Strain Name:
C57BL/6J-MtgxR0336Btlr/Mmmh
Stock Number:
038545-MU
Citation ID:
RRID:MMRRC_038545-MU
Other Names:
R0336 (G1), C57BL/6J-MtgxR0336Btlr
Major Collection:

Strain Information

Fga
Name: fibrinogen alpha chain
Synonyms: Fib, ENSMUSG00000059807
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 14161
HGNC: HGNC:3661
Homologene: 428
Rfx3
Name: regulatory factor X, 3 (influences HLA class II expression)
Synonyms: MRFX3, C230093O12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 19726
HGNC: HGNC:9984
Homologene: 7917
Rictor
Name: RPTOR independent companion of MTOR, complex 2
Synonyms: 6030405M08Rik, D530039E11Rik, 4921505C17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 78757
VEGA: 15
Homologene: 34317
Lrig3
Name: leucine-rich repeats and immunoglobulin-like domains 3
Synonyms: 9030421L11Rik, 9130004I02Rik, 9430095K15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 320398
VEGA: 10
Homologene: 62452
Col18a1
Name: collagen, type XVIII, alpha 1
Synonyms: endostatin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 12822
HGNC: HGNC:2195
Homologene: 7673
Rnf38
Name: ring finger protein 38
Synonyms: Oip1, 1700065B19Rik, 2610202O07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 73469
Homologene: 32550
Tlr6
Name: toll-like receptor 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 21899
Homologene: 21223
Polr2a
Name: polymerase (RNA) II (DNA directed) polypeptide A
Synonyms: 220kDa, Rpo2-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20020
HGNC: HGNC:9187
Homologene: 721
Zc3h4
Name: zinc finger CCCH-type containing 4
Synonyms: LOC330474, Bwq1, Kiaa1064-hp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 330474
Homologene: 87150
Fbrsl1
Name: fibrosin-like 1
Synonyms: LOC381668, 2410025L10Rik, Gm29766
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 381668
Homologene: 45966
Brca1
Name: breast cancer 1, early onset
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 12189
HGNC: HGNC:1100
Homologene: 5276
Hip1
Name: huntingtin interacting protein 1
Synonyms: 2610109B09Rik, A930014B11Rik, E130315I21Rik, HIP-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 215114
HGNC: HGNC:4913
Homologene: 68463
Xdh
Name: xanthine dehydrogenase
Synonyms: Xox-1, Xox1, Xor, xanthine oxidase, XO
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 22436
VEGA: 17
Homologene: 324
Strn3
Name: striatin, calmodulin binding protein 3
Synonyms: SG2NA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 94186
VEGA: 12
Homologene: 82078
Ric1
Name: RAB6A GEF complex partner 1
Synonyms: C130057E09Rik, C030046E11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 226089
Homologene: 13806
Cep135
Name: centrosomal protein 135
Synonyms: LOC381644, Cep4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 381644
Homologene: 45709
Podxl2
Name: podocalyxin-like 2
Synonyms: PODLX2, D130074J02Rik, Endoglycan
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 319655
Homologene: 9254
Vps13b
Name: vacuolar protein sorting 13B
Synonyms: 1810042B05Rik, Coh1, C330002D13Rik, 2310042E16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 666173
VEGA: 15
HGNC: HGNC:2183
Homologene: 49516
Ttc23
Name: tetratricopeptide repeat domain 23
Synonyms: 1600012K10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 67009
Homologene: 11289
Arhgef1
Name: Rho guanine nucleotide exchange factor (GEF) 1
Synonyms: Lsc, Lbcl2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16801
HGNC: HGNC:681
Homologene: 3454
Cog1
Name: component of oligomeric golgi complex 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16834
HGNC: HGNC:6545
Homologene: 8411
Trap1
Name: TNF receptor-associated protein 1
Synonyms: HSP75, 2410002K23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 68015
Homologene: 9457
Zfp597
Name: zinc finger protein 597
Synonyms: 4933407K12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 71063
Homologene: 33641
Zfp979
Name: zinc finger protein 979
Synonyms: 2610305D13Rik, Ssm1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 112422
Homologene: 133076
Dach1
Name: dachshund family transcription factor 1
Synonyms: Dac, E130112M23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 13134
HGNC: HGNC:2663
Homologene: 7288
Abca13
Name: ATP-binding cassette, sub-family A (ABC1), member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 268379
