Strain Name:
C57BL/6J-MtgxR0468Btlr/Mmmh
Stock Number:
038668-MU
Citation ID:
RRID:MMRRC_038668-MU
Other Names:
R0468 (G1), C57BL/6J-MtgxR0468Btlr
Major Collection:

Gene Information

Cltc
Name: clathrin, heavy polypeptide (Hc)
Synonyms: CHC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 67300
HGNC: HGNC:2092
Homologene: 3572
Safb
Name: scaffold attachment factor B
Synonyms: 5330423C17Rik, 3110021E02Rik, SAFB1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 224903
Homologene: 2229
Zgrf1
Name: zinc finger, GRF-type containing 1
Synonyms: 4930422G04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 71643
Homologene: 34708
Lrp6
Name: low density lipoprotein receptor-related protein 6
Synonyms: skam26Jus, skax26, Cd, ska26
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 16974
HGNC: HGNC:6698
Homologene: 1747
Zfyve1
Name: zinc finger, FYVE domain containing 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 217695
VEGA: 12
Homologene: 10945
L3mbtl3
Name: L3MBTL3 histone methyl-lysine binding protein
Synonyms: MBT-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 237339
Homologene: 18226
Plxna4
Name: plexin A4
Synonyms: Plxa4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 243743
HGNC: HGNC:9102
Homologene: 77587
Kcnn2
Name: potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
Synonyms: bc, small conductance calcium-activated potassium channel 2, SK2, fri
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 140492
HGNC: HGNC:6291
Homologene: 135651
Srp68
Name: signal recognition particle 68
Synonyms: 2610024I03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 217337
Homologene: 7056
Irx4
Name: Iroquois homeobox 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 50916
HGNC: HGNC:6129
Homologene: 9485
Hspg2
Name: perlecan (heparan sulfate proteoglycan 2)
Synonyms: Pcn, Plc, perlecan, per
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 15530
HGNC: HGNC:5273
Homologene: 68473
Bcl7b
Name: B cell CLL/lymphoma 7B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 12054
HGNC: HGNC:1005
Homologene: 1290
Bsdc1
Name: BSD domain containing 1
Synonyms: 1110063F24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 100383
Homologene: 32386
Pdia5
Name: protein disulfide isomerase associated 5
Synonyms: 2700053F16Rik, Pdir
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 72599
VEGA: 16
Homologene: 4957
2700049A03Rik
Name: RIKEN cDNA 2700049A03 gene
Synonyms: talpid3, Ta3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 76967
Homologene: 8839
Dhx29
Name: DEAH (Asp-Glu-Ala-His) box polypeptide 29
Synonyms: E130202M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 218629
VEGA: 13
Homologene: 10387
Ehbp1
Name: EH domain binding protein 1
Synonyms: Flj21950, KIAA0903-like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 216565
Homologene: 22880
Steap3
Name: STEAP family member 3
Synonyms: pHyde, 1010001D01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 68428
Homologene: 10084
Hibadh
Name: 3-hydroxyisobutyrate dehydrogenase
Synonyms: 6430402H10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 58875
HGNC: HGNC:4907
Homologene: 15088
Sec31b
Name: Sec31 homolog B (S. cerevisiae)
Synonyms: Sec31l2, LOC240667
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 240667
Homologene: 56708
Hydin
Name: HYDIN, axonemal central pair apparatus protein
Synonyms: 4930545D19Rik, hy-3, hy3, 1700034M11Rik, hyrh
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 244653
Homologene: 52118
Pclo
Name: piccolo (presynaptic cytomatrix protein)
Synonyms: Acz, Pico
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 26875
Homologene: 69111
Nell1
Name: NEL-like 1
Synonyms: B230343H07Rik, l7R6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 338352
HGNC: HGNC:7750
Homologene: 4486
Pkd1l3
Name: polycystic kidney disease 1 like 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 244646
Homologene: 14627
