Strain Name:
C57BL/6J-MtgxR8923Btlr/Mmmh
Stock Number:
068768-MU
Citation ID:
RRID:MMRRC_068768-MU
Other Names:
R8923 (G1)
Major Collection:

Strain Information

Cmtm5
Name: CKLF-like MARVEL transmembrane domain containing 5
Synonyms: Cklfsf5, 2900052H21Rik, 1500005P16Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 67272
VEGA: 14
Homologene: 16322
Rubcn
Name: RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein
Synonyms: 1700021K19Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 100502698
Homologene: 15687
Lefty1
Name: left right determination factor 1
Synonyms: Stra3, Lefty, Ebaf, lefty-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13590
HGNC: HGNC:6552
Homologene: 49231
Frrs1
Name: ferric-chelate reductase 1
Synonyms: Sdfr2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20321
Homologene: 40653
Ep400
Name: E1A binding protein p400
Synonyms: 1700020J09Rik, p400, mDomino
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75560
Homologene: 38779
Utp20
Name: UTP20 small subunit processome component
Synonyms: DRIM, 3830408P06Rik, mDRIM
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70683
VEGA: 10
Homologene: 38373
Dip2c
Name: disco interacting protein 2 homolog C
Synonyms: 2900024P20Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 208440
Homologene: 40996
Ano1
Name: anoctamin 1, calcium activated chloride channel
Synonyms: Tmem16a
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101772
Homologene: 75079
Prkci
Name: protein kinase C, iota
Synonyms: 2310021H13Rik, Prkcl, Pkcl, aPKClambda, Pkci, PKClambda
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18759
HGNC: HGNC:9404
Homologene: 37667
Prkd2
Name: protein kinase D2
Synonyms: PKD2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101540
Homologene: 9516
Ano6
Name: anoctamin 6
Synonyms: Tmem16f, 2900059G15Rik, F730003B03Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105722
VEGA: 15
Homologene: 27888
Arid1a
Name: AT-rich interaction domain 1A
Synonyms: BAF250a, Osa1, Smarcf1, 1110030E03Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 93760
Homologene: 21216
Naa15
Name: N(alpha)-acetyltransferase 15, NatA auxiliary subunit
Synonyms: Tbdn-1, ASTBDN, Narg1, mNAT1, 5730450D16Rik, tubedown
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74838
Homologene: 14211
Ubap1
Name: ubiquitin-associated protein 1
Synonyms: NAG20, 2700092A01Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67123
Homologene: 9554
Sdha
Name: succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
Synonyms: FP, SDHF, SDH2, 2310034D06Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 66945
Homologene: 3073
Ash1l
Name: ASH1 like histone lysine methyltransferase
Synonyms: 8030453L17Rik, KMT2H, chromatin remodeling factor, E430018P19Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 192195
Homologene: 10225
Ccni
Name: cyclin I
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12453
HGNC: HGNC:1595
Homologene: 4979
Gp5
Name: glycoprotein 5 platelet
Synonyms: GPV, GP V
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 14729
VEGA: 16
HGNC: HGNC:4443
Homologene: 74523
Wdfy1
Name: WD repeat and FYVE domain containing 1
Synonyms: Jr1, 1700013B03Rik, 1700120F24Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 69368
Homologene: 10825
Lmo7
Name: LIM domain only 7
Synonyms: LOC380928, FBXO20
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 380928
HGNC: HGNC:6646
Homologene: 83924
Muc15
Name: mucin 15
Synonyms: D730046L02Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 269328
Homologene: 51680
Muc16
Name: mucin 16
Synonyms: 1110008I14Rik, LOC385009, Gm21044
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 73732
Homologene: 141193
Ercc1
Name: excision repair cross-complementing rodent repair deficiency, complementation group 1
