Strain Name:
C57BL/6J-MtgxR8467Btlr/Mmmh
Stock Number:
067911-MU
Citation ID:
RRID:MMRRC_067911-MU
Other Names:
R8467 (G1)
Major Collection:

Strain Information

Gpd2
Name: glycerol phosphate dehydrogenase 2, mitochondrial
Synonyms: Gdm1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14571
HGNC: HGNC:4456
Homologene: 352
Scarb1
Name: scavenger receptor class B, member 1
Synonyms: Cla-1, D5Ertd460e, Hdlq1, Chohd1, Hlb398, SRBI, Srb1, Cd36l1, Chohd1, SR-BI
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20778
HGNC: HGNC:1664
Homologene: 21132
Nup155
Name: nucleoporin 155
Synonyms: D930027M19Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 170762
VEGA: 15
HGNC: HGNC:8063
Homologene: 43155
Kif13b
Name: kinesin family member 13B
Synonyms: N-3 kinesin, C130021D12Rik, 5330429L19Rik, GAKIN
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 16554
VEGA: 14
Homologene: 9073
Hunk
Name: hormonally upregulated Neu-associated kinase
Synonyms: Bstk1, Mak-v
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 26559
VEGA: 16
Homologene: 8742
Cep350
Name: centrosomal protein 350
Synonyms: 4933409L06Rik, 6430546F08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74081
Homologene: 8879
Otud7b
Name: OTU domain containing 7B
Synonyms: Za20d1, 2900060B22Rik, 4930463P07Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229603
Homologene: 10624
Iqsec3
Name: IQ motif and Sec7 domain 3
Synonyms: synarfGEF, BRAG3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243621
Homologene: 46091
Sp3
Name: trans-acting transcription factor 3
Synonyms: D130027J01Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20687
Homologene: 7952
Il7r
Name: interleukin 7 receptor
Synonyms: CD127, IL-7Ralpha, IL-7 receptor alpha chain
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16197
VEGA: 15
HGNC: HGNC:6024
Homologene: 1646
Igfbp3
Name: insulin-like growth factor binding protein 3
Synonyms: IGFBP-3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16009
HGNC: HGNC:5472
Homologene: 500
Nobox
Name: NOBOX oogenesis homeobox
Synonyms: Og2x
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 18291
Homologene: 51066
Myo6
Name: myosin VI
Synonyms: Myo6rsv, rsv, Tlc
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17920
HGNC: HGNC:7605
Homologene: 56417
Dhx57
Name: DExH-box helicase 57
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106794
VEGA: 17
Homologene: 56267
Lrp1
Name: low density lipoprotein receptor-related protein 1
Synonyms: b2b1554Clo, A2mr, CD91
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16971
HGNC: HGNC:6692
Homologene: 1744
Lgsn
Name: lengsin, lens protein with glutamine synthetase domain
Synonyms: Gluld1, lengsin, Lgs
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 266744
Homologene: 9569
Arl9
Name: ADP-ribosylation factor-like 9
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 384185
Homologene: 66207
Scn9a
Name: sodium channel, voltage-gated, type IX, alpha
Synonyms: PN1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20274
Homologene: 2237
C4b
Name: complement C4B (Chido blood group)
Synonyms: Ss, C4
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12268
Homologene: 36030
Grid2
Name: glutamate receptor, ionotropic, delta 2
Synonyms: B230104L07Rik, GluRdelta2, tpr
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14804
HGNC: HGNC:4576
Homologene: 74399
Smarca2
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
Synonyms: 2610209L14Rik, Snf2l2, brm
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 67155
Homologene: 2308
Kif21b
Name: kinesin family member 21B
Synonyms: N-5 kinesin, 2610511N21Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16565
Homologene: 56868
Phgdh
Name: 3-phosphoglycerate dehydrogenase
Synonyms: PGDH, PGD, PGAD, 3PGDH, SERA, 3-PGDH, A10
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 236539
HGNC: HGNC:8923
Homologene: 39318
Marchf10
Name: membrane associated ring-CH-type finger 10
Synonyms: March10, 4933417C16Rik, Rnf190, OTTMUSG00000002847
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 632687
