Strain Name:
C57BL/6J-MtgxR8491Btlr/Mmmh
Stock Number:
067933-MU
Citation ID:
RRID:MMRRC_067933-MU
Other Names:
R8491 (G1)
Major Collection:

Strain Information

Dlc1
Name: deleted in liver cancer 1
Synonyms: Arhgap7, p122-RhoGAP, STARD12, A730069N07Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 50768
HGNC: HGNC:2897
Homologene: 4442
Agap1
Name: ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
Synonyms: Ggap1, Centg2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 347722
Homologene: 56689
Pigl
Name: phosphatidylinositol glycan anchor biosynthesis, class L
Synonyms: LOC327942
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 327942
HGNC: HGNC:8966
Homologene: 3159
Aard
Name: alanine and arginine rich domain containing protein
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239435
Homologene: 17041
Gdnf
Name: glial cell line derived neurotrophic factor
Synonyms: glial cell line-derived neurotrophic factor
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 14573
VEGA: 15
HGNC: HGNC:4232
Homologene: 433
Gmps
Name: guanine monophosphate synthetase
Synonyms: Gm9479
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229363
HGNC: HGNC:4378
Homologene: 68367
Washc4
Name: WASH complex subunit 4
Synonyms: A230046K03Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 319277
VEGA: 10
Homologene: 123926
Psme4
Name: proteasome (prosome, macropain) activator subunit 4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 103554
Homologene: 113742
Triobp
Name: TRIO and F-actin binding protein
Synonyms: Tara, Mus EST 478828, EST478828
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 110253
Homologene: 5104
Trmt13
Name: tRNA methyltransferase 13
Synonyms: Ccdc76, A930028L21Rik, 4631408H19Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229780
Homologene: 6875
Idh3a
Name: isocitrate dehydrogenase 3 (NAD+) alpha
Synonyms: 1500012E04Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 67834
VEGA: 9
HGNC: HGNC:5384
Homologene: 4037
Aspm
Name: abnormal spindle microtubule assembly
Synonyms: Sha1, MCPH5, D330028K02Rik, Aspm, Calmbp1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12316
Homologene: 7650
Ins1
Name: insulin I
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 16333
VEGA: 19
HGNC: HGNC:6081
Homologene: 7383
Tmem245
Name: transmembrane protein 245
Synonyms: D730040F13Rik, A630051L19Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242474
HGNC: HGNC:1363
Homologene: 41841
Prkcq
Name: protein kinase C, theta
Synonyms: Pkcq, PKC-0, PKC theta, PKC-theta, A130035A12Rik, PKCtheta
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18761
HGNC: HGNC:9410
Homologene: 21263
Vdac2
Name: voltage-dependent anion channel 2
Synonyms: Vdac6
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 22334
Homologene: 37765
Casc3
Name: exon junction complex subunit
Synonyms: Mln51, Btz
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192160
Homologene: 7208
Slitrk3
Name: SLIT and NTRK-like family, member 3
Synonyms: ST3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 386750
Homologene: 8955
Hspg2
Name: perlecan (heparan sulfate proteoglycan 2)
Synonyms: Plc, perlecan, Pcn, per
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 15530
HGNC: HGNC:5273
Homologene: 68473
Tob1
Name: transducer of ErbB-2.1
Synonyms: Trob, Tob
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 22057
Homologene: 31334
Svil
Name: supervillin
Synonyms: B430302E16Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225115
Homologene: 25090
Zfp958
Name: zinc finger protein 958
Synonyms: BC003267
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 233987
Homologene: 129582
Ndufs1
Name: NADH:ubiquinone oxidoreductase core subunit S1
Synonyms: 5830412M15Rik, 9930026A05Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227197
HGNC: HGNC:7707
Homologene: 3670
Zbtb5
Name: zinc finger and BTB domain containing 5
Synonyms: 9430083K24Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230119
Homologene: 8913
Pclo
Name: piccolo (presynaptic cytomatrix protein)
Synonyms: Pico, Acz
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 26875
Homologene: 69111
Ushbp1
Name: USH1 protein network component harmonin binding protein 1
Synonyms: 2210404N08Rik, MCC2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234395
Homologene: 12914
Cdh16
Name: cadherin 16
Synonyms: KSP-cadherin
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12556
HGNC: HGNC:1755
Homologene: 2997
Zfp53
Name: zinc finger protein 53
Synonyms: D030067O06Rik, Zfp118, Zfp-53, zfas8, KRAZ1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 24132
VEGA: 17
Homologene: 135946
Ubqlnl
Name: ubiquilin-like
Synonyms: LOC244179, 4922504M18Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244179
Homologene: 17034
Bcl9l
Name: B cell CLL/lymphoma 9-like
Synonyms: DLNB11
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 80288
VEGA: 9
Homologene: 65615
Cyp4a12a
Name: cytochrome P450, family 4, subfamily a, polypeptide 12a
Synonyms: Cyp4a12
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 277753
Homologene: 134044
Mug1
Name: murinoglobulin 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 17836
HGNC: HGNC:9750
Homologene: 136663
Cdh2
Name: cadherin 2
Synonyms: N-cadherin, N-CAD, Ncad
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 12558
HGNC: HGNC:1759
Homologene: 20424
Vwa5a
Name: von Willebrand factor A domain containing 5A