Synonyms: Ercc-1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13870
HGNC: HGNC:3433
Homologene: 1501
Dync2h1
Name: dynein cytoplasmic 2 heavy chain 1
Synonyms: Dnchc2, m152Asp, m407Asp, b2b414Clo, D030010H02Rik, D330044F14Rik, 4432416O06Rik, DHC1b, DHC2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 110350
HGNC: HGNC:2962
Homologene: 14468
Bsdc1
Name: BSD domain containing 1
Synonyms: 1110063F24Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100383
Homologene: 32386
Rab40c
Name: Rab40C, member RAS oncogene family
Synonyms: RAR3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224624
Homologene: 10907
Stat5a
Name: signal transducer and activator of transcription 5A
Synonyms: STAT5
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20850
Homologene: 20680
Atp5f1e
Name: ATP synthase F1 subunit epsilon
Synonyms: Atp5e, 2410043G19Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67126
Or10al2
Name: olfactory receptor family 10 subfamily AL member 2
Synonyms: GA_x6K02T2PSCP-2131124-2132089, Olfr118, MOR263-13
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 404308
Homologene: 110622
Ap3b2
Name: adaptor-related protein complex 3, beta 2 subunit
Synonyms: Naptb, beta3B
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11775
HGNC: HGNC:567
Homologene: 55837
Myt1l
Name: myelin transcription factor 1-like
Synonyms: Pmng1, C630034G21Rik, 2900093J19Rik, Png-1, 2900046C06Rik, Nztf1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 17933
VEGA: 12
HGNC: HGNC:7623
Homologene: 7435
Itgal
Name: integrin alpha L
Synonyms: Ly-15, LFA-1, Ly-21, Cd11a
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16408
HGNC: HGNC:6148
Homologene: 1666
Flnc
Name: filamin C, gamma
Synonyms: 1110055E19Rik, actin binding protein 280, Fln2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 68794
HGNC: HGNC:3756
Homologene: 37481
Mss51
Name: MSS51 mitochondrial translational activator
Synonyms: Zmynd17, 4833444M15Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 74843
VEGA: 14
Homologene: 27997
Parpbp
Name: PARP1 binding protein
Synonyms: 4930547N16Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 75317
Homologene: 49519
Vmn1r173
Name: vomeronasal 1 receptor 173
Synonyms: Gm5892
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 545934
Homologene: 79577
Rad51d
Name: RAD51 paralog D
Synonyms: R51H3, Rad51l3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19364
HGNC: HGNC:9823
Homologene: 2156
Dhrs2
Name: dehydrogenase/reductase member 2
Synonyms: 5430405K24Rik, SDR family
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 71412
Homologene: 69438
Dsel
Name: dermatan sulfate epimerase-like
Synonyms: 9330132E09Rik, DS-epi2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 319901
Homologene: 12964
Efcab12
Name: EF-hand calcium binding domain 12
Synonyms: BC060267
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 212516
Homologene: 18905
Rgs22
Name: regulator of G-protein signalling 22
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 626596
Homologene: 75047
Or5ac20
Name: olfactory receptor family 5 subfamily AC member 20
Synonyms: GA_x54KRFPKG5P-55498766-55497843, Olfr202, MOR182-1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 258997
Homologene: 138323
Cyp3a41b
Name: cytochrome P450, family 3, subfamily a, polypeptide 41B
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100041375
HGNC: HGNC:2638
Homologene: 133568
Spdl1
Name: spindle apparatus coiled-coil protein 1
Synonyms: 1700018I02Rik, Ccdc99, 2600001J17Rik, 2810049B11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70385
Homologene: 9837
Klhl33
Name: kelch-like 33
Synonyms: EG546611
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 546611
VEGA: 14
Homologene: 52385
Or1e26
Name: olfactory receptor family 1 subfamily E member 26