Homologene: 34988
Or6n1
Name: olfactory receptor family 6 subfamily N member 1
Synonyms: Olfr429, GA_x6K02T2P20D-21090094-21089156, MOR105-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 258717
Homologene: 17366
Hivep3
Name: human immunodeficiency virus type I enhancer binding protein 3
Synonyms: Shn3, E030045D18Rik, Krc, 2900056N03Rik, Schnurri-3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16656
Homologene: 7803
Zfyve16
Name: zinc finger, FYVE domain containing 16
Synonyms: B130024H06Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218441
Homologene: 8826
Gbp11
Name: guanylate binding protein 11
Synonyms: Gm7141
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 634650
Homologene: 128731
Fam98a
Name: family with sequence similarity 98, member A
Synonyms: 2810405J04Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 72722
Homologene: 41042
Cd55b
Name: CD55 molecule, decay accelerating factor for complement B
Synonyms: TM-DAF, Daf-TM, Daf2, complement-transmembrane
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13137
HGNC: HGNC:2665
Homologene: 479
D17H6S53E
Name: DNA segment, Chr 17, human D6S53E
Synonyms: NG34
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 114585
Homologene: 75155
Gimap8
Name: GTPase, IMAP family member 8
Synonyms: LOC243374, IAN9
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243374
Homologene: 69703
Ehd1
Name: EH-domain containing 1
Synonyms: RME-1, Past1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 13660
HGNC: HGNC:3242
Homologene: 81678
Mup9
Name: major urinary protein 9
Synonyms: Gm14076
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100038948
Homologene: 74304
Apon
Name: apolipoprotein N
Synonyms: D10Ucla2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 28194
VEGA: 10
Homologene: 51183
Vmn1r21
Name: vomeronasal 1 receptor 21
Synonyms: V1rc28
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 171201
Homologene: 74363
Fbxl22
Name: F-box and leucine-rich repeat protein 22
Synonyms: 1110004B15Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74165
VEGA: 9
Homologene: 35275
Msantd5
Name: Myb/SANT DNA binding domain containing 5
Synonyms: Gm12569
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 622699
Homologene: 141209
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 31,203,650 bp
  • A to C, chromosome 1 at 130,419,764 bp
  • A to G, chromosome 1 at 136,172,283 bp
  • A to G, chromosome 1 at 155,915,575 bp
  • A to T, chromosome 1 at 174,089,441 bp
  • A to G, chromosome 2 at 57,364,584 bp
  • A to G, chromosome 2 at 66,501,671 bp
  • G to A, chromosome 2 at 72,971,138 bp
  • A to G, chromosome 3 at 96,155,676 bp
  • A to G, chromosome 3 at 98,321,311 bp
  • C to T, chromosome 4 at 60,420,482 bp
  • T to C, chromosome 4 at 120,095,041 bp
  • T to C, chromosome 5 at 77,006,599 bp
  • T to A, chromosome 5 at 105,327,591 bp
  • A to T, chromosome 5 at 125,298,667 bp
  • G to T, chromosome 6 at 43,305,545 bp
  • A to G, chromosome 6 at 48,650,335 bp
  • A to T, chromosome 6 at 57,844,456 bp
  • A to G, chromosome 6 at 64,533,651 bp
  • G to A, chromosome 6 at 121,381,717 bp
  • C to T, chromosome 9 at 66,514,567 bp
  • T to A, chromosome 9 at 80,228,886 bp
  • G to A, chromosome 10 at 127,558,650 bp
  • G to A, chromosome 10 at 128,255,133 bp
  • A to G, chromosome 11 at 7,213,523 bp
  • A to G, chromosome 11 at 51,234,278 bp
  • A to T, chromosome 11 at 105,390,153 bp
  • A to T, chromosome 13 at 92,508,282 bp
  • A to T, chromosome 14 at 64,758,705 bp
  • A to G, chromosome 15 at 8,121,531 bp
  • T to C, chromosome 15 at 9,512,887 bp
  • A to G, chromosome 16 at 90,496,620 bp
  • T to C, chromosome 17 at 34,732,813 bp
  • T to A, chromosome 17 at 35,127,270 bp
  • C to A, chromosome 17 at 75,544,835 bp
  • G to C, chromosome 17 at 80,254,424 bp
  • T to G, chromosome 19 at 6,281,288 bp
  • T to A, chromosome 19 at 26,619,721 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8467 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067911-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.