Strain Name:
C57BL/6J-MtgxR8883Btlr/Mmmh
Stock Number:
068689-MU
Citation ID:
RRID:MMRRC_068689-MU
Other Names:
R8883 (G1)
Major Collection:

Strain Information

Ntmt1
Name: N-terminal Xaa-Pro-Lys N-methyltransferase 1
Synonyms: Mettl11a, 2610205E22Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66617
Homologene: 5439
Dcaf1
Name: DDB1 and CUL4 associated factor 1
Synonyms: Vprbp, B930007L02Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 321006
Homologene: 8805
Vps13c
Name: vacuolar protein sorting 13C
Synonyms: C230055H22Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320528
VEGA: 9
Homologene: 41188
Kif1b
Name: kinesin family member 1B
Synonyms: Kif1b beta, A530096N05Rik, N-3 kinesin, D4Mil1e, KIF1Bp204, KIF1Bp130, Kif1b alpha
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16561
Homologene: 99835
Racgap1
Name: Rac GTPase-activating protein 1
Synonyms: Band25, gtl11, GTPase, MgcRacGAP
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 26934
HGNC: HGNC:9804
Homologene: 8077
Mepce
Name: methylphosphate capping enzyme
Synonyms: Bcdin3, D5Wsu46e
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231803
Homologene: 32447
Spg11
Name: SPG11, spatacsin vesicle trafficking associated
Synonyms: spastic paraplegia 11, 6030465E24Rik, C530005A01Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 214585
Homologene: 41614
Arih2
Name: ariadne RBR E3 ubiquitin protein ligase 2
Synonyms: TRIAD1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 23807
HGNC: HGNC:690
Homologene: 48424
Muc2
Name: mucin 2
Synonyms: 2010015E03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17831
HGNC: HGNC:7512
Homologene: 136755
Tap1
Name: transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
Synonyms: Ham1, Ham-1, Tap-1, RING4, Abcb2, PSF-1, MTP1, TAP
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 21354
HGNC: HGNC:43
Homologene: 495
Map3k14
Name: mitogen-activated protein kinase kinase kinase 14
Synonyms: Nik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 53859
HGNC: HGNC:6853
Homologene: 2940
Stim1
Name: stromal interaction molecule 1
Synonyms: SIM
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20866
Homologene: 20681
Atp1b3
Name: ATPase, Na+/K+ transporting, beta 3 polypeptide
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 11933
HGNC: HGNC:806
Homologene: 37510
Hmces
Name: 5-hydroxymethylcytosine (hmC) binding, ES cell specific
Synonyms: Srap1, 8430410A17Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232210
Homologene: 6636
Lap3
Name: leucine aminopeptidase 3
Synonyms: Pep-S, LAP, peptidase S, Pep-7, Pep7
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 66988
Homologene: 41072
Cep76
Name: centrosomal protein 76
Synonyms: 6230425F05Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225659
VEGA: 18
Homologene: 11774
Rprd1a
Name: regulation of nuclear pre-mRNA domain containing 1A
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225283
VEGA: 18
Homologene: 124432
Kalrn
Name: kalirin, RhoGEF kinase
Synonyms: LOC224126, E530005C20Rik, 2210407G14Rik, Hapip
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 545156
HGNC: HGNC:4814
Homologene: 57160
Gata4
Name: GATA binding protein 4
Synonyms: Gata-4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 14463
HGNC: HGNC:4173
Homologene: 1551
Gjc1
Name: gap junction protein, gamma 1
Synonyms: Cx45, Gja-7, C130009G16Rik, connexin 45, Gja7
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14615
HGNC: HGNC:4280
Homologene: 4016
Abca13
Name: ATP-binding cassette, sub-family A member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268379
Homologene: 27991
Zfyve28
Name: zinc finger, FYVE domain containing 28
Synonyms: 9630058O20Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231125
Homologene: 15119
Fermt3
Name: fermitin family member 3
Synonyms: Kindlin-3, C79673