Neb
Name: nebulin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 17996
HGNC: HGNC:7720
Homologene: 136285
Ifi208
Name: interferon activated gene 208
Synonyms: Pydc3, Pyr-rv1, E430029J22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 100033459
HGNC: HGNC:5395
Homologene: 115929
Pmfbp1
Name: polyamine modulated factor 1 binding protein 1
Synonyms: F77, 1700016D22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 56523
Homologene: 23182
Anxa3
Name: annexin A3
Synonyms: Anx3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 11745
HGNC: HGNC:541
Homologene: 68445
Kcnh4
Name: potassium voltage-gated channel, subfamily H (eag-related), member 4
Synonyms: BEC2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 380728
HGNC: HGNC:6253
Homologene: 8180
Col14a1
Name: collagen, type XIV, alpha 1
Synonyms: 5730412L22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 12818
HGNC: HGNC:2191
Homologene: 18741
Ccdc180
Name: coiled-coil domain containing 180
Synonyms: LOC381522, E230008N13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 381522
Homologene: 117988
Cep162
Name: centrosomal protein 162
Synonyms: 4922501C03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 382090
Homologene: 8930
5530400C23Rik
Name: RIKEN cDNA 5530400C23 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 232426
Homologene: 79760
Pxdn
Name: peroxidasin
Synonyms: 2310075M15Rik, VPO1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 69675
Homologene: 33907
Col11a1
Name: collagen, type XI, alpha 1
Synonyms: C530001D20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 12814
HGNC: HGNC:2186
Homologene: 56389
Tmem132d
Name: transmembrane protein 132D
Synonyms: C630028F04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 243274
Homologene: 71684
Vmn1r214
Name: vomeronasal 1 receptor 214
Synonyms: V1rh5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 171248
Homologene: 110880
Map9
Name: microtubule-associated protein 9
Synonyms: ASAP, 5033421J10Rik, 5330427D05Rik, Mtap9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 213582
Homologene: 41591
Olfr1115
Name: olfactory receptor 1115
Synonyms: MOR273-4P, GA_x6K02T2Q125-48736906-48737886, Olfr1530-ps1, MOR264-20, MOR273-4P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258294
Homologene: 27114
Slc7a13
Name: solute carrier family 7, (cationic amino acid transporter, y+ system) member 13
Synonyms: AGT-1, 0610009O04Rik, XAT2, AGT1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 74087
Homologene: 23656
Mettl14
Name: methyltransferase like 14
Synonyms: G430022H21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 210529
Homologene: 10865
Fam171a1
Name: family with sequence similarity 171, member A1
Synonyms: 9630050M13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 269233
Homologene: 19521
Aldh1l2
Name: aldehyde dehydrogenase 1 family, member L2
Synonyms: D330038I09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 216188
Homologene: 51942
Shank3
Name: SH3 and multiple ankyrin repeat domains 3
Synonyms: ProSAP2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 58234
Homologene: 75163
Vcam1
Name: vascular cell adhesion molecule 1
Synonyms: CD106, Vcam-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 22329
Homologene: 838
Brinp1
Name: bone morphogenic protein/retinoic acid inducible neural specific 1
Synonyms: Dbccr1, Fam5a, Dbc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 56710
HGNC: HGNC:2687
Homologene: 8754
Igsf8
Name: immunoglobulin superfamily, member 8
Synonyms: KCT-4, PGRL, PG regulatory-like protein, ESTM34, EWI-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 140559
Homologene: 14163
Slc23a3
Name: solute carrier family 23 (nucleobase transporters), member 3
Synonyms: SVCT3, Yspl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 22626
Homologene: 65865
Slamf1
Name: signaling lymphocytic activation molecule family member 1
Synonyms: IPO-3, CD150, ESTM51, CDw150, Slam
