Strain Name:
C57BL/6J-MtgxR8671Btlr/Mmmh
Stock Number:
068526-MU
Citation ID:
RRID:MMRRC_068526-MU
Other Names:
R8671 (G1)
Major Collection:

Strain Information

Npr1
Name: natriuretic peptide receptor 1
Synonyms: guanylyl cyclase-A, NPRA, GC-A, NPR-A
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18160
HGNC: HGNC:7943
Homologene: 37367
Pcdh9
Name: protocadherin 9
Synonyms: 1500001L12Rik, C630029H24Rik, A730003J17Rik, LOC382930, C530050I23Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 211712
HGNC: HGNC:8661
Homologene: 10698
Pmpca
Name: peptidase (mitochondrial processing) alpha
Synonyms: INPP5E, Alpha-MPP, 4933435E07Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66865
Homologene: 6078
Rcbtb1
Name: regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
Synonyms: 5430409I18Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 71330
Homologene: 10061
Larp4
Name: La ribonucleoprotein 4
Synonyms: D330037H05Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 207214
VEGA: 15
Homologene: 19173
Eif2ak4
Name: eukaryotic translation initiation factor 2 alpha kinase 4
Synonyms: GCN2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 27103
Homologene: 40891
Cux1
Name: cut-like homeobox 1
Synonyms: CDP, Cutl1, Cux, Cux-1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13047
HGNC: HGNC:2557
Elp1
Name: elongator complex protein 1
Synonyms: C78473, Ikbkap, IKAP, 3110040G09Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230233
HGNC: HGNC:5959
Homologene: 2699
Med13
Name: mediator complex subunit 13
Synonyms: 1110067M05Rik, Trap240, Thrap1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 327987
Homologene: 21067
Zfp369
Name: zinc finger protein 369
Synonyms: B930030B22Rik, NRIF2, D230020H11Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 170936
Homologene: 129707
Hpcal4
Name: hippocalcin-like 4
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 170638
Homologene: 9441
Tnc
Name: tenascin C
Synonyms: C130033P17Rik, TN, hexabrachion, Hxb, cytotactin, tenascin-C, TN-C
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 21923
HGNC: HGNC:5318
Homologene: 55636
Hectd3
Name: HECT domain E3 ubiquitin protein ligase 3
Synonyms: 1700064K09Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 76608
Homologene: 18426
Tinagl1
Name: tubulointerstitial nephritis antigen-like 1
Synonyms: Arg1, androgen-regulated gene 1, Lcn7, 1110021J17Rik, AZ-1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 94242
Homologene: 41472
Idh2
Name: isocitrate dehydrogenase 2 (NADP+), mitochondrial
Synonyms: IDPm, Idh-2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 269951
HGNC: HGNC:5383
Homologene: 37590
Syn2
Name: synapsin II
Synonyms: Synapsin IIa, Synapsin IIb, 2900074L19Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20965
Homologene: 49348
Wdfy4
Name: WD repeat and FYVE domain containing 4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 545030
Homologene: 83473
Nynrin
Name: NYN domain and retroviral integrase containing
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 277154
VEGA: 14
Homologene: 19483
Pwwp2b
Name: PWWP domain containing 2B
Synonyms: D930023J19Rik, D7Ertd517e, Pwwp2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101631
Homologene: 19056
Atg9b
Name: autophagy related 9B
Synonyms: Nos3as, LOC213948, Apg9l2, eONE
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 213948
Homologene: 72638
Stab1
Name: stabilin 1
Synonyms: MS-1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 192187
Homologene: 9035
Ankrd36
Name: ankyrin repeat domain 36
Synonyms: 1700012M14Rik, GC3, 1700008J08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76389
Homologene: 137366
Grm5
Name: glutamate receptor, metabotropic 5
