Strain Name:
C57BL/6J-MtgxR8839Btlr/Mmmh
Stock Number:
068667-MU
Citation ID:
RRID:MMRRC_068667-MU
Other Names:
R8839 (G1)
Major Collection:

Strain Information

Sema3b
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
Synonyms: LUCA-1, SemA, sema5, Semaa, semaV, SemA
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20347
Homologene: 20972
Gpr37
Name: G protein-coupled receptor 37
Synonyms: parkin-associated endothelin B-like receptor, Pael-R
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14763
HGNC: HGNC:4494
Homologene: 3875
Ptch1
Name: patched 1
Synonyms: wig, Ptc, A230106A15Rik, Ptc1, Patched 1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 19206
HGNC: HGNC:9585
Homologene: 223
Inpp5d
Name: inositol polyphosphate-5-phosphatase D
Synonyms: Src homology 2 domain-containing inositol-5-phosphatase, s-SHIP, SHIP-1, SHIP, SHIP1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16331
HGNC: HGNC:6079
Homologene: 4046
Inpp5a
Name: inositol polyphosphate-5-phosphatase A
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 212111
HGNC: HGNC:6076
Homologene: 4045
Ints6
Name: integrator complex subunit 6
Synonyms: DICE1, 2900075H24Rik, Ddx26, Notch2l
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 18130
VEGA: 14
Homologene: 8121
Smug1
Name: single-strand selective monofunctional uracil DNA glycosylase
Synonyms: A930006H09Rik, 1200013B09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 71726
VEGA: 15
Homologene: 8629
Sec23a
Name: SEC23 homolog A, COPII coat complex component
Synonyms: Sec23r, Msec23
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20334
Homologene: 4642
Ltn1
Name: listerin E3 ubiquitin protein ligase 1
Synonyms: 4930528H02Rik, Listerin, Zfp294, Rnf160
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 78913
VEGA: 16
Homologene: 32272
Cabin1
Name: calcineurin binding protein 1
Synonyms: A330070M20Rik, Cain, Ppp3in
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 104248
VEGA: 10
Homologene: 49307
Trappc9
Name: trafficking protein particle complex 9
Synonyms: 2900005P22Rik, TRS130, 4632408O18Rik, Nibp, 1810044A24Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 76510
VEGA: 15
Homologene: 81931
Anln
Name: anillin, actin binding protein
Synonyms: 1110037A17Rik, Scraps, 2900037I21Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 68743
VEGA: 9
Homologene: 41281
Fxr1
Name: FMR1 autosomal homolog 1
Synonyms: 9530073J07Rik, Fxr1h, 1110050J02Rik, Fxr1p
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14359
HGNC: HGNC:4023
Homologene: 3573
Srbd1
Name: S1 RNA binding domain 1
Synonyms: D530025C17Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 78586
VEGA: 17
Homologene: 9994
Ankfy1
Name: ankyrin repeat and FYVE domain containing 1
Synonyms: Ankhzn
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11736
Homologene: 9491
Ipo7
Name: importin 7
Synonyms: A330055O14Rik, RanBP7, Imp7
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233726
HGNC: HGNC:9852
Homologene: 4659
Tiam1
Name: T cell lymphoma invasion and metastasis 1
Synonyms: D16Ium10e, D16Ium10
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 21844
Homologene: 2443
Arb2a
Name: ARB2 cotranscriptional regulator A
Synonyms: 9430037D06Rik, pEN87, 1110033M05Rik, Fam172a, 53-E6, 2610318O14Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 68675
VEGA: 13
Homologene: 12933
Hmg20b
Name: high mobility group 20B
Synonyms: Hmgx2, BRAF35, Smarce1r, BRCA2-associated factor 35, Hmgxb2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 15353
HGNC: HGNC:5002
Homologene: 74949
Ncapd3
Name: non-SMC condensin II complex, subunit D3
Synonyms: 2810487N22Rik, B130055D15Rik, 4632407J06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 78658
VEGA: 9