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 27218
Homologene: 48162
Tagln2
Name: transgelin 2
Synonyms: 2700094C18Rik, Sm22B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 21346
Homologene: 20789
Ptgs1
Name: prostaglandin-endoperoxide synthase 1
Synonyms: Pghs1, Cox-1, cyclooxygenase 1, Cox-3, COX1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 19224
HGNC: HGNC:9604
Homologene: 743
6820408C15Rik
Name: RIKEN cDNA 6820408C15 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 228778
Homologene: 51916
Slc7a11
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 11
Synonyms: System xc, 9930009M05Rik, xc, xCT, sut
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 26570
Homologene: 22684
Gm4553
Name: predicted gene 4553
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 100043617
Olfr319
Name: olfactory receptor 319
Synonyms: MOR285-2, GA_x6K02T2NKPP-708319-707399
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 258493
Ehd3
Name: EH-domain containing 3
Synonyms: Ehd2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 57440
HGNC: HGNC:3244
Homologene: 81837
Men1
Name: multiple endocrine neoplasia 1
Synonyms: menin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 17283
HGNC: HGNC:7010
Homologene: 7418
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 75,133,230 bp
  • A to T, chromosome 1 at 120,234,300 bp
  • A to G, chromosome 1 at 171,792,371 bp
  • G to A, chromosome 1 at 172,318,796 bp
  • A to G, chromosome 1 at 172,506,221 bp
  • A to T, chromosome 1 at 173,683,481 bp
  • T to C, chromosome 2 at 3,225,396 bp
  • A to G, chromosome 2 at 36,249,193 bp
  • G to T, chromosome 2 at 52,211,556 bp
  • A to T, chromosome 2 at 87,252,255 bp
  • A to T, chromosome 2 at 152,441,266 bp
  • A to G, chromosome 3 at 50,384,051 bp
  • T to C, chromosome 3 at 82,374,203 bp
  • T to C, chromosome 3 at 114,217,058 bp
  • A to T, chromosome 3 at 116,115,946 bp
  • T to C, chromosome 3 at 123,371,412 bp
  • T to A, chromosome 3 at 127,562,041 bp
  • T to A, chromosome 4 at 19,841,500 bp
  • T to C, chromosome 4 at 45,923,271 bp
  • T to A, chromosome 4 at 68,762,776 bp
  • T to C, chromosome 4 at 129,461,718 bp
  • G to A, chromosome 4 at 137,533,529 bp
  • C to A, chromosome 5 at 14,677,288 bp
  • T to C, chromosome 5 at 96,811,099 bp
  • T to C, chromosome 5 at 128,269,203 bp
  • T to C, chromosome 5 at 135,180,883 bp
  • C to A, chromosome 6 at 32,215,246 bp
  • C to T, chromosome 6 at 52,557,770 bp
  • T to C, chromosome 6 at 133,294,458 bp
  • T to C, chromosome 6 at 134,485,661 bp
  • A to G, chromosome 7 at 50,228,846 bp
  • C to A, chromosome 7 at 142,165,625 bp
  • A to G, chromosome 8 at 109,513,968 bp
  • C to G, chromosome 8 at 109,623,649 bp
  • G to T, chromosome 8 at 110,413,223 bp
  • A to G, chromosome 9 at 87,193,697 bp
  • C to T, chromosome 10 at 26,327,732 bp
  • T to A, chromosome 10 at 83,518,678 bp
  • A to G, chromosome 11 at 22,169,184 bp
  • A to T, chromosome 11 at 58,701,793 bp
  • G to A, chromosome 11 at 86,704,626 bp
  • C to T, chromosome 11 at 100,746,932 bp
  • A to T, chromosome 11 at 116,248,764 bp
  • G to T, chromosome 12 at 29,994,486 bp
  • A to G, chromosome 12 at 71,193,310 bp
  • A to T, chromosome 12 at 83,555,274 bp
  • A to G, chromosome 13 at 23,035,253 bp
  • G to T, chromosome 13 at 73,266,720 bp
  • A to G, chromosome 13 at 112,963,277 bp
  • A to T, chromosome 15 at 55,388,646 bp
  • G to A, chromosome 15 at 89,549,275 bp
  • A to G, chromosome 16 at 35,397,507 bp
  • C to T, chromosome 17 at 56,606,025 bp
  • A to G, chromosome 17 at 73,805,379 bp
  • C to T, chromosome 18 at 45,559,471 bp
  • T to A, chromosome 19 at 6,336,923 bp
  • T to A, chromosome 19 at 44,518,508 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0468 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
038668-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.