Strain Name:
C57BL/6J-MtgxR8756Btlr/Mmmh
Stock Number:
068597-MU
Citation ID:
RRID:MMRRC_068597-MU
Other Names:
R8756 (G1)
Major Collection:

Strain Information

Ppp1r16b
Name: protein phosphatase 1, regulatory subunit 16B
Synonyms: ANKRD4, Wdt4, C130078N17Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228852
Homologene: 9194
Nsd1
Name: nuclear receptor-binding SET-domain protein 1
Synonyms: KMT3B
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18193
VEGA: 13
Homologene: 32543
Tars2
Name: threonyl-tRNA synthetase 2, mitochondrial (putative)
Synonyms: Tarsl1, 2610024N01Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 71807
Homologene: 23520
Tpp2
Name: tripeptidyl peptidase II
Synonyms: TppII
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22019
Homologene: 2471
Dync1h1
Name: dynein cytoplasmic 1 heavy chain 1
Synonyms: 9930018I23Rik, MAP1C, Swl, Dnec1, Loa, Dnchc1, dynein heavy chain, retrograde transport
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13424
HGNC: HGNC:2961
Homologene: 1053
Tmem245
Name: transmembrane protein 245
Synonyms: D730040F13Rik, A630051L19Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242474
HGNC: HGNC:1363
Homologene: 41841
Slit2
Name: slit guidance ligand 2
Synonyms: Drad-1, E130320P19Rik, E030015M03Rik, Slil3, b2b1200.1Clo
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20563
Homologene: 3516
Trim71
Name: tripartite motif-containing 71
Synonyms: 636931, LOC382112, 2610206G21Rik, lin-41, mLin41, Lin41, mlin-41
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 636931
Homologene: 9076
Crebbp
Name: CREB binding protein
Synonyms: KAT3A, CBP
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 12914
HGNC: HGNC:2348
Homologene: 68393
Dtl
Name: denticleless E3 ubiquitin protein ligase
Synonyms: 2810047L02Rik, 5730564G15Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 76843
Homologene: 32313
Vegfa
Name: vascular endothelial growth factor A
Synonyms: VEGF164, VEGF-A, Vegf, VEGF120, VEGF188, VPF
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22339
Homologene: 2534
Atraid
Name: all-trans retinoic acid induced differentiation factor
Synonyms: p18, HSPC013, 0610007C21Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381629
Homologene: 15412
Zfp37
Name: zinc finger protein 37
Synonyms: Tzn, Zfp-37
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 22696
Homologene: 40682
R3hcc1l
Name: R3H domain and coiled-coil containing 1 like
Synonyms: D19Ertd386e, 1700036B12Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 52013
Homologene: 8707
Lrch3
Name: leucine-rich repeats and calponin homology (CH) domain containing 3
Synonyms: 2210409B11Rik, LOC385628
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 70144
Homologene: 13111
Sec63
Name: SEC63 homolog, protein translocation regulator
Synonyms: 5730478J10Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 140740
Homologene: 5220
Cp
Name: ceruloplasmin
Synonyms: D3Ertd555e
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12870
HGNC: HGNC:2295
Homologene: 75
Myof
Name: myoferlin
Synonyms: Fer1l3, E030042N20Rik, 2310051D19Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226101
VEGA: 19
HGNC: HGNC:3656
Homologene: 40882
Pclo
Name: piccolo (presynaptic cytomatrix protein)
Synonyms: Pico, Acz
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 26875
Homologene: 69111
Fat3
Name: FAT atypical cadherin 3
Synonyms: D430038H04Rik, LOC234973, LOC382129, 9430076A06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270120
VEGA: 9
Homologene: 82252
Ush2a
Name: usherin
Synonyms: MUSH2A, LOC269160, Ush2a, A930037M10Rik, A930011D15Rik, LOC381317, Ushrn
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22283
Homologene: 66151
Flt1
Name: FMS-like tyrosine kinase 1
Synonyms: Flt-1, VEGFR1, sFlt1, vascular endothelial growth factor receptor-1, VEGFR-1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14254
HGNC: HGNC:3763
Homologene: 134179
Sos2
Name: SOS Ras/Rho guanine nucleotide exchange factor 2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20663
Homologene: 38253
Serpinh1
Name: serine (or cysteine) peptidase inhibitor, clade H, member 1
Synonyms: Cbp1, Hsp47, Cbp2, J6, colligin, gp46, Serpinh2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12406
HGNC: HGNC:1546
Homologene: 20331
Gtf2ird2
Name: GTF2I repeat domain containing 2
Synonyms: 1700012P16Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 114674
Homologene: 24941
Jsrp1
Name: junctional sarcoplasmic reticulum protein 1
Synonyms: JP-45, JP45, 2300003C06Rik, 2310032K21Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71912
Homologene: 12422
Sun1
Name: Sad1 and UNC84 domain containing 1
Synonyms: 4632417G13Rik, Unc84a, 5730434D03Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 77053
Homologene: 11544
Matn2
Name: matrilin 2
Synonyms: Crtm2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 17181
VEGA: 15
HGNC: HGNC:6908
Homologene: 20538
Spag4
Name: sperm associated antigen 4
Synonyms: Sun4, 1700041K21Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 245865
Homologene: 2343
Atp8b5
Name: ATPase, class I, type 8B, member 5