Synonyms: Glu5R, mGluR5, Gprc1e, 6430542K11Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 108071
HGNC: HGNC:4597
Homologene: 37354
Rasgrp4
Name: RAS guanyl releasing protein 4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233046
Homologene: 15635
Zfp454
Name: zinc finger protein 454
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237758
Homologene: 72226
Flnc
Name: filamin C, gamma
Synonyms: 1110055E19Rik, actin binding protein 280, Fln2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 68794
HGNC: HGNC:3756
Homologene: 37481
Ube2q1
Name: ubiquitin-conjugating enzyme E2Q family member 1
Synonyms: 1110002C01Rik, PRO3094, NICE-5, 2310012M18Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 70093
Homologene: 9730
Msh5
Name: mutS homolog 5
Synonyms: Mut5, G7
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 17687
HGNC: HGNC:7328
Homologene: 8415
Clcnkb
Name: chloride channel, voltage-sensitive Kb
Synonyms: Clcnk2, Clcnk1l, Clck2, ClC-K2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56365
Homologene: 107317
Thsd4
Name: thrombospondin, type I, domain containing 4
Synonyms: B230114P05Rik, ADAMTSL6
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 207596
Homologene: 49796
Myo18b
Name: myosin XVIIIb
Synonyms: 4932408L24Rik, 4933411E19Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 74376
Homologene: 53435
Prkd1
Name: protein kinase D1
Synonyms: Pkcm, Prkcm, PKD1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 18760
VEGA: 12
HGNC: HGNC:9407
Homologene: 55680
Or2l5
Name: olfactory receptor family 2 subfamily L member 5
Synonyms: MOR272-1, GA_x54KRFPKG5P-15963726-15962788, Olfr167
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 258937
Homologene: 78689
Pcare
Name: photoreceptor cilium actin regulator
Synonyms: BC027072
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 225004
VEGA: 17
Homologene: 19792
Musk
Name: muscle, skeletal, receptor tyrosine kinase
Synonyms: Nsk2, Nsk3, MDK4, Nsk1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18198
HGNC: HGNC:7525
Homologene: 4084
Or4c103
Name: olfactory receptor family 4 subfamily C member 103
Synonyms: Olfr1195, GA_x6K02T2Q125-50163514-50162588, MOR230-12_p, MOR230-4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258748
Homologene: 103782
Or5w15
Name: olfactory receptor family 5 subfamily W member 15
Synonyms: Olfr1138, MOR177-8, GA_x6K02T2Q125-49242149-49241214
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258632
Homologene: 74082
Slfn3
Name: schlafen 3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20557
Homologene: 133236
Ccdc7a
Name: coiled-coil domain containing 7A
Synonyms: 4930517G15Rik, 4930540C21Rik, Ccdc7
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 74703
Homologene: 134760
Slc22a2
Name: solute carrier family 22 (organic cation transporter), member 2
Synonyms: Orct2, Oct2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 20518
VEGA: 17
Homologene: 68293
Catsperb
Name: cation channel sperm associated auxiliary subunit beta
Synonyms: 4932415G16Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 271036
VEGA: 12
Homologene: 81904
Potefam1
Name: POTE ankyrin domain family member 1
Synonyms: Potea, Pote1, A26c3, 4930430A15Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67575
Homologene: 69410
Marchf8
Name: membrane associated ring-CH-type finger 8
Synonyms: Mir, March8, 1300017E09Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 71779
Homologene: 12412
2310002L09Rik
Name: RIKEN cDNA 2310002L09 gene
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 71886
Homologene: 36448
Apol7e
Name: apolipoprotein L 7e
Synonyms: ENSMUSG00000071716
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 666348