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 108101
VEGA: 19
Homologene: 12877
Spta1
Name: spectrin alpha, erythrocytic 1
Synonyms: Spna1, ihj, erythroid, Spna-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20739
Homologene: 74460
Fsip2
Name: fibrous sheath-interacting protein 2
Synonyms: OTTMUSG00000013335
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241516
Homologene: 110349
Pik3r6
Name: phosphoinositide-3-kinase regulatory subunit 5
Synonyms: p87PIKAP, p84 Pikap
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 104709
Homologene: 46215
Stxbp5l
Name: syntaxin binding protein 5-like
Synonyms: tomosyn-2, A830015P08Rik, insulin level locus 1, LLGL4, t2md1, T2dm1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 207227
Homologene: 18173
Bsn
Name: bassoon
Synonyms: presynaptic cytomatrix protein
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12217
HGNC: HGNC:1117
Homologene: 31161
Ccnb1ip1
Name: cyclin B1 interacting protein 1
Synonyms: LOC239083, mei4, Hei10
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239083
VEGA: 14
Homologene: 18819
Evpl
Name: envoplakin
Synonyms: 210kDa protein
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14027
HGNC: HGNC:3503
Homologene: 1506
Spmap2
Name: sperm microtubule associated protein 2
Synonyms: Theg
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 21830
Homologene: 7976
Tent5c
Name: terminal nucleotidyltransferase 5C
Synonyms: Fam46c, 4930431B09Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74645
Homologene: 56783
Zfp521
Name: zinc finger protein 521
Synonyms: B930086A16Rik, Evi3
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225207
VEGA: 18
Homologene: 9151
Or8g19
Name: olfactory receptor family 8 subfamily G member 19
Synonyms: MTPCR56, MOR171-6, GA_x6K02T2KYVW-1037-120, GA_x6K02T2PVTD-32841223-32842158, Olfr242, Olfr27
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258826
VEGA: 9
HGNC: HGNC:8484
Homologene: 110610
Or2ag15
Name: olfactory receptor family 2 subfamily AG member 15
Synonyms: GA_x6K02T2PBJ9-9119301-9118348, MOR283-5, Olfr697
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258592
Fbxo11
Name: F-box protein 11
Synonyms: Jf, GENA 104
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 225055
Homologene: 11843
Srrd
Name: SRR1 domain containing
Synonyms: 2810002G02Rik, Srr1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 70118
Homologene: 33447
Usp45
Name: ubiquitin specific petidase 45
Synonyms: Gcap7, 3110003C05Rik, 4930550B20Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 77593
Homologene: 17674
Pebp4
Name: phosphatidylethanolamine binding protein 4
Synonyms: 1700081D17Rik, 1700051A02Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 73523
VEGA: 14
Homologene: 51650
Kndc1
Name: kinase non-catalytic C-lobe domain (KIND) containing 1
Synonyms: 2410012C07Rik, very-kind, VKIND, B830014K08Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76484
Homologene: 45138
Plekhd1
Name: pleckstrin homology domain containing, family D (with coiled-coil domains) member 1
Synonyms: 3830431G21Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217682
Homologene: 15090
Fbh1
Name: F-box DNA helicase 1
Synonyms: Fbx18, Fbxo18
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 50755
Homologene: 9272
Dgki
Name: diacylglycerol kinase, iota
Synonyms: C130010K08Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 320127
HGNC: HGNC:2855
Homologene: 37956
Prss3b
Name: serine protease 3B
Synonyms: T7, 2210010C04Rik, cationic trypsinogen (isoform T7)
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 67373
Homologene: 134055
Mical1
Name: microtubule associated monooxygenase, calponin and LIM domain containing 1
Synonyms: Nical
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 171580
Homologene: 11246
Ldlrad1
Name: low density lipoprotein receptor class A domain containing 1
Synonyms: OTTMUSG00000008594