Synonyms: Loh11cr2a, BCSC-1, 5830475I06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 67776
HGNC: HGNC:6658
Homologene: 18222
Faxc
Name: failed axon connections homolog
Synonyms: 6230409E13Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 76132
Homologene: 32781
Cfap57
Name: cilia and flagella associated protein 57
Synonyms: C130004B06Rik, LOC384050, 1110020C03Rik, Wdr65
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68625
Homologene: 51350
Cers5
Name: ceramide synthase 5
Synonyms: 2310081H14Rik, Lass5, CerS5, Trh4
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 71949
Homologene: 23634
Serpini2
Name: serine (or cysteine) peptidase inhibitor, clade I, member 2
Synonyms: 1810006A24Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 67931
HGNC: HGNC:8945
Homologene: 21248
Cntnap3
Name: contactin associated protein-like 3
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238680
VEGA: 13
Homologene: 129602
Or52d3
Name: olfactory receptor family 52 subfamily D member 3
Synonyms: GA_x6K02T2PBJ9-7206970-7207923, Olfr653, MOR33-1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 57250
Homologene: 115518
Or8k25
Name: olfactory receptor family 8 subfamily K member 25
Synonyms: MOR188-1, MOR188-7, Olfr1061, Olfr1515, MOR188-9, GA_x6K02T2Q125-47883395-47882454, MOR188-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 259022
Homologene: 79468
Psg16
Name: pregnancy specific beta-1-glycoprotein 16
Synonyms: Cea11, bCEA
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 26436
Fez2
Name: fasciculation and elongation protein zeta 2
Synonyms: D17Ertd315e, zygin 2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 225020
HGNC: HGNC:3660
Homologene: 3742
Aoc3
Name: amine oxidase, copper containing 3
Synonyms: VAP1, semicarbazide-sensitive amine oxidase, SSAO
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11754
HGNC: HGNC:550
Homologene: 2770
Cxcl15
Name: C-X-C motif chemokine ligand 15
Synonyms: lungkine, Il8, weche, Scyb15
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20309
Atp8b2
Name: ATPase, class I, type 8B, member 2
Synonyms: Id
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 54667
Homologene: 23226
Dusp6
Name: dual specificity phosphatase 6
Synonyms: 1300019I03Rik, PYST1, MKP3, MKP-3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67603
VEGA: 10
HGNC: HGNC:3072
Homologene: 55621
Rpp14
Name: ribonuclease P 14 subunit
Synonyms: 2610511E03Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 67053
Homologene: 5113
Gm6040
Name: predicted gene 6040
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 100503992
Homologene: 134341
Gm12258
Name: predicted gene 12258
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 108167848
Trim21
Name: tripartite motif-containing 21
Synonyms: Ro52, Ssa1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20821
Homologene: 2365
Gm5460
Name: predicted gene 5460
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 432838
VEGA: 14
G530012D18Rik
Name: RIKEN cDNA G530012D1 gene
Type: Gene
Species: Mouse
Chromosome: 1
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 63,157,225 bp
  • C to G, chromosome 1 at 85,577,214 bp
  • A to G, chromosome 1 at 89,609,572 bp
  • T to G, chromosome 1 at 139,457,695 bp
  • T to C, chromosome 2 at 11,279,524 bp
  • A to G, chromosome 2 at 86,413,755 bp
  • A to G, chromosome 3 at 64,014,358 bp
  • A to G, chromosome 3 at 73,051,259 bp
  • A to C, chromosome 3 at 75,252,515 bp
  • A to G, chromosome 3 at 89,958,369 bp
  • T to C, chromosome 3 at 116,582,579 bp
  • T to A, chromosome 4 at 21,993,319 bp
  • T to C, chromosome 4 at 44,995,090 bp
  • T to C, chromosome 4 at 56,906,261 bp
  • C to A, chromosome 4 at 115,301,453 bp
  • C to T, chromosome 4 at 118,614,931 bp
  • T to C, chromosome 4 at 137,553,719 bp
  • C to A, chromosome 5 at 14,515,230 bp
  • T to A, chromosome 5 at 90,795,230 bp
  • A to T, chromosome 6 at 121,882,729 bp
  • T to C, chromosome 7 at 17,090,512 bp
  • A to C, chromosome 7 at 102,559,482 bp
  • A to G, chromosome 7 at 104,149,375 bp
  • G to A, chromosome 7 at 104,580,035 bp
  • G to T, chromosome 8 at 4,626,215 bp
  • T to G, chromosome 8 at 20,917,119 bp
  • A to T, chromosome 8 at 36,584,846 bp
  • A to G, chromosome 8 at 71,392,397 bp
  • T to C, chromosome 8 at 104,617,049 bp
  • A to G, chromosome 9 at 38,741,180 bp
  • A to G, chromosome 9 at 44,500,768 bp
  • T to C, chromosome 9 at 54,599,679 bp
  • A to G, chromosome 10 at 83,576,123 bp
  • C to A, chromosome 10 at 99,266,219 bp
  • G to A, chromosome 11 at 30,772,161 bp
  • A to G, chromosome 11 at 58,854,296 bp
  • A to G, chromosome 11 at 62,473,467 bp
  • A to G, chromosome 11 at 94,214,289 bp
  • G to T, chromosome 11 at 98,823,151 bp
  • G to T, chromosome 11 at 101,332,216 bp
  • A to T, chromosome 13 at 64,785,343 bp
  • A to T, chromosome 14 at 8,083,925 bp
  • T to A, chromosome 14 at 21,837,770 bp
  • T to C, chromosome 14 at 34,039,783 bp
  • A to G, chromosome 15 at 7,834,791 bp
  • A to T, chromosome 15 at 52,040,312 bp
  • C to T, chromosome 15 at 78,994,126 bp
  • T to A, chromosome 15 at 99,740,950 bp
  • A to G, chromosome 17 at 21,509,359 bp
  • C to A, chromosome 17 at 78,384,771 bp
  • T to C, chromosome 18 at 5,106,678 bp
  • A to G, chromosome 18 at 16,624,718 bp
  • A to G, chromosome 19 at 52,264,370 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8491 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067933-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.