Strain Name:
C57BL/6J-MtgxR0552Btlr/Mmmh
Stock Number:
038744-MU
Citation ID:
RRID:MMRRC_038744-MU
Other Names:
R0552 (G1), C57BL/6J-MtgxR0552Btlr
Major Collection:

Gene Information

Sptbn1
Name: spectrin beta, non-erythrocytic 1
Synonyms: elf1, brain spectrin, elf3, spectrin G, non-erythrocytic, Spnb2, Spnb-2, 9930031C03Rik, beta fodrin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20742
Homologene: 2354
Tfap2b
Name: transcription factor AP-2 beta
Synonyms: AP-2(beta), E130018K07Rik, Tcfap2b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 21419
Homologene: 20688
Nmu
Name: neuromedin U
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 56183
HGNC: HGNC:7859
Homologene: 4863
Ssbp4
Name: single stranded DNA binding protein 4
Synonyms: 1210002E11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 76900
Homologene: 41881
Plekha1
Name: pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
Synonyms: TAPP1, C920009D07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 101476
Homologene: 11001
Hsd17b12
Name: hydroxysteroid (17-beta) dehydrogenase 12
Synonyms: keratonectin, keratoadhesin, 2610510O05Rik, KIK-I
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 56348
Homologene: 95094
Golga5
Name: golgi autoantigen, golgin subfamily a, 5
Synonyms: Ret-II
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 27277
VEGA: 12
HGNC: HGNC:4428
Homologene: 38009
Rufy3
Name: RUN and FYVE domain containing 3
Synonyms: D5Bwg0860e, 2810428M05Rik, 6330416M07Rik, Rpipx
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 52822
Homologene: 87809
Tango6
Name: transport and golgi organization 6
Synonyms: Tango6, Tmco7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 272538
Homologene: 52121
Txlna
Name: taxilin alpha
Synonyms: IL14, 2600010N21Rik, Txln
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 109658
Homologene: 14062
Ralgapa1
Name: Ral GTPase activating protein, alpha subunit 1
Synonyms: Tulip1, 4930400K19Rik, Garnl1, 2310003F20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 56784
VEGA: 12
Homologene: 84805
Pyroxd1
Name: pyridine nucleotide-disulphide oxidoreductase domain 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232491
Homologene: 11758
Myh14
Name: myosin, heavy polypeptide 14
Synonyms: 2400004E04Rik, NMHC II-C
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 71960
Homologene: 23480
Slit2
Name: slit guidance ligand 2
Synonyms: b2b1200.1Clo, E030015M03Rik, E130320P19Rik, Drad-1, Slil3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 20563
Homologene: 3516
Clca4b
Name: chloride channel accessory 4B
Synonyms: AI747448
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 99709
HGNC: HGNC:2018
Homologene: 40808
Muc20
Name: mucin 20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224116
Homologene: 17135
Pbrm1
Name: polybromo 1
Synonyms: 2310032M22Rik, 2610016F04Rik, Pb1, BAF180
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 66923
Homologene: 10044
Rasgef1b
Name: RasGEF domain family, member 1B
Synonyms: Gpig4, 4732452O09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 320292
Homologene: 14860
Col1a2
Name: collagen, type I, alpha 2
Synonyms: Cola-2, Col1a-2, Cola2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12843
HGNC: HGNC:2198
Homologene: 69
Syne2
Name: spectrin repeat containing, nuclear envelope 2
Synonyms: Nesp2g, nesprin-2, syne-2, Cpfl8, diminished cone electroretinogram, 6820443O06Rik, dice, D12Ertd777e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 319565
Homologene: 56700
Pkhd1l1
Name: polycystic kidney and hepatic disease 1-like 1
Synonyms: D86 mRNA, PKHDL1, fibrocystin L
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 192190