Synonyms: FetA, 4930417M19Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 320571
Homologene: 99882
Igfn1
Name: immunoglobulin-like and fibronectin type III domain containing 1
Synonyms: 9830123M21Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226438
Homologene: 130054
Cyp2c65
Name: cytochrome P450, family 2, subfamily c, polypeptide 65
Synonyms: 2210009K14Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 72303
Homologene: 133566
Mad2l1
Name: MAD2 mitotic arrest deficient-like 1
Synonyms: MAD2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 56150
HGNC: HGNC:6763
Homologene: 1768
Krt90
Name: keratin 90
Synonyms: 4732456N10Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239673
Homologene: 72272
Nid1
Name: nidogen 1
Synonyms: entactin 1, entactin-1, entactin, nidogen-1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18073
VEGA: 13
HGNC: HGNC:7821
Homologene: 1878
Antxr1
Name: anthrax toxin receptor 1
Synonyms: 2810405N18Rik, Tem8, 2310008J16Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 69538
Homologene: 12976
Armh1
Name: armadillo-like helical domain containing 1
Synonyms: Ncrna00082, LOC381544, LOC381543, Gm1661
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 381544
Homologene: 28727
Vmn2r124
Name: vomeronasal 2, receptor 124
Synonyms: Vmn2r-ps113, Gm7196
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 637021
Homologene: 115024
Or2d2
Name: olfactory receptor family 2 subfamily D member 2
Synonyms: MOR260-1, GA_x6K02T2PBJ9-9479517-9478573, Olfr715
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258776
HGNC: HGNC:8244
Homologene: 81541
Hoga1
Name: 4-hydroxy-2-oxoglutarate aldolase 1
Synonyms: Npl2, Dhdpsl, 0610010D20Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 67432
Homologene: 12130
Zfp112
Name: zinc finger protein 112
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 57745
Homologene: 49338
Zdhhc2
Name: zinc finger, DHHC domain containing 2
Synonyms: 6430583A19Rik, 5730415P04Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 70546
Homologene: 81667
Nemp1
Name: nuclear envelope integral membrane protein 1
Synonyms: Tmem194
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 210035
Homologene: 18346
Trafd1
Name: TRAF type zinc finger domain containing 1
Synonyms: Fln29, 1110008K06Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231712
Homologene: 31399
Onecut3
Name: one cut domain, family member 3
Synonyms: OC-3, Oc3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 246086
Homologene: 82258
Malrd1
Name: MAM and LDL receptor class A domain containing 1
Synonyms: Gm13364, Gm13318, Diet1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 102635496
Homologene: 136214
Or4s2
Name: olfactory receptor family 4 subfamily S member 2
Synonyms: Olfr526-ps1, GA_x6K02T2Q125-50121628-50122030, GA_x6K02T2PRF0-44595-45531, MOR230-9, Olfr1191
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 404399
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 43,960,135 bp
  • G to T, chromosome 1 at 135,967,960 bp
  • T to A, chromosome 1 at 188,911,944 bp
  • T to C, chromosome 1 at 191,539,259 bp
  • T to C, chromosome 2 at 15,752,895 bp
  • T to A, chromosome 2 at 88,642,839 bp
  • T to C, chromosome 2 at 156,066,573 bp
  • G to A, chromosome 2 at 158,751,178 bp
  • G to C, chromosome 3 at 20,005,572 bp
  • A to G, chromosome 3 at 95,741,360 bp
  • T to C, chromosome 4 at 43,342,439 bp
  • C to A, chromosome 4 at 56,899,025 bp
  • T to C, chromosome 4 at 62,192,134 bp
  • T to A, chromosome 4 at 117,237,664 bp
  • T to A, chromosome 5 at 14,714,384 bp
  • T to A, chromosome 5 at 31,054,041 bp
  • G to T, chromosome 5 at 48,302,487 bp
  • T to C, chromosome 5 at 121,375,815 bp
  • C to T, chromosome 5 at 134,197,249 bp
  • T to C, chromosome 5 at 139,236,689 bp
  • T to C, chromosome 5 at 147,639,414 bp
  • T to C, chromosome 6 at 66,535,585 bp
  • A to T, chromosome 6 at 87,188,253 bp
  • T to C, chromosome 7 at 24,125,572 bp
  • A to G, chromosome 7 at 99,347,152 bp
  • T to C, chromosome 7 at 107,128,812 bp
  • T to A, chromosome 8 at 40,467,510 bp
  • T to A, chromosome 9 at 16,376,589 bp
  • T to C, chromosome 9 at 114,513,537 bp
  • C to T, chromosome 10 at 42,810,909 bp
  • C to A, chromosome 10 at 80,513,916 bp
  • T to A, chromosome 10 at 80,812,106 bp
  • T to A, chromosome 10 at 127,692,976 bp
  • C to A, chromosome 12 at 69,648,536 bp
  • G to T, chromosome 12 at 110,616,827 bp
  • A to G, chromosome 13 at 13,508,801 bp
  • T to C, chromosome 13 at 55,313,693 bp
  • A to C, chromosome 15 at 34,423,730 bp
  • A to C, chromosome 15 at 101,562,344 bp
  • A to G, chromosome 16 at 4,085,903 bp
  • T to A, chromosome 16 at 32,988,440 bp
  • A to T, chromosome 17 at 18,073,832 bp
  • T to C, chromosome 17 at 46,031,539 bp
  • A to T, chromosome 19 at 37,939,952 bp
  • A to T, chromosome 19 at 39,061,108 bp
  • A to G, chromosome 19 at 42,060,277 bp
  • G to A, chromosome 19 at 42,563,634 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8756 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068597-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.