Strain Name:
C57BL/6J-MtgxR0733Btlr/Mmmh
Stock Number:
038914-MU
Citation ID:
RRID:MMRRC_038914-MU
Other Names:
R0733 (G1), C57BL/6J-MtgxR0733Btlr
Major Collection:

Strain Information

Hprt
Name: hypoxanthine guanine phosphoribosyl transferase
Synonyms: Hprt1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 15452
HGNC: HGNC:5157
Homologene: 56590
Inpp5d
Name: inositol polyphosphate-5-phosphatase D
Synonyms: SHIP, Src homology 2 domain-containing inositol-5-phosphatase, s-SHIP, SHIP-1, SHIP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 16331
HGNC: HGNC:6079
Homologene: 4046
Fastk
Name: Fas-activated serine/threonine kinase
Synonyms: 0610011K02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 66587
Homologene: 4884
Zfp113
Name: zinc finger protein 113
Synonyms: 4732456B05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 56314
Homologene: 50027
Wdr47
Name: WD repeat domain 47
Synonyms: 1810073M12Rik, nemitin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 99512
Homologene: 8984
Eml4
Name: echinoderm microtubule associated protein like 4
Synonyms: 4930443C24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 78798
VEGA: 17
HGNC: HGNC:1316
Homologene: 56841
Mllt10
Name: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10
Synonyms: Af10, D630001B22Rik, B130021D15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17354
Homologene: 20973
Ltn1
Name: listerin E3 ubiquitin protein ligase 1
Synonyms: 4930528H02Rik, Zfp294, Listerin, Rnf160
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 78913
VEGA: 16
Homologene: 32272
Ube2k
Name: ubiquitin-conjugating enzyme E2K
Synonyms: D5Ertd601e, Hip2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 53323
HGNC: HGNC:4914
Homologene: 3903
Kntc1
Name: kinetochore associated 1
Synonyms: jgl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 208628
Homologene: 32227
Cobl
Name: cordon-bleu WH2 repeat
Synonyms: C530045F18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 12808
Homologene: 9058
Acbd3
Name: acyl-Coenzyme A binding domain containing 3
Synonyms: Pap7, 8430407O11Rik, D1Ertd10e, Gocap1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 170760
Homologene: 11227
Mcm5
Name: minichromosome maintenance complex component 5
Synonyms: mCD46, Cdc46, Mcmd5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 17218
HGNC: HGNC:6948
Homologene: 4904
Kctd3
Name: potassium channel tetramerisation domain containing 3
Synonyms: NY-REN-45, E330032J19Rik, 4930438A20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226823
Homologene: 9395
Nbr1
Name: NBR1, autophagy cargo receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 17966
HGNC: HGNC:6746
Homologene: 7438
Abl1
Name: c-abl oncogene 1, non-receptor tyrosine kinase
Synonyms: c-Abl, E430008G22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 11350
HGNC: HGNC:76
Homologene: 3783
Exosc4
Name: exosome component 4
Synonyms: 1500001N04Rik, 1110039I09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 109075
Homologene: 6017
Clcc1
Name: chloride channel CLIC-like 1
Synonyms: Mclc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229725
Homologene: 9032
Nkiras2
Name: NFKB inhibitor interacting Ras-like protein 2
Synonyms: 4930527H08Rik, KBRAS2, 2410003M04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 71966
Homologene: 9738
Lama5
Name: laminin, alpha 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16776
HGNC: HGNC:6485
Homologene: 4060
Tent2
Name: terminal nucleotidyltransferase 2
Synonyms: 8030446C20Rik, Papd4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 100715
VEGA: 13
Homologene: 44022
Snrnp40
Name: small nuclear ribonucleoprotein 40 (U5)
Synonyms: 0610009C03Rik, Wdr57
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 66585
Homologene: 3538
Dera
Name: deoxyribose-phosphate aldolase (putative)
Synonyms: 2010002D22Rik, 2500002K03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232449
Homologene: 14562
Snx27
Name: sorting nexin family member 27
Synonyms: ESTM47, 5730552M22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 76742
Homologene: 12797
Lrp3
Name: low density lipoprotein receptor-related protein 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 435965