Homologene: 16332
Wdr17
Name: WD repeat domain 17
Synonyms: B230207L18Rik, 3010002I12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244484
Homologene: 12460
Neb
Name: nebulin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17996
HGNC: HGNC:7720
Homologene: 136285
Ptpro
Name: protein tyrosine phosphatase, receptor type, O
Synonyms: Ptpn15, GLEPP1, PTP-U2, PTP-BK, PTP-phi, PTPROt, D28, PTP-oc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 19277
HGNC: HGNC:9678
Homologene: 21564
Pde8a
Name: phosphodiesterase 8A
Synonyms: Pde8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18584
HGNC: HGNC:8793
Homologene: 1957
Tns1
Name: tensin 1
Synonyms: E030018G17Rik, 1200014E20Rik, E030037J05Rik, 1110018I21Rik, Tns
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 21961
Homologene: 11219
Mppe1
Name: metallophosphoesterase 1
Synonyms: Pgap5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225651
VEGA: 18
Homologene: 41512
Tmprss15
Name: transmembrane protease, serine 15
Synonyms: A130097D21Rik, enteropeptidase, Prss7, enterokinase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 19146
HGNC: HGNC:9490
Homologene: 2075
Adam9
Name: a disintegrin and metallopeptidase domain 9 (meltrin gamma)
Synonyms: MDC9, Mltng, MDC9, Mltng
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 11502
HGNC: HGNC:216
Homologene: 20824
Vmn2r92
Name: vomeronasal 2, receptor 92
Synonyms: EG627111
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 627111
Homologene: 115024
Ablim3
Name: actin binding LIM protein family, member 3
Synonyms: D930036B08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 319713
VEGA: 18
Homologene: 69175
Dab2
Name: disabled 2, mitogen-responsive phosphoprotein
Synonyms: 5730435J12Rik, D15Wsu122e, D630005B22Rik, p96
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 13132
HGNC: HGNC:2662
Homologene: 1026
Cacna2d1
Name: calcium channel, voltage-dependent, alpha2/delta subunit 1
Synonyms: Cchl2a, Cacna2, Ca(v)alpha2delta1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 12293
HGNC: HGNC:1399
Homologene: 579
Kbtbd10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Plxnc1
Name: plexin C1
Synonyms: vespr, CD232, 2510048K12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 54712
HGNC: HGNC:9106
Homologene: 4211
Zfp563
Name: zinc finger protein 563
Synonyms: zinc finger protein, Zfp413
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 240068
Homologene: 77346
C9
Name: complement component 9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 12279
HGNC: HGNC:1358
Homologene: 74406
Gm4737
Name: predicted gene 4737
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 11615
VEGA: 16
Olfr482
Name: olfactory receptor 482
Synonyms: MOR204-14, GA_x6K02T2PBJ9-10424354-10423383
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258728
Homologene: 133604
Inf2
Name: inverted formin, FH2 and WH2 domain containing
Synonyms: EG629699, 2610204M08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 70435
VEGA: 12
Homologene: 82406
Kcnh3
Name: potassium voltage-gated channel, subfamily H (eag-related), member 3
Synonyms: Elk2, Melk2, C030044P22Rik, ether a go-go like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 16512
VEGA: 15
HGNC: HGNC:6252
Homologene: 32150
Tlr5
Name: toll-like receptor 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 53791
Homologene: 20698
Try4
Name: trypsin 4
Synonyms: 0910001B19Rik, Td
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 22074
HGNC: HGNC:9486
Homologene: 106639
Klhdc8b
Name: kelch domain containing 8B
Synonyms: 4931406O17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 78267
