Strain Name:
C57BL/6J-MtgxR0470Btlr/Mmmh
Stock Number:
038670-MU
Citation ID:
RRID:MMRRC_038670-MU
Other Names:
R0470 (G1), C57BL/6J-MtgxR0470Btlr
Major Collection:

Gene Information

Tgfb1
Name: transforming growth factor, beta 1
Synonyms: TGF-beta 1, Tgfb-1, Tgfb, TGFbeta1, TGF-beta1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 21803
Homologene: 540
Slc27a4
Name: solute carrier family 27 (fatty acid transporter), member 4
Synonyms: fatty acid transport protein 4, FATP4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 26569
Homologene: 68437
Prrc1
Name: proline-rich coiled-coil 1
Synonyms: 2310058D16Rik, 9430085A19Rik, 3110038B19Rik, 1190002C06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 73137
VEGA: 18
Homologene: 12491
Atm
Name: ataxia telangiectasia mutated
Synonyms: C030026E19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 11920
HGNC: HGNC:795
Homologene: 30952
Shmt1
Name: serine hydroxymethyltransferase 1 (soluble)
Synonyms: mshmt2, mshmt1, mshmt, Shmt
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20425
Homologene: 3074
Ankrd12
Name: ankyrin repeat domain 12
Synonyms: ANCO-2, GAC-1, 2900001A12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 106585
Homologene: 9059
Mbnl2
Name: muscleblind like splicing factor 2
Synonyms: 1110002M11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 105559
VEGA: 14
Homologene: 76766
Sf3a2
Name: splicing factor 3a, subunit 2
Synonyms: SFA66, PRP11, Sap62, 66kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 20222
Homologene: 133823
Usp34
Name: ubiquitin specific peptidase 34
Synonyms: A530081C03Rik, Murr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 17847
Homologene: 40978
Cyth1
Name: cytohesin 1
Synonyms: CLM1, CTH-1, Pscd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 19157
HGNC: HGNC:9501
Homologene: 31262
Trim66
Name: tripartite motif-containing 66
Synonyms: D7H11orf29, Tif1d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 330627
Homologene: 28044
Bcl2
Name: B cell leukemia/lymphoma 2
Synonyms: Bcl-2, C430015F12Rik, D830018M01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12043
HGNC: HGNC:990
Homologene: 527
Kcnh5
Name: potassium voltage-gated channel, subfamily H (eag-related), member 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 238271
VEGA: 12
HGNC: HGNC:6254
Homologene: 15858
Lef1
Name: lymphoid enhancer binding factor 1
Synonyms: lymphoid enhancer factor 1, Lef-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 16842
HGNC: HGNC:6551
Homologene: 7813
Zranb1
Name: zinc finger, RAN-binding domain containing 1
Synonyms: D7Wsu87e, 9330160G10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 360216
Homologene: 9728
Setd1a
Name: SET domain containing 1A
Synonyms: KMT2F
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233904
Homologene: 52251
Sec13
Name: SEC13 homolog, nuclear pore and COPII coat complex component
Synonyms: 1110003H02Rik, Sec13r, Sec13l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 110379
Homologene: 6479
Dnah8
Name: dynein, axonemal, heavy chain 8
Synonyms: Hst6.7b, P1-Loop, Dnahc8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 13417
VEGA: 17
HGNC: HGNC:2952
Homologene: 1049
Nipal3
Name: NIPA-like domain containing 3
Synonyms: 9130020G22Rik, Npal3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 74552
Homologene: 10722
Ptov1
Name: prostate tumor over expressed gene 1
Synonyms: 1110030G05Rik, Gcap3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 84113
HGNC: HGNC:9632
Homologene: 9687
Ank
Name: progressive ankylosis
Synonyms: D15Ertd221e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 11732
Homologene: 10664
Scin
Name: scinderin
Synonyms: adseverin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 20259
Homologene: 36296
Ccn4
Name: cellular communication network factor 4
Synonyms: Elm1, CCN4, Wisp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 22402