HGNC: HGNC:6695
Homologene: 1745
Ddr2
Name: discoidin domain receptor family, member 2
Synonyms: Ntrkr3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 18214
HGNC: HGNC:2731
Homologene: 68505
Lcn5
Name: lipocalin 5
Synonyms: MEP10, mE-RABP, Erabp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 13863
Homologene: 7305
Sh3rf1
Name: SH3 domain containing ring finger 1
Synonyms: Posh, 2200003J05Rik, Sh3md2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 59009
Homologene: 10988
Serpinb6e
Name: serine (or cysteine) peptidase inhibitor, clade B, member 6e
Synonyms: ovalbumin, SPI3B, Gm11396
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 435350
HGNC: HGNC:8950
Homologene: 50933
Gstt4
Name: glutathione S-transferase, theta 4
Synonyms: 4930583C14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 75886
Homologene: 57104
4931408C20Rik
Name: RIKEN cDNA 4931408C20 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 210940
Homologene: 86827
St8sia2
Name: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
Synonyms: ST8SiaII, Siat8b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20450
Homologene: 4384
Fem1b
Name: fem 1 homolog b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 14155
VEGA: 9
HGNC: HGNC:3649
Homologene: 7714
AU018091
Name: expressed sequence AU018091
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 245128
Homologene: 106376
Col4a1
Name: collagen, type IV, alpha 1
Synonyms: Col4a-1, Del(8)Bru44H, Del(8)44H, Bru, Svc, Raw, alpha1(IV) collagen
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 12826
HGNC: HGNC:2202
Homologene: 20437
Ube2m
Name: ubiquitin-conjugating enzyme E2M
Synonyms: UBC12, Ubc-rs2, 2510040H03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 22192
Homologene: 2952
Paox
Name: polyamine oxidase (exo-N4-amino)
Synonyms: Pao, 2410012F02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 212503
Homologene: 72096
Fam171a2
Name: family with sequence similarity 171, member A2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217219
Homologene: 19144
Nlrp4d
Name: NLR family, pyrin domain containing 4D
Synonyms: Nalp-beta, Nalp4d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 384752
Sun1
Name: Sad1 and UNC84 domain containing 1
Synonyms: 4632417G13Rik, 5730434D03Rik, Unc84a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 77053
Homologene: 11544
Vmn2r27
Name: vomeronasal 2, receptor27
Synonyms: EG232367
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232367
Dsg1a
Name: desmoglein 1 alpha
Synonyms: Dsg1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 13510
HGNC: HGNC:3048
Homologene: 1463
Rwdd3
Name: RWD domain containing 3
Synonyms: 3110037C01Rik, 2510027J23Rik, RSUME
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 66568
Homologene: 22899
Spsb1
Name: splA/ryanodine receptor domain and SOCS box containing 1
Synonyms: 1110014L01Rik, SSB1, 4930422J18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 74646
Homologene: 11832
Slc28a1
Name: solute carrier family 28 (sodium-coupled nucleoside transporter), member 1
Synonyms: Cnt1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 434203
Homologene: 37902
Cdh26
Name: cadherin-like 26
Synonyms: LOC381409
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 381409
Homologene: 18643
Ints6l
Name: integrator complex subunit 6 like
Synonyms: 4930535D10Rik, 6330505F04Rik, Ddx26b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 236790
Homologene: 52110
Prss54
Name: protease, serine 54
Synonyms: 4931432M23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 70993
Homologene: 19278
Slco6d1
Name: solute carrier organic anion transporter family, member 6d1
Synonyms: 4921511I05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 70866
Homologene: 86643
Prpsap2
Name: phosphoribosyl pyrophosphate synthetase-associated protein 2
Synonyms: A230054F23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 212627
HGNC: HGNC:9467
Homologene: 2073
Apba2
Name: amyloid beta (A4) precursor protein-binding, family A, member 2
Synonyms: X11-like, X11L, Mint 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 11784
HGNC: HGNC:579