Homologene: 41021
Flii
Name: flightless I actin binding protein
Synonyms: Fliih, 3632430F08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14248
HGNC: HGNC:3750
Homologene: 11092
Emc3
Name: ER membrane protein complex subunit 3
Synonyms: 0610039A15Rik, Tmem111
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 66087
Homologene: 100707
Edrf1
Name: erythroid differentiation regulatory factor 1
Synonyms: 2700050L05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 214764
Homologene: 27985
Caprin2
Name: caprin family member 2
Synonyms: RNG140, C1qdc1, Eeg1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232560
Homologene: 11393
Zfhx4
Name: zinc finger homeodomain 4
Synonyms: Zfh4, Zfh-4, C130041O22Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 80892
Homologene: 23477
Pdzph1
Name: PDZ and pleckstrin homology domains 1
Synonyms: 2610034M16Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 69239
Homologene: 130756
Cyp2b9
Name: cytochrome P450, family 2, subfamily b, polypeptide 9
Synonyms: phenobarbitol inducible, type a, Cyp2b
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13094
HGNC: HGNC:2615
Homologene: 74933
Tubgcp6
Name: tubulin, gamma complex component 6
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 328580
Homologene: 32477
Serpina3g
Name: serine (or cysteine) peptidase inhibitor, clade A, member 3G
Synonyms: alpha-1 antiproteinase, Spi2A, alpha-1 antiproteinase,, Spi2-1, 2A2, Spi2/eb.1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20715
HGNC: HGNC:16
Homologene: 115927
Or10ak14
Name: olfactory receptor family 10 subfamily AK member 14
Synonyms: Olfr1338, GA_x6K02T2QD9B-18795136-18796077, Olfr1524-ps1, MOR259-9, MOR259-4P, MOR259-4P
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 258259
Homologene: 115537
S100pbp
Name: S100P binding protein
Synonyms: 4930429A08Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 74648
Homologene: 81892
Ugt2b37
Name: UDP glucuronosyltransferase 2 family, polypeptide B37
Synonyms: 0610033E06Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 112417
Homologene: 137225
Aoc1l2
Name: amine oxidase copper containing 1-like 2
Synonyms: 1600015I10Rik, Doxl1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 69761
HGNC: HGNC:80
Homologene: 79726
Csmd2
Name: CUB and Sushi multiple domains 2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329942
Homologene: 89034
Tbc1d16
Name: TBC1 domain family, member 16
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 207592
Homologene: 10380
Nnt
Name: nicotinamide nucleotide transhydrogenase
Synonyms: 4930423F13Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18115
HGNC: HGNC:7863
Plekhn1
Name: pleckstrin homology domain containing, family N member 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 231002
VEGA: 4
Homologene: 12949
Ost4
Name: oligosaccharyltransferase complex subunit 4 (non-catalytic)
Synonyms: 2310016E02Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 67695
Cyp3a59
Name: cytochrome P450, family 3, subfamily a, polypeptide 59
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100041449
Homologene: 135775
Vmn2r20
Name: vomeronasal 2, receptor 20
Synonyms: EG667180
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 667180
Homologene: 84037
Vmn2r65
Name: vomeronasal 2, receptor 65
Synonyms: ENSMUSG00000070600
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100009609
B3galt4
Name: UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
Synonyms: Gal-T2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 54218
HGNC: HGNC:919
Homologene: 2805
Prkd1
Name: protein kinase D1
Synonyms: Pkcm, Prkcm, PKD1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 18760
VEGA: 12
HGNC: HGNC:9407
Homologene: 55680
Slc23a2