Homologene: 45463
Olfr418
Name: olfactory receptor 418
Synonyms: Olfr418-ps1, MOR267-8, GA_x6K02T2R7CC-581296-580364, MOR267-12P, Olfr1403, GA_x6K02T2P20D-20826777-20827719
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 258645
HGNC: HGNC:8175
Homologene: 8218
Phyh
Name: phytanoyl-CoA hydroxylase
Synonyms: Lnap1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16922
HGNC: HGNC:8940
Homologene: 4530
Lcn3
Name: lipocalin 3
Synonyms: Vnsp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16820
Homologene: 74958
Olfr1257
Name: olfactory receptor 1257
Synonyms: GA_x6K02T2Q125-51319458-51320387, MOR232-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258984
Homologene: 115501
Arsj
Name: arylsulfatase J
Synonyms: 9330196J05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 271970
Homologene: 35257
Akr1b10
Name: aldo-keto reductase family 1, member B10 (aldose reductase)
Synonyms: 2310005E10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 67861
Homologene: 128412
4921507P07Rik
Name: RIKEN cDNA 4921507P07 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 70821
Homologene: 69433
E430018J23Rik
Name: RIKEN cDNA E430018J23 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 101604
Homologene: 138471
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 19,234,225 bp
  • A to T, chromosome 1 at 73,920,563 bp
  • T to C, chromosome 1 at 173,270,805 bp
  • A to G, chromosome 1 at 182,975,696 bp
  • A to G, chromosome 2 at 4,936,101 bp
  • T to C, chromosome 2 at 25,766,409 bp
  • T to C, chromosome 2 at 52,148,756 bp
  • G to A, chromosome 2 at 69,670,210 bp
  • C to T, chromosome 2 at 89,880,891 bp
  • A to T, chromosome 2 at 94,043,935 bp
  • A to G, chromosome 3 at 126,439,344 bp
  • C to T, chromosome 3 at 144,916,775 bp
  • A to T, chromosome 4 at 129,629,191 bp
  • A to G, chromosome 5 at 16,328,043 bp
  • A to T, chromosome 5 at 48,238,379 bp
  • A to T, chromosome 5 at 76,344,107 bp
  • A to G, chromosome 5 at 88,584,270 bp
  • T to C, chromosome 5 at 99,221,350 bp
  • A to G, chromosome 6 at 4,516,960 bp
  • A to G, chromosome 6 at 34,392,985 bp
  • T to A, chromosome 6 at 41,302,337 bp
  • C to T, chromosome 6 at 50,584,528 bp
  • T to A, chromosome 6 at 137,443,594 bp
  • A to G, chromosome 6 at 142,345,737 bp
  • T to C, chromosome 7 at 44,613,681 bp
  • A to G, chromosome 7 at 81,317,347 bp
  • A to G, chromosome 7 at 108,094,778 bp
  • A to T, chromosome 7 at 127,392,332 bp
  • T to C, chromosome 7 at 130,882,399 bp
  • A to T, chromosome 8 at 24,963,010 bp
  • C to T, chromosome 8 at 54,693,096 bp
  • A to G, chromosome 8 at 70,599,859 bp
  • G to T, chromosome 8 at 106,747,279 bp
  • G to C, chromosome 9 at 108,449,223 bp
  • A to T, chromosome 10 at 94,833,701 bp
  • A to G, chromosome 11 at 30,145,985 bp
  • G to T, chromosome 12 at 55,676,765 bp
  • A to G, chromosome 12 at 75,931,004 bp
  • A to T, chromosome 12 at 102,484,493 bp
  • A to G, chromosome 12 at 112,612,574 bp
  • T to A, chromosome 14 at 31,035,959 bp
  • C to T, chromosome 15 at 6,435,414 bp
  • A to T, chromosome 15 at 6,445,437 bp
  • T to C, chromosome 15 at 44,489,546 bp
  • T to A, chromosome 15 at 99,229,456 bp
  • G to A, chromosome 16 at 32,793,930 bp
  • T to A, chromosome 16 at 46,154,592 bp
  • C to T, chromosome 16 at 79,024,749 bp
  • A to T, chromosome 17 at 18,168,964 bp
  • A to T, chromosome 17 at 33,104,685 bp
  • T to C, chromosome 18 at 61,871,560 bp
  • A to G, chromosome 18 at 67,237,348 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0552 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
038744-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.