Homologene: 4021
Dus2
Name: dihydrouridine synthase 2
Synonyms: 2310016K04Rik, Dus2l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 66369
Homologene: 6838
Ears2
Name: glutamyl-tRNA synthetase 2, mitochondrial
Synonyms: 3230401I01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 67417
Homologene: 6907
Nppc
Name: natriuretic peptide type C
Synonyms: natriuretic peptide precursor C, CNP, lbab
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 18159
HGNC: HGNC:7941
Homologene: 7867
Castor2
Name: cytosolic arginine sensor for mTORC1 subunit 2
Synonyms: Gats, Gatsl2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 80909
Homologene: 84866
Ormdl2
Name: ORM1-like 2 (S. cerevisiae)
Synonyms: 0610012C09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 66844
VEGA: 10
Homologene: 39087
Prl7a2
Name: prolactin family 7, subfamily a, member 2
Synonyms: PLP-F, Prlpf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 19114
HGNC: HGNC:9445
Homologene: 49263
Fut11
Name: fucosyltransferase 11
Synonyms: 3110009G03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 73068
VEGA: 14
Homologene: 18313
Gm6797
Name: predicted pseudogene 6797
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 387284
Homologene: 85956
Scml2
Name: Scm polycomb group protein like 2
Synonyms: 4932420G07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 107815
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 26,682,932 bp
  • T to C, chromosome 1 at 86,669,634 bp
  • T to A, chromosome 1 at 87,668,077 bp
  • T to A, chromosome 1 at 98,428,269 bp
  • A to G, chromosome 1 at 170,004,812 bp
  • A to G, chromosome 1 at 180,752,218 bp
  • A to G, chromosome 1 at 188,997,050 bp
  • A to G, chromosome 2 at 18,203,766 bp
  • G to T, chromosome 2 at 25,661,101 bp
  • A to G, chromosome 2 at 31,778,945 bp
  • T to C, chromosome 2 at 178,486,931 bp
  • A to T, chromosome 2 at 180,180,718 bp
  • A to G, chromosome 3 at 94,562,013 bp
  • A to T, chromosome 3 at 108,618,623 bp
  • A to G, chromosome 3 at 108,674,740 bp
  • T to C, chromosome 3 at 121,171,607 bp
  • C to G, chromosome 4 at 130,378,043 bp
  • C to T, chromosome 4 at 149,906,917 bp
  • A to C, chromosome 5 at 24,443,923 bp
  • A to G, chromosome 5 at 65,581,452 bp
  • G to T, chromosome 5 at 123,790,916 bp
  • T to C, chromosome 5 at 134,136,215 bp
  • A to G, chromosome 5 at 138,145,583 bp
  • A to G, chromosome 5 at 139,231,163 bp
  • A to T, chromosome 6 at 124,192,188 bp
  • C to A, chromosome 6 at 137,796,848 bp
  • A to G, chromosome 7 at 3,159,161 bp
  • T to A, chromosome 7 at 10,382,522 bp
  • C to A, chromosome 7 at 13,035,752 bp
  • A to T, chromosome 7 at 35,202,120 bp
  • T to C, chromosome 7 at 64,750,164 bp
  • C to T, chromosome 7 at 73,960,840 bp
  • T to C, chromosome 7 at 81,124,900 bp
  • T to A, chromosome 7 at 122,048,129 bp
  • G to C, chromosome 7 at 140,127,527 bp
  • C to T, chromosome 8 at 11,218,934 bp
  • G to A, chromosome 8 at 61,372,560 bp
  • A to G, chromosome 8 at 75,127,248 bp
  • T to C, chromosome 8 at 95,559,740 bp
  • G to T, chromosome 8 at 106,046,070 bp
  • G to T, chromosome 9 at 62,796,843 bp
  • T to C, chromosome 10 at 75,817,314 bp
  • T to A, chromosome 10 at 128,819,999 bp
  • C to T, chromosome 11 at 12,365,167 bp
  • A to G, chromosome 11 at 61,741,000 bp
  • T to C, chromosome 11 at 100,624,932 bp
  • T to A, chromosome 11 at 101,576,371 bp
  • T to A, chromosome 11 at 102,439,722 bp
  • T to C, chromosome 13 at 27,662,688 bp
  • T to A, chromosome 13 at 33,841,218 bp
  • T to A, chromosome 13 at 93,155,039 bp
  • C to A, chromosome 14 at 20,695,359 bp
  • A to T, chromosome 15 at 76,329,416 bp
  • T to A, chromosome 16 at 87,412,507 bp
  • T to A, chromosome 17 at 83,454,464 bp
  • A to C, chromosome 18 at 20,338,668 bp
  • T to C, chromosome X at 8,645,149 bp
  • G to A, chromosome X at 53,002,150 bp
  • T to A, chromosome X at 56,501,748 bp
  • C to G, chromosome X at 56,504,812 bp
  • A to G, chromosome X at 161,243,557 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0733 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
038914-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.