Homologene: 27991
Txnip
Name: thioredoxin interacting protein
Synonyms: THIF, VDUP1, mVDUP1, Hyplip1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 56338
Homologene: 38186
Epha3
Name: Eph receptor A3
Synonyms: Tyro4, Mek4, Hek4, Hek, Cek4, End3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 13837
VEGA: 16
HGNC: HGNC:3387
Homologene: 21083
Col12a1
Name: collagen, type XII, alpha 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 12816
HGNC: HGNC:2188
Homologene: 3217
Adamts16
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 271127
Homologene: 15146
Stk33
Name: serine/threonine kinase 33
Synonyms: 4921505G21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 117229
Homologene: 75307
Tmem94
Name: transmembrane protein 94
Synonyms: 2310067B10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 71947
Homologene: 8831
Mybpc2
Name: myosin binding protein C, fast-type
Synonyms: Fast-type C-protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233199
HGNC: HGNC:7550
Homologene: 3331
Vmn2r79
Name: vomeronasal 2, receptor 79
Synonyms: EG621430
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 621430
Homologene: 115466
Mss51
Name: MSS51 mitochondrial translational activator
Synonyms: 4833444M15Rik, Zmynd17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 74843
VEGA: 14
Homologene: 27997
Zfp944
Name: zinc finger protein 944
Synonyms: 6330416L07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 319615
VEGA: 17
Homologene: 133237
Fyn
Name: Fyn proto-oncogene
Synonyms: Src Kinase p59
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 14360
HGNC: HGNC:4037
Homologene: 48068
Lilrb4b
Name: leukocyte immunoglobulin-like receptor, subfamily B, member 4B
Synonyms: gp49, Gp49a, Lilr4b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 14727
HGNC: HGNC:6608
Homologene: 86756
B3glct
Name: beta-3-glucosyltransferase
Synonyms: LOC381694, B3galtl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 381694
Homologene: 14978
Vmn1r61
Name: vomeronasal 1 receptor 61
Synonyms: Gm7186
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 636731
Homologene: 41799
Adgrb1
Name: adhesion G protein-coupled receptor B1
Synonyms: B830018M07Rik, Bai1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 107831
HGNC: HGNC:943
Homologene: 1287
Slc6a21
Name: solute carrier family 6 member 21
Synonyms: 1700039E15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 76713
Homologene: 66347
Vmn1r121
Name: vomeronasal 1 receptor 121
Synonyms: Gm8533
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 667240
Homologene: 104166
Hivep3
Name: human immunodeficiency virus type I enhancer binding protein 3
Synonyms: Krc, 2900056N03Rik, E030045D18Rik, Shn3, Schnurri-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 16656
Homologene: 7803
Galnt6
Name: polypeptide N-acetylgalactosaminyltransferase 6
Synonyms: GalNAc-T6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 207839
HGNC: HGNC:4128
Homologene: 5218
St8sia4
Name: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
Synonyms: ST8SiaIV, PST, PST-1, Siat8d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 20452
Homologene: 4147
Or4a27
Name: olfactory receptor family 4 subfamily A member 27
Synonyms: GA_x6K02T2Q125-50202854-50201910, MOR225-10P, MOR225-14, Olfr1197
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 433449
Homologene: 123770
Zc3h6
Name: zinc finger CCCH type containing 6
Synonyms: 4631426G04Rik, 4833425H18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 78751
Homologene: 35328
Ccn5
Name: cellular communication network factor 5
Synonyms: rCop1, Crgr4, CCN5, Wisp2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22403
Homologene: 2882
Tspan2
Name: tetraspanin 2
Synonyms: B230119D02Rik, 6330415F13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 70747
Homologene: 21169
Ifna6
Name: interferon alpha 6
Synonyms: Ifa6, Ifna8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 15969
Homologene: 68536
Tmem129
Name: transmembrane protein 129
Synonyms: 2410015J15Rik, 0610039G24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 68366
Homologene: 44528
Grsf1
Name: G-rich RNA sequence binding factor 1
Synonyms: D5Wsu31e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231413
HGNC: HGNC:4610
Homologene: 20482
Vmn1r82
Name: vomeronasal 1 receptor 82
Synonyms: V1rg12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 171268
