Strain Name:
C57BL/6J-MtgxR8440Btlr/Mmmh
Stock Number:
067884-MU
Citation ID:
RRID:MMRRC_067884-MU
Other Names:
R8440 (G1)
Major Collection:

Strain Information

Kifc3
Name: kinesin family member C3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16582
HGNC: HGNC:6326
Homologene: 124421
Prkdc
Name: protein kinase, DNA activated, catalytic polypeptide
Synonyms: slip, DNAPDcs, DNA-PKcs, DNA-PK, DOXNPH, XRCC7, dxnph
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 19090
HGNC: HGNC:9413
Homologene: 5037
Dcaf1
Name: DDB1 and CUL4 associated factor 1
Synonyms: Vprbp, B930007L02Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 321006
Homologene: 8805
Fus
Name: fused in sarcoma
Synonyms: translocated in liposarcoma, D430004D17Rik, hnRNP P2, Tls, pigpen, D930039C12Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233908
HGNC: HGNC:4010
Homologene: 134091
Suco
Name: SUN domain containing ossification factor
Synonyms: osteopotentia, AI848100, Opt
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226551
HGNC: HGNC:1240
Homologene: 32212
Chka
Name: choline kinase alpha
Synonyms: Chk, choline/ethanolamine kinase alpha, EtnK-alpha, ChoK, CK/EK-alpha
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 12660
HGNC: HGNC:1937
Homologene: 88575
Nedd4l
Name: neural precursor cell expressed, developmentally down-regulated gene 4-like
Synonyms: Nedd4b, 1300012C07Rik, Nedd4-2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 83814
VEGA: 18
HGNC: HGNC:7728
Homologene: 86986
Eif3l
Name: eukaryotic translation initiation factor 3, subunit L
Synonyms: PAF67, HSP-66Y, 0610011H21Rik, D15N1e, Eif3s6ip, Eif3eip
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223691
VEGA: 15
Homologene: 9380
Rabgap1
Name: RAB GTPase activating protein 1
Synonyms: Gapcena
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227800
Homologene: 49301
Rtn1
Name: reticulon 1
Synonyms: Rtn1-b, 4930441F12Rik, Nsp, Rtn1-a, 0710005K15Rik, Rtn1-c
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 104001
Homologene: 49654
Bbs9
Name: Bardet-Biedl syndrome 9
Synonyms: EST 3159894, E130103I17Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 319845
Homologene: 44480
Zfp592
Name: zinc finger protein 592
Synonyms: A730014M16Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233410
Homologene: 8759
Egfr
Name: epidermal growth factor receptor
Synonyms: 9030024J15Rik, Erbb, Errb1, avian erythroblastic leukemia viral (v-erb-b) oncogene homolog, Wa5
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 13649
HGNC: HGNC:3236
Homologene: 74545
Cpq
Name: carboxypeptidase Q
Synonyms: Lal-1, Pgcp, 1190003P12Rik, HLS2, 2610034C17Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 54381
VEGA: 15
Homologene: 9401
Frmd8
Name: FERM domain containing 8
Synonyms: 4931429L16Rik, iTAP, 2310035N23Rik, 1200004M23Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 67457
Homologene: 32653
Ppip5k2
Name: diphosphoinositol pentakisphosphate kinase 2
Synonyms: Hisppd1, Vip2, Cfap160
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227399
Homologene: 49409
Map1s
Name: microtubule-associated protein 1S
Synonyms: 6430517J16Rik, Bpy2ip1, Map8, Mtap1s, VCY2IP1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 270058
Homologene: 10047
St6galnac2
Name: ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
Synonyms: ST6GalNAc II, Siat7b, Siat7
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20446
Homologene: 4714
Omp
Name: olfactory marker protein
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18378
HGNC: HGNC:8136
Homologene: 36195
Hmcn2
Name: hemicentin 2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 665700
Homologene: 90772
Hmcn1
Name: hemicentin 1
Synonyms: LOC240793, EG545370
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 545370
Homologene: 23741
Plek
Name: pleckstrin
Synonyms: 2010300B13Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 56193
HGNC: HGNC:9070
Homologene: 2000
Vmn2r61
Name: vomeronasal 2, receptor 61
Synonyms: Gprc2a-rs2, EG637873, Casr-rs2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 637873
Homologene: 129683
Xkr9
Name: X-linked Kx blood group related 9
Synonyms: LOC381246
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 381246
Homologene: 20056
Ssu2
Name: ssu-2 homolog
Synonyms: D630042P16Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243612
Homologene: 136556
Lgi4
Name: leucine-rich repeat LGI family, member 4
Synonyms: clp
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243914
Homologene: 16408
Bsn
Name: bassoon