Homologene: 2883
Vwf
Name: Von Willebrand factor
Synonyms: B130011O06Rik, 6820430P06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 22371
Homologene: 466
Vmn1r179
Name: vomeronasal 1 receptor 179
Synonyms: V1rd17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 404286
Homologene: 134022
Il17ra
Name: interleukin 17 receptor A
Synonyms: VDw217, Il17r
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 16172
HGNC: HGNC:5985
Homologene: 7378
Akr1c13
Name: aldo-keto reductase family 1, member C13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 27384
Homologene: 121208
Atp10b
Name: ATPase, class V, type 10B
Synonyms: 5930426O13Rik, 9030605H24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 319767
Homologene: 70969
Ahnak
Name: AHNAK nucleoprotein (desmoyokin)
Synonyms: DY6, 2310047C17Rik, 1110004P15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 66395
VEGA: 19
HGNC: HGNC:347
Homologene: 67425
Vmn1r231
Name: vomeronasal 1 receptor 231
Synonyms: V1re7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 171230
Tmc5
Name: transmembrane channel-like gene family 5
Synonyms: 4932443L08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74424
Homologene: 11713
Plekha6
Name: pleckstrin homology domain containing, family A member 6
Synonyms: Pepp3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 240753
Homologene: 135779
Ptk6
Name: PTK6 protein tyrosine kinase 6
Synonyms: Sik, Tksk
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20459
HGNC: HGNC:9617
Homologene: 68494
Zbtb6
Name: zinc finger and BTB domain containing 6
Synonyms: A830092L04Rik, Zfp482
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241322
Homologene: 4829
Minar2
Name: membrane integral NOTCH2 associated receptor 2
Synonyms: A730017C20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225583
Homologene: 18350
Herc6
Name: hect domain and RLD 6
Synonyms: 4930427L17Rik, 1700121D12Rik, CEB1, 2510038N07Rik, Herc5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 67138
Homologene: 70768
Cdadc1
Name: cytidine and dCMP deaminase domain containing 1
Synonyms: NYD-SP15, 2310010M10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 71891
VEGA: 14
Homologene: 12794
Lilrb4a
Name: leukocyte immunoglobulin-like receptor, subfamily B, member 4A
Synonyms: CD85K, ILT3, HM18, Gp49b, Lilrb4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 14728
VEGA: 10
HGNC: HGNC:6608
Homologene: 86756
Cilp2
Name: cartilage intermediate layer protein 2
Synonyms: CLIP-2, 1110031K21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 68709
Homologene: 17713
Hexb
Name: hexosaminidase B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 15212
VEGA: 13
HGNC: HGNC:4879
Homologene: 437
Slc41a2
Name: solute carrier family 41, member 2
Synonyms: A230035L05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 338365
Homologene: 9870
Sorcs3
Name: sortilin-related VPS10 domain containing receptor 3
Synonyms: 6330404A12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 66673
VEGA: 19
Homologene: 8986
Tspoap1
Name: TSPO associated protein 1
Synonyms: peripheral, Bzrap1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 207777
Homologene: 37961
Vmn1r71
Name: vomeronasal 1 receptor 71
Synonyms: V1re13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 252910
Homologene: 74352
Vmn2r109
Name: vomeronasal 2, receptor 109
Synonyms: EG627814
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 627814
Homologene: 129678
Cfhr2
Name: complement factor H-related 2
Synonyms: FHR-B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 545366
Homologene: 134349
Chp1
Name: calcineurin-like EF hand protein 1
Synonyms: Sid470p, 1500003O03Rik, vac
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 56398
Homologene: 5235
Prkar1b
Name: protein kinase, cAMP dependent regulatory, type I beta
Synonyms: RIbeta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 19085