Synonyms: GA_x6K02T2P1NL-3760313-3759375, Olfr385, MOR135-3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 259025
Homologene: 133670
Sult1b1
Name: sulfotransferase family 1B, member 1
Synonyms: Dopa/tyrosine sulfotransferase
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56362
Homologene: 69169
Cyp3a44
Name: cytochrome P450, family 3, subfamily a, polypeptide 44
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 337924
HGNC: HGNC:2638
Homologene: 133568
Pbxip1
Name: pre B cell leukemia transcription factor interacting protein 1
Synonyms: 4732463H20Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229534
Homologene: 10740
Sesn3
Name: sestrin 3
Synonyms: SEST3, 5630400E15Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 75747
Homologene: 14386
Mtmr11
Name: myotubularin related protein 11
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 194126
Homologene: 82382
Spag8
Name: sperm associated antigen 8
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 433700
Homologene: 8250
Cdk5
Name: cyclin dependent kinase 5
Synonyms: Crk6
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12568
HGNC: HGNC:1774
Homologene: 3623
H2-Q5
Name: histocompatibility 2, Q region locus 5
Synonyms: Qa5, H-2Q5, Qat-5, Qa-5
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 15016
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 79,706,300 bp
  • T to C, chromosome 1 at 111,860,554 bp
  • T to A, chromosome 1 at 180,937,753 bp
  • A to T, chromosome 2 at 110,731,867 bp
  • G to T, chromosome 2 at 174,462,516 bp
  • T to A, chromosome 3 at 31,041,101 bp
  • G to A, chromosome 3 at 51,460,022 bp
  • T to C, chromosome 3 at 88,985,667 bp
  • T to C, chromosome 3 at 89,445,614 bp
  • C to T, chromosome 3 at 96,164,871 bp
  • A to T, chromosome 3 at 116,902,421 bp
  • A to G, chromosome 4 at 41,379,170 bp
  • T to A, chromosome 4 at 43,651,471 bp
  • C to T, chromosome 4 at 129,461,612 bp
  • A to G, chromosome 4 at 133,684,993 bp
  • A to G, chromosome 5 at 24,420,286 bp
  • A to C, chromosome 5 at 87,515,034 bp
  • T to C, chromosome 5 at 93,188,084 bp
  • A to G, chromosome 5 at 110,683,998 bp
  • A to G, chromosome 5 at 145,584,638 bp
  • A to T, chromosome 5 at 145,799,361 bp
  • G to T, chromosome 6 at 29,452,237 bp
  • G to C, chromosome 6 at 115,811,021 bp
  • C to G, chromosome 7 at 16,865,757 bp
  • T to A, chromosome 7 at 19,347,137 bp
  • T to A, chromosome 7 at 23,702,343 bp
  • T to C, chromosome 7 at 81,477,183 bp
  • A to T, chromosome 7 at 127,296,361 bp
  • A to G, chromosome 7 at 144,650,551 bp
  • T to C, chromosome 9 at 7,168,515 bp
  • T to C, chromosome 9 at 14,306,266 bp
  • A to T, chromosome 9 at 18,638,676 bp
  • C to T, chromosome 10 at 88,111,612 bp
  • G to A, chromosome 10 at 88,791,742 bp
  • T to C, chromosome 11 at 34,813,651 bp
  • T to C, chromosome 11 at 73,589,250 bp
  • A to G, chromosome 11 at 82,882,972 bp
  • T to C, chromosome 11 at 100,880,482 bp
  • A to G, chromosome 12 at 29,910,801 bp
  • A to G, chromosome 13 at 9,623,865 bp
  • G to A, chromosome 13 at 74,339,060 bp
  • A to G, chromosome 14 at 20,487,109 bp
  • A to T, chromosome 14 at 50,892,425 bp
  • G to A, chromosome 14 at 54,938,888 bp
  • A to T, chromosome 14 at 55,240,852 bp
  • A to T, chromosome 14 at 101,900,243 bp
  • T to A, chromosome 15 at 36,092,960 bp
  • T to C, chromosome 15 at 95,913,547 bp
  • G to T, chromosome 16 at 30,309,404 bp
  • G to T, chromosome 16 at 32,825,679 bp
  • G to C, chromosome 16 at 59,284,036 bp
  • A to C, chromosome 17 at 25,883,690 bp
  • A to G, chromosome 17 at 35,395,006 bp
  • A to T, chromosome 17 at 37,672,811 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8923 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068768-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.