Synonyms: presynaptic cytomatrix protein
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12217
HGNC: HGNC:1117
Homologene: 31161
Inpp4b
Name: inositol polyphosphate-4-phosphatase, type II
Synonyms: E130107I17Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234515
HGNC: HGNC:6075
Homologene: 20832
Stk19
Name: serine/threonine kinase 19
Synonyms: G11, RP1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 54402
Homologene: 10449
Meiob
Name: meiosis specific with OB domains
Synonyms: 4930528F23Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 75178
VEGA: 17
Homologene: 102013
Hsd11b1
Name: hydroxysteroid 11-beta dehydrogenase 1
Synonyms: 11beta-hydroxysteroid dehydrogenase type 1, 11beta-HSD-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 15483
HGNC: HGNC:5208
Homologene: 68471
Vmn2r54
Name: vomeronasal 2, receptor 54
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 666085
Homologene: 104040
Or51h1
Name: olfactory receptor family 51 subfamily H member 1
Synonyms: MOR10-1, Olfr555, GA_x6K02T2PBJ9-5375442-5376389
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259107
Homologene: 51817
Or5a1
Name: olfactory receptor family 5 subfamily A member 1
Synonyms: MOR215-3, GA_x6K02T2RE5P-2479601-2478648, V5, Olfr76
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258677
HGNC: HGNC:8319
Homologene: 17342
Or1ad6
Name: olfactory receptor family 1 subfamily AD member 6
Synonyms: GA_x6K02T2QP88-4469162-4468215, Olfr1378, MOR129-2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258912
HGNC: HGNC:8182
Homologene: 133679
Ak5
Name: adenylate kinase 5
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229949
HGNC: HGNC:365
Homologene: 76103
Uck1
Name: uridine-cytidine kinase 1
Synonyms: URK1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22245
Homologene: 7990
Vmn1r128
Name: vomeronasal 1 receptor 128
Synonyms: Gm8509
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 667199
Homologene: 104166
Cbr3
Name: carbonyl reductase 3
Synonyms: 1110001J05Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 109857
HGNC: HGNC:1549
Homologene: 20332
Pcdha3
Name: protocadherin alpha 3
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 192163
HGNC: HGNC:8669
Homologene: 129613
Trbv20
Name: T cell receptor beta, variable 20
Synonyms: Tcrb-V15, Gm16911
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 100124685
Igkv4-91
Name: immunoglobulin kappa chain variable 4-91
Synonyms: Gm10879, ENSMUSG00000056850
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 434033
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 13,701,379 bp
  • T to C, chromosome 1 at 97,747,551 bp
  • T to A, chromosome 1 at 150,694,920 bp
  • G to A, chromosome 1 at 161,852,338 bp
  • T to C, chromosome 1 at 193,222,112 bp
  • C to A, chromosome 2 at 31,391,076 bp
  • C to A, chromosome 2 at 32,260,141 bp
  • T to C, chromosome 2 at 37,542,680 bp
  • G to C, chromosome 3 at 152,504,043 bp
  • T to A, chromosome 6 at 41,188,958 bp
  • C to T, chromosome 6 at 68,768,572 bp
  • T to A, chromosome 6 at 112,387,989 bp
  • A to T, chromosome 7 at 12,616,086 bp
  • G to A, chromosome 7 at 21,349,820 bp
  • T to A, chromosome 7 at 31,060,624 bp
  • A to T, chromosome 7 at 42,266,656 bp
  • G to C, chromosome 7 at 81,041,523 bp
  • A to G, chromosome 7 at 98,145,046 bp
  • G to A, chromosome 7 at 102,659,068 bp
  • T to C, chromosome 7 at 127,969,826 bp
  • A to G, chromosome 8 at 70,912,519 bp
  • G to A, chromosome 8 at 82,041,895 bp
  • G to T, chromosome 8 at 95,109,794 bp
  • T to A, chromosome 9 at 22,567,750 bp
  • T to A, chromosome 9 at 106,847,874 bp
  • G to A, chromosome 9 at 108,111,452 bp
  • T to C, chromosome 11 at 16,909,831 bp
  • T to C, chromosome 11 at 16,995,276 bp
  • T to C, chromosome 11 at 50,969,197 bp
  • T to C, chromosome 11 at 116,677,548 bp
  • T to A, chromosome 12 at 72,223,399 bp
  • T to A, chromosome 15 at 33,213,195 bp
  • T to C, chromosome 15 at 79,076,920 bp
  • CAAA to CAAAA, chromosome 16 at 15,835,158 bp
  • T to C, chromosome 16 at 93,683,533 bp
  • G to T, chromosome 17 at 24,818,328 bp
  • T to C, chromosome 17 at 34,836,480 bp
  • T to C, chromosome 18 at 36,947,861 bp
  • G to T, chromosome 18 at 64,889,055 bp
  • T to C, chromosome 19 at 3,893,375 bp
  • T to C, chromosome 19 at 5,865,174 bp
  • C to T, chromosome 19 at 12,119,944 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8440 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067884-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.