Name: solute carrier family 23 (nucleobase transporters), member 2
Synonyms: SVCT2, Slc23a1, YSPL3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 54338
Homologene: 68440
Fkbp7
Name: FK506 binding protein 7
Synonyms: FKBP23
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14231
HGNC: HGNC:3723
Homologene: 22568
Musk
Name: muscle, skeletal, receptor tyrosine kinase
Synonyms: Nsk2, Nsk3, MDK4, Nsk1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18198
HGNC: HGNC:7525
Homologene: 4084
Or11h23
Name: olfactory receptor family 11 subfamily G member 23
Synonyms: Olfr748, GA_x6K02T2PMLR-6454789-6455712, MOR106-9P
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258113
Homologene: 134081
Mfsd9
Name: major facilitator superfamily domain containing 9
Synonyms: 4931419K03Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 211798
Homologene: 13100
Or52ae9
Name: olfactory receptor family 52 subfamily AE member 9
Synonyms: Olfr629, GA_x6K02T2PBJ9-6466772-6465828, MOR26-2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258818
Homologene: 105159
Ace3
Name: angiotensin I converting enzyme 3
Synonyms: EG217246
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217246
Homologene: 80337
Ighv9-3
Name: immunoglobulin heavy variable V9-3
Synonyms: ENSMUSG00000072803
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 780825
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 40,774,394 bp
  • T to A, chromosome 1 at 87,691,711 bp
  • T to C, chromosome 2 at 76,667,237 bp
  • C to T, chromosome 2 at 132,101,472 bp
  • A to G, chromosome 3 at 5,401,855 bp
  • A to G, chromosome 3 at 34,046,682 bp
  • A to G, chromosome 4 at 58,286,151 bp
  • A to G, chromosome 4 at 118,754,214 bp
  • A to C, chromosome 4 at 128,442,888 bp
  • A to G, chromosome 4 at 129,182,207 bp
  • T to A, chromosome 4 at 156,222,589 bp
  • T to C, chromosome 5 at 30,907,591 bp
  • A to G, chromosome 5 at 87,254,556 bp
  • A to T, chromosome 5 at 146,109,086 bp
  • T to G, chromosome 6 at 25,669,370 bp
  • T to C, chromosome 6 at 48,931,040 bp
  • G to A, chromosome 6 at 113,519,970 bp
  • A to T, chromosome 6 at 123,396,556 bp
  • A to T, chromosome 6 at 148,873,027 bp
  • T to G, chromosome 7 at 26,200,760 bp
  • A to T, chromosome 7 at 84,946,281 bp
  • A to G, chromosome 7 at 103,740,814 bp
  • A to T, chromosome 7 at 110,042,016 bp
  • A to G, chromosome 7 at 133,653,915 bp
  • T to C, chromosome 7 at 139,389,433 bp
  • G to A, chromosome 9 at 22,356,172 bp
  • T to C, chromosome 9 at 27,094,434 bp
  • C to T, chromosome 9 at 107,601,353 bp
  • T to C, chromosome 10 at 75,656,816 bp
  • A to C, chromosome 10 at 81,348,915 bp
  • T to C, chromosome 11 at 60,718,607 bp
  • T to C, chromosome 11 at 72,730,566 bp
  • T to C, chromosome 11 at 105,998,368 bp
  • G to A, chromosome 11 at 119,156,648 bp
  • T to C, chromosome 12 at 50,342,833 bp
  • T to C, chromosome 12 at 58,990,995 bp
  • A to G, chromosome 12 at 104,237,779 bp
  • G to A, chromosome 12 at 114,140,765 bp
  • A to T, chromosome 13 at 63,541,224 bp
  • A to T, chromosome 13 at 77,999,662 bp
  • A to T, chromosome 13 at 119,357,637 bp
  • A to T, chromosome 14 at 50,710,500 bp
  • A to G, chromosome 14 at 62,693,673 bp
  • T to A, chromosome 15 at 73,058,238 bp
  • A to T, chromosome 15 at 89,103,478 bp
  • T to C, chromosome 15 at 103,155,820 bp
  • C to A, chromosome 16 at 87,418,502 bp
  • A to G, chromosome 16 at 89,884,939 bp
  • A to G, chromosome 17 at 33,950,893 bp
  • T to C, chromosome 17 at 58,950,242 bp
  • T to A, chromosome 17 at 85,988,421 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8839 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068667-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.