HGNC: HGNC:9390
Homologene: 37665
Olfr441
Name: olfactory receptor 441
Synonyms: GA_x6K02T2P3E9-4442577-4441645, MOR261-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 258649
Homologene: 88438
Vmn1r62
Name: vomeronasal 1 receptor 62
Synonyms: V3R2, V1rd8, V1rd2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 81016
Homologene: 41799
Psg22
Name: pregnancy-specific glycoprotein 22
Synonyms: cea9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 243862
Homologene: 110989
Olfr640
Name: olfactory receptor 640
Synonyms: GA_x6K02T2PBJ9-6756759-6755815, MOR13-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258819
Homologene: 17404
Tex24
Name: testis expressed gene 24
Synonyms: TESF-1, 1700108N07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 541463
Trappc13
Name: trafficking protein particle complex 13
Synonyms: 2610524F24Rik, 2410002O22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 66975
Homologene: 11792
Gja3
Name: gap junction protein, alpha 3
Synonyms: connexin 46, alpha 3 connexin, Gja-3, Cx46
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 14611
VEGA: 14
HGNC: HGNC:4277
Homologene: 9670
Gsdmcl1
Name: gasdermin C-like 1
Synonyms: 1700022L20Rik, Gsdmdc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 74236
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 106,712,562 bp
  • G to A, chromosome 1 at 133,272,307 bp
  • A to T, chromosome 1 at 139,821,779 bp
  • T to A, chromosome 2 at 29,804,185 bp
  • A to C, chromosome 2 at 37,429,493 bp
  • C to T, chromosome 2 at 119,560,763 bp
  • T to C, chromosome 2 at 181,195,939 bp
  • T to C, chromosome 3 at 131,112,826 bp
  • A to G, chromosome 4 at 135,447,372 bp
  • A to G, chromosome 5 at 139,050,749 bp
  • C to G, chromosome 6 at 43,116,624 bp
  • C to T, chromosome 6 at 57,619,452 bp
  • T to C, chromosome 6 at 113,740,632 bp
  • T to G, chromosome 6 at 120,481,806 bp
  • G to A, chromosome 6 at 125,628,428 bp
  • T to A, chromosome 7 at 5,676,067 bp
  • G to C, chromosome 7 at 10,748,092 bp
  • A to C, chromosome 7 at 18,719,664 bp
  • A to C, chromosome 7 at 23,928,393 bp
  • T to A, chromosome 7 at 25,687,930 bp
  • A to G, chromosome 7 at 44,864,811 bp
  • A to T, chromosome 7 at 104,021,670 bp
  • A to G, chromosome 7 at 109,457,542 bp
  • A to G, chromosome 7 at 118,639,931 bp
  • G to A, chromosome 7 at 127,785,057 bp
  • G to T, chromosome 7 at 132,982,771 bp
  • C to T, chromosome 8 at 27,344,908 bp
  • A to T, chromosome 8 at 69,885,405 bp
  • A to T, chromosome 9 at 53,460,966 bp
  • T to A, chromosome 10 at 51,494,827 bp
  • G to A, chromosome 10 at 80,804,554 bp
  • T to C, chromosome 10 at 83,316,222 bp
  • C to T, chromosome 11 at 23,436,001 bp
  • T to A, chromosome 11 at 43,203,039 bp
  • T to C, chromosome 11 at 60,792,963 bp
  • T to C, chromosome 11 at 87,776,162 bp
  • T to C, chromosome 11 at 118,132,248 bp
  • A to C, chromosome 12 at 40,073,292 bp
  • G to A, chromosome 12 at 75,114,414 bp
  • T to A, chromosome 13 at 4,198,501 bp
  • A to G, chromosome 13 at 97,177,999 bp
  • C to T, chromosome 13 at 104,161,004 bp
  • T to C, chromosome 14 at 57,036,427 bp
  • A to T, chromosome 14 at 59,573,841 bp
  • A to T, chromosome 14 at 120,404,650 bp
  • G to A, chromosome 15 at 27,571,635 bp
  • C to T, chromosome 15 at 63,850,431 bp
  • A to G, chromosome 15 at 66,917,378 bp
  • T to C, chromosome 17 at 20,552,886 bp
  • G to A, chromosome 17 at 20,890,003 bp
  • T to A, chromosome 17 at 30,708,540 bp
  • T to C, chromosome 17 at 65,986,134 bp
  • C to T, chromosome 18 at 57,363,397 bp
  • C to T, chromosome 18 at 59,075,639 bp
  • T to G, chromosome 19 at 9,008,967 bp
  • T to C, chromosome 19 at 48,797,517 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0470 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
038670-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.