VEGA: 15
HGNC: HGNC:619
Homologene: 40940
Ambp
Name: alpha 1 microglobulin/bikunin precursor
Synonyms: Intin4, UTI, ulinastatin, ASPI, HI-30, Itil, Urinary Trypsin Inhibitor
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11699
HGNC: HGNC:453
Homologene: 1234
Rptn
Name: repetin
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20129
Homologene: 84780
Zfp971
Name: zinc finger protein 971
Synonyms: Etohi1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 626848
Homologene: 134324
Cfap54
Name: cilia and flagella associated protein 54
Synonyms: 4930485B16Rik, Gm872, LOC380653
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 380654
Homologene: 133438
Potefam3e
Name: POTE ankyrin domain family member 3E
Synonyms: 4930467E23Rik, OTTMUSG00000018948, Pote3e, TSAP, ENSMUSG00000074453
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 626415
Homologene: 128726
Xcl1
Name: chemokine (C motif) ligand 1
Synonyms: lymphotactin, Lptn, SCM-1, SCM-1a, LTN, ATAC, Scyc1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16963
Homologene: 2250
Or4f14c
Name: olfactory receptor family 4 subfamily F member 14C
Synonyms: MOR245-1, GA_x6K02T2Q125-73157028-73156524, Olfr1315
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 404497
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 164,931,850 bp
  • G to C, chromosome 2 at 26,395,034 bp
  • A to T, chromosome 2 at 87,737,646 bp
  • A to T, chromosome 2 at 88,683,105 bp
  • T to C, chromosome 2 at 111,229,532 bp
  • T to A, chromosome 2 at 112,110,988 bp
  • A to G, chromosome 2 at 118,422,186 bp
  • A to C, chromosome 2 at 178,033,937 bp
  • A to G, chromosome 3 at 89,776,078 bp
  • A to T, chromosome 3 at 90,456,157 bp
  • A to G, chromosome 3 at 93,398,194 bp
  • A to G, chromosome 4 at 56,771,453 bp
  • T to G, chromosome 4 at 58,286,051 bp
  • A to T, chromosome 4 at 63,150,419 bp
  • A to T, chromosome 4 at 64,017,446 bp
  • C to T, chromosome 4 at 73,942,929 bp
  • T to G, chromosome 4 at 116,996,581 bp
  • G to T, chromosome 4 at 123,189,183 bp
  • T to C, chromosome 4 at 130,167,804 bp
  • T to A, chromosome 4 at 141,412,230 bp
  • A to T, chromosome 5 at 24,386,109 bp
  • T to C, chromosome 5 at 112,874,743 bp
  • C to T, chromosome 5 at 136,250,600 bp
  • T to C, chromosome 6 at 29,443,502 bp
  • C to A, chromosome 6 at 115,278,167 bp
  • A to G, chromosome 6 at 116,401,854 bp
  • G to A, chromosome 7 at 29,143,027 bp
  • TCCCAGG to T, chromosome 7 at 80,098,331 bp
  • T to C, chromosome 7 at 88,116,290 bp
  • C to T, chromosome 7 at 139,256,410 bp
  • T to A, chromosome 8 at 19,734,759 bp
  • T to A, chromosome 8 at 128,920,467 bp
  • A to T, chromosome 9 at 60,394,445 bp
  • G to T, chromosome 10 at 92,955,072 bp
  • C to T, chromosome 11 at 5,629,312 bp
  • A to C, chromosome 11 at 50,873,768 bp
  • T to A, chromosome 11 at 83,212,999 bp
  • A to C, chromosome 11 at 86,271,097 bp
  • T to A, chromosome 12 at 50,388,408 bp
  • T to A, chromosome 12 at 101,594,337 bp
  • T to C, chromosome 13 at 65,296,281 bp
  • T to A, chromosome 14 at 31,157,408 bp
  • G to T, chromosome 14 at 32,971,765 bp
  • T to A, chromosome 14 at 55,870,442 bp
  • T to G, chromosome 14 at 59,230,524 bp
  • T to C, chromosome 14 at 93,888,650 bp
  • A to T, chromosome 15 at 77,717,603 bp
  • C to A, chromosome 15 at 100,010,458 bp
  • T to C, chromosome 16 at 19,515,054 bp
  • C to T, chromosome 17 at 12,605,976 bp
  • T to A, chromosome 17 at 35,045,933 bp
  • G to T, chromosome 17 at 71,751,377 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8671 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068526-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.