Xkr5
Name: X-linked Kx blood group related 5
Synonyms: 5430438H03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 319581
Homologene: 52219
Defb39
Name: defensin beta 39
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 360214
Homologene: 86857
Zfp709
Name: zinc finger protein 709
Synonyms: GIOT-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 236193
Homologene: 136795
Ctsh
Name: cathepsin H
Synonyms: Cat H
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 13036
HGNC: HGNC:2535
Homologene: 36159
Bcl2a1c
Name: B cell leukemia/lymphoma 2 related protein A1c
Synonyms: A1-c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 12046
HGNC: HGNC:991
Gm2042
Name: predicted gene 2042
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 100039087
Homologene: 103830
Coa8
Name: cytochrome c oxidase assembly factor 8
Synonyms: 1700081D05Rik, Apop-1, 2810002N01Rik, Apopt1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 68020
Homologene: 12225
Mpped1
Name: metallophosphoesterase domain containing 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223726
HGNC: HGNC:1306
Homologene: 15012
Fndc1
Name: fibronectin type III domain containing 1
Synonyms: 1110027O12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 68655
Pygm
Name: muscle glycogen phosphorylase
Synonyms: PG
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 19309
HGNC: HGNC:9726
Homologene: 2145
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 95,653,558 bp
  • T to C, chromosome 2 at 88,729,154 bp
  • A to G, chromosome 2 at 129,015,412 bp
  • C to A, chromosome 2 at 163,832,322 bp
  • T to C, chromosome 3 at 83,030,857 bp
  • T to A, chromosome 3 at 96,559,979 bp
  • A to G, chromosome 3 at 102,735,027 bp
  • A to T, chromosome 4 at 44,152,350 bp
  • T to C, chromosome 4 at 88,827,941 bp
  • G to A, chromosome 4 at 120,103,847 bp
  • A to C, chromosome 4 at 147,613,135 bp
  • G to T, chromosome 5 at 33,655,602 bp
  • G to T, chromosome 5 at 64,953,946 bp
  • A to G, chromosome 5 at 76,601,502 bp
  • C to A, chromosome 5 at 88,663,153 bp
  • A to G, chromosome 5 at 110,447,951 bp
  • A to T, chromosome 5 at 135,428,613 bp
  • A to G, chromosome 5 at 149,746,592 bp
  • G to A, chromosome 6 at 88,849,595 bp
  • G to A, chromosome 7 at 5,611,067 bp
  • T to C, chromosome 7 at 12,305,321 bp
  • T to C, chromosome 7 at 16,435,178 bp
  • T to A, chromosome 7 at 21,098,462 bp
  • T to A, chromosome 7 at 24,921,957 bp
  • T to C, chromosome 7 at 44,505,616 bp
  • T to A, chromosome 7 at 45,286,468 bp
  • A to T, chromosome 7 at 67,662,483 bp
  • A to C, chromosome 7 at 87,002,079 bp
  • T to C, chromosome 7 at 109,331,474 bp
  • C to A, chromosome 8 at 18,940,636 bp
  • G to T, chromosome 8 at 19,052,969 bp
  • T to C, chromosome 8 at 71,890,605 bp
  • A to T, chromosome 9 at 79,702,345 bp
  • A to G, chromosome 9 at 90,075,738 bp
  • G to T, chromosome 9 at 114,330,285 bp
  • C to A, chromosome 10 at 39,526,901 bp
  • T to A, chromosome 10 at 51,481,293 bp
  • A to G, chromosome 10 at 77,058,736 bp
  • C to T, chromosome 10 at 125,966,705 bp
  • A to G, chromosome 11 at 9,298,481 bp
  • C to T, chromosome 11 at 69,736,893 bp
  • A to G, chromosome 11 at 101,523,993 bp
  • A to C, chromosome 11 at 113,662,250 bp
  • A to G, chromosome 11 at 115,787,385 bp
  • A to G, chromosome 12 at 51,661,608 bp
  • T to C, chromosome 12 at 88,178,191 bp
  • T to C, chromosome 12 at 111,733,658 bp
  • A to G, chromosome 13 at 70,791,794 bp
  • T to A, chromosome 14 at 20,483,186 bp
  • C to T, chromosome 14 at 98,168,748 bp
  • G to A, chromosome 15 at 6,776,753 bp
  • T to G, chromosome 15 at 35,455,133 bp
  • A to G, chromosome 15 at 74,587,149 bp
  • C to T, chromosome 15 at 83,836,282 bp
  • A to T, chromosome 15 at 100,699,206 bp
  • A to G, chromosome 16 at 3,866,379 bp
  • A to C, chromosome 16 at 4,044,626 bp
  • A to G, chromosome 16 at 63,566,648 bp
  • C to T, chromosome 17 at 7,765,107 bp
  • C to A, chromosome 17 at 22,339,028 bp
  • C to T, chromosome 17 at 73,922,463 bp
  • C to T, chromosome 19 at 6,388,758 bp
  • A to G, chromosome 19 at 27,806,262 bp
  • A to T, chromosome 19 at 29,587,793 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0336 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
038545-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.