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 546840
Homologene: 54473
Or5w17
Name: olfactory receptor family 5 subfamily W member 17
Synonyms: Olfr1141, MOR177-10, GA_x6K02T2Q125-49257818-49256883
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258630
Homologene: 74080
Cox10
Name: heme A:farnesyltransferase cytochrome c oxidase assembly factor 10
Synonyms: 2410004F01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70383
HGNC: HGNC:2260
Homologene: 80170
Gnl1
Name: guanine nucleotide binding protein-like 1
Synonyms: Gna-rs1, Gnal1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14670
HGNC: HGNC:4413
Homologene: 3862
Pigm
Name: phosphatidylinositol glycan anchor biosynthesis, class M
Synonyms: C920011G20Rik, 4933437L05Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67556
Homologene: 6274
Mboat2
Name: membrane bound O-acyltransferase domain containing 2
Synonyms: 2810049G06Rik, Oact2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 67216
VEGA: 12
Homologene: 6971
Lsm8
Name: LSM8 homolog, U6 small nuclear RNA associated
Synonyms: 2010003I05Rik, Lsm8
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 76522
Homologene: 9419
Or2d3
Name: olfactory receptor family 2 subfamily D member 3
Synonyms: MOR260-8P, Olfr707, GA_x6K02T2PBJ9-9276470-9275547
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 194433
Homologene: 133899
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 172,377,518 bp
  • A to T, chromosome 1 at 174,193,579 bp
  • A to G, chromosome 2 at 11,749,111 bp
  • G to A, chromosome 2 at 30,822,454 bp
  • G to T, chromosome 2 at 82,979,180 bp
  • T to A, chromosome 2 at 87,753,494 bp
  • T to C, chromosome 2 at 122,113,080 bp
  • C to A, chromosome 3 at 100,472,391 bp
  • G to A, chromosome 4 at 21,825,006 bp
  • A to G, chromosome 4 at 107,216,215 bp
  • A to T, chromosome 4 at 149,276,885 bp
  • T to C, chromosome 5 at 34,217,867 bp
  • C to A, chromosome 5 at 45,511,930 bp
  • A to T, chromosome 5 at 112,339,924 bp
  • C to A, chromosome 5 at 137,786,517 bp
  • T to C, chromosome 6 at 18,851,748 bp
  • A to T, chromosome 6 at 37,016,673 bp
  • G to T, chromosome 6 at 41,032,371 bp
  • G to A, chromosome 6 at 87,933,414 bp
  • A to T, chromosome 7 at 102,431,050 bp
  • A to G, chromosome 7 at 106,741,067 bp
  • A to C, chromosome 7 at 106,891,329 bp
  • C to T, chromosome 7 at 139,927,795 bp
  • A to G, chromosome 7 at 141,700,900 bp
  • A to G, chromosome 9 at 39,144,787 bp
  • G to T, chromosome 9 at 67,948,197 bp
  • A to T, chromosome 9 at 96,364,069 bp
  • T to G, chromosome 9 at 106,847,640 bp
  • G to A, chromosome 9 at 108,113,028 bp
  • A to G, chromosome 9 at 108,609,793 bp
  • G to A, chromosome 10 at 41,479,640 bp
  • T to C, chromosome 10 at 79,576,640 bp
  • T to C, chromosome 11 at 9,333,168 bp
  • T to C, chromosome 11 at 63,993,949 bp
  • T to C, chromosome 11 at 68,533,642 bp
  • A to G, chromosome 11 at 102,800,943 bp
  • T to G, chromosome 11 at 103,239,452 bp
  • T to C, chromosome 11 at 116,230,417 bp
  • T to G, chromosome 12 at 24,959,034 bp
  • T to C, chromosome 12 at 80,720,594 bp
  • G to C, chromosome 14 at 50,789,902 bp
  • T to C, chromosome 14 at 63,204,755 bp
  • G to T, chromosome 14 at 69,847,649 bp
  • A to G, chromosome 15 at 99,628,659 bp
  • A to T, chromosome 16 at 33,993,655 bp
  • ATTTT to ATTTTT, chromosome 16 at 37,216,052 bp
  • T to C, chromosome 17 at 34,187,893 bp
  • A to G, chromosome 17 at 35,982,598 bp
  • A to G, chromosome 17 at 87,997,616 bp
  • C to A, chromosome 18 at 13,846,080 bp
  • T to C, chromosome 18 at 24,507,203 bp
  • T to C, chromosome 18 at 67,633,470 bp
  • G to T, chromosome 19 at 7,003,232 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8883 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068689-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.