomeromodulin, 4833413D08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71425
Homologene: 128535
Spata16
Name: spermatogenesis associated 16
Synonyms: Nyd-sp12, spermatogenesis-related protein, 4930503K02Rik, 4921511F01Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 70862
Homologene: 49974
Fbrs
Name: fibrosin
Synonyms: Fbs1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14123
Homologene: 79554
Celsr3
Name: cadherin, EGF LAG seven-pass G-type receptor 3
Synonyms: Adgrc3, flamingo, Fmi1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 107934
HGNC: HGNC:3230
Homologene: 1077
Slc26a11
Name: solute carrier family 26, member 11
Synonyms: F630021I08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268512
Homologene: 13685
Aim2
Name: absent in melanoma 2
Synonyms: Ifi210, LOC383619
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 383619
HGNC: HGNC:357
Homologene: 83226
Cacnb3
Name: calcium channel, voltage-dependent, beta 3 subunit
Synonyms: Cchb3, Beta3
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12297
VEGA: 15
HGNC: HGNC:1403
Homologene: 20187
Sh3tc1
Name: SH3 domain and tetratricopeptide repeats 1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231147
Homologene: 10360
Cluap1
Name: clusterin associated protein 1
Synonyms: 2310030D15Rik, 2610111M03Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 76779
Homologene: 14831
Chml
Name: choroideremia-like
Synonyms: Rep2, E030003F13Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12663
HGNC: HGNC:1941
Homologene: 31055
Disc1
Name: disrupted in schizophrenia 1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244667
HGNC: HGNC:2888
Homologene: 10257
Htra3
Name: HtrA serine peptidase 3
Synonyms: 9530081K03Rik, 2210021K23Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 78558
Homologene: 12697
Itga3
Name: integrin alpha 3
Synonyms: VLA-3 alpha 3, alpha3-integrin
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16400
HGNC: HGNC:6139
Homologene: 21129
Gnas
Name: GNAS complex locus
Synonyms: Galphas, Oedsml, Nespl, Gnas1, XLalphas, Nesp, G alpha s, SCG6, neuroendocrine-specific Golgi protein p55 isoform 1, Gs alpha, Gs-alpha, Gsa, P1, P3, Nesp55, P2, Gnasxl
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14683
HGNC: HGNC:4392
Homologene: 55534
Cd200l1
Name: CD200 molecule like 1
Synonyms: LOC385647, Gm609, iSEC1, LOC208166
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 208166
Homologene: 86707
Car8
Name: carbonic anhydrase 8
Synonyms: Cals1, CA-RP VIII, wdl, Carp
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12319
HGNC: HGNC:1382
Homologene: 20861
Lrrc58
Name: leucine rich repeat containing 58
Synonyms: C330018J07Rik, 1810012N18Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 320184
Homologene: 14598
Vmn1r16
Name: vomeronasal 1 receptor 16
Synonyms: V1rc29
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 171202
Homologene: 123821
Cryge
Name: crystallin, gamma E
Synonyms: Cryg-6
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12968
HGNC: HGNC:2411
Homologene: 128417
Gstt1
Name: glutathione S-transferase, theta 1
Synonyms: Gstt1-1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14871
HGNC: HGNC:4641
Homologene: 134739
Prorsd1
Name: prolyl-tRNA synthetase domain containing 1
Synonyms: Prdxdd1, 2010316F05Rik, Ncrna00117
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67939
Homologene: 12215
Cmtm1
Name: CKLF-like MARVEL transmembrane domain containing 1
Synonyms: CHLFH1a, CKLFH1, Cklfsf1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 100504164
Homologene: 134399
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 65,048,682 bp
  • CTTGTTGT to CTTGT, chromosome 1 at 173,461,970 bp
  • T to C, chromosome 1 at 175,688,031 bp
  • C to A, chromosome 2 at 25,352,538 bp
  • T to A, chromosome 2 at 82,979,678 bp
  • A to G, chromosome 2 at 91,162,526 bp
  • T to G, chromosome 2 at 154,260,233 bp
  • A to T, chromosome 2 at 174,284,939 bp
  • A to G, chromosome 3 at 26,667,527 bp
  • T to G, chromosome 3 at 60,622,207 bp
  • C to T, chromosome 4 at 8,189,302 bp
  • A to G, chromosome 4 at 58,821,379 bp
  • A to T, chromosome 4 at 113,846,284 bp
  • T to C, chromosome 4 at 123,480,314 bp
  • G to A, chromosome 5 at 35,671,225 bp
  • C to A, chromosome 5 at 35,721,589 bp
  • A to G, chromosome 5 at 94,682,883 bp
  • A to G, chromosome 5 at 110,708,891 bp
  • A to C, chromosome 6 at 57,323,362 bp
  • A to G, chromosome 6 at 90,107,253 bp
  • C to T, chromosome 7 at 127,483,157 bp
  • T to C, chromosome 8 at 23,115,512 bp
  • A to G, chromosome 8 at 104,309,511 bp
  • A to C, chromosome 8 at 125,165,155 bp
  • G to T, chromosome 9 at 82,876,053 bp
  • A to G, chromosome 9 at 108,829,630 bp
  • G to A, chromosome 10 at 5,424,277 bp
  • G to A, chromosome 10 at 75,794,109 bp
  • G to C, chromosome 10 at 93,232,427 bp
  • A to G, chromosome 10 at 93,516,315 bp
  • T to C, chromosome 11 at 29,513,286 bp
  • A to G, chromosome 11 at 95,068,807 bp
  • T to A, chromosome 11 at 119,368,817 bp
  • G to A, chromosome 12 at 115,507,636 bp
  • C to T, chromosome 15 at 98,639,512 bp
  • T to C, chromosome 16 at 3,937,589 bp
  • A to G, chromosome 16 at 37,878,510 bp
  • T to A, chromosome 16 at 45,417,908 bp
  • A to T, chromosome 16 at 58,999,985 bp
  • T to C, chromosome 17 at 30,725,247 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8